메뉴 건너뛰기




Volumn 1194, Issue , 2010, Pages 112-117

Thymosin β4: A candidate for treatment of stroke?

Author keywords

Neurogenesis; Neurorestorative; Stroke; Thymosin 4

Indexed keywords

ERYTHROPOIETIN; FIBRINOLYTIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NITRIC OXIDE DONOR; THYMOSIN BETA4; RECOMBINANT ERYTHROPOIETIN; THYMOSIN; THYMOSIN BETA(4);

EID: 77951776928     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05469.x     Document Type: Conference Paper
Times cited : (19)

References (45)
  • 1
    • 62149099593 scopus 로고    scopus 로고
    • Worldwide stroke incidence and early case fatality reported in 56 population-based studies: A systematic review
    • Feigin, V.L. et al. 2009. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: A systematic review. Lancet Neurol. 8: 355-369.
    • (2009) Lancet Neurol. , vol.8 , pp. 355-369
    • Feigin, V.L.1
  • 2
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke. The national institute of neurological disorders and stroke rt-PA stroke study group
    • NINDS
    • NINDS. 1995. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N. Engl. J. Med. 333: 1581-1587.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1581-1587
  • 3
    • 52649165720 scopus 로고    scopus 로고
    • Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    • Hacke, W. et al. 2008. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N. Engl. J. Med. 359: 1317-1329.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1317-1329
    • Hacke, W.1
  • 4
    • 13944280025 scopus 로고    scopus 로고
    • Prioritizing interventions to improve rates of thrombolysis for ischemic stroke
    • CASPER Investigators
    • CASPER Investigators. 2005. Prioritizing interventions to improve rates of thrombolysis for ischemic stroke. Neurology 64: 654-659.
    • (2005) Neurology , vol.64 , pp. 654-659
  • 5
    • 33646191849 scopus 로고    scopus 로고
    • IV tissue plasminogen activator use in acute stroke: Experience froma statewide registry
    • Deng, Y.Z. et al. 2006. IV tissue plasminogen activator use in acute stroke: Experience froma statewide registry. Neurology 66: 306-312.
    • (2006) Neurology , vol.66 , pp. 306-312
    • Deng, Y.Z.1
  • 6
    • 70350521869 scopus 로고    scopus 로고
    • US geographic distribution of rt-PA utilization by hospital for acute ischemic stroke
    • Kleindorfer, D. et al. 2009. US geographic distribution of rt-PA utilization by hospital for acute ischemic stroke. Stroke 40: 3580-3584.
    • (2009) Stroke , vol.40 , pp. 3580-3584
    • Kleindorfer, D.1
  • 7
    • 20444389338 scopus 로고    scopus 로고
    • Acute stroke care in the US: Results from 4 pilot prototypes of the paul coverdell national acute stroke registry
    • Reeves, M.J. et al. 2005. Acute stroke care in the US: Results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry. Stroke 36: 1232-1240.
    • (2005) Stroke , vol.36 , pp. 1232-1240
    • Reeves, M.J.1
  • 8
    • 0034213060 scopus 로고    scopus 로고
    • Recovery recapitulates ontogeny
    • Cramer, S.C. & M. Chopp. 2000. Recovery recapitulates ontogeny. Trends Neurosci. 23: 265-271.
    • (2000) Trends Neurosci. , vol.23 , pp. 265-271
    • Cramer, S.C.1    Chopp, M.2
  • 9
    • 0030693379 scopus 로고    scopus 로고
    • Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats
    • Hayashi, T. et al. 1997. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke 28: 2039-2044.
    • (1997) Stroke , vol.28 , pp. 2039-2044
    • Hayashi, T.1
  • 10
    • 0031692291 scopus 로고    scopus 로고
    • Neuronal damage and plasticity identified by microtubule-associated protein 2, growthassociated protein 43, and cyclin D1 immunoreactivity after focal cerebral ischemia in rats
    • discussion 1980-11971
