Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47phox pathway

Toxicology and Applied Pharmacology

Volumn 279, Issue 2, 2014, Pages 240-251

  Tsai, Ming Horng ^a   Lin, Zih Chan ^b   Liang, Chan Jung ^c   Yen, Feng Lin ^b,g   Chiang, Yao Chang ^d,e   Lee, Chiang Wen ^f,g  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

^g CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Cyclooxygenase; Eupafolin; Human dermal fibroblasts; NADPH oxidase; Phyla nodiflora

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOCYNIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; EUPAFOLIN; HERBACEOUS AGENT; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; PROTEIN C FOS; PROTEIN C JUN; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TANSHINONE IIA; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DNA BINDING; DRUG EFFECT; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE CONTROL; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PHYLA NODIFLORA; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

CYCLOOXYGENASE; EUPAFOLIN; HUMAN DERMAL FIBROBLASTS; NADPH OXIDASE; PHYLA NODIFLORA;

ANTIOXIDANTS; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FIBROBLASTS; FLAVONES; GENES, REPORTER; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; OXIDATIVE STRESS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 84904258833     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.06.012     Document Type: Article

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