Bone marrow fat

Joint Bone Spine

Volumn 81, Issue 4, 2014, Pages 313-319

  Hardouin, Pierre ^a,b,c   Pansini, Vittorio ^a,c,d   Cortet, Bernard ^a,c,d  

^a UNIV LILLE   (France)

^b UNIVERSITÉ DU LITTORAL CÔTE D OPALE   (France)

^c Physiopathologie des Maladies Osseuses Inflammatoires   (France)

^d LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

Adipocyte; Anorexia nervosa; Bone marrow; Fat; Osteoblast; Osteoporosis

Indexed keywords

ADIPONECTIN; FATTY ACID; GADOLINIUM; MESSENGER RNA; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; SATURATED FATTY ACID;

ABDOMINAL FAT; ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANOREXIA NERVOSA; BODY FAT; BONE DENSITY; BONE MARROW; BONE MARROW FAT; BONE MASS; BONE MINERAL; BONE NECROSIS; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; DIAPHYSIS; ENERGY METABOLISM; EPIPHYSIS; FAT EMBOLISM; FRACTURE; FRAGILITY FRACTURE; HUMAN; INTERVERTEBRAL DISK DISEASE; INTRAABDOMINAL FAT; LIPID STORAGE; MESENCHYMAL STEM CELL; METABOLIC DISORDER; METAPHYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; PHENOTYPE; POSTMENOPAUSE; PROTEIN FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE; SHORT SURVEY; SLEEP DISORDERED BREATHING; SUBCUTANEOUS FAT; THERMOGENESIS; WHITE ADIPOSE TISSUE; AGE; DIAGNOSTIC PROCEDURE; FAT MASS; FEMUR HEAD NECROSIS; HEMATOLOGIC DISEASE; IMAGING; IN VIVO STUDY; MICROSCOPY; RISK ASSESSMENT; RISK FACTOR; TREATMENT INDICATION;

ADIPOCYTE; ANOREXIA NERVOSA; BONE MARROW; FAT; OSTEOBLAST; OSTEOPOROSIS;

ADIPOCYTES; ADIPOSE TISSUE; BONE MARROW; HUMANS; OSTEOPOROSIS;

EID: 84904129037     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2014.02.013     Document Type: Short Survey

References (60)

