메뉴 건너뛰기




Volumn 31, Issue 4, 2014, Pages 1940-1946

Abnormal activation of the EGFR signaling pathway mediates the downregulation of miR-145 through the ERK1/2 in non-small cell lung cancer

Author keywords

Epidermal growth factor receptor; Lung cancer; MiR 145; Regulation; Signal transduction

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MICRORNA 145; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; STAT3 PROTEIN;

EID: 84904110196     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3021     Document Type: Article
Times cited : (24)

References (30)
  • 1
    • 79959324452 scopus 로고    scopus 로고
    • MicroRNA dysregulation during chemical carcinogenesis
    • Pogribny IP: MicroRNA dysregulation during chemical carcinogenesis. Epigenomics 1: 281-290, 2009.
    • (2009) Epigenomics , vol.1 , pp. 281-290
    • Pogribny, I.P.1
  • 2
    • 74249114436 scopus 로고    scopus 로고
    • Recent proceedings in epigenetics research of lung cancer
    • (In Japanese)
    • Takai D: Recent proceedings in epigenetics research of lung cancer. Nihon Rinsho 67: 2387-2396, 2009 (In Japanese).
    • (2009) Nihon Rinsho , vol.67 , pp. 2387-2396
    • Takai, D.1
  • 3
    • 84863377480 scopus 로고    scopus 로고
    • MicroRNAs: Novel biomarkers for lung cancer diagnosis, prediction and treatment
    • Wang Q, Wang S, Wang H, Li P and Ma Z: MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment. Exp Biol Med 237: 227-235, 2012.
    • (2012) Exp Biol Med , vol.237 , pp. 227-235
    • Wang, Q.1    Wang, S.2    Wang, H.3    Li, P.4    Ma, Z.5
  • 4
    • 84855382989 scopus 로고    scopus 로고
    • MicroRNA-99b acts as a tumor suppressor in non-small cell lung cancer by directly targeting fibroblast growth factor receptor 3
    • Kang J, Lee SY, Lee SY, et al: microRNA-99b acts as a tumor suppressor in non-small cell lung cancer by directly targeting fibroblast growth factor receptor 3. Exp Ther Med 3: 149-153, 2012.
    • (2012) Exp Ther Med , vol.3 , pp. 149-153
    • Kang, J.1    Lee, S.Y.2    Lee, S.Y.3
  • 5
    • 81255205360 scopus 로고    scopus 로고
    • Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis
    • Darido C, Georgy SR, Wilanowski T, et al: Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell 20: 635-648, 2011.
    • (2011) Cancer Cell , vol.20 , pp. 635-648
    • Darido, C.1    Georgy, S.R.2    Wilanowski, T.3
  • 6
    • 84860466755 scopus 로고    scopus 로고
    • MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer
    • Lu Y, Govindan R, Wang L, et al: MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. Carcinogenesis 33: 1046-1054, 2012.
    • (2012) Carcinogenesis , vol.33 , pp. 1046-1054
    • Lu, Y.1    Govindan, R.2    Wang, L.3
  • 7
    • 78549269168 scopus 로고    scopus 로고
    • MiRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc
    • Chen Z, Zeng H, Guo Y, et al: miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. J Exp Clin Cancer Res 29: 151, 2010.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 151
    • Chen, Z.1    Zeng, H.2    Guo, Y.3
  • 9
    • 84861495556 scopus 로고    scopus 로고
    • Therapeutic targeting of the epidermal growth factor receptor in human cancer
    • Dhomen NS, Mariadason J, Tebbutt N and Scott AM: Therapeutic targeting of the epidermal growth factor receptor in human cancer. Crit Rev Oncog 17: 31-50, 2012.
    • (2012) Crit Rev Oncog , vol.17 , pp. 31-50
    • Dhomen, N.S.1    Mariadason, J.2    Tebbutt, N.3    Scott, A.M.4
  • 10
    • 84861042428 scopus 로고    scopus 로고
    • Primary and acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer: An update
    • Ayoola A, Barochia A, Belani K and Belani CP: Primary and acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer: an update. Cancer Invest 30: 433-446, 2012.
    • (2012) Cancer Invest , vol.30 , pp. 433-446
    • Ayoola, A.1    Barochia, A.2    Belani, K.3    Belani, C.P.4
  • 11
    • 82955162659 scopus 로고    scopus 로고
    • MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas
    • Wang Y, Wang X, Zhang J, et al: MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas. J Neurooncol 106: 217-224, 2012.
    • (2012) J Neurooncol , vol.106 , pp. 217-224
    • Wang, Y.1    Wang, X.2    Zhang, J.3
  • 12
    • 0030772168 scopus 로고    scopus 로고
    • Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
    • Schmidt-Ullrich RK, Mikkelsen RB, Dent P, et al: Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 15: 1191-1197, 1997.
    • (1997) Oncogene , vol.15 , pp. 1191-1197
    • Schmidt-Ullrich, R.K.1    Mikkelsen, R.B.2    Dent, P.3
  • 13
    • 33646044696 scopus 로고    scopus 로고
    • Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase
    • Ellis AG, Doherty MM, Walker F, et al: Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase. Biochem Pharmacol 71: 1422-1434, 2006.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1422-1434
    • Ellis, A.G.1    Doherty, M.M.2    Walker, F.3
  • 14
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, et al: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2: e73, 2005.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 15
    • 85047698100 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
    • Burke WM, Jin X, Lin HJ, et al: Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene 20: 7925-7934, 2001.
    • (2001) Oncogene , vol.20 , pp. 7925-7934
    • Burke, W.M.1    Jin, X.2    Lin, H.J.3
