BI-69A11 enhances susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt

British Journal of Cancer

Volumn 111, Issue 1, 2014, Pages 101-111

  Pal, I ^a   Sarkar, S ^b   Rajput, S ^a   Dey, K K ^a   Chakraborty, S ^c   Dash, R ^d   Das, S K ^b   Sarkar, D ^b,e   Barile, E ^f   De, S K ^f   Pellecchia, M ^f   Fisher, P B ^b,e   Mandal, M ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c R G KAR MEDICAL COLLEGE   (India)

^d Institute of Life Science   (India)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^f BURNHAM INSTITUTE   (United States)

Author keywords

Akt; apoptosis; BI 69A11; colorectal carcinoma; mda 7 IL 24

Indexed keywords

ADENOVIRUS VECTOR; BI 69A 11; IMIDAZOLE DERIVATIVE; INTERLEUKIN 24; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; COLORECTAL CARCINOMA; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GROWTH INHIBITION; HCT116 CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BENZIMIDAZOLES; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; COLORECTAL NEOPLASMS; FEMALE; HCT116 CELLS; HT29 CELLS; HUMANS; INTERLEUKINS; MICE; MICE, NUDE; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLONES; RANDOM ALLOCATION; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84904094408     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.227     Document Type: Article

References (41)

1. Barile E, De SK, Feng Y, Chen V, Yang L, Ronai Z, Pellecchia M (2013) Synthesis and SAR Studies of Dual AKT/NF-kappaB Inhibitors Against Melanoma. Chem Biol Drug Des 82(5): 520-533.
2. Bellacosa A, Kumar CC, Di Cristofano A, Testa JR (2005) Activation of AKT kinases in cancer: Implications for therapeutic targeting. Adv Cancer Res 94: 29-86.
3. Bos JL, Fearon ER, Hamilton SR, Verlaan-de Vries M, van Boom JH, van der Eb AJ, Vogelstein B (1987) Prevalence of ras gene mutations in human colorectal cancers. Nature 327(6120): 293-297.
4. Bussink J, van der Kogel AJ, Kaanders JH (2008) Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol 9(3): 288-296.
5. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296(5573): 1655-1657.
6. Castellano E, Downward J (2010) Role of RAS in the regulation of PI 3-kinase. Curr Top Microbiol Immunol 346: 143-169.
7. Chang YJ, Huang YP, Li ZL, Chen CH (2012) GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells. PLoS One 7(4): E35123.
8. Chen Z, Htay A, Dos Santos W, Gillies GT, Fillmore HL, Sholley MM, Broaddus WC (2009) In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells. J Neurooncol 92(2): 121-128.
9. Dai RY, Chen SK, Yan DM, Chen R, Lui YP, Duan CY, Li J, He T, Li H (2010) PI3K/Akt promotes GRP78 accumulation and inhibits endoplasmic reticulum stress-induced apoptosis in HEK293 cells. Folia Biol (Praha) 56(2): 37-46.
10. Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, Wang HG, Tsang BK, Cheng JQ (2004) Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 279(7): 5405-5412.
11. Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, Pellecchia M, Reed JC, Sarkar D, Fisher PB (2011) Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Proc Natl Acad Sci USA 108(21): 8785-8790.
12. Dash R, Bhutia SK, Azab B, Su ZZ, Quinn BA, Kegelmen TP, Das SK, Kim K, Lee SG, Park MA, Yacoub A, Rahmani M, Emdad L, Dmitriev IP, Wang XY, Sarkar D, Grant S, Dent P, Curiel DT, Fisher PB (2010) mda-7/IL-24: A unique member of the IL-10 gene family promoting cancertargeted toxicity. Cytokine Growth Factor Rev 21(5): 381-391.
13. Dash R, Dmitriev I, Su ZZ, Bhutia SK, Azab B, Vozhilla N, Yacoub A, Dent P, Curiel DT, Sarkar D, Fisher PB (2010) Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells. Cancer Gene Ther 17(7): 447-456.
14. Feng Y, Barile E, De SK, Stebbins JL, Cortez A, Aza-Blanc P, Villanueva J, Heryln M, Krajewski S, Pellecchia M, Ronai ZA, Chiang GG (2011) Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-kappaB pathways. Pigment Cell Melanoma Res 24(4): 703-713.
15. Fisher PB (2005) Is mda-7/IL-24 a 'magic bullet' for cancer? Cancer Res 65(22): 10128-10138.
16. Forino M, Jung D, Easton JB, Houghton PJ, Pellecchia M (2005) Virtual docking approaches to protein kinase B inhibition. J Med Chem 48(7): 2278-2281.
