Innate NKTγδ and NKTαβ cells exert similar functions and compete for a thymic niche

European Journal of Immunology

Volumn 42, Issue 5, 2012, Pages 1272-1281

  Pereira, Pablo ^a   Boucontet, Laurent ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

T cells; Innate cells; NKT cells; PLZF

Indexed keywords

CD4 ANTIGEN; CD45RB ANTIGEN; CD5 ANTIGEN; GAMMA INTERFERON; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 4; INTERLEUKIN 7 RECEPTOR; NK1.1 PROTEIN; PROMYELOCYTIC LEUKEMIA ZINC FINGER; PROTEIN; T LYMPHOCYTE RECEPTOR; THY 1 ANTIGEN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CELL DIVISION; CELL FUNCTION; CELL POPULATION; CELL PROLIFERATION; CELL SIZE; CONTROLLED STUDY; FLOW CYTOMETRY; IN VIVO STUDY; INNATE IMMUNITY; MOUSE; NATURAL KILLER ALPHA BETA T CELL; NATURAL KILLER GAMMA DELTA T CELL; NATURAL KILLER T CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMOCYTE; TRANSCRIPTION INITIATION;

ANIMALS; ANTIGENS, LY; CD8-POSITIVE T-LYMPHOCYTES; INTERFERON-GAMMA; INTERLEUKIN-4; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; NATURAL KILLER T-CELLS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY B; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; THYMUS GLAND;

EID: 84860333124     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142109     Document Type: Article

References (39)