1. Vande Berg B.C., Malghem J., Lecouvet F.E., et al. Magnetic resonance imaging of normal bone marrow. Eur Radiol 1998, 8:1327-1334.
2. Wehrli F.W., Hopkins J.A., Hwang S.N., et al. Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry. Radiology 2000, 217:527-538.
3. Shen W., Chen J., Gantz M., et al. MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults. Eur J Clin Nutr 2012, 66:983-988.
4. Scheller E., Cawthorn W., Learman B., et al. The metabolic nature of marrow fat: insulin signaling. CREB phosphorylation and the «adiponectin paradox». J Bone Miner Res 2013, S241. [ASBMR 2013 Annual Meeting].
5. Meunier P., Aaron J., Edouard C., et al. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Rel Res 1971, 80:147-154.
6. Justesen J., Stenderup K., Ebbesen E.N., et al. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology 2001, 2:165-171.
7. Verma S., Rajaratnam J.H., Denton J., et al. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 2002, 55:693-698.
8. Abella E., Feliu E., Granada I., et al. Bone marrow changes in anorexia nervosa are correlated with the amount of weight loss and not with other clinical findings. Am J Clin Pathol 2002, 118:582-588.
9. Cohen A., Dempster D.W., Stein E.M., et al. Increased marrow adiposity in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab 2012, 97:2782-2791.
10. Di Iorgi N., Rosol M., Mittelman S.D., et al. Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults. J Clin Endocrinol Metab 2008, 93:2281-2286.
11. Schellinger D., Lin C.S., Lim J., et al. Bone marrow fat and bone mineral density on proton MR spectroscopy and dual-energy X-ray absorptiometry: their ratio as a new indicator of bone weakening. AJR Am J Roentgenol 2004, 183:1761-1765.
12. Li X., Kuo D., Schafer A.L., et al. Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis. J Magn Reson Imaging 2011, 33:974-979.
13. Pansini V., Monnet A., Salleron J., et al. 3 Tesla (1) H MR spectroscopy of hip bone marrow in a healthy population, assessment of normal fat value and influence of age and sex. J Magn Reson Imaging 2014, 39:369-376.
14. Schellinger D., Lin C.S., Hatipoglu H.G., et al. Potential value of vertebral proton MR spectroscopy in determining bone weakness. AJNR Am J Neuroradiol 2001, 22:1620-1627.
15. Griffith J.F., Yeung D.K.W., Ahuja A.T., et al. A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density. Bone 2009, 44:1092-1096.
16. Shen W., Scherzer R., Gantz M., et al. Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants: the CARDIA study. J Clin Endocrinol Metab 2012, 97:1337-1346.
17. Di Iorgi N., Mo A.O., Grimm K., et al. Bone acquisition in healthy young females is reciprocally related to marrow adiposity. J Clin Endocrinol Metab 2010, 95:2977-2982.
18. Ecklund K., Vajapeyam S., Feldman H.A., et al. Bone marrow changes in adolescent girls with anorexia nervosa. J Bone Miner Res 2010, 25:298-304.
19. Liu L.-F., Shen W.-J., Ueno M., et al. Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes. BMC Genomics 2011, 12:212.
20. Poloni A., Maurizi G., Serrani F., et al. Molecular and functional characterization of human bone marrow adipocytes. Exp Hematol 2013, 41:558e2-566e2.
21. Laharrague P., Fontanilles A.M., Tkaczuk J., et al. Inflammatory/haematopoietic cytokine production by human bone marrow adipocytes. Eur Cytokine Netw 2000, 11:634-639.
22. Lecka-Czernik B. Marrow fat metabolism is linked to the systemic energy metabolism. Bone 2012, 50:534-539.
23. Wang D., Haile A., Jones L.C. Dexamethasone-induced lipolysis increases the adverse effect of adipocytes on osteoblasts using cells derived from human mesenchymal stem cells. Bone 2013, 53:520-530.
24. Pittenger M.F., Mackay A.M., Beck S.C., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
25. Sadie-Van Gijsen H., Hough F.S., Ferris W.F. Determinants of bone marrow adiposity: The modulation of peroxisome proliferator-activated receptor-γ2 activity as a central mechanism. Bone 2013, 56:255-265.
26. Marie P.J., Saidak S. Bone marrow adipocytes and bone aging. Osteoporos Int 2013, 24:S453-S455.
27. Nuttall M.E., Shah F., Singh V., et al. Adipocytes and the Regulation of Bone Remodeling: A Balancing Act. Calcif Tissue Int 2014, 94:78-87.
28. Hamrick M.W., Pennington C., Newton D., et al. Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone 2004, 34:376-383.
29. Rosen C.J., Bouxsein M.L. Mechanisms of disease: is osteoporosis the obesity of bone?. Nat Clin Pract Rheumatol 2006, 2:35-43.
30. Fazeli P.K., Horowitz M.C., MacDougald O.A., et al. Marrow fat and bone-new perspectives. J Clin Endocrinol Metab 2013, 98:935-945.
31. Krings A., Rahman S., Huang S., et al. Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes. Bone 2012, 50:546-552.
32. Lucas S., Clabaut A., Ghali O., et al. Implication of fatty acids in the inhibitory effect of human adipocytes on osteoblastic differentiation. Bone 2013, 55:429-430.
