A new method for generating distributions of biomonitoring equivalents to support exposure assessment and prioritization

Regulatory Toxicology and Pharmacology

Volumn 69, Issue 3, 2014, Pages 434-442

  Phillips, Martin B ^a   Sobus, Jon R ^a   George, Barbara J ^b   Isaacs, Kristin ^a   Conolly, Rory ^b   Tan, Yu Mei ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Biomarker; Biomonitoring; Biomonitoring equivalent; NHANES; PBPK; Perchlorate; Prioritization; Urine

Indexed keywords

BIOLOGICAL MARKER; CREATININE; PERCHLORATE; POLLUTANT;

ARTICLE; BIOLOGICAL MONITORING; BIOMONITORING EQUIVALENT; CREATININE URINE LEVEL; DIETARY INTAKE; ENVIRONMENTAL PARAMETERS; HAZARD QUOTIENT; HEALTH HAZARD; HUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SIMULATION; STATISTICAL ANALYSIS; URINE LEVEL; URINE VOLUME; ADULT; CHEMISTRY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; MALE; MIDDLE AGED; NUTRITION; POLLUTANT; PROCEDURES; STATISTICAL MODEL; URINE; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED, 80 AND OVER; BIOLOGICAL MARKERS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, STATISTICAL; NUTRITION SURVEYS; PERCHLORATES; RISK ASSESSMENT; YOUNG ADULT;

EID: 84904071206     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2014.05.008     Document Type: Article

References (38)

