The complement receptors CD46, CD55 and CD59 are regulated by the tumour microenvironment of head and neck cancer to facilitate escape of complement attack

European Journal of Cancer

Volumn 50, Issue 12, 2014, Pages 2152-2161

  Kesselring, Rebecca ^a,b   Thiel, Annette ^a,b   Pries, Ralph ^a   Fichtner Feigl, Stefan ^b   Brunner, Stefan ^b   Seidel, Philipp ^a   Bruchhage, Karl Ludwig ^a   Wollenberg, Barbara ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

CD46; CD55; CD59; Complement receptors; Head and neck cancer; HNSCC

Indexed keywords

CD59 ANTIGEN; DECAY ACCELERATING FACTOR; MEMBRANE COFACTOR PROTEIN; SMALL INTERFERING RNA;

ADULT; AGED; ARTICLE; CANCER CELL LINE; CANCER PATIENT; CLINICAL ARTICLE; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE SILENCING; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HEAD AND NECK SURGERY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHARYNX CARCINOMA; LARYNX CARCINOMA; LYMPH NODE; LYMPH NODE METASTASIS; LYMPHOCYTE; MCF 7 CELL LINE; MOUTH CARCINOMA; OROPHARYNX CARCINOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR DRAINING LYMPH NODE; TUMOR LOCALIZATION; TUMOR MICROENVIRONMENT; UPREGULATION; WESTERN BLOTTING;

CD46; CD55; CD59; COMPLEMENT RECEPTORS; HEAD AND NECK CANCER; HNSCC;

AGED; AGED, 80 AND OVER; ANTIGENS, CD46; ANTIGENS, CD55; ANTIGENS, CD59; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; COMPLEMENT ACTIVATION; FEMALE; GENE SILENCING; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; TUMOR MICROENVIRONMENT;

EID: 84904049996     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2014.05.005     Document Type: Article

References (40)