33. Clabaut A., Delplace S., Chauveau C., et al. Human osteoblasts derived from mesenchymal stem cells express adipogenic markers upon coculture with bone marrow adipocytes. Differentiation 2010, 80:40-45.
34. Pino A.M., Ríos S., Astudillo P., et al. Concentration of adipogenic and pro-inflammatory cytokines in the bone marrow supernatant fluid of osteoporotic women. J Bone Miner Res 2010, 25:492-498.
35. Goto H., Hozumi A., Osaki M., et al. Primary human bone marrow adipocytes support TNF-α-induced osteoclast differentiation and function through RANKL expression. Cytokine 2011, 56:662-668.
36. Elbaz A., Rivas D., Duque G. Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice. Biogerontology 2009, 10:747-755.
37. Griffith J.F., Yeung D.K.W., Antonio G.E., et al. Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation. Radiology 2006, 241:831-838.
38. Syed F.A., Oursler M.J., Hefferanm T.E., et al. Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA 2008, 19:1323-1330.
39. Fazeli P.K., Bredella M.A., Misra M., et al. Preadipocyte factor-1 is associated with marrow adiposity and bone mineral density in women with anorexia nervosa. J Clin Endocrinol Metab 2010, 95:407-413.
40. Devlin M.J., Cloutier A.M., Thomas N.A., et al. Caloric restriction leads to high marrow adiposity and low bone mass in growing mice. J Bone Miner Res 2010, 25:2078-2088.
41. Devlin M., Conlon C., Van Vliet M., et al. Leptin blunts the starvation-induced increase in bone marow adiposity. J Bone Miner Res 2013, S 342. [ASBMR Annual Meeting].
42. De Abreu M.R., Wesselly M., Chung C.B., et al. Bone marrow MR imaging findings in disuse osteoporosis. Skeletal Radiol 2011, 40:571-575.
43. Rantalainen T., Nikander R., Heinonen A., et al. Differential effects of exercise on tibial shaft marrow density in young female athletes. J Clin Endocrinol Metab 2013, 98:2037-2044.
44. Vande Berg B.C., Gilon R., Malghem J., et al. Correlation between baseline femoral neck marrow status and the development of femoral head osteonecrosis in corticosteroid-treated patients: a longitudinal study by MR imaging. Eur J Radiol 2006, 58:444-449.
45. Slade J.M., Coe L.M., Meyer R.A., et al. Human bone marrow adiposity is linked with serum lipid levels not T1-diabetes. J Diabetes Complications 2012, 26:1-9.
46. Liu Q., Jin L., Shen F.H., et al. Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells-a potential novel treatment for intervertebral disc degeneration. Spine 2013, 13:1571-1580.
47. Naveiras O., Nardi V., Wenzel P.L., et al. Bone marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 2009, 460:259-263.
48. Belaid-Choucair Z., Lepelletier Y., Poncin G., et al. Human bone marrow adipocytes block granulopoiesis through neuropilin-1-induced granulocyte colony-stimulating factor inhibition. Stem Cells Dayt Ohio 2008, 26:1556-1564.
49. Shen W., Gong X., Weiss J., et al. Comparison among T1-weighted magnetic resonance imaging, modified dixon method, and magnetic resonance spectroscopy in measuring bone marrow fat. J Obes 2013, 2013:75-2986.
50. Pichardo J.C., Milner R.J., Bolch W.E. MRI measurement of bone marrow cellularity for radiation dosimetry. J Nucl Med 2011, 52:1482-1489.
51. Patsch J.M., Li X., Baum T., et al. Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures. J Bone Miner Res 2013, 28:1721-1728.
52. Griffith J.F., Yeung D.K.W., Leung J.C.S., et al. Prediction of bone loss in elderly female subjects by MR perfusion imaging and spectroscopy. Eur Radiol 2011, 21:1160-1169.
53. Schwartz A.V., Sigurdsson S., Hue T.F., et al. Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults. J Clin Endocrinol Metab 2013, 98:2294-2300.
54. Loke Y.K., Singh S., Furberg C.D. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ Can Med Assoc J 2009, 180:32-39.
55. García A.I., Milinkovic A., Tomás X., et al. MRI signal changes of the bone marrow in HIV-infected patients with lipodystrophy: correlation with clinical parameters. Skeletal Radiol 2011, 40:1295-1301.
56. Georgiou K.R., Hui S.K., Xian C.J. Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy. Am J Stem Cells 2012, 1:205-224.
57. Duque G., Li W., Adams M., et al. Effects of risedronate on bone marrow adipocytes in postmenopausal women. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA 2011, 22:1547-1553.
58. Duque G., Li W., Vidal C., et al. Pharmacological inhibition of PPARγ increases osteoblastogenesis and bone mass in male C57BL/6 mice. J Bone Miner Res 2013, 28:639-648.
59. Iyer S., Ambrogini E., Bartell S.M., et al. FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest 2013, 123:3409-3419.
60. Tseng P.-C., Hou S.-M., Chen R.-J., et al. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis. J Bone Miner Res 2011, 26:2552-2563.