Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 15, 2014, Pages 3480-3485

  Ohgane, Kenji ^a,b   Karaki, Fumika ^a   Noguchi Yachide, Tomomi ^a   Dodo, Kosuke ^b   Hashimoto, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN   (Japan)

Author keywords

Niemann Pick disease type C; NPC1; Oxysterol; Pharmacological chaperone; Structure activity relationships

Indexed keywords

MUTANT PROTEIN; NIEMANN PICK TYPE C1 PROTEIN; OXYSTEROL; PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; MEMBRANE PROTEIN; NPC1 PROTEIN, HUMAN; STEROL; CHAPERONE; HYDROXYL GROUP; NPC1 PROTEIN;

ARTICLE; CONTROLLED STUDY; EMBRYO; HEK293 CELL LINE; HUMAN; HUMAN CELL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GENETICS; MUTATION; NIEMANN PICK DISEASE; SYNTHESIS; DRUG HYDROXYLATION; EC50; METHYLATION; STEREOCHEMISTRY;

CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MEMBRANE GLYCOPROTEINS; MOLECULAR STRUCTURE; MUTATION; NIEMANN-PICK DISEASE, TYPE C; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904066446     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.05.064     Document Type: Article

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