메뉴 건너뛰기




Volumn 9, Issue 7, 2014, Pages

Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple Cullin ligases

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FACTOR; CLASPIN; CULLIN 1 LIGASE; CULLIN 2 LIGASE; CULLIN 4 LIGASE; CULLIN LIGASE; LIGASE; PROTEIN P21; RAD51 PROTEIN; REGULATOR PROTEIN; REPLICATION LICENSING FACTOR CDT1; REPLICATION LICENSING FACTOR CDT2; SMALL INTERFERING RNA; UBE2M; UBIQUITIN CONJUGATING ENZYME E2; UNCLASSIFIED DRUG; CDT1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CUL2 PROTEIN, HUMAN; CULLIN; DTL PROTEIN, HUMAN; NUCLEAR PROTEIN; UBE2M PROTEIN, HUMAN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

EID: 84904263051     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101844     Document Type: Article
Times cited : (29)

References (60)
  • 1
    • 60549091914 scopus 로고    scopus 로고
    • E2- RING expansion of the NEDD8 cascade confers specificity to cullin modification
    • Huang DT, Ayrault O, Hunt HW, Taherbhoy AM, Duda DM, et al. (2009) E2- RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell 33: 483-495.
    • (2009) Mol Cell , vol.33 , pp. 483-495
    • Huang, D.T.1    Ayrault, O.2    Hunt, H.W.3    Taherbhoy, A.M.4    Duda, D.M.5
  • 2
    • 84876849263 scopus 로고    scopus 로고
    • RNF111-dependent neddylation activates DNA damage-induced ubiquitination
    • Ma T, Chen Y, Zhang F, Yang CY, Wang S, et al. (2013) RNF111-dependent neddylation activates DNA damage-induced ubiquitination. Mol Cell 49: 897- 907.
    • (2013) Mol Cell , vol.49 , pp. 897-907
    • Ma, T.1    Chen, Y.2    Zhang, F.3    Yang, C.Y.4    Wang, S.5
  • 3
    • 3142570737 scopus 로고    scopus 로고
    • Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
    • DOI 10.1016/j.cell.2004.06.016, PII S0092867404005859
    • Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP (2004) Mdm2- mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 118: 83-97. (Pubitemid 38902816)
    • (2004) Cell , vol.118 , Issue.1 , pp. 83-97
    • Xirodimas, D.P.1    Saville, M.K.2    Bourdon, J.-C.3    Hay, R.T.4    Lane, D.P.5
  • 5
    • 84934876123 scopus 로고    scopus 로고
    • Control of cullin-ring ubiquitin ligase activity by nedd8
    • Deshaies RJ, Emberley ED, Saha A (2010) Control of cullin-ring ubiquitin ligase activity by nedd8. Subcell Biochem 54: 41-56.
    • (2010) Subcell Biochem , vol.54 , pp. 41-56
    • Deshaies, R.J.1    Emberley, E.D.2    Saha, A.3
  • 6
    • 0141493447 scopus 로고    scopus 로고
    • BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
    • DOI 10.1038/nature01985
    • Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, et al. (2003) BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 425: 316-321. (Pubitemid 37158409)
    • (2003) Nature , vol.425 , Issue.6955 , pp. 316-321
    • Xu, L.1    Wei, Y.2    Reboul, J.3    Vaglio, P.4    Shin, T.-H.5    Vidal, M.6    Elledge, S.J.7    Harper, J.W.8
  • 7
    • 34250318465 scopus 로고    scopus 로고
    • DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase
    • DOI 10.1016/j.molcel.2007.06.001, PII S1097276507003619
    • Lee J, Zhou P (2007) DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase. Mol Cell 26: 775-780. (Pubitemid 46921011)
    • (2007) Molecular Cell , vol.26 , Issue.6 , pp. 775-780
    • Lee, J.1    Zhou, P.2
  • 11
    • 84871975033 scopus 로고    scopus 로고
    • CRL Ubiquitin Ligases and DNA Damage Response
    • Li JM, Jin J (2012) CRL Ubiquitin Ligases and DNA Damage Response. Front Oncol 2: 29.
    • (2012) Front Oncol , vol.2 , pp. 29
    • Li, J.M.1    Jin, J.2
  • 12
    • 84904261166 scopus 로고    scopus 로고
    • Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy
    • Zhao Y, Morgan MA, Sun Y (2014) Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy. Antioxid Redox Signal.
