Development of innate CD4+and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways

Journal of Immunology

Volumn 193, Issue 2, 2014, Pages 688-699

  Prince, Amanda L ^a   Kraus, Zachary ^b   Carty, Shannon A ^c   Ng, Caleb ^c   Yin, Catherine C ^a   Jordan, Martha S ^c   Schwartzberg, Pamela L ^b   Berg, Leslie J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; EOMESODERMIN; INTERLEUKIN 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; INNATE IMMUNITY; MEMORY CELL; MEMORY T LYMPHOCYTE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; THYMOCYTE; WILD TYPE;

ANIMALS; ANTIGENS, CD1D; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; FLOW CYTOMETRY; INTERLEUKIN-15; INTERLEUKIN-4; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NATURAL KILLER T-CELLS; PROTEIN-TYROSINE KINASES; RATS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; THYMOCYTES;

EID: 84904248558     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302059     Document Type: Article

References (40)

1. Berg, L. J. 2007. Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development. Nat. Rev. Immunol. 7: 479-485. (Pubitemid 46834846)
2. Veillette, A., Z. Dong, and S. Latour. 2007. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity 27: 698-710. (Pubitemid 350102266)
3. + T-cell differentiation. Proc. Natl. Acad. Sci. USA 109: E2794-E2802.
4. Moran, A. E., K. L. Holzapfel, Y. Xing, N. R. Cunningham, J. S. Maltzman, J. Punt, and K. A. Hogquist. 2011. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208: 1279-1289.
5. Qiao, Y., L. Zhu, H. Sofi, P. E. Lapinski, R. Horai, K. Mueller, G. L. Stritesky, X. He, H.-S. Teh, D. L. Wiest, et al. 2012. Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proc. Natl. Acad. Sci. USA 109: 16264-16269.
6. + T cells with innate lymphocyte characteristics. Immunity 33: 203-215.
7. + T cells. J. Immunol. 186: 4573-4578.
8. + T cells. Nat. Immunol. 11: 709-716.
9. Weinreich, M. A., K. Takada, C. Skon, S. L. Reiner, S. C. Jameson, and K. A. Hogquist. 2009. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity 31: 122-130.
10. + T-cell development. Mol. Cell. Biol. 29: 3894-3904.
11. Felices, M., C. C. Yin, Y. Kosaka, J. Kang, and L. J. Berg. 2009. Tec kinase Itk in γδT cells is pivotal for controlling IgE production in vivo. Proc. Natl. Acad. Sci. USA 106: 8308-8313.
12. + γδ T cells in the absence of Itk results in elevated IgE production. Blood 114: 564-571.
13. Alonzo, E. S., and D. B. Sant'Angelo. 2011. Development of PLZF-expressing innate T cells. Curr. Opin. Immunol. 23: 220-227.
14. + T cells have different requirements for active Itk for their development. J. Immunol. 180: 6544-6552.
15. Atherly, L. O., J. A. Lucas, M. Felices, C. C. Yin, S. L. Reiner, and L. J. Berg. 2006. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity 25: 79-91. (Pubitemid 44066834)
16. Schaeffer, E. M., G. S. Yap, C. M. Lewis, M. J. Czar, D. W. McVicar, A. W. Cheever, A. Sher, and P. L. Schwartzberg. 2001. Mutation of Tec family kinases alters T helper cell differentiation. Nat. Immunol. 2: 1183-1188. (Pubitemid 33130154)
17. Lucas, J. A., L. O. Atherly, and L. J. Berg. 2002. The absence of Itk inhibits positive selection without changing lineage commitment. J. Immunol. 168: 6142-6151. (Pubitemid 34620032)
18. Czar, M. J., E. N. Kersh, L. A. Mijares, G. Lanier, J. Lewis, G. Yap, A. Chen, A. Sher, C. S. Duckett, R. Ahmed, and P. L. Schwartzberg. 2001. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc. Natl. Acad. Sci. USA 98: 7449-7454. (Pubitemid 32567969)
