메뉴 건너뛰기




Volumn 8, Issue 3, 2014, Pages 1249-1254

Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma

Author keywords

Cancer related genes; Hepatocellular carcinoma; KRAS; Mutation analysis

Indexed keywords


EID: 84904258206     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2253     Document Type: Article
Times cited : (32)

References (47)
  • 2
    • 79959296814 scopus 로고    scopus 로고
    • The global epidemiology of hepatocellular carcinoma: Present and future
    • McGlynn KA and London WT: The global epidemiology of hepatocellular carcinoma: present and future. Clin Liver Dis 15: 223-243, vii-x, 2011.
    • (2011) Clin Liver Dis , vol.15
    • McGlynn, K.A.1    London, W.T.2
  • 3
    • 84945990416 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT/mTOR pathway: Biomarkers of success and tribulation
    • doi: 10.1200/EdBook_AM.2013.33.e395
    • Owonikoko TK and Khuri FR: Targeting the PI3K/AKT/mTOR pathway: biomarkers of success and tribulation. Am Soc Clin Oncol Educ Book: 2013. doi: 10.1200/EdBook_AM.2013.33.e395.
    • (2013) Am Soc Clin Oncol Educ Book
    • Owonikoko, T.K.1    Khuri, F.R.2
  • 4
    • 42449146501 scopus 로고    scopus 로고
    • Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
    • McCubrey JA, Steelman LS, Abrams SL, et al: Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy. Leukemia 22: 708-722, 2008.
    • (2008) Leukemia , vol.22 , pp. 708-722
    • McCubrey, J.A.1    Steelman, L.S.2    Abrams, S.L.3
  • 5
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J: Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3: 11-22, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 6
    • 0038421104 scopus 로고    scopus 로고
    • Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway
    • Zheng Y, Li J, Johnson DL and Ou JH: Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway. J Virol 77: 7707-7712, 2003.
    • (2003) J Virol , vol.77 , pp. 7707-7712
    • Zheng, Y.1    Li, J.2    Johnson, D.L.3    Ou, J.H.4
  • 7
    • 84255200363 scopus 로고    scopus 로고
    • Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway
    • Liu H, Xu J, Zhou L, et al: Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway. Cancer Res 71: 7547-7557, 2011.
    • (2011) Cancer Res , vol.71 , pp. 7547-7557
    • Liu, H.1    Xu, J.2    Zhou, L.3
  • 8
    • 79961173138 scopus 로고    scopus 로고
    • Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
    • Steelman LS, Chappell WH, Abrams SL, et al: Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY) 3: 192-222, 2011.
    • (2011) Aging (Albany NY) , vol.3 , pp. 192-222
    • Steelman, L.S.1    Chappell, W.H.2    Abrams, S.L.3
  • 9
    • 79960052850 scopus 로고    scopus 로고
    • Ras in cancer and developmental diseases
    • Fernández-Medarde A and Santos E: Ras in cancer and developmental diseases. Genes Cancer 2: 344-358, 2011.
    • (2011) Genes Cancer , vol.2 , pp. 344-358
    • Fernández-Medarde, A.1    Santos, E.2
  • 11
    • 26444468886 scopus 로고    scopus 로고
    • Analysis of BRAF mutation in primary and metastatic melanoma
    • Libra M, Malaponte G, Navolanic PM, et al: Analysis of BRAF mutation in primary and metastatic melanoma. Cell Cycle 4: 1382-1384, 2005.
    • (2005) Cell Cycle , vol.4 , pp. 1382-1384
    • Libra, M.1    Malaponte, G.2    Navolanic, P.M.3
  • 12
    • 0142135475 scopus 로고    scopus 로고
    • BRAF mutations in papillary carcinomas of the thyroid
    • Fukushima T, Suzuki S, Mashiko M, et al: BRAF mutations in papillary carcinomas of the thyroid. Oncogene 22: 6455-6457, 2003.
    • (2003) Oncogene , vol.22 , pp. 6455-6457
    • Fukushima, T.1    Suzuki, S.2    Mashiko, M.3
  • 13
    • 0034820828 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinases in tumor progression
    • Roymans D and Slegers H: Phosphatidylinositol 3-kinases in tumor progression. Eur J Biochem 268: 487-498, 2001.
    • (2001) Eur J Biochem , vol.268 , pp. 487-498
