Implication of fatty acids in the inhibitory effect of human adipocytes on osteoblastic differentiation

Bone

Volumn 55, Issue 2, 2013, Pages 429-430

  Lucas, S ^a   Clabaut, A ^a   Ghali, O ^a   Haren, N ^a   Hardouin, P ^a   Broux, O ^a  

^a Physiopathologie des Maladies Osseuses Inflammatoires   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; FATTY ACID; ISOPRENALINE; MESSENGER RNA; OLEIC ACID; PALMITIC ACID; SATURATED FATTY ACID; STEARIC ACID;

ADIPOCYTE; APOPTOSIS; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELLULAR SECRETION; COCULTURE; CONCENTRATION RESPONSE; FATTY ACID BLOOD LEVEL; HUMAN; IN VITRO STUDY; LETTER; LIPOLYSIS; MESENCHYMAL STEM CELL; OSTEOBLAST; SUPERNATANT;

DEXAMETHASONE; HUMANS; LIPOLYSIS; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS;

EID: 84878926459     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.04.010     Document Type: Letter

References (5)

1. Wang A., Haile A., Jones L.C. Dexamethasone-induced lipolysis increases the adverse effect of adipocytes on osteoblasts using cells derived from human mesenchymal stem cells. Bone 2013, 53:520-530.
2. Clabaut A., Delplace S., Chauveau C., Hardouin P., Broux O. Human osteoblasts derived from mesenchymal stem cells express adipogenic markers upon coculture with bone marrow adipocytes. Differentiation 2010, 80:40-45.
3. Elbaz A., Wu X., Rivas D., Gimble J.M., Duque G. Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro. J Cell Mol Med 2010, 14:982-991.
4. Maurin A.C., Chavassieux P.M., Vericel E., Meunier P.J. Role of polyunsaturated fatty acids in the inhibitory effect of human adipocytes on osteoblastic proliferation. Bone 2002, 31:260-266.
5. Laharrague P., Larrouy D., Fontanilles A.M., Truel N., Campfield A., Tenenbaum R., et al. High expression of leptin by human bone marrow adipocytes in primary culture. FASEB J 1998, 12:747-752.