19. Jordan, M. S., J. E. Smith, J. C. Burns, J.-E. T. Austin, K. E. Nichols, A. C. Aschenbrenner, and G. A. Koretzky. 2008. Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity 28: 359-369. (Pubitemid 351343858)
20. + T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25: 93-104.
21. Kronenberg, M., and I. Engel. 2007. On the road: progress in finding the unique pathway of invariant NKT cell differentiation. Curr. Opin. Immunol. 19: 186-193. (Pubitemid 46356970)
22. Dubois, S., T. A. Waldmann, and J. R. Müller. 2006. ITK and IL-15 support two distinct subsets of CD8+ T cells. Proc. Natl. Acad. Sci. USA 103: 12075-12080. (Pubitemid 44215813)
23. Treiner, E., L. Duban, S. Bahram, M. Radosavljevic, V. Wanner, F. Tilloy, P. Affaticati, S. Gilfillan, and O. Lantz. 2003. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422: 164-169. (Pubitemid 36362748)
24. Kawachi, I., J. Maldonado, C. Strader, and S. Gilfillan. 2006. MR1-restricted Vα19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response. J. Immunol. 176: 1618-1627. (Pubitemid 43134306)
25. Savage, A. K., M. G. Constantinides, J. Han, D. Picard, E. Martin, B. Li, O. Lantz, and A. Bendelac. 2008. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29: 391-403.
26. Gadue, P., and P. L. Stein. 2002. NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. J. Immunol. 169: 2397-2406. (Pubitemid 34920982)
27. Felices, M., and L. J. Berg. 2008. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J. Immunol. 180: 3007-3018.
28. Au-Yeung, B. B., and D. J. Fowell. 2007. A key role for Itk in both IFNγ and IL-4 production by NKT cells. J. Immunol. 179: 111-119. (Pubitemid 46986524)
29. Perona-Wright, G., K. Mohrs, K. D. Mayer, and M. Mohrs. 2010. Differential regulation of IL-4Rα expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. J. Immunol. 184: 615-623.
30. Pereira, P., and L. Boucontet. 2012. Innate NKTγδ and NKTαβ cells exert similar functions and compete for a thymic niche. Eur. J. Immunol. 42: 1272-1281.
31. Yin, C. C., O. H. Cho, K. E. Sylvia, K. Narayan, A. L. Prince, J. W. Evans, J. Kang, and L. J. Berg. 2013. The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cells. J. Immunol. 190: 2659-2669.
32. Mohrs, M., K. Shinkai, K. Mohrs, and R. M. Locksley. 2001. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15: 303-311. (Pubitemid 32816878)
33. Horai, R., K. L. Mueller, R. A. Handon, J. L. Cannons, S. M. Anderson, M. R. Kirby, and P. L. Schwartzberg. 2007. Requirements for selection of conventional and innate T lymphocyte lineages. Immunity 27: 775-785. (Pubitemid 350102265)
34. + αβ T cells develop and expand in the absence of Itk. J. Immunol. 193: 673-687.
35. Lucas, J. A., M. Felices, J. W. Evans, and L. J. Berg. 2007. Subtle defects in pre- TCR signaling in the absence of the Tec kinase Itk. J. Immunol. 179: 7561-7567.
36. Li, W., M.-G. Kim, T. S. Gourley, B. P. McCarthy, D. B. Sant'Angelo, and C.-H. Chang. 2005. An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population. Immunity 23: 375-386. (Pubitemid 41443439)
37. Choi, E. Y., K. C. Jung, H. J. Park, D. H. Chung, J. S. Song, S. D. Yang, E. Simpson, and S. H. Park. 2005. Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity 23: 387-396. (Pubitemid 41443440)
38. + T cells selected by homotypic thymocyte interaction. Immunity 27: 763-774.
39. + T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans. J. Exp. Med. 207: 237-246.
40. Min, H. S., Y. J. Lee, Y. K. Jeon, E. J. Kim, B. H. Kang, K. C. Jung, C.-H. Chang, and S. H. Park. 2011. MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells. J. Immunol. 186: 5749-5757.