Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation

Journal of B.U.ON.

Volumn 19, Issue 2, 2014, Pages 372-376

  Zhang, Hua ^a   Zhang, Ming ^b   Tao, Yun ^c   Wang, Ge ^a   Xia, Bing ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b Department of Cardiology Central Hospital of Hubei Xianggang   (China)

^c HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Antitumor effects; Cell apoptosis; Immunomodulation; Madecassic add; Tumor growth

Indexed keywords

MADECASSIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASCITES; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CD4 CD8 RATIO; COLON CANCER; CONTROLLED STUDY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; T LYMPHOCYTE SUBPOPULATION; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CD4-CD8 RATIO; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; IMMUNOLOGIC FACTORS; INTERLEUKIN-4; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; T-LYMPHOCYTES; TRITERPENES;

EID: 84904166296     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Mushiake H, Tsunoda T, Nukatsuka M et al. Dendritic cells might be one of key factors for eliciting antitumor effect by chemoimmunotherapy in vivo. Cancer Immunol Immun 2005;54:120-128. (Pubitemid 40100834)
2. Salgaller ML, Lodge PA. Use of cellular and cytokine adjuvants in the immunotherapy of cancer. J Surg Oncol 1998;68:122-138. (Pubitemid 28269982)
3. Chabner BA, Roberts TG Jr. Timeline: Chemotherapy and the war on cancer. Nat Rev Cancer 2005;5:65-72
4. Bonte F, Dumas M, Chaudagne C et al. Influence of asiatic add, madecassic add, and asiaticoside on human collagen I synthesis. Planta Med 1994;60:133-135. (Pubitemid 24120896)
5. Won JH, Shin JS, Park HJ et al. Anti-inflammatory Effects of Madecassic Add via the Suppression of NF-κB Pathway in LPS-Induced RAW 264.7 Macrophage Cells. Planta Med 2010;76:251-257.
6. Harada T, Miura NN, Adachi Y et al. IFN-gamma induction by SCG, 1,3-beta-D-glucan from Sparassis crispa, in DBA/2 mice in vitro. J Interf Cytok Res 2002;221:227-1239.
7. Yoon YD, Han SB, Kang JS et al. Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum. Int Immunopharmacol 2003;3:1873-1882. (Pubitemid 37421270)
8. Nergard CS, Diallo D, Michaelsen TE et al. Isolation, partial characterization and immunomodulating activities of polysacchrides from Vernonia kotschyana Sch. Bip. ex Walp. J Ethnopharmacol 2004;91:141-152. (Pubitemid 38292046)
9. Nam KS, Shon YH. Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells. BMB Rep 2009;42:277-280.
10. Won DP, Lee JS, Kwon DS et al. Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus. Mol Cells 2011;31:165-173.
11. Schulze-Bergkamen H, Krammer PH. Apoptosis in cancer-implications for therapy. Semin Oncol 2004;31:90-119.
12. Han SK, Yee SC, Taeseok K et al. Enhancement of antitumor immunity of dendritic cells pulsed with heat-treated tumor lysate in murine pancreatic cancer. Immunol Lett 2006;103:142-148.
13. Levitsky HI, Lazenby A, Hayashi RJ et al. In vivo priming of two distinct antitumor effector populations: the role of MHC Qass I expression. J Exp Med 1994;179:1215-1224. (Pubitemid 24091780)
14. Mumberg D, Monach PA, Wanderling S et al. CD4+T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-g. Immunology 1999;96:8633-8638. (Pubitemid 29354843)
15. Schüler T, Qin Z, Ibe S, Noben-Trauth N et al. T Helper Cell Type 1-assodated and Cytotoxic T Lymphocyte-mediated Tumor Immunity Is Impaired in Interleukin 4-defident Mice. J Exp Med 1999;189:803-810. (Pubitemid 29189685)