  • 16
    • 0037179847 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
    • Pene F, Claessens YE, Muller O, et al: Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene 21: 6587-6597, 2002.
    • (2002) Oncogene , vol.21 , pp. 6587-6597
    • Pene, F.1    Claessens, Y.E.2    Muller, O.3
  • 17
    • 0034648063 scopus 로고    scopus 로고
    • Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons
    • Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi H and Namura S: Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci Lett 288: 163-166, 2000.
    • (2000) Neurosci Lett , vol.288 , pp. 163-166
    • Satoh, T.1    Nakatsuka, D.2    Watanabe, Y.3    Nagata, I.4    Kikuchi, H.5    Namura, S.6
  • 18
    • 67649383498 scopus 로고    scopus 로고
    • Janus kinase 2 inhibitor AG490 inhibits the STAT3 signaling pathway by suppressing protein translation of gp130
    • Seo IA, Lee HK, Shin YK, et al: Janus kinase 2 inhibitor AG490 inhibits the STAT3 signaling pathway by suppressing protein translation of gp130. Korean J Physiol Pharmacol 13: 131-138, 2009.
    • (2009) Korean J Physiol Pharmacol , vol.13 , pp. 131-138
    • Seo, I.A.1    Lee, H.K.2    Shin, Y.K.3
  • 19
    • 0033634827 scopus 로고    scopus 로고
    • Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
    • Walker EH, Pacold ME, Perisic O, et al: Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 6: 909-919, 2000.
    • (2000) Mol Cell , vol.6 , pp. 909-919
    • Walker, E.H.1    Pacold, M.E.2    Perisic, O.3
  • 20
    • 14444279192 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of mitogen-activated protein kinase kinase
    • Favata MF, Horiuchi KY, Manos EJ, et al: Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 18623-18632
    • Favata, M.F.1    Horiuchi, K.Y.2    Manos, E.J.3
  • 21
    • 10344258041 scopus 로고    scopus 로고
    • Targeting the mitogen-activated protein kinase cascade to treat cancer
    • Sebolt-Leopold JS and Herrera R: Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 4: 937-947, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 937-947
    • Sebolt-Leopold, J.S.1    Herrera, R.2
  • 22
    • 62549148270 scopus 로고    scopus 로고
    • P53 represses c-Myc through induction of the tumor suppressor miR-145
    • Sachdeva M, Zhu S, Wu F, et al: p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc Natl Acad Sci USA 106: 3207-3212, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3207-3212
    • Sachdeva, M.1    Zhu, S.2    Wu, F.3
  • 23
    • 84864451711 scopus 로고    scopus 로고
    • Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of ApcMin Mice
    • Takaoka Y, Shimizu Y, Hasegawa H, et al: Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of ApcMin Mice. PLoS One 7: e42137, 2012.
    • (2012) PLoS One , vol.7
    • Takaoka, Y.1    Shimizu, Y.2    Hasegawa, H.3
  • 24
    • 84872682314 scopus 로고    scopus 로고
    • Human lung cancer cell line SPC-A1 contains cells with characteristics of cancer stem cells
    • Zhou CH, Yang SF and Li PQ: Human lung cancer cell line SPC-A1 contains cells with characteristics of cancer stem cells. Neoplasma 59: 685-692, 2012.
    • (2012) Neoplasma , vol.59 , pp. 685-692
    • Zhou, C.H.1    Yang, S.F.2    Li, P.Q.3
  • 25
    • 84867863624 scopus 로고    scopus 로고
    • MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells
    • Wang Z, Zhang X, Yang Z, et al: MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells. Biochem Biophys Res Commun 427: 444-449, 2012.
    • (2012) Biochem Biophys Res Commun , vol.427 , pp. 444-449
    • Wang, Z.1    Zhang, X.2    Yang, Z.3
  • 26
    • 78650305974 scopus 로고    scopus 로고
    • MiR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness
    • Gotte M, Mohr C, Koo CY, et al: miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. Oncogene 29: 6569-6580, 2010.
    • (2010) Oncogene , vol.29 , pp. 6569-6580
    • Gotte, M.1    Mohr, C.2    Koo, C.Y.3
  • 27
    • 75349110926 scopus 로고    scopus 로고
    • Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer
    • Eck MJ and Yun CH: Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer. Biochim Biophys Acta 1804: 559-566, 2010.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 559-566
    • Eck, M.J.1    Yun, C.H.2
  • 28
    • 0038505594 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC)
    • Mukohara T, Kudoh S, Yamauchi S, et al: Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC). Lung Cancer 41: 123-130, 2003.
    • (2003) Lung Cancer , vol.41 , pp. 123-130
    • Mukohara, T.1    Kudoh, S.2    Yamauchi, S.3
  • 29
    • 48249114422 scopus 로고    scopus 로고
    • EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
    • Koivunen JP, Mermel C, Zejnullahu K, et al: EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 14: 4275-4283, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 4275-4283
    • Koivunen, J.P.1    Mermel, C.2    Zejnullahu, K.3
  • 30
    • 13644252983 scopus 로고    scopus 로고
    • A cell-based immunocytochemical assay for monitoring kinase signaling pathways and drug efficacy
    • Chen H, Kovar J, Sissons S, et al: A cell-based immunocytochemical assay for monitoring kinase signaling pathways and drug efficacy. Anal Biochem 338: 136-142, 2005.
    • (2005) Anal Biochem , vol.338 , pp. 136-142
    • Chen, H.1    Kovar, J.2    Sissons, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.