    • Roymans, D.1    Slegers, H.2
  • 14
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y, Wang Z, Bardelli A, et al: High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554, 2004.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 15
    • 20044388328 scopus 로고    scopus 로고
    • PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
    • Lee JW, Soung YH, Kim SY, et al: PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene 24: 1477-1480, 2005.
    • (2005) Oncogene , vol.24 , pp. 1477-1480
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 16
    • 0032590011 scopus 로고    scopus 로고
    • PIK3CA is implicated as an oncogene in ovarian cancer
    • Shayesteh L, Lu Y, Kuo WL, et al: PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 21: 99-102, 1999.
    • (1999) Nat Genet , vol.21 , pp. 99-102
    • Shayesteh, L.1    Lu, Y.2    Kuo, W.L.3
  • 17
    • 65949092291 scopus 로고    scopus 로고
    • PIK3CA mutations in human solid tumors: Role in sensitivity to various therapeutic approaches
    • Ligresti G, Militello L, Steelman LS, et al: PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches. Cell Cycle 8: 1352-1358, 2009.
    • (2009) Cell Cycle , vol.8 , pp. 1352-1358
    • Ligresti, G.1    Militello, L.2    Steelman, L.S.3
  • 18
    • 79958820962 scopus 로고    scopus 로고
    • PIK3R1 (p85alpha) is somatically mutated at high frequency in primary endometrial cancer
    • Urick ME, Rudd ML, Godwin AK, Sgroi D, Merino M and Bell DW: PIK3R1 (p85alpha) is somatically mutated at high frequency in primary endometrial cancer. Cancer Res 71: 4061-4067, 2011.
    • (2011) Cancer Res , vol.71 , pp. 4061-4067
    • Urick, M.E.1    Rudd, M.L.2    Godwin, A.K.3    Sgroi, D.4    Merino, M.5    Bell, D.W.6
  • 19
    • 0035886016 scopus 로고    scopus 로고
    • The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors
    • Philp AJ, Campbell IG, Leet C, et al: The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res 61: 7426-7429, 2001.
    • (2001) Cancer Res , vol.61 , pp. 7426-7429
    • Philp, A.J.1    Campbell, I.G.2    Leet, C.3
  • 20
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic V, Suzuki A, de la Pompa JL, et al: Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95: 29-39, 1998.
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    de la Pompa, J.L.3
  • 21
    • 38349030742 scopus 로고    scopus 로고
    • New insights into PTEN
    • Tamguney T and Stokoe D: New insights into PTEN. J Cell Sci 120: 4071-4079, 2007.
    • (2007) J Cell Sci , vol.120 , pp. 4071-4079
    • Tamguney, T.1    Stokoe, D.2
  • 22
    • 79959712087 scopus 로고    scopus 로고
    • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health
    • Chappell WH, Steelman LS, Long JM, et al: Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget 2: 135-164, 2011.
    • (2011) Oncotarget , vol.2 , pp. 135-164
    • Chappell, W.H.1    Steelman, L.S.2    Long, J.M.3
  • 23
    • 0032879468 scopus 로고    scopus 로고
    • Prognosis of hepatocellular carcinoma: The BCLC staging classification
    • Llovet JM, Bru C and Bruix J: Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 19: 329-338, 1999.
    • (1999) Semin Liver Dis , vol.19 , pp. 329-338
    • Llovet, J.M.1    Bru, C.2    Bruix, J.3
  • 24
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
    • Forbes SA, Bindal N, Bamford S, et al: COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res 39: D945-D950, 2011.
    • (2011) Nucleic Acids Res , vol.39
    • Forbes, S.A.1    Bindal, N.2    Bamford, S.3
  • 25
    • 38049080992 scopus 로고    scopus 로고
    • Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma
    • Zhu AX: Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma. Cancer 112: 250-259, 2008.
    • (2008) Cancer , vol.112 , pp. 250-259
    • Zhu, A.X.1
  • 26
    • 67649313759 scopus 로고    scopus 로고
    • Notch and Kras in pancreatic cancer: At the crossroads of mutation, differentiation and signaling
