Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2

Biochemical Journal

Volumn 461, Issue 3, 2014, Pages 403-412

  Sullivan, Adrienne E ^a   Raimondo, Anne ^a,f   Schwab, Tanja A ^a   Bruning, John B ^a   Froguel, Philippe ^b,c,d   Farooqi, I Sadaf ^e   Peet, Daniel J ^a   Whitelaw, Murray L ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b INSTITUT PASTEUR DE LILLE   (France)

^c UNIV LILLE   (France)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Aryl hydrocarbon nuclear translocator 2 (ARNT2); Obesity; Per Arnt Sim (PAS); Single nucleotide variant SNV; Single minded (SIM)

Indexed keywords

ARYL HYDROCARBON NUCLEAR TRANSLOCATOR 2; HELIX LOOP HELIX PROTEIN; PROTEIN DERIVATIVE; SINGLE MINDED 1; UNCLASSIFIED DRUG;

ARTICLE; CODING; DATA BASE; DIMERIZATION; GENOMICS; HUMAN; HUMAN CELL; HYPOTHALAMUS; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL NUCLEUS; DATABASES, GENETIC; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT;

EID: 84904105260     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131618     Document Type: Article

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