    • (2014) Antioxid Redox Signal
    • Zhao, Y.1    Morgan, M.A.2    Sun, Y.3
  • 13
    • 84856709112 scopus 로고    scopus 로고
    • SCF ubiquitin ligases in the maintenance of genome stability
    • Silverman JS, Skaar JR, Pagano M (2012) SCF ubiquitin ligases in the maintenance of genome stability. Trends Biochem Sci 37: 66-73.
    • (2012) Trends Biochem Sci , vol.37 , pp. 66-73
    • Silverman, J.S.1    Skaar, J.R.2    Pagano, M.3
  • 15
    • 61849128915 scopus 로고    scopus 로고
    • Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis
    • Kee Y, Kim JM, D'Andrea AD (2009) Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. Genes Dev 23: 555-560.
    • (2009) Genes Dev , vol.23 , pp. 555-560
    • Kee, Y.1    Kim, J.M.2    D'Andrea, A.D.3
  • 16
    • 33746413746 scopus 로고    scopus 로고
    • betaTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response
    • DOI 10.1016/j.molcel.2006.06.013, PII S109727650600428X
    • Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, et al. (2006) SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell 23: 319-329. (Pubitemid 44128849)
    • (2006) Molecular Cell , vol.23 , Issue.3 , pp. 319-329
    • Peschiaroli, A.1    Dorrello, N.V.2    Guardavaccaro, D.3    Venere, M.4    Halazonetis, T.5    Sherman, N.E.6    Pagano, M.7
  • 17
    • 33746429958 scopus 로고    scopus 로고
    • betaTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress
    • DOI 10.1016/j.molcel.2006.06.016, PII S109727650600431X
    • Mailand N, Bekker-Jensen S, Bartek J, Lukas J (2006) Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell 23: 307-318. (Pubitemid 44128852)
    • (2006) Molecular Cell , vol.23 , Issue.3 , pp. 307-318
    • Mailand, N.1    Bekker-Jensen, S.2    Bartek, J.3    Lukas, J.4
  • 18
    • 84868623430 scopus 로고    scopus 로고
    • DNA damage-induced activation of ATM promotes beta-TRCP-mediated Mdm2 ubiquitination and destruction
    • Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, et al. (2012) DNA damage-induced activation of ATM promotes beta-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget 3: 1026-1035.
    • (2012) Oncotarget , vol.3 , pp. 1026-1035
    • Wang, Z.1    Inuzuka, H.2    Zhong, J.3    Fukushima, H.4    Wan, L.5
  • 22
    • 33744781568 scopus 로고    scopus 로고
    • Histone H3 and H4 Ubiquitylation by the CUL4-DDB-ROC1 Ubiquitin Ligase Facilitates Cellular Response to DNA Damage
    • DOI 10.1016/j.molcel.2006.03.035, PII S1097276506002309
    • Wang H, Zhai L, Xu J, Joo HY, Jackson S, et al. (2006) Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell 22: 383-394. (Pubitemid 44308132)
    • (2006) Molecular Cell , vol.22 , Issue.3 , pp. 383-394
    • Wang, H.1    Zhai, L.2    Xu, J.3    Joo, H.-Y.4    Jackson, S.5    Erdjument-Bromage, H.6    Tempst, P.7    Xiong, Y.8    Zhang, Y.9
  • 23
    • 77957378110 scopus 로고    scopus 로고
    • CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
    • Abbas T, Shibata E, Park J, Jha S, Karnani N, et al. (2010) CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Mol Cell 40: 9-21.
    • (2010) Mol Cell , vol.40 , pp. 9-21
    • Abbas, T.1    Shibata, E.2    Park, J.3    Jha, S.4    Karnani, N.5
  • 24
    • 11844273174 scopus 로고    scopus 로고
    • Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts
    • DOI 10.1101/gad.1255805
    • Arias EE, Walter JC (2005) Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev 19: 114-126. (Pubitemid 40095821)
    • (2005) Genes and Development , vol.19 , Issue.1 , pp. 114-126
    • Arias, E.E.1    Walter, J.C.2
  • 25
    • 77957367739 scopus 로고    scopus 로고
    • CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase
    • Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, et al. (2010) CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell 40: 22-33.
