Thymosin β4 up-regulation of MicroRNA-146a promotes oligodendrocyte differentiation and suppression of the toll-like proinflammatory pathway

Journal of Biological Chemistry

Volumn 289, Issue 28, 2014, Pages 19508-19518

  Santra, Manoranjan ^a   Zhang, Zheng Gang ^a   Yang, James ^b   Santra, Sutapa ^a   Santra, Soumi ^a   Chopp, Michael ^a,c   Morris, Daniel C ^b  

^a HENRY FORD HOSPITAL   (United States)

^b HENRY FORD HEALTH SYSTEM   (United States)

^c OAKLAND UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELLS; NEUROLOGY; POLYMERASE CHAIN REACTION; PROTEINS; RATS; RNA; SIGNALING; TISSUE;

IL-1 RECEPTOR-ASSOCIATED KINASE; INFLAMMATORY RESPONSE; INNATE IMMUNE RESPONSE; NEUROLOGICAL RECOVERIES; PRO-INFLAMMATORY CYTOKINES; QUANTITATIVE REAL TIME PCR; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED FACTORS; WESTERN-BLOT ANALYSIS;

MOLECULAR BIOLOGY;

EARLY GROWTH RESPONSE FACTOR 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; JANUS KINASE 1; MESSENGER RNA; MICRORNA; MICRORNA 146A; MICRORNA 146B; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELIN BASIC PROTEIN; PROTEIN C JUN; SMALL INTERFERING RNA; THYMOSIN BETA4; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; RNA ANALYSIS; UPREGULATION; WESTERN BLOTTING;

ACTIN; MICRORNA (MIRNA); MYELIN; OLIGODENDROCYTE; TOLL-LIKE RECEPTOR (TLR);

ANIMALS; CELL DIFFERENTIATION; CYTOKINES; HEP G2 CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MICE; MICRORNAS; MYELIN BASIC PROTEIN; OLIGODENDROGLIA; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; THYMOSIN; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 84904163909     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.529966     Document Type: Article

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