Increased marrow adiposity in premenopausal women with idiopathic osteoporosis

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 8, 2012, Pages 2782-2791

  Cohen, Adi ^a   Dempster, David W ^b   Stein, Emily M ^a   Nickolas, Thomas L ^a   Zhou, Hua ^b   McMahon, Donald J ^a   Müller, Ralph ^d   Kohler, Thomas ^d   Zwahlen, Alexander ^d   Lappe, Joan M ^c   Young, Polly ^a   Recker, Robert R ^c   Shane, Elizabeth ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b HELEN HAYES HOSPITAL   (United States)

^c CREIGHTON UNIVERSITY   (United States)

^d ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE; ADIPOGENESIS; ADULT; AGE; ARTICLE; BODY MASS; BONE BIOPSY; BONE DENSITY; BONE MARROW; BONE MASS; BONE REMODELING; CELL COUNT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IDIOPATHIC LOW BONE MINERAL DENSITY; IDIOPATHIC OSTEOPOROSIS; ILIAC BONE; INCREASED BONE MARROW ADIPOSITY; MAJOR CLINICAL STUDY; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; PREMENOPAUSE; PRIORITY JOURNAL;

ADIPOSITY; ADOLESCENT; ADULT; BONE DENSITY; BONE MARROW; BONE REMODELING; FEMALE; HUMANS; MIDDLE AGED; OSTEOGENESIS; OSTEOPOROSIS; PREMENOPAUSE;

EID: 84864797142     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-1477     Document Type: Article

References (37)