    • Li, Y. et al. 1998. Neuronal damage and plasticity identified by microtubule-associated protein 2, growthassociated protein 43, and cyclin D1 immunoreactivity after focal cerebral ischemia in rats. Stroke 29:1972-1980; discussion 1980-11971
    • (1998) Stroke , vol.29 , pp. 1972-1980
    • Li, Y.1
  • 11
    • 0030576878 scopus 로고    scopus 로고
    • Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination
    • Jones, T.A., J.A. Kleim &W.T. Greenough. 1996. Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination. Brain Res. 733: 142-148.
    • (1996) Brain Res. , vol.733 , pp. 142-148
    • Jones, T.A.1    Kleim, J.A.2    Greenough, W.T.3
  • 12
    • 0026642175 scopus 로고
    • Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage
    • Jones, T.A. & T. Schallert. 1992. Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage. Brain Res. 581: 156-160.
    • (1992) Brain Res. , vol.581 , pp. 156-160
    • Jones, T.A.1    Schallert, T.2
  • 13
    • 64349107251 scopus 로고    scopus 로고
    • Neurorestorative therapies for stroke: Underlying mechanisms and translation to the clinic
    • Zhang, Z.G. & M. Chopp. 2009. Neurorestorative therapies for stroke: Underlying mechanisms and translation to the clinic. Lancet Neurol. 8: 491-500.
    • (2009) Lancet Neurol. , vol.8 , pp. 491-500
    • Zhang, Z.G.1    Chopp, M.2
  • 14
    • 0036843061 scopus 로고    scopus 로고
    • Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats
    • Zhang, R. et al. 2002. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 33: 2675-2680.
    • (2002) Stroke , vol.33 , pp. 2675-2680
    • Zhang, R.1
  • 15
    • 0038443056 scopus 로고    scopus 로고
    • Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke
    • Chen, J. et al. 2003. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann.Neurol. 53: 743-751.
    • (2003) Ann.Neurol. , vol.53 , pp. 743-751
    • Chen, J.1
  • 16
    • 25444461637 scopus 로고    scopus 로고
    • Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury
    • Lu, D. et al. 2005. Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J. Neurotrauma 22: 1011-1017.
    • (2005) J. Neurotrauma , vol.22 , pp. 1011-1017
    • Lu, D.1
  • 17
    • 3042688444 scopus 로고    scopus 로고
    • Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats
    • Wang, L. et al. 2004. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke 35: 1732-1737.
    • (2004) Stroke , vol.35 , pp. 1732-1737
    • Wang, L.1
  • 18
    • 33646520086 scopus 로고    scopus 로고
    • N-cadherin mediates nitric oxideinduced neurogenesis in young and retired breeder neurospheres
    • Chen, J. et al. 2006. N-cadherin mediates nitric oxideinduced neurogenesis in young and retired breeder neurospheres. Neuroscience 140: 377-388.
    • (2006) Neuroscience , vol.140 , pp. 377-388
    • Chen, J.1
  • 19
    • 0031928119 scopus 로고    scopus 로고
    • Multipotent progenitor cells in the adult dentate gyrus
    • Gage, F.H. et al. 1998.Multipotent progenitor cells in the adult dentate gyrus. J. Neurobiol. 36: 249-266.
    • (1998) J. Neurobiol. , vol.36 , pp. 249-266
    • Gage, F.H.1
  • 20
    • 0033040497 scopus 로고    scopus 로고
    • Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
    • Doetsch, F. et al. 1999. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97: 703-716.
    • (1999) Cell , vol.97 , pp. 703-716
    • Doetsch, F.1
  • 21
  • 22
    • 33745576853 scopus 로고    scopus 로고
    • Olig gene function in CNS development and disease
    • Ligon, K.L. et al. 2006. Olig gene function in CNS development and disease. Glia 54: 1-10.
    • (2006) Glia , vol.54 , pp. 1-10
    • Ligon, K.L.1
  • 23
    • 0036735672 scopus 로고    scopus 로고
    • Neuronal replacement from endogenous precursors in the adult brain after stroke
    • Arvidsson, A. et al. 2002. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8: 963-970.