1. Aylward L.L., Lakind J.S., Hays S.M. Derivation of biomonitoring equivalent (BE) values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds: a screening tool for interpretation of biomonitoring data in a risk assessment context. J. Toxicol. Environ. Health A 2008, 71(22):1499-1508.
2. Aylward L.L., Hays S.M., Gagne M., Krishnan K. Derivation of biomonitoring equivalents for di(2-ethylhexyl)phthalate (CAS No. 117-81-7). Regul. Toxicol. Pharmacol. 2009, 55(3):249-258.
3. Aylward L.L., Kirman C.R., Adgate J.L., McKenzie L.M., Hays S.M. Interpreting variability in population biomonitoring data: role of elimination kinetics. J. Expo. Sci. Environ. Epidemiol. 2012, 22(4):398-408.
4. Aylward L.L., Kirman C.R., Schoeny R., Portier C.J., Hays S.M. Evaluation of biomonitoring data from the CDC National Exposure Report in a risk assessment context: perspectives across chemicals. Environ. Health Perspect. 2013, 121(3):287-294.
5. Blount B.C., Valentin-Blasini L., Osterloh J.D., Mauldin J.P., Pirkle J.L. Perchlorate exposure of the US Population, 2001-2002. J. Expo. Sci. Environ. Epidemiol. 2007, 17(4):400-407.
6. Fields R.L., Horstman S.W. Biomonitoring of industrial styrene exposures. Am. Ind. Hyg. Assoc. J. 1979, 40(6):451-459.
7. Fortin M.C., Carrier G., Bouchard M. Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure. Environ. Health 2008, 7:55.
8. Greer M.A., Goodman G., Pleus R.C., Greer S.E. Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans. Environ. Health Perspect. 2002, 110(9):927-937.
9. Hays S.M., Becker R.A., Leung H.W., Aylward L.L., Pyatt D.W. Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective. Regul. Toxicol. Pharmacol. 2007, 47(1):96-109.
10. Hays S.M., Aylward L.L., Gagne M., Nong A., Krishnan K. Biomonitoring equivalents for inorganic arsenic. Regul. Toxicol. Pharmacol. 2010, 58(1):1-9.
11. Huber D.R., Blount B.C., Mage D.T., Letkiewicz F.J., Kumar A., Allen R.H. Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data. J. Expo. Sci. Environ. Epidemiol. 2011, 21(4):395-407.
12. Kavlock R., Chandler K., Houck K., Hunter S., Judson R., Kleinstreuer N., Knudsen T., Martin M., Padilla S., Reif D., Richard A., Rotroff D., Sipes N., Dix D. Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management. Chem. Res. Toxicol. 2012, 25(7):1287-1302.
13. Lorber M. Use of a simple pharmacokinetic model to characterize exposure to perchlorate. J. Expo. Sci. Environ. Epidemiol. 2009, 19(3):260-273.
14. Mendez W., Dederick E., Cohen J. Drinking water contribution to aggregate perchlorate intake of reproductive-age women in the United States estimated by dietary intake simulation and analysis of urinary excretion data. J. Expo. Sci. Environ. Epidemiol. 2010, 20(3):288-297.
15. Merrill E.A., Clewell R.A., Robinson P.J., Jarabek A.M., Gearhart J.M., Sterner T.R., Fisher J.W. PBPK model for radioactive iodide and perchlorate kinetics and perchlorate-induced inhibition of iodide uptake in humans. Toxicol. Sci. 2005, 83(1):25-43.
16. Motzer W.E. Perchlorate: problems, detection, and solutions. Environ. Forensics 2001, 2:301-311.
17. Murray C.W., Egan S.K., Kim H., Beru N., Bolger P.M. US Food and Drug Administration's Total Diet Study: dietary intake of perchlorate and iodine. J. Expo. Sci. Environ. Epidemiol. 2008, 18(6):571-580.
18. Peters S.A. Variability, uncertainty, and sensitivity analysis. Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry 2012, 161-181. AstraZeneca R&D Mölndal, Mölndal, Sweden.
19. Pleil J.D., Sobus J.R. Estimating lifetime risk from spot biomarker data and intraclass correlation coefficients (ICC). J. Toxicol. Environ. Health A 2013, 76(12):747-766.
20. Rao B., Estrada N., McGee S., Mangold J., Gu B., Jackson W.A. Perchlorate production by photodecomposition of aqueous chlorine solutions. Environ. Sci. Technol. 2012, 46(21):11635-11643.
21. Rappaport, S.M., Kupper, L.L., 2008. Quantitative Exposure Assessment, Stephen Rappaport.
22. Tan Y.M., Liao K.H., Conolly R.B., Blount B.C., Mason A.M., Clewell H.J. Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform. J. Toxicol. Environ. Health A 2006, 69(18):1727-1756.
23. USEPA, 1992. Guidelines for Exposure Assessment, Washington, D.C.
24. USEPA, 2009. Inhibition of the Sodium-Iodide Symporter by Perchlorate: An Evaluation of Life Stage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (Final Report), Washington, D.C.
25. USEPA, 2012. Chemical Safety for Sustainability Strategic Research Action Plan 2012-2016, Washington, D.C.
26. USEPA, 2013a. "Glossary - Risk Assessment Portal - US EPA." Last updated July 2, 2013. retrieved 31.01.2014. http://www.epa.gov/risk/glossary.htm.
27. USEPA, 2013b. Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft), Washington, D.C.
28. USEPA, 2013c. "What is the TSCA Chemical Substance Inventory? - New Chemicals Program - US EPA." Last updated April 3, 2013. retrieved 22.05.2013. http://www.epa.gov/oppt/newchems/pubs/invntory.htm.
29. USEPA, 2014. "Vocabulary Catalog List Detail - Terminology Services - US EPA." Last updated January 31, 2014. Retrieved 31.01.2014. http://ofmpub.epa.gov/sor_internet/registry/termreg/searchandretrieve/glossariesandkeywordlists/search.do?details=%26glossaryName=IRIS%20Glossary.
30. USNRC Health Implications of Perchlorate Ingestion 2005, The National Academies Press, Washington, D.C.
31. USNRC Human Biomonitoring for Environmental Chemicals 2006, The National Academies Press, Washington, D.C.
32. USNRC Toxicity Testing in the 21st Century: A Vision and a Strategy 2007, The National Academies Press, Washington, D.C.
33. USNRC Exposure Science in the 21st Century: A Vision and a Strategy 2012, The National Academies Press, Washington, D.C.
34. Wambaugh J.F., Setzer R.W., Reif D.M., Gangwal S., Mitchell-Blackwood J., Arnot J.A., Joliet O., Frame A., Rabinowitz J., Knudsen T.B., Judson R.S., Egeghy P., Vallero D., Cohen Hubal E.A. High-throughput models for exposure-based chemical prioritization in the ExpoCast project. Environ. Sci. Technol. 2013, 47(15):8479-8488.
35. Wetmore B.A., Wambaugh J.F., Ferguson S.S., Sochaski M.A., Rotroff D.M., Freeman K., Clewell H.J., Dix D.J., Andersen M.E., Houck K.A., Allen B., Judson R.S., Singh R., Kavlock R.J., Richard A.M., Thomas R.S. Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment. Toxicol. Sci. 2012, 125(1):157-174.
36. WHO, 1996. Biological Monitoring of Chemical Exposure in the Workplace: Guidelines. Geneva, Switzerland.
37. Yang Y., Tan Y.M., Blount B., Murray C., Egan S., Bolger M., Clewell H. Using a physiologically based pharmacokinetic model to link urinary biomarker concentrations to dietary exposure of perchlorate. Chemosphere 2012, 88(8):1019-1027.
38. Zewdie T., Smith C.M., Hutcheson M., West C.R. Basis of the Massachusetts reference dose and drinking water standard for perchlorate. Environ. Health Perspect. 2010, 118(1):42-48.