1. D. Chin, G.M. Boyle, S. Porceddu, D.R. Theile, P.G. Parsons, and W.B. Coman Head and neck cancer: past, present and future Expert Rev Anticancer Ther 6 7 2006 1111 1118
2. M.L. Gillison Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity Semin Oncol 31 6 2004 744 754
3. A. Psyrri, and B. Burtness Viruses in head and neck cancers: prevention and therapy Expert Rev Anticancer Ther 8 9 2008 1365 1371
4. I. Astsaturov, R.B. Cohen, and P. Harari EGFR-targeting monoclonal antibodies in head and neck cancer Curr Cancer Drug Targets 7 7 2007 650 665
5. P.M. Harari, D.L. Wheeler, and J.R. Grandis Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond Semin Radiat Oncol 19 1 2009 63 68
6. J.B. Cooper, and E.E. Cohen Mechanisms of resistance to EGFR inhibitors in head and neck cancer Head Neck 31 8 2009 1086 1094
7. J. Yan, D.J. Allendorf, B. Li, R. Yan, R. Hansen, and R. Donev The role of membrane complement regulatory proteins in cancer immunotherapy Adv Exp Med Biol 632 2008 159 174
8. S.Y. Wang, and G. Weiner Complement and cellular cytotoxicity in antibody therapy of cancer Expert Opin Biol Ther 8 6 2008 759 768
9. P. Gasque Complement: a unique innate immune sensor for danger signals Mol Immunol 41 11 2004 1089 1098
10. D.D. Kim, and W.C. Song Membrane complement regulatory proteins Clin Immunol 118 2-3 2006 127 136
11. A. Gorter, and S. Meri Immune evasion of tumor cells using membrane-bound complement regulatory proteins Immunol Today 20 12 1999 576 582
12. M.R. Young Protective mechanisms of head and neck squamous cell carcinomas from immune assault Head Neck 28 5 2006 462 470
13. N.M. Ravindranath, and C. Shuler Expression of complement restriction factors (CD46, CD55 & CD59) in head and neck squamous cell carcinomas J Oral Pathol Med 35 9 2006 560 567
14. N.M. Ravindranath, K. Nishimoto, K. Chu, and C. Shuler Cell-surface expression of complement restriction factors and sialyl Lewis antigens in oral carcinoma: relevance to chemo-immunotherapy Anticancer Res 20 1A 2000 21 26
15. N.M. Ravindranath, and C. Shuler Cell-surface density of complement restriction factors (CD46, CD55, and CD59): oral squamous cell carcinoma versus other solid tumors Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 2 2007 231 239
16. J.M. Curry, J. Sprandio, D. Cognetti, A. Luginbuhl, V. Bar-Ad, and E. Pribitkin et al. Tumor microenvironment in head and neck squamous cell carcinoma Semin Oncol 41 2 2014 217 234
17. M. Tezal, F.A. Scannapieco, J. Wactawski-Wende, A. Hyland, J.R. Marshall, and N.R. Rigual et al. Local inflammation and human papillomavirus status of head and neck cancers Arch Otolaryngol Head Neck Surg 138 7 2012 669 675
18. F. Wang, P. Arun, J. Friedman, Z. Chen, and C. Van Waes Current and potential inflammation targeted therapies in head and neck cancer Curr Opin Pharmacol 9 4 2009 389 395
19. M.E. Freiser, P. Serafini, and D.T. Weed The immune system and head and neck squamous cell carcinoma: from carcinogenesis to new therapeutic opportunities Immunol Res 57 1-3 2013 52 69
20. H.B. Jie, N. Gildener-Leapman, J. Li, R.M. Srivastava, S.P. Gibson, and T.L. Whiteside et al. Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients Br J Cancer 109 10 2013 2629 2635
21. A.K. Schott, R. Pries, and B. Wollenberg Permanent up-regulation of regulatory T-lymphocytes in patients with head and neck cancer Int J Mol Med 26 1 2010 67 75
22. D. Pretscher, L.V. Distel, G.G. Grabenbauer, M. Wittlinger, M. Buettner, and G. Niedobitek Distribution of immune cells in head and neck cancer: CD8+ T-cells and CD20+ B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma BMC Cancer 9 2009 292
23. F. Gao, B. Liang, S.T. Reddy, R. Farias-Eisner, and X. Su Role of inflammation-associated microenvironment in tumorigenesis and metastasis Curr Cancer Drug Targets 14 1 2014 30 45
24. E. Elinav, R. Nowarski, C.A. Thaiss, B. Hu, C. Jin, and R.A. Flavell Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms Nat Rev Cancer 13 11 2013 759 771
25. M. Baniyash, M. Sade-Feldman, and J. Kanterman Chronic inflammation and cancer: suppressing the suppressors Cancer Immunol Immunother 63 1 2014 11 20
26. T. Irrazabal, A. Belcheva, S.E. Girardin, A. Martin, and D.J. Philpott The multifaceted role of the intestinal microbiota in colon cancer Mol Cell 54 2 2014 309 320
27. S.J. Bultman Emerging roles of the microbiome in cancer Carcinogenesis 35 2 2014 249 255
28. S. Schwitalla, P.K. Ziegler, D. Horst, V. Becker, I. Kerle, and Y. Begus-Nahrmann et al. Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors Cancer Cell 23 1 2013 93 106
29. R.F. Schwabe, and C. Jobin The microbiome and cancer Nat Rev Cancer 13 11 2013 800 812
30. C. Jobin Colorectal cancer: looking for answers in the microbiota Cancer Discov 3 4 2013 384 387
31. J.C. Arthur, E. Perez-Chanona, M. Muhlbauer, S. Tomkovich, J.M. Uronis, and T.J. Fan et al. Intestinal inflammation targets cancer-inducing activity of the microbiota Science 338 6103 2012 120 123
32. C. Zhang, C.L. Ge, R.X. Guo, and S.G. He Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis World J Gastroenterol 11 43 2005 6770 6774
33. A. Hyc, A. Osiecka-Iwan, P. Strzelczyk, and S. Moskalewski Effect of IL-1beta, TNF-alpha and IL-4 on complement regulatory protein mRNA expression in human articular chondrocytes Int J Mol Med 11 1 2003 91 94
34. S.H. Li, P.E. Szmitko, R.D. Weisel, C.H. Wang, P.W. Fedak, and R.K. Li et al. C-reactive protein upregulates complement-inhibitory factors in endothelial cells Circulation 109 7 2004 833 836
35. E.T. Cocuzzi, D.S. Bardenstein, A. Stavitsky, N. Sundarraj, and M.E. Medof Upregulation of DAF (CD55) on orbital fibroblasts by cytokines. Differential effects of TNF-beta and TNF-alpha Curr Eye Res 23 2 2001 86 92
36. M.C. Pasch, J.D. Bos, M.R. Daha, and S.S. Asghar Transforming growth factor-beta isoforms regulate the surface expression of membrane cofactor protein (CD46) and CD59 on human keratinocytes [corrected] Eur J Immunol 29 1 1999 100 108
37. R. Pries, S. Nitsch, and B. Wollenberg Role of cytokines in head and neck squamous cell carcinoma Expert Rev Anticancer Ther 6 9 2006 1195 1203
38. R. Pries, and B. Wollenberg Cytokines in head and neck cancer Cytokine Growth Factor Rev 17 3 2006 141 146
39. C. Kemper, A.C. Chan, J.M. Green, K.A. Brett, K.M. Murphy, and J.P. Atkinson Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype Nature 421 6921 2003 388 392
40. A.L. Astier T-cell regulation by CD46 and its relevance in multiple sclerosis Immunology 124 2 2008 149 154