Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor

Journal of Biological Chemistry

Volumn 289, Issue 28, 2014, Pages 19351-19363

  Woo, Anthony Yiu Ho ^a,b   Jozwiak, Krzysztof ^c   Toll, Lawrence ^d   Tanga, Mary J ^e   Kozocas, Joseph A ^e   Jimenez, Lucita ^e   Huang, Ying ^a   Song, Ying ^a   Plazinska, Anita ^c   Pajak, Karolina ^c   Paul, Rajib K ^b   Bernier, Michel ^b   Wainer, Irving W ^b   Xiao, Rui Ping ^a  

^a PEKING UNIVERSITY   (China)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^d TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^e SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; LIGANDS; PHOSPHORYLATION;

AMINO ACID RESIDUES; COUPLING SELECTIVITY; DOCKING SIMULATIONS; G PROTEIN COUPLED RECEPTORS; G PROTEIN-COUPLED RECEPTOR KINASE; SITE DIRECTED MUTAGENESIS; SPECIFIC INTERACTION; STRUCTURAL FEATURE;

PROTEINS;

BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; INTRACELLULAR SIGNALING; LIGAND BINDING; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ADRENERGIC RECEPTOR; CARDIOMYOCYTE CONTRACTION; CARDIOVASCULAR; FUNCTIONAL SELECTIVITY; G PROTEIN-COUPLED RECEPTOR (GPCR); MOLECULAR DOCKING; MOLECULAR PHARMACOLOGY; SIGNAL TRANSDUCTION; SITE-DIRECTED MUTAGENESIS;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; AMINO ACID SUBSTITUTION; ANIMALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HUMANS; MALE; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN STABILITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION; TYROSINE;

EID: 84904204362     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.558882     Document Type: Article

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