    • (2002) Nat. Med. , vol.8 , pp. 963-970
    • Arvidsson, A.1
  • 24
    • 1842586126 scopus 로고    scopus 로고
    • Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats
    • Zhang, R. et al. 2004. Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats. J. Cereb. Blood Flow Metab. 24: 441-448.
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , pp. 441-448
    • Zhang, R.1
  • 25
    • 0033153135 scopus 로고    scopus 로고
    • Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons
    • Francis, F. et al. 1999. Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron 23: 247-256.
    • (1999) Neuron , vol.23 , pp. 247-256
    • Francis, F.1
  • 26
    • 0013945220 scopus 로고
    • Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin)
    • Goldstein, A.L., F.D. Slater & A. White. 1966. Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin). Proc. Natl. Acad. Sci. USA 56: 1010-1017.
    • (1966) Proc. Natl. Acad. Sci. USA , vol.56 , pp. 1010-1017
    • Goldstein, A.L.1    Slater, F.D.2    White, A.3
  • 27
    • 24344500165 scopus 로고    scopus 로고
    • Thymosin beta4: Actin-sequestering protein moonlights to repair injured tissues
    • Goldstein, A.L., E. Hannappel & H.K. Kleinman. 2005. Thymosin beta4: Actin-sequestering protein moonlights to repair injured tissues. Trends Mol. Med. 11: 421-429.
    • (2005) Trends Mol. Med. , vol.11 , pp. 421-429
    • Goldstein, A.L.1    Hannappel, E.2    Kleinman, H.K.3
  • 28
    • 9644281738 scopus 로고    scopus 로고
    • Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
    • Bock-Marquette, I. et al. 2004. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432: 466-472.
    • (2004) Nature , vol.432 , pp. 466-472
    • Bock-Marquette, I.1
  • 29
    • 33846243239 scopus 로고    scopus 로고
    • Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization
    • Smart, N. et al. 2007. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature 445: 177-182.
    • (2007) Nature , vol.445 , pp. 177-182
    • Smart, N.1
  • 30
    • 44049106474 scopus 로고    scopus 로고
    • Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection
    • Hinkel, R. et al. 2008. Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation 117: 2232-2240.
    • (2008) Circulation , vol.117 , pp. 2232-2240
    • Hinkel, R.1
  • 31
    • 0032589242 scopus 로고    scopus 로고
    • 4 messenger RNA in normal and kainate-treated rat forebrain
    • DOI 10.1016/S0306-4522(98)00494-1, PII S0306452298004941
    • Carpintero, P. et al. 1999. Expression of thymosin beta4 messenger RNA in normal and kainate-treated rat forebrain. Neuroscience 90: 1433-1444. (Pubitemid 29170158)
    • (1999) Neuroscience , vol.90 , Issue.4 , pp. 1433-1444
    • Carpintero, P.1    Anadon, R.2    Diaz-Regueira, S.3    Gomez-Marquez, J.4
  • 32
    • 0041466154 scopus 로고    scopus 로고
    • The betathymosins, small actin-binding peptides widely expressed in the developing and adult cerebellum
    • Gomez-Marquez, J. & R. Anadon. 2002. The betathymosins, small actin-binding peptides widely expressed in the developing and adult cerebellum. Cerebellum 1: 95-102.
    • (2002) Cerebellum , vol.1 , pp. 95-102
    • Gomez-Marquez, J.1    Anadon, R.2
  • 33
    • 30744472648 scopus 로고    scopus 로고
    • Local synthesis of actinbinding protein beta-thymosin regulates neurite outgrowth
    • van Kesteren, R.E. et al. 2006. Local synthesis of actinbinding protein beta-thymosin regulates neurite outgrowth. J. Neurosci. 26: 152-157.
    • (2006) J. Neurosci. , vol.26 , pp. 152-157
    • Van Kesteren, R.E.1
  • 34
    • 52549114744 scopus 로고    scopus 로고
    • The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression
    • Yang, H. et al. 2008. The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression. Neurochem. Res. 33: 2269-2280.
    • (2008) Neurochem. Res. , vol.33 , pp. 2269-2280
