Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes i and II and transmembrane cancer-associated isozymes IX and XII

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 3656-3661

  Brzozowski, Zdzisław ^a   Sławiński, Jarosław ^a   Innocenti, Alessio ^b   Supuran, Claudiu T ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

1,4 Dihydro 4 oxo 3 pyridinesulfonamides; Carbonic anhydrase isozymes I, II, IX and XII inhibitors; Synthesis

Indexed keywords

1 (3,4 DICHLOROPHENACYL) 1,4 DIHYDRO 4 OXO 3 PYRIDINESULFONAMIDE; 1 (4 CHLOROPHENACYL) 1,4 DIHYDRO 4 OXO 3 PYRIDINESULFONAMIDE; 1 (4 FLUOROPHENACYL) 1,4 DIHYDRO 4 OXO 3 PYRIDINESULFONAMIDE; 1 (CARBAMOYLMETHYL) 1,4 DIHYDRO 4 OXO 3 PYRIDINESULFONAMIDE; 1 BENZYL 1,4 DIHYDRO 4 OXO 3 PYRIDINESULFONAMIDE; 1,4 DIHYDRO 1 (2 METHOXYCARBONYLAMINOBENZOYL) 4 OXO 3 PYRIDINESULFONAMIDE; 1,4 DIHYDRO 1 (2 NAPHTHOYLMETHYL) 4 OXO 3 PYRIDINESULFONAMIDE; 1,4 DIHYDRO 1 (2,4 DINITROPHENYL) 4 OXO 3 PYRIDINESULFONAMIDE; 1,4 DIHYDRO 1 (2,6 DINITROPHENYL) 4 OXO 3 PYRIDINESULFONAMIDE; 1,4 DIHYDRO 1 (3 NITROPHENACYL) 4 OXO 3 PYRIDINESULFONAMIDE; 1,4 DIHYDRO 1 (4 NITROPHENACYL) 4 OXO 3 PYRIDINESULFONAMIDE; 1,4 DIHYDRO 1 (7 NITROFURAZON 4 YL) 4 OXO 3 PYRIDINESULFONAMIDE; 1,4 DIHYDRO 1 METHYL 4 OXO 3 PYRIDINESULFONAMIDE; 1,4 DIHYDRO 4 OXO 1 (3 SULFAMOYLPYRID 4 YL) 3 PYRIDIENSULFONAMIDE; 1,4 DIHYDRO 4 OXO 1 (6 PURINYL) 3 PYRIDINESULFONAMIDE; 4 METHOXY 3 PYRIDINESULFONAMIDE; ACETAZOLAMIDE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; DICLOFENAMIDE; ETHOXZOLAMIDE; METHAZOLAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; HUMAN; INHIBITION KINETICS;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL MEMBRANE; CYTOSOL; HUMANS; ISOENZYMES; NEOPLASMS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; SULFONAMIDES;

EID: 77955555759     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.05.011     Document Type: Article

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