Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Lo Sasso, Giuseppe ^a   Ryu, Dongryeol ^a   Mouchiroud, Laurent ^a   Fernando, Samodha C ^b   Anderson, Christopher L ^b,c   Katsyuba, Elena ^a   Piersigilli, Alessandra ^a,d   Hottiger, Michael O ^e   Schoonjans, Kristina ^a   Auwerx, Johan ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c UNIVERSITY OF NEBRASKA   (United States)

^d UNIVERSITY OF BERN   (Switzerland)

^e UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

SIRTUIN 1; CAENORHABDITIS ELEGANS PROTEIN; DODECYL SULFATE SODIUM; SIRT1 PROTEIN, MOUSE; SPDEF PROTEIN, MOUSE; TRANSCRIPTION FACTOR ETS;

ACETYLATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; COLITIS; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION; GOBLET CELL; INTESTINE CELL; INTESTINE FLORA; INTESTINE FUNCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANETH CELL; PROTEIN DEPLETION; PROTEIN LOCALIZATION; REGULATOR GENE; SIRT1 GENE; ANIMAL; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; CELL LINE; CHEMICALLY INDUCED; COLORECTAL NEOPLASMS; COMPLICATION; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL DIFFERENTIATION; CELL LINE; COLITIS; COLORECTAL NEOPLASMS; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GOBLET CELLS; HUMANS; MICE; MICE, KNOCKOUT; PANETH CELLS; PROTO-ONCOGENE PROTEINS C-ETS; SIGNAL TRANSDUCTION; SIRTUIN 1; SODIUM DODECYL SULFATE;

EID: 84904255092     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102495     Document Type: Article

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