Synthesis of a new series of N4-substituted 4-(2-aminoethyl) benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes i and II and transmembrane tumor-associated isozymes IX and XII

European Journal of Medicinal Chemistry

Volumn 84, Issue , 2014, Pages 59-67

  Sławiński, Jarosław ^a   Brzozowski, Zdzisław ^a   Zołnowska, Beata ^a   Szafrański, Krzysztof ^a   Pogorzelska, Aneta ^a   Vullo, Daniela ^b   Supuran, Claudiu T ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic anhydrase isozymes I, II, IX and XII inhibitors; Sulfonamide; Synthesis

Indexed keywords

3 SULFAMOYL 4 [2 (4 SULFAMOYLPHENYL)ETHYLAMINO] 1 METHYLPYRIDINIUM IODIDE; 4 (2 HYDROXY 5 METHYLPHENYL) 3 [2 (4 SULFAMOYLPHENYL)ETHYLAMINO] 4H PYRIDO[4,3 E] 1,2,4 THIADIAZINE; 4 (2 HYDROXYPHENYL) 3 [2 (4 SULFAMOYLPHENYL)ETHYLAMINO] 4H PYRIDO[4,3 E] 1,2,4 THIADIAZINE; 4 (5 CHLORO 2 HYDROXYPHENYL) 3 [2 (4 SULFAMOYLPHENYL)ETHYLAMINO] 4H PYRIDO[4,3 E] 1,2,4 THIADIAZINE 1,1 DIOXIDE; 4 [2 (4 CHLORO 3 NITROBENZYLIDENEAMINO)ETHYL]BENZENESULFONAMIDE; 4 [2 (4 SULFAMOYLPHENYL)ETHYLAMINO] 1 METHYLPYRIDINIUM 3 SULFONAMIDATE; 4 [2 (5 NITRO 2 THIENYLIDENEAMINO)ETHYL]BENZENESULFONAMIDE; 4 [2 [(6 CHLORO 1,1 DIOXO 7 METHYL 1,4,2 BENZODITHIAZIN 3 YL)AMINO]ETHYL]BENZENESULFONAMIDE; 4 [2 [6 CHLORO 1,1 DIOXO 7 (4 METHYLPHENYLCARBAMOYL) 1,4,2 BENZODITHIAZIN 3 YLAMINO]ETHYL]BENZENESULFONAMIDE; 4 [2 [6 CHLORO 7 (4 CHLOROPHENYLCARBAMOYL) 1,1 DIOXO 1,4,2 BENZODITHIAZIN 3 YLAMINO]ETHYL]BENZENESULFONAMIDE; ACETAZOLAMIDE; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; DICLOFENAMIDE; ETHOXZOLAMIDE; INDISULAM; METHAZOLAMIDE; N (4 CHLOROPHENYL) 2 [(4 SULFAMOYLPHENYL)ETHYL]AMINOACETAMIDE; N (4 SULFAMOYLPHENYL) 2 [(4 SULFAMOYLPHENYL)ETHYL]AMINOACETAMIDE; UNCLASSIFIED DRUG; 4 (2 AMINOETHYL)BENZENESULFONAMIDE DERIVATIVE; 4 (2 HYDROXY 5 METHYLPHENYL) 3 [2 (4 SULFAMOYLPHENYL)ETHYLAMINO] 4H PYRIDO[4,3 E] 1,2,4 THIADIAZINE 1,1 DIOXIDE; 4 (2 HYDROXYPHENYL) 3 [2 (4 SULFAMOYLPHENYL)ETHYLAMINO] 4H PYRIDO[4,3 E] 1,2,4 THIADIAZINE 1,1 DIOXIDE; 4 [2 [(6 CHLORO 1,1 DIOXO 7 METHYL 1,4,2 BENZODITHIAZIN 3YL)AMINO]ETHYL]BENZENESULFONAMIDE; 4 [2 [6 CHLORO 7 (4 CHLOROPHENYLCARBAMOYL) 1,1 DIOXO 1,4,2 BENZODITHIAZIN 3 YLAMINO]ETHYL]BENZENSULFONAMIDE; N,N' BIS[2 (4 SULFAMOYLPHENYL)ETHYL]SULFAMIDE; BENZENESULFONAMIDE; CARBONATE DEHYDRATASE; ISOENZYME; SULFONAMIDE;

ADDITION REACTION; ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOPHILICITY; POLYMERIZATION; BINDING AFFINITY; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME BINDING; HUMAN; IC50; INHIBITION CONSTANT; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOENZYMES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84904157823     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.074     Document Type: Article

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