    • (2010) Mol Cell , vol.40 , pp. 22-33
    • Centore, R.C.1    Havens, C.G.2    Manning, A.L.3    Li, J.M.4    Flynn, R.L.5
  • 26
    • 0242525214 scopus 로고    scopus 로고
    • Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint
    • DOI 10.1038/ncb1061
    • Higa LA, Mihaylov IS, Banks DP, Zheng J, Zhang H (2003) Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat Cell Biol 5: 1008-1015. (Pubitemid 37406915)
    • (2003) Nature Cell Biology , vol.5 , Issue.11 , pp. 1008-1015
    • Higa, L.A.A.1    Mihaylov, I.S.2    Banks, D.P.3    Zheng, J.4    Zhang, H.5
  • 27
    • 5444274523 scopus 로고    scopus 로고
    • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage
    • DOI 10.1038/ncb1172
    • Hu J, McCall CM, Ohta T, Xiong Y (2004) Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol 6: 1003-1009. (Pubitemid 39359854)
    • (2004) Nature Cell Biology , vol.6 , Issue.10 , pp. 1003-1009
    • Hu, J.1    McCall, C.M.2    Ohta, T.3    Xiong, Y.4
  • 28
    • 33747873322 scopus 로고    scopus 로고
    • A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1
    • DOI 10.1016/j.molcel.2006.08.010, PII S1097276506005703
    • Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006) A family of diverse Cul4- Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell 23: 709-721. (Pubitemid 44292562)
    • (2006) Molecular Cell , vol.23 , Issue.5 , pp. 709-721
    • Jin, J.1    Arias, E.E.2    Chen, J.3    Harper, J.W.4    Walter, J.C.5
  • 29
    • 78651330886 scopus 로고    scopus 로고
    • SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
    • Jorgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, et al. (2011) SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol 192: 43-54.
    • (2011) J Cell Biol , vol.192 , pp. 43-54
    • Jorgensen, S.1    Eskildsen, M.2    Fugger, K.3    Hansen, L.4    Larsen, M.S.5
  • 30
    • 51949112601 scopus 로고    scopus 로고
    • The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing
    • Kim Y, Starostina NG, Kipreos ET (2008) The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev 22: 2507-2519.
    • (2008) Genes Dev , vol.22 , pp. 2507-2519
    • Kim, Y.1    Starostina, N.G.2    Kipreos, E.T.3
  • 31
    • 64749098830 scopus 로고    scopus 로고
    • An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
    • Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, et al. (2009) An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 458: 732-736.
    • (2009) Nature , vol.458 , pp. 732-736
    • Soucy, T.A.1    Smith, P.G.2    Milhollen, M.A.3    Berger, A.J.4    Gavin, J.M.5
  • 32
    • 78650355357 scopus 로고    scopus 로고
    • NEDD8- targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells
    • Lin JJ, Milhollen MA, Smith PG, Narayanan U, Dutta A (2010) NEDD8- targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells. Cancer Res 70: 10310-10320.
    • (2010) Cancer Res , vol.70 , pp. 10310-10320
    • Lin, J.J.1    Milhollen, M.A.2    Smith, P.G.3    Narayanan, U.4    Dutta, A.5
  • 33
    • 84863380384 scopus 로고    scopus 로고
    • The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme
    • Yang D, Tan M, Wang G, Sun Y (2012) The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. PLoS One 7: e34079.
    • (2012) PLoS One , vol.7
    • Yang, D.1    Tan, M.2    Wang, G.3    Sun, Y.4
  • 34
    • 79958165085 scopus 로고    scopus 로고
    • Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression
    • Jia L, Li H, Sun Y (2011) Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression. Neoplasia 13: 561-569.
    • (2011) Neoplasia , vol.13 , pp. 561-569
    • Jia, L.1    Li, H.2    Sun, Y.3
  • 35
    • 84863370346 scopus 로고    scopus 로고
    • Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents
    • Kee Y, Huang M, Chang S, Moreau LA, Park E, et al. (2012) Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents. Mol Cancer Res 10: 369-377.
    • (2012) Mol Cancer Res , vol.10 , pp. 369-377
    • Kee, Y.1    Huang, M.2    Chang, S.3    Moreau, L.A.4    Park, E.5
  • 36
    • 84879849959 scopus 로고    scopus 로고
    • Disrupting protein NEDDylation with MLN4924 is a novel strategy to target cisplatin resistance in ovarian cancer
    • Nawrocki ST, Kelly KR, Smith PG, Espitia CM, Possemato A, et al. (2013) Disrupting protein NEDDylation with MLN4924 is a novel strategy to target cisplatin resistance in ovarian cancer. Clin Cancer Res 19: 3577-3590.
