Primary human bone marrow adipocytes support TNF-α-induced osteoclast differentiation and function through RANKL expression

Cytokine

Volumn 56, Issue 3, 2011, Pages 662-668

  Goto, Hisataka ^a   Hozumi, Akira ^a   Osaki, Makoto ^a   Fukushima, Tatsuya ^a   Sakamoto, Kazutaka ^a   Yonekura, Akihiko ^a   Tomita, Masato ^a   Furukawa, Keizo ^a   Shindo, Hiroyuki ^a   Baba, Hideo ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bone marrow adipocyte; Osteoclast differentiation; Receptor Activator of Nuclear factor B Ligand (RANKL); Tumor necrosis factor alpha (TNF )

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CALCIUM PHOSPHATE; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADULT; AGED; ARTICLE; BONE MARROW CULTURE; CELL FUNCTION; CELL INTERACTION; CELL STRUCTURE; COCULTURE; CONTROLLED STUDY; FEMALE; GENE; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; MACROPHAGE COLONY STIMULATING FACTOR GENE; MALE; MULTINUCLEAR CELL; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOPROTEGERIN GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B LIGAND GENE; STRUCTURE ANALYSIS; UPREGULATION;

ACID PHOSPHATASE; ADIPOCYTES; AGED; AGED, 80 AND OVER; BONE MARROW CELLS; CELL ADHESION; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; ISOENZYMES; MALE; MIDDLE AGED; OSTEOCLASTS; RANK LIGAND; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAINING AND LABELING; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 81455158814     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.09.005     Document Type: Article

References (34)

1. Rosen C.J., Bouxsein M.L. Mechanisms of disease: is osteoporosis the obesity of bone?. Nat Clin Pract Rheumatol 2006, 2:35-43.
2. Gimble J.M., Robinson C.E., Wu X., Kelly K.A. The function of adipocytes in the bone marrow stroma: an update. Bone 1996, 19:421-428.
3. Trayhurn P., Wood I.S. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004, 92:347-355.
4. Akune T., Ohba S., Kamekura S., Yamaguchi M., Chung U.I., Kubota N., et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004, 113:846-855.
5. Luo X.H., Guo L.J., Xie H., Yuan L.Q., Wu X.P., Zhou H.D., et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res 2006, 21:1648-1656.
6. Shinoda Y., Yamaguchi M., Ogata N., Akune T., Kubota N., Yamauchi T., et al. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 2006, 99:196-208.
7. Takeda S., Elefteriou F., Levasseur R., Liu X., Zhao L., Parker K.L., et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002, 111:305-317.
8. Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998, 93:165-176.
9. Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Mochizuki S., et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 1998, 95:3597-3602.
10. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
11. An J.J., Han D.H., Kim D.M., Kim S.H., Rhee Y., Lee E.J., et al. Expression and regulation of osteoprotegerin in adipose tissue. Yonsei Med J 2007, 48:765-772.
12. Beutler B., Greenwald D., Hulmes J.D., Chang M., Pan Y.C., Mathison J., et al. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 1985, 316:552-554.
13. Zou W., Hakim I., Tschoep K., Endres S., Bar-Shavit Z. Tumor necrosis factor-alpha mediates RANK ligand stimulation of osteoclast differentiation by an autocrine mechanism. J Cell Biochem 2001, 83:70-83.
14. Firestein G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423:356-361.
15. Suganami T., Nishida J., Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 2005, 25:2062-2068.
16. Hozumi A., Osaki M., Goto H., Sakamoto K., Inokuchi S., Shindo H. Bone marrow adipocytes support dexamethasone-induced osteoclast differentiation. Biochem Biophys Res Commun 2009, 382:780-784.
17. Goto H., Osaki M., Fukushima T., Sakamoto K., Hozumi A., Baba H., et al. Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression. Biomed Res 2011, 32:37-44.
18. Sugihara H., Yonemitsu N., Miyabara S., Toda S. Proliferation of unilocular fat cells in the primary culture. J Lipid Res 1987, 28:1038-1045.
19. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808.
20. Kelly K.A., Tanaka S., Baron R., Gimble J.M. Murine bone marrow stromally derived BMS2 adipocytes support differentiation and function of osteoclast-like cells in vitro. Endocrinology 1998, 139:2092-2101.
21. Vignery A. Osteoclasts and giant cells: macrophage-macrophage fusion mechanism. Int J Exp Pathol 2000, 81:291-304.
22. Nanes M.S. Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology. Gene 2003, 321:1-15.
23. Kudo O., Fujikawa Y., Itonaga I., Sabokbar A., Torisu T., Athanasou N.A. Proinflammatory cytokine (TNFalpha/IL-1alpha) induction of human osteoclast formation. J Pathol 2002, 198:220-227.
24. Gilbert L., He X., Farmer P., Rubin J., Drissi H., van Wijnen A.J., et al. Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem 2002, 277:2695-2701.
25. Canalis E. Effects of tumor necrosis factor on bone formation in vitro. Endocrinology 1987, 121:1596-1604.
26. Komine M., Kukita A., Kukita T., Ogata Y., Hotokebuchi T., Kohashi O. Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture. Bone 2001, 28:474-483.
27. Mayur N., Lewis S., Catherwood B.D., Nanes M.S. Tumor necrosis factor alpha decreases 1, 25-dihydroxyvitamin D3 receptors in osteoblastic ROS 17/2.8 cells. J Bone Miner Res 1993, 8:997-1003.
28. Boyce B.F., Li P., Yao Z., Zhang Q., Badell I.R., Schwarz E.M., et al. TNF-alpha and pathologic bone resorption. Keio J Med 2005, 54:127-131.
29. Yao Z., Li P., Zhang Q., Schwarz E.M., Keng P., Arbini A., et al. Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression. J Biol Chem 2006, 281:11846-11855.
30. Zhang Y.H., Heulsmann A., Tondravi M.M., Mukherjee A., Abu-Amer Y. Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J Biol Chem 2001, 276:563-568.
31. Takahashi N., Yamana H., Yoshiki S., Roodman G.D., Mundy G.R., Jones S.J., et al. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 1988, 122:1373-1382.
32. Udagawa N., Takahashi N., Akatsu T., Sasaki T., Yamaguchi A., Kodama H., et al. The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 1989, 125:1805-1813.
33. Jiang Y., Mishima H., Sakai S., Liu Y.K., Ohyabu Y., Uemura T. Gene expression analysis of major lineage-defining factors in human bone marrow cells: effect of aging, gender, and age-related disorders. J Orthop Res 2008, 26:910-917.
34. Zhao L.J., Jiang H., Papasian C.J., Maulik D., Drees B., Hamilton J., et al. Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res 2008, 23:17-29.