1. Cohen A, Fleischer J, Freeby MJ, McMahon DJ, Irani D, Shane E 2009 Clinical characteristics and medication use among premenopausal women with osteoporosis and low BMD: the experience of an osteoporosis referral center. J Womens Health (Larchmt) 18:79-84
2. Cohen A, Shane E 2008 Premenopausal osteoporosis. In: Rosen CJ, ed. Primer on the metabolic bone diseases and other disorders of bone and mineral metabolism. Washington, DC: American Society for Bone and Mineral Research; 289-293
3. Heshmati HM, Khosla S 1998 Idiopathic osteoporosis: a heterogeneous entity. Ann Med Interne (Paris) 149:77-81 (Pubitemid 28227801)
4. Cohen A, Recker RR, Lappe J, Dempster DW, Cremers S, McMahon DJ, Stein EM, Fleischer J, Rosen CJ, Rogers H, Staron RB, Lemaster J, Shane E 2012 Premenopausal women with idiopathic low-trauma fractures and/or low bone mineral density. Osteoporos Int 23:171-182
5. Cohen A, Dempster DW, Recker RR, Stein EM, Lappe JM, Zhou H, Wirth AJ, van Lenthe GH, Kohler T, Zwahlen A, Müller R, Rosen CJ, Cremers S, Nickolas TL, McMahon DJ, Rogers H, Staron RB, LeMaster J, Shane E 2011 Abnormal bone microarchitecture and evidence of osteoblast dysfunction in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab 96:3095-3105
6. Cohen A, Liu XS, Stein EM, McMahon DJ, Rogers HF, Lemaster J, Recker RR, Lappe JM, Guo XE, Shane E 2009 Bone microarchitecture and stiffness in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab 94:4351-4360
7. Cohen A, Lang T, Rogers H, Stein E, Guo XE, Liu XS, Dempster D, McMahon DJ, Lappe JM, Zhang C, Recker R, Shane E 2010 Central QCT reveals cortical and trabecular structural deficits in premenopausal women with idiopathic osteoporosis whether diagnosis is based on fragility fracture or low areal bone mineral density. Proc 32nd Annual Meeting of American Society for Bone and Mineral Research, Toronto, 2010, p 1128 (Abstract)
8. Rosen CJ, Bouxsein ML 2006 Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2:35-43 (Pubitemid 43153647)
9. Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL 2002 Divergent effects of selective peroxisome proliferator-activated receptor-γ2 ligands on adipocyte versus osteoblast differentiation. Endocrinology 143:2376-2384 (Pubitemid 34521584)
10. Grey A 2009 Thiazolidinedione-induced skeletal fragility - mechanisms and implications. Diabetes Obes Metab 11:275-284
11. Canalis E, Mazziotti G, Giustina A, Bilezikian JP 2007 Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int 18:1319-1328 (Pubitemid 47389469)
12. Meunier P, Aaron J, Edouard C, Vignon G 1971 Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. Aquantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res 80:147-154
13. Justesen J, Stenderup K, Ebbesen EN, Mosekilde L, Steiniche T, Kassem M 2001 Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology 2:165-171 (Pubitemid 32851325)
14. Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ 2002 Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 55:693-698 (Pubitemid 34970093)
15. Syed FA, Oursler MJ, Hefferanm TE, Peterson JM, Riggs BL, Khosla S 2008 Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int 19:1323-1330
16. Bredella MA, Fazeli PK, Miller KK, Misra M, Torriani M, Thomas BJ, Ghomi RH, Rosen CJ, Klibanski A 2009 Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab 94:2129-2136
17. Schellinger D, Lin CS, Hatipoglu HG, Fertikh D 2001 Potential value of vertebral proton MR spectroscopy in determining bone weakness. AJNR Am J Neuroradiol 22:1620-1627 (Pubitemid 32862282)
18. Schellinger D, Lin CS, Lim J, Hatipoglu HG, Pezzullo JC, Singer AJ 2004 Bone marrow fat and bone mineral density on proton MR spectroscopy and dual-energy x-ray absorptiometry: their ratio as a new indicator of bone weakening. AJR Am J Roentgenol 183:1761-1765 (Pubitemid 44210553)
19. Justesen J, Mosekilde L, Holmes M, Stenderup K, Gasser J, Mullins JJ, Seckl JR, Kassem M 2004 Mice deficient in 11β-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation. Endocrinology 145:1916-1925 (Pubitemid 38402401)
20. Martin RB, Zissimos SL 1991 Relationships between marrow fat and bone turnover in ovariectomized and intact rats. Bone 12:123-131
21. Tornvig L, Mosekilde LI, Justesen J, Falk E, Kassem M 2001 Troglitazone treatment increases bone marrow adipose tissue volume but does not affect trabecular bone volume in mice. Calcif Tissue Int 69:46-50 (Pubitemid 32702265)
22. Dempster DW, Shane E 2002 Bone quantification and dynamics of bone turnover. In: Becker KL, ed. Principles and practice of endocrinology and metabolism. Philadelphia: J. B. Lippincott Co.; 475-479
23. Rüegsegger P, Koller B,Müller R 1996 A microtomographic system for the nondestructive evaluation of bone architecture. Calcif Tissue Int 58:24-29 (Pubitemid 26028374)
24. Cohen A, Dempster DW, Müller R, Guo XE, Nickolas TL, Liu XS, Zhang XH, Wirth AJ, van Lenthe GH, Kohler T, McMahon DJ, Zhou H, Rubin MR, Bilezikian JP, Lappe JM, Recker RR, Shane E 2010 Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy. Osteoporos Int 21:263-273
25. Hildebrand T, Laib A, Müller R, Dequeker J, Rüegsegger P 1999 Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res 14:1167-1174 (Pubitemid 29314060)
26. Arbenz P, van Lenthe GH, Mennel U, Müller R, Sala M 2008 A scalable multi-level preconditioner for matrix-free micro-finite element analysis of human bone structures. Int J Numer Meth Engrg 73:927-947 (Pubitemid 351308542)
27. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610
28. Bredella MA, Torriani M, Ghomi RH, Thomas BJ, Brick DJ, Gerweck AV, Rosen CJ, Klibanski A, Miller KK 2011 Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women. Obesity (Silver Spring) 19:49-53
29. Di Iorgi N, Rosol M, Mittelman SD, Gilsanz V 2008 Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults. J Clin Endocrinol Metab 93:2281-2286 (Pubitemid 351831548)
30. Dunnill MS, Anderson JA, Whitehead R 1967 Quantitative histological studies on age changes in bone. J Pathol Bacteriol 94:275-291
31. Kawai M, Rosen CJ 2010 PPARγ: a circadian transcription factor in adipogenesis and osteogenesis. Nat Rev Endocrinol 6:629-636
32. Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM 2009 Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr 19:109-124
33. Ng A, Duque G 2010 Osteoporosis as a lipotoxic disease. IBMS BoneKEy 7:103-107
34. Moerman EJ, Teng K, Lipschitz DA, Lecka-Czernik B 2004 Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-γ2 transcription factor and TGF-β/BMP signaling pathways. Aging Cell 3:379-389 (Pubitemid 40246708)
35. Kassem M, Marie PJ 2011 Senescence-associated intrinsic mechanisms of osteoblast dysfunctions. Aging Cell 10:191-197
36. Griffith JF, Yeung DK, Antonio GE, Lee FK, Hong AW, Wong SY, Lau EM, Leung PC 2005 Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy. Radiology 236:945-951 (Pubitemid 41170858)
37. Shen W, Chen J, Punyanitya M, Shapses S, Heshka S, Heymsfield SB 2007 MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women. Osteoporos Int 18:641-647 (Pubitemid 46525539)