    • Yang, H.1
  • 35
    • 29144460816 scopus 로고    scopus 로고
    • Expression of thymosin beta4 mRNA by activated microglia in the denervated hippocampus
    • Dong, J.H. et al. 2005. Expression of thymosin beta4 mRNA by activated microglia in the denervated hippocampus. Neuroreport 16: 1629-1633.
    • (2005) Neuroreport , vol.16 , pp. 1629-1633
    • Dong, J.H.1
  • 36
    • 0035111235 scopus 로고    scopus 로고
    • Early and progressive accumulation of reactive microglia in the Huntington disease brain
    • Sapp, E. et al. 2001. Early and progressive accumulation of reactive microglia in the Huntington disease brain. J. Neuropathol. Exp. Neurol. 60: 161-172.
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 161-172
    • Sapp, E.1
  • 37
    • 0029743803 scopus 로고    scopus 로고
    • Induction of thymosin beta(4) mRNA following focal brain ischemia
    • Vartiainen,N. et al. 1996. Induction of thymosin beta(4) mRNA following focal brain ischemia. Neuroreport 7: 1613-1616.
    • (1996) Neuroreport , vol.7 , pp. 1613-1616
    • Vartiainen, N.1
  • 38
    • 0035215010 scopus 로고    scopus 로고
    • Postischemic (6-hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemia
    • Zhang, L. et al. 2001. Postischemic (6-hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemia. Stroke 32: 2926-2931.
    • (2001) Stroke , vol.32 , pp. 2926-2931
    • Zhang, L.1
  • 39
    • 0028059959 scopus 로고
    • Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat
    • Zhang, R.L. et al. 1994. Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat. Neurology 44: 1747-1751.
    • (1994) Neurology , vol.44 , pp. 1747-1751
    • Zhang, R.L.1
  • 40
    • 0030955304 scopus 로고    scopus 로고
    • A rat model of focal embolic cerebral ischemia
    • Zhang, R.L. et al. 1997. A rat model of focal embolic cerebral ischemia. Brain Res. 766: 83-92.
    • (1997) Brain Res. , vol.766 , pp. 83-92
    • Zhang, R.L.1
  • 41
    • 0001373003 scopus 로고    scopus 로고
    • Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain
    • Zhang, R.L. et al. 1999. Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain. Stroke 30: 624-629.
    • (1999) Stroke , vol.30 , pp. 624-629
    • Zhang, R.L.1
  • 42
    • 0028802225 scopus 로고
    • Postischemic treatment (2-4 h) with anti-CD11b and anti-CD18 monoclonal antibodies are neuroprotective after transient (2 h) focal cerebral ischemia in the rat
    • Zhang, Z.G. et al. 1995. Postischemic treatment (2-4 h) with anti-CD11b and anti-CD18 monoclonal antibodies are neuroprotective after transient (2 h) focal cerebral ischemia in the rat. Brain Res. 698: 79-85.
    • (1995) Brain Res. , vol.698 , pp. 79-85
    • Zhang, Z.G.1
  • 43
    • 17944362830 scopus 로고    scopus 로고
    • Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion
    • Zhang, Z.G. et al. 2001. Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion. Brain Res. 912: 181-194.
    • (2001) Brain Res. , vol.912 , pp. 181-194
    • Zhang, Z.G.1
  • 44
    • 0036637271 scopus 로고    scopus 로고
    • Animal models of neurological deficits: How relevant is the rat?
    • Cenci, M.A., I.Q.Whishaw & T. Schallert. 2002. Animal models of neurological deficits: How relevant is the rat? Nat. Rev. Neurosci. 3: 574-579.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 574-579
    • Cenci, M.A.1    Whishaw, I.Q.2    Schallert, T.3
  • 45
    • 0021187529 scopus 로고
    • Bilateral cutaneous stimulation of the somatosensory system in hemidecorticate rats
    • Schallert, T. & I.Q. Whishaw. 1984. Bilateral cutaneous stimulation of the somatosensory system in hemidecorticate rats. Behav. Neurosci. 98: 518-540.
    • (1984) Behav. Neurosci. , vol.98 , pp. 518-540
    • Schallert, T.1    Whishaw, I.Q.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.