    • (2013) Clin Cancer Res , vol.19 , pp. 3577-3590
    • Nawrocki, S.T.1    Kelly, K.R.2    Smith, P.G.3    Espitia, C.M.4    Possemato, A.5
  • 37
    • 84885674162 scopus 로고    scopus 로고
    • Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924
    • Jazaeri AA, Shibata E, Park J, Bryant JL, Conaway MR, et al. (2013) Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924. Mol Cancer Ther 12: 1958-1967.
    • (2013) Mol Cancer Ther , vol.12 , pp. 1958-1967
    • Jazaeri, A.A.1    Shibata, E.2    Park, J.3    Bryant, J.L.4    Conaway, M.R.5
  • 38
    • 84902667412 scopus 로고    scopus 로고
    • Nedd8- Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2 and Chromatin Dynamics Pathways
    • Garcia K, Blank JL, Bouck DC, Liu XJ, Sappal DS, et al. (2014) Nedd8- Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2 and Chromatin Dynamics Pathways. Mol Cancer Ther.
    • (2014) Mol Cancer Ther
    • Garcia, K.1    Blank, J.L.2    Bouck, D.C.3    Liu, X.J.4    Sappal, D.S.5
  • 39
    • 34547628200 scopus 로고    scopus 로고
    • Proteasome function is required for DNA damage response and fanconi anemia pathway activation
    • DOI 10.1158/0008-5472.CAN-07-1015
    • Jacquemont C, Taniguchi T (2007) Proteasome function is required for DNA damage response and fanconi anemia pathway activation. Cancer Res 67: 7395-7405. (Pubitemid 47206570)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7395-7405
    • Jacquemont, C.1    Taniguchi, T.2
  • 41
    • 79960150694 scopus 로고    scopus 로고
    • Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
    • Johnson N, Li YC, Walton ZE, Cheng KA, Li D, et al. (2011) Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med 17: 875-882.
    • (2011) Nat Med , vol.17 , pp. 875-882
    • Johnson, N.1    Li, Y.C.2    Walton, Z.E.3    Cheng, K.A.4    Li, D.5
  • 42
    • 84878109215 scopus 로고    scopus 로고
    • EVI1 splice variants modulate functional responses in ovarian cancer cells
    • Dutta P, Bui T, Bauckman KA, Keyomarsi K, Mills GB, et al. (2013) EVI1 splice variants modulate functional responses in ovarian cancer cells. Mol Oncol 7: 647-668.
    • (2013) Mol Oncol , vol.7 , pp. 647-668
    • Dutta, P.1    Bui, T.2    Bauckman, K.A.3    Keyomarsi, K.4    Mills, G.B.5
  • 44
    • 84868592402 scopus 로고    scopus 로고
    • I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks
    • Gunn A, Stark JM (2012) I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks. Methods Mol Biol 920: 379-391.
    • (2012) Methods Mol Biol , vol.920 , pp. 379-391
    • Gunn, A.1    Stark, J.M.2
  • 45
    • 0034595849 scopus 로고    scopus 로고
    • A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo
    • DOI 10.1074/jbc.275.22.17008
    • Wada H, Yeh ET, Kamitani T (2000) A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo. J Biol Chem 275: 17008-17015. (Pubitemid 30398942)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 17008-17015
    • Wada, H.1    Yeh, E.T.H.2    Kamitani, T.3
  • 46
    • 73649119600 scopus 로고    scopus 로고
    • Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma
    • Yarde DN, Oliveira V, Mathews L, Wang X, Villagra A, et al. (2009) Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. Cancer Res 69: 9367-9375.
    • (2009) Cancer Res , vol.69 , pp. 9367-9375
    • Yarde, D.N.1    Oliveira, V.2    Mathews, L.3    Wang, X.4    Villagra, A.5
  • 47
    • 84883543030 scopus 로고    scopus 로고
    • Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer
    • Cron KR, Zhu K, Kushwaha DS, Hsieh G, Merzon D, et al. (2013) Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS One 8: e73710.
    • (2013) PLoS One , vol.8
    • Cron, K.R.1    Zhu, K.2    Kushwaha, D.S.3    Hsieh, G.4    Merzon, D.5
  • 48
    • 17944401842 scopus 로고    scopus 로고
    • Identification of the receptor component of the IkappaBalpha-ubiquitin ligase
    • Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, et al. (1998) Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature 396: 590- 594.
    • (1998) Nature , vol.396 , pp. 590-594
    • Yaron, A.1    Hatzubai, A.2    Davis, M.3    Lavon, I.4    Amit, S.5
  • 49
    • 0033176887 scopus 로고    scopus 로고
    • SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    • Carrano AC, Eytan E, Hershko A, Pagano M (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1: 193- 199.