    • De La O JP and Murtaugh LC: Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling. Cell Cycle 8: 1860-1864, 2009.
    • (2009) Cell Cycle , vol.8 , pp. 1860-1864
    • De La, O.J.P.1    Murtaugh, L.C.2
  • 27
    • 0037624602 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma
    • Tannapfel A, Sommerer F, Benicke M, et al: Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut 52: 706-712, 2003.
    • (2003) Gut , vol.52 , pp. 706-712
    • Tannapfel, A.1    Sommerer, F.2    Benicke, M.3
  • 28
    • 80054052229 scopus 로고    scopus 로고
    • KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications
    • Balschun K, Haag J, Wenke AK, von Schonfels W, Schwarz NT and Rocken C: KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications. J Mol Diagn 13: 436-445, 2011.
    • (2011) J Mol Diagn , vol.13 , pp. 436-445
    • Balschun, K.1    Haag, J.2    Wenke, A.K.3    von Schonfels, W.4    Schwarz, N.T.5    Rocken, C.6
  • 29
    • 84862976633 scopus 로고    scopus 로고
    • Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
    • Fujimoto A, Totoki Y, Abe T, et al: Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet 44: 760-764, 2012.
    • (2012) Nat Genet , vol.44 , pp. 760-764
    • Fujimoto, A.1    Totoki, Y.2    Abe, T.3
  • 30
    • 84861625981 scopus 로고    scopus 로고
    • Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    • Guichard C, Amaddeo G, Imbeaud S, et al: Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet 44: 694-698, 2012.
    • (2012) Nat Genet , vol.44 , pp. 694-698
    • Guichard, C.1    Amaddeo, G.2    Imbeaud, S.3
  • 31
    • 84866868120 scopus 로고    scopus 로고
    • Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma
    • Huang J, Deng Q, Wang Q, et al: Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Nat Genet 44: 1117-1121, 2012.
    • (2012) Nat Genet , vol.44 , pp. 1117-1121
    • Huang, J.1    Deng, Q.2    Wang, Q.3
  • 32
    • 0026553679 scopus 로고
    • Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas
    • Challen C, Guo K, Collier JD, Cavanagh D and Bassendine MF: Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas. J Hepatol 14: 342-346, 1992.
    • (1992) J Hepatol , vol.14 , pp. 342-346
    • Challen, C.1    Guo, K.2    Collier, J.D.3    Cavanagh, D.4    Bassendine, M.F.5
  • 33
    • 84878483955 scopus 로고    scopus 로고
    • A rare point mutation in the Ras oncogene in hepatocellular carcinoma
    • Taketomi A, Shirabe K, Muto J, et al: A rare point mutation in the Ras oncogene in hepatocellular carcinoma. Surg Today 43: 289-292, 2013.
    • (2013) Surg Today , vol.43 , pp. 289-292
    • Taketomi, A.1    Shirabe, K.2    Muto, J.3
  • 34
    • 2542473135 scopus 로고    scopus 로고
    • Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: Its role in tumor progression and apoptosis
    • Huynh H, Nguyen TT, Chow KH, Tan PH, Soo KC and Tran E: Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis. BMC Gastroenterol 3: 19, 2003.
    • (2003) BMC Gastroenterol , vol.3 , pp. 19
    • Huynh, H.1    Nguyen, T.T.2    Chow, K.H.3    Tan, P.H.4    Soo, K.C.5    Tran, E.6
  • 35
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F, Martini M, Molinari F, et al: Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 26: 5705-5712, 2008.
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 36
    • 84857056401 scopus 로고    scopus 로고
    • Multivariate analysis of several molecular markers and clinicopathological features in postoperative prognosis of hepatocellular carcinoma
    • Zuo Q, Huang H, Shi M, et al: Multivariate analysis of several molecular markers and clinicopathological features in postoperative prognosis of hepatocellular carcinoma. Anat Rec (Hoboken) 295: 423-431, 2012.
    • (2012) Anat Rec (Hoboken) , vol.295 , pp. 423-431
    • Zuo, Q.1    Huang, H.2    Shi, M.3
  • 37
    • 84856845687 scopus 로고    scopus 로고
    • BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy
    • Colombino M, Sperlongano P, Izzo F, et al: BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy. Cell Death Dis 3: e259, 2012.
    • (2012) Cell Death Dis , vol.3
    • Colombino, M.1    Sperlongano, P.2    Izzo, F.3
  • 38
    • 33646672648 scopus 로고    scopus 로고
    • Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients
    • Tanaka Y, Kanai F, Tada M, et al: Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients. Oncogene 25: 2950-2952, 2006.
    • (2006) Oncogene , vol.25 , pp. 2950-2952
    • Tanaka, Y.1    Kanai, F.2    Tada, M.3
  • 40
    • 84855291181 scopus 로고    scopus 로고
    • Low frequency of PIK3CA gene mutations in hepatocellular carcinoma in Chinese population
    • Li X, Zhang Q, He W, et al: Low frequency of PIK3CA gene mutations in hepatocellular carcinoma in Chinese population. Pathol Oncol Res 18: 57-60, 2012.
    • (2012) Pathol Oncol Res , vol.18 , pp. 57-60
    • Li, X.1    Zhang, Q.2    He, W.3
  • 41
    • 38449101817 scopus 로고    scopus 로고
    • Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients
    • Bae JJ, Rho JW, Lee TJ, et al: Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients. Oncol Rep 18: 1007-1013, 2007.
    • (2007) Oncol Rep , vol.18 , pp. 1007-1013
    • Bae, J.J.1    Rho, J.W.2    Lee, T.J.3
  • 42
    • 34247277178 scopus 로고    scopus 로고
    • Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma
    • Wang L, Wang WL, Zhang Y, Guo SP, Zhang J and Li QL: Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma. Hepatol Res 37: 389-396, 2007.
    • (2007) Hepatol Res , vol.37 , pp. 389-396
    • Wang, L.1    Wang, W.L.2    Zhang, Y.3    Guo, S.P.4    Zhang, J.5    Li, Q.L.6
  • 43
    • 0024801490 scopus 로고
    • Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma
    • Tsuda H, Hirohashi S, Shimosato Y, Ino Y, Yoshida T and Terada M: Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma. Jpn J Cancer Res 80: 196-199, 1989.
    • (1989) Jpn J Cancer Res , vol.80 , pp. 196-199
    • Tsuda, H.1    Hirohashi, S.2    Shimosato, Y.3    Ino, Y.4    Yoshida, T.5    Terada, M.6
  • 44
    • 77957307009 scopus 로고    scopus 로고
    • Genetic and epigenetic characteristics of human multiple hepatocellular carcinoma
    • Taniguchi K, Yamada T, Sasaki Y and Kato K: Genetic and epigenetic characteristics of human multiple hepatocellular carcinoma. BMC Cancer 10: 530, 2010.
    • (2010) BMC Cancer , vol.10 , pp. 530
    • Taniguchi, K.1    Yamada, T.2    Sasaki, Y.3    Kato, K.4
  • 45
    • 0025169651 scopus 로고
    • Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing
    • Tada M, Omata M and Ohto M: Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing. Cancer Res 50: 1121-1124, 1990.
    • (1990) Cancer Res , vol.50 , pp. 1121-1124
    • Tada, M.1    Omata, M.2    Ohto, M.3
  • 46
    • 78650385124 scopus 로고    scopus 로고
    • Hepatocellular carcinoma with persistent hepatitis B virus infection shows unusual downregulation of Ras expression and differential response to Ras mediated signaling
    • Bose S, Sakhuja P, Bezawada L, et al: Hepatocellular carcinoma with persistent hepatitis B virus infection shows unusual downregulation of Ras expression and differential response to Ras mediated signaling. J Gastroenterol Hepatol 26: 135-144, 2011.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 135-144
    • Bose, S.1    Sakhuja, P.2    Bezawada, L.3
  • 47
    • 0035815230 scopus 로고    scopus 로고
    • Frequent k-ras-2 mutations and p16(INK4A)methylation in hepatocellular carcinomas in workers exposed to vinyl chloride
    • Weihrauch M, Benicke M, Lehnert G, Wittekind C, Wrbitzky R and Tannapfel A: Frequent k-ras-2 mutations and p16(INK4A)methylation in hepatocellular carcinomas in workers exposed to vinyl chloride. Br J Cancer 84: 982-989, 2001.
    • (2001) Br J Cancer , vol.84 , pp. 982-989
    • Weihrauch, M.1    Benicke, M.2    Lehnert, G.3    Wittekind, C.4    Wrbitzky, R.5    Tannapfel, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.