Human bone marrow adipocytes block granulopoiesis through neuropilin-1-induced granulocyte colony-stimulating factor inhibition

Stem Cells

Volumn 26, Issue 6, 2008, Pages 1556-1564

  Belaid Choucair, Zakia ^a,b   Lepelletier, Yves ^b   Poncin, Géraldine ^a   Thiry, Albert ^a   Humblet, Chantal ^a   Maachi, Mustapha ^c   Beaulieu, Aurore ^a   Schneider, Elke ^b   Briquet, Alexandra ^a   Mineur, Pierre ^a   Lambert, Charles ^a   Mendes Da Cruz, Daniella ^b   Ahui, Marie Louise ^b   Asnafi, Vahid ^d   Dy, Michel ^b   Boniver, Jacques ^a   Nusgens, Betty V ^a   Hermine, Olivier ^b,d   Defresne, Marie Paule ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b CNRS   (France)

^c HÔPITAL TENON   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Adult human bone marrow; Bone marrow adipocytes; Bone marrow stromal cells; Granulopoiesis; In vitro differentiation; Macrophages; Neuropilin 1; Stem cell microenvironment interactions

Indexed keywords

CD34 ANTIGEN; COLONY STIMULATING FACTOR 1; DEXAMETHASONE; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; NEUROPILIN 1; DLK1 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; PRIMER DNA; SIGNAL PEPTIDE;

ADIPOCYTE; ARTICLE; BONE MARROW; CELL CONTACT; CELL DIFFERENTIATION; CONTROLLED STUDY; GRANULOPOIESIS; HUMAN; HUMAN CELL; MACROPHAGE; ANIMAL; BONE MARROW CELL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; MOUSE; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOCYTES; ANIMALS; ANTIGENS, CD; ANTIGENS, CD34; BONE MARROW CELLS; CELL DIFFERENTIATION; DNA PRIMERS; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED NOD; MICE, SCID; NEUROPILIN-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 48649106521     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2008-0068     Document Type: Article

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