17. Gaitonde S, De SK, Tcherpakov M, Dewing A, Yuan H, Riel-Mehan M, Krajewski S, Robertson G, Pellecchia M, Ronai Z (2009) BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma. Pigment Cell Melanoma Res 22(2): 187-195.
18. Gray MJ, Mhawech-Fauceglia P, Yoo E, Yang W, Wu E, Lee AS, Lin YG (2013) AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers. Int J Cancer 133(1): 21-30.
19. Gulhati P, Zaytseva YY, Valentino JD, Stevens PD, Kim JT, Sasazuki T, Shirasawa S, Lee EY, Weiss HL, Dong J, Gao T, Evers BM (2012) Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA. Carcinogenesis 33(9): 1782-1790.
20. Gupta P, Su ZZ, Lebedeva IV, Sarkar D, Sauane M, Emdad L, Bachelor MA, Grant S, Curiel DT, Dent P, Fisher PB (2006a) mda-7/IL-24: Multifunctional cancer-specific apoptosis-inducing cytokine. Pharmacol Ther 111(3): 596-628.
21. Gupta P, Walter MR, Su ZZ, Lebedeva IV, Emdad L, Randolph A, Valerie K, Sarkar D, Fisher PB (2006b) BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis. Cancer Res 66(16): 8182-8191.
22. Hanada M, Feng J, Hemmings BA (2004) Structure, regulation and function of PKB/AKT-a major therapeutic target. Biochim Biophys Acta 1697(1-2): 3-16.
23. Hirai H, Sootome H, Nakatsuru Y, Miyama K, Taguchi S, Tsujioka K, Ueno Y, Hatch H, Majumder PK, Pan BS, Kotani H (2010) MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther 9(7): 1956-1967.
24. Huang WC, Hung MC (2009) Induction of Akt activity by chemotherapy confers acquired resistance. J Formos Med Assoc 108(3): 180-194.
25. Jiang BH, Liu LZ (2008) AKT signaling in regulating angiogenesis. Curr Cancer Drug Targets 8(1): 19-26.
26. Langer R, Feith M, Siewert JR, Wester HJ, Hoefler H (2008) Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus. BMC Cancer 8: 70.
27. Lebedeva IV, Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, Gupta P, Nemunaitis J, Cunningham C, Yacoub A, Dent P, Fisher PB (2005) mda-7/IL-24: Exploiting cancer's Achilles' heel. Mol Ther 11(1): 4-18.
28. Lebedeva IV, Su ZZ, Emdad L, Kolomeyer A, Sarkar D, Kitada S, Waxman S, Reed JC, Fisher PB (2007) Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells. Oncogene 26(5): 733-744.
29. Mandal M, Kim S, Younes MN, Jasser SA, El-Naggar AK, Mills GB, Myers JN (2005) The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. Br J Cancer 92(10): 1899-1905.
30. Miyaki M, Iijima T, Yamaguchi T, Takahashi K, Matsumoto H, Yasutome M, Funata N, Mori T (2007) Mutations of the PIK3CA gene in hereditary colorectal cancers. Int J Cancer 121(7): 1627-1630.
31. Nosho K, Kawasaki T, Ohnishi M, Suemoto Y, Kirkner GJ, Zepf D, Yan L, Longtine JA, Fuchs CS, Ogino S (2008) PIK3CA mutation in colorectal cancer: Relationship with genetic and epigenetic alterations. Neoplasia 10(6): 534-541.
32. Okumura N, Yoshida H, Kitagishi Y, Murakami M, Nishimura Y, Matsuda S (2012) PI3K/AKT/PTEN signaling as a molecular target in leukemia angiogenesis. Adv Hematol 2012: 843085.
33. Pal I, Mandal M (2012) PI3K and Akt as molecular targets for cancer therapy: Current clinical outcomes. Acta Pharmacol Sin 33(12): 1441-1458.
34. Rajput S, Kumar BN, Sarkar S, Das S, Azab B, Santhekadur PK, Das SK, Emdad L, Sarkar D, Fisher PB, Mandal M (2013) Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer. PLoS One 8(4): E61342.
35. Ribatti D, Nico B, Vacca A, Presta M (2006) The gelatin spongechorioallantoic membrane assay. Nat Protoc 1(1): 85-91.
36. Samuels Y, Waldman T (2010) Oncogenic mutations of PIK3CA in human cancers. Curr Top Microbiol Immunol 347: 21-41.
37. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB (2008) Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 68(5): 1478-1484.
38. Sarkar S, Mazumdar A, Dash R, Sarkar D, Fisher PB, Mandal M (2010) ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. Cancer Biol Ther 9(8): 592-603.
39. Sarkar S, Mazumdar A, Dash R, Sarkar D, Fisher PB, Mandal M (2011) ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells. J Cell Physiol 226(2): 375-384.
40. Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2(7): 489-501.
41. Xing X, Li Y, Liu H, Wang L, Sun L (2011) Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis. Acta Histochem 113(8): 777-782.