    • (1999) Nat Cell Biol , vol.1 , pp. 193-199
    • Carrano, A.C.1    Eytan, E.2    Hershko, A.3    Pagano, M.4
  • 51
    • 78149486374 scopus 로고    scopus 로고
    • CRL2(LRR- 1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells
    • Starostina NG, Simpliciano JM, McGuirk MA, Kipreos ET (2010) CRL2(LRR- 1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells. Dev Cell 19: 753-764.
    • (2010) Dev Cell , vol.19 , pp. 753-764
    • Starostina, N.G.1    Simpliciano, J.M.2    McGuirk, M.A.3    Kipreos, E.T.4
  • 52
    • 80051525031 scopus 로고    scopus 로고
    • Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase
    • Havens CG, Walter JC (2011) Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes Dev 25: 1568-1582.
    • (2011) Genes Dev , vol.25 , pp. 1568-1582
    • Havens, C.G.1    Walter, J.C.2
  • 53
    • 5044224075 scopus 로고    scopus 로고
    • ATR, claspin and the Rad9-Rad1-Hus1 complex Chk1 and Cdc25A in the absence of DNA damage
    • Sorensen CS, Syljuasen RG, Lukas J, Bartek J (2004) ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle 3: 941-945. (Pubitemid 40179476)
    • (2004) Cell Cycle , vol.3 , Issue.7 , pp. 941-945
    • Sorensen, C.S.1    Syljuasen, R.G.2    Lukas, J.3    Bartek, J.4
  • 54
    • 78649861218 scopus 로고    scopus 로고
    • Break-induced ATR and Ddb1-Cul4(Cdt)(2) ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast
    • Moss J, Tinline-Purvis H, Walker CA, Folkes LK, Stratford MR, et al. (2010) Break-induced ATR and Ddb1-Cul4(Cdt)(2) ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast. Genes Dev 24: 2705-2716.
    • (2010) Genes Dev , vol.24 , pp. 2705-2716
    • Moss, J.1    Tinline-Purvis, H.2    Walker, C.A.3    Folkes, L.K.4    Stratford, M.R.5
  • 55
    • 84880528179 scopus 로고    scopus 로고
    • The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)- mediated proteolysis in human cells
    • Bacquin A, Pouvelle C, Siaud N, Perderiset M, Salome-Desnoulez S, et al. (2013) The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)- mediated proteolysis in human cells. Nucleic Acids Res 41: 6501-6513.
    • (2013) Nucleic Acids Res , vol.41 , pp. 6501-6513
    • Bacquin, A.1    Pouvelle, C.2    Siaud, N.3    Perderiset, M.4    Salome-Desnoulez, S.5
  • 56
    • 35948942408 scopus 로고    scopus 로고
    • Altered pattern of Cul-1 protein expression and neddylation in human lung tumours: Relationships with CANDI and cyclin e protein levels
    • DOI 10.1002/path.2223
    • Salon C, Brambilla E, Brambilla C, Lantuejoul S, Gazzeri S, et al. (2007) Altered pattern of Cul-1 protein expression and neddylation in human lung tumours: relationships with CAND1 and cyclin E protein levels. J Pathol 213: 303-310. (Pubitemid 350074020)
    • (2007) Journal of Pathology , vol.213 , Issue.3 , pp. 303-310
    • Salon, C.1    Brambilla, E.2    Brambilla, C.3    Lantuejoul, S.4    Gazzeri, S.5    Eymin, B.6
  • 58
    • 0036614698 scopus 로고    scopus 로고
    • TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas
    • DOI 10.1053/jhep.2002.33683
    • Yasui K, Arii S, Zhao C, Imoto I, Ueda M, et al. (2002) TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology 35: 1476-1484. (Pubitemid 34966902)
    • (2002) Hepatology , vol.35 , Issue.6 , pp. 1476-1484
    • Yasui, K.1    Arii, S.2    Zhao, C.3    Imoto, I.4    Ueda, M.5    Nagai, H.6    Emi, M.7    Inazawa, J.8
  • 59
    • 79951576642 scopus 로고    scopus 로고
    • Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer
    • Bai J, Zhou Y, Chen G, Zeng J, Ding J, et al. (2011) Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer. Hum Pathol 42: 375-383.
    • (2011) Hum Pathol , vol.42 , pp. 375-383
    • Bai, J.1    Zhou, Y.2    Chen, G.3    Zeng, J.4    Ding, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.