Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes i and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4403-4410

  Brzozowski, Zdzisław ^a   Sławiński, Jarosław ^a   Gdaniec, Maria ^b   Innocenti, Alessio ^c   Supuran, Claudiu T ^c  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b ADAM MICKIEWICZ UNIVERSITY   (Poland)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

3 Pyridinesulfonamides; Carbonic anhydrase isozymes I, II, IX, XII and XIV inhibitors; Synthesis; X ray structure

Indexed keywords

1 (3 SULFAMOYLPYRID 4 YL)PYRIDINIUM CHLORIDE; 2 [8 METHOXY 5,5 DIOXO 6,6A DIHYDRODIPYRIDO[2,1 C:4',3' E](1,2,4)THIADIAZINE]SULFONAMIDE; 2 METHYL 1 (3 SULFAMOYLPYRID 4 YL)PYRIDINIUM CHLORIDE; 4 (1,2 DIHYDRO 2 OXOPYRID 1 YL) 3 PYRIDINESULFONAMIDE; 4 (1,4 DIHYDRO 4 OXO 3 SULFOMOYLPYRIDIN 1 YL) 3 PYRIDINESULFONAMIDE; 4 (1,4 DIHYDRO 4 OXOPYRID 1 YL) 3 PYRIDINESULFONAMIDE; 4 DIMETHYLAMINO 1 (3 SULFAMOYLPYRID 4 YL)PYRIDINIUM CHLORIDE; 4 METHYL 1 (3 SULFAMOYLPYRID 4 YL)PYRIDINIUM CHLORIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; CARBONATE DEHYDRATASE XIV; PYRIDINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENZYME INHIBITION; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONE POT SYNTHESIS; X RAY DIFFRACTION;

CARBONIC ANHYDRASE INHIBITORS; CYTOSOL; HUMANS; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SULFONAMIDES;

EID: 80052947513     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.011     Document Type: Article

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