1. Bendelac, A., Savage, P. B. and Teyton, L., The biology of NKT cells. Annu. Rev. Immunol. 2007. 25: 297-336.
2. Benlagha, K., Kyin, T., Beavis, A., Teyton, L. and Bendelac, A., A thymic precursor to the NKT cell lineage. Science 2002. 296: 553-555.
3. Pellicci, D. G., Hammond, K. J. L., Uldrich, A. P., Baxter, A. G., Smyth, M. J. and Godfrey, D. I., A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1-CD4 +CD1d-dependent precursor stage. J. Exp. Med. 2002. 195: 835-844.
4. Gadue, P. and Stein, P. L., NKT cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. J. Immunol. 2002. 169: 2397-2406.
5. Benlagha, K., Wei, D. G., Veiga, J., Teyton, L. and Bendelac, A., Characterization of the early stages of thymic NKT cell development. J. Exp. Med. 2005. 202: 485-492.
6. dull γδ thymocytes. Eur. J. Immunol. 2001. 31: 205-214.
7. dull γδ T cell population is due to cellular selection. Eur. J. Immunol. 1998. 28: 3456-3467.
8. Azuara, V., Levraud, J. P., Lembezat, M. P. and Pereira, P., A novel subset of adult γδ thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell peceptor repertoire. Eur. J. Immunol. 1997. 27: 544-553.
9. Gerber, D. J., Azuara, V., Levraud, J.-P., Huang, S. Y., Lembezat, M.-P. and Pereira, P., IL-4-producing γδ T cells that express a very restricted TCR repertoire are preferentially localized in liver and spleen. J. Immunol. 1999. 163: 3076-3082.
10. Grigoriadou, K., Boucontet, L. and Pereira, P., Most IL-4-producing γδ thymocytes of adult mice originate from fetal precursors. J. Immunol. 2003. 171: 2413-2420.
11. Arase, H., Ono, S., Arase, N., Park, S. Y., Wakizaka, K., Watanabe, H., Ohno, H. et al., Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-α/β+ T cells and expansion of NK1.1+ TCR-γ/δ+ T cell development in CD3ζ-deficient mice. J. Exp. Med. 1995. 182: 891-895.
12. Lees, R. K., Ferrero, I. and MacDonald, H. R., Tissue-specific segregation of TCR γδ + NKT cells according to phenotype TCR repertoire and activation status: parallels with TCRαβ+NKT cells. Eur. J. Immunol. 2001. 31: 2901-2909.
13. + thymocytes. Eur. J. Immunol. 1996. 26: 1424-1429.
14. Alonzo, E. S., Gottschalk, R. A., Das, J., Egawa, T., Hobbs, R. M., Pandolfi, P. P., Pereira, P. et al., Development of promyelocytic zinc finger and ThPOK-expressing innate γδ T cells is controlled by strength of TCR signaling and Id3. J. Immunol. 2010. 184: 1268-1279.
15. Kovalovsky, D., Uche, O. U., Eladad, S., Hobbs, R. M., Yi, W., Alonzo, E., Chua, K. et al., The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat. Immunol. 2008. 9: 1055-1064.
16. Kreslavsky, T., Savage, A., Hobbs, R., Gounari, F., Bronson, R., Pereira, P., Pandolfi, P. P. et al., TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity. Proc. Natl. Acad. Sci. USA 2009. 106: 12453-12458.
17. Savage, A. K., Constantinides, M. G., Han, J., Picard, D., Martin, E., Li, B., Lantz, O. et al., The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 2008. 29: 391-403.
18. Verykokakis, M., Boos, M. D., Bendelac, A., Adams, E. J., Pereira, P. and Kee, B. L., Inhibitor of DNA binding 3 limits development of slam-associated adaptor protein-dependent "innate" γδ T cells. PLos One 2010. 5: e9303.
19. Weinreich, M. A., Odumade, O. A., Jameson, S. C. and Hogquist, K. A., T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat. Immunol. 2010. 11: 709-716.
20. + T cell development and early IL-4 production in CD1-deficient mice. Immunity 1997. 6: 459-467.
21. Mendiratta, S. K., Martin, W. D., Hong, S., Boesteanu, A., Joyce, S. and van Kaer, L., CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 1997. 6: 469-477.
22. Eberl, G., Lees, R., Smiley, S. T., Taniguchi, M., Grusby, M. J. and MacDonald, H. R., Tissue-specific segregation of CD1d-dependent and CD1d-independent NKT cells. J. Immunol. 1999. 162: 6410-6419.
23. Atherly, L. O., Lucas, J. A., Felices, M., Yin, C. C., Reiner, S. L. and Berg, L. J., The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity 2006. 25: 79-91.
24. Broussard, C., Fleischacker, C., Horai, R., Chetana, M., Venegas, A. M., Sharp, L. L., Hedrick, S. M. et al., Altered development of CD8 +T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 2006. 25: 93-104.
25. Malissen, M., Pereira, P., Gerber, D. J., Malissen, B. and DiSanto, J. P., The common cytokine receptor γ chain controls survival of γ/δ T cells. J. Exp. Med. 1997. 186: 1277-1285.
26. Matsuda, J. L., Gapin, L., Sidobre, S., Kieper, W. C., Tan, J. T., Ceredig, R., Surh, C. D. et al., Homeostasis of Va14i NKT cells. Nat. Immunol. 2002. 3: 966-974.
27. Griewank, K., Borowski, C., Rietdijk, S., Wang, N., Julien, A., Wei, D. G., Mamchak, A. A. et al., Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 2007. 27: 751-762.
28. Jordan, M. A., Fletcher, J. M., Pellicci, D. and Baxter, A. G., Slamf1, the NKT cell control gene Nkt1. J. Immunol. 2007. 178: 1618-1627.
29. Ishida, I., Verbeck, S., Bonneville, M., Itohara, S., Berns, A. and Tonegawa, S., T-cell receptor γδ and γ transgenic mice suggest a role of a γ gene silencer in the generation of αβ T-cells. Proc. Natl. Acad. Sci. USA 1990. 87: 3067-3071.
30. Chien, Y. H., Iwashima, M., Kaplan, K. B., Elliott, J. F. and Davis, M. M., A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. Nature 1987. 327: 677-682.
31. Shires, J., Theodoridis, E. and Hayday, A. C., Biological insights into TCRγδ+ and TCRαβ +intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 2001. 15: 419-434.
32. Denning, T. L., Granger, S. W., Mucida, D., Graddy, R., Leclercq, G., Zhang, W., Honey, K. et al., Mouse TCRαβ+CD8αα intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J. Immunol. 2007. 178: 4230-4239.
33. Kisielow, J., Tortola, L., Weber, J., Karjalainen, K. and Kopf, M., Evidence for the divergence of innate and adaptive T-cell precursors before commitment to the αβ and γδ lineages. Blood 2011. 118: 6591-6600.
34. Felices, M., Yin, C. C., Kosaka, Y., Kang, J. and Berg, L. J., Tec kinase Itk in γδT cells is pivotal for controlling IgE production in vivo. Proc. Natl. Acad. Sci. USA 2009. 106: 8308-8313.
35. Lauritsen, J., Wong, G., Lee, S., Lefebvre, J., Ciofani, M., Rhodes, M., Kappes, D. et al., Marked induction of the helix-loop-helix protein Id3 promotes the γδ T cell fate and renders their functional maturation Notch independent. Immunity 2009. 31: 565-575.
36. Qi, Q., Xia, M., Hu, J., Hicks, E., Iyer, A., Xiong, N. and August, A., Enhanced development of CD4+ γδ T cells in the absence of Itk results in elevated IgE production. Blood 2009. 114: 564-571.
37. Ueda-Hayakawa, I., Mahlios, J. and Zhuang, Y., Id3 restricts the developmental potential of γδ lineage during thymopoiesis. J. Immunol. 2009. 182: 5306-5316.
38. Alonzo, E. S. and Sant'Angelo, D. B., Development of PLZF-expressing innate T cells. Curr. Opinion Immunol. 2011. 23: 1-8.
39. Gerber, D., Boucontet, L. and Pereira, P., Early expression of a functional TCRβ chain inhibits TCRγ gene rearrangement without altering the frequency of TCRγδ lineage cells. J. Immunol. 2004. 173: 2516-2523.