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Volumn 55, Issue 7, 2014, Pages 1489-1497

Abnormal n-6 fatty acid metabolism in cystic fi brosis is caused by activation of AMP-activated protein kinase

Author keywords

Adenosine 5 monophosphateactivated protein kinase; Arachidonic acid; Fatty acid desaturase; Linoleic acid; Polyunsaturated fatty acid

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG; CFTR PROTEIN, HUMAN;

EID: 84904022653     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M050369     Document Type: Article
Times cited : (15)

References (59)
  • 1
  • 3
    • 33645307384 scopus 로고    scopus 로고
    • The ABC protein turned chloride channel whose failure causes cystic fi brosis
    • Gadsby, D. C., P. Vergani, and L. Csanady. 2006. The ABC protein turned chloride channel whose failure causes cystic fi brosis. Nature. 440: 477-483.
    • (2006) Nature. , vol.440 , pp. 477-483
    • Gadsby, D.C.1    Vergani, P.2    Csanady, L.3
  • 9
    • 0035192463 scopus 로고    scopus 로고
    • Essential fatty acid defi ciency in relation to genotype in patients with cystic fi brosis
    • Strandvik, B., E. Gronowitz, F. Enlund, T. Martinsson, and J. Wahlstrom. 2001. Essential fatty acid defi ciency in relation to genotype in patients with cystic fi brosis. J. Pediatr. 139: 650-655.
    • (2001) J. Pediatr. , vol.139 , pp. 650-655
    • Strandvik, B.1    Gronowitz, E.2    Enlund, F.3    Martinsson, T.4    Wahlstrom, J.5
  • 13
    • 0033598714 scopus 로고    scopus 로고
    • A membrane lipid imbalance plays a role in the phenotypic expression of cystic fi brosis in cftr(-/-) mice
    • Freedman, S. D., M. H. Katz, E. M. Parker, M. Laposata, M. Y. Urman, and J, G. Alvarez. 1999. A membrane lipid imbalance plays a role in the phenotypic expression of cystic fi brosis in cftr(-/-) mice. Proc. Natl. Acad. Sci. USA. 96: 13995-14000.
    • (1999) Proc. Natl. Acad. Sci. USA. , vol.96 , pp. 13995-14000
    • Freedman, S.D.1    Katz, M.H.2    Parker, E.M.3    Laposata, M.4    Urman, M.Y.5    Alvarez, J.G.6
  • 15
    • 72249084127 scopus 로고    scopus 로고
    • Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fi brosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid
    • Mimoun, M., T. C. Coste, J. Lebacq, P. Lebecque, P. Wallemacq, T. Leal, and M. Armand. 2009. Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fi brosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid. J. Nutr. 139: 2358-2364.
    • (2009) J. Nutr. , vol.139 , pp. 2358-2364
    • Mimoun, M.1    Coste, T.C.2    Lebacq, J.3    Lebecque, P.4    Wallemacq, P.5    Leal, T.6    Armand, M.7
  • 19
    • 79959379898 scopus 로고    scopus 로고
    • Increased-5-and-6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fi brosis
    • Njoroge, S. W., A. C. Seegmiller, W. Katrangi, and M. Laposata. 2011. Increased-5-and-6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fi brosis. Biochim. Biophys. Acta. 1811: 431-440.
    • (2011) Biochim. Biophys. Acta. , vol.1811 , pp. 431-440
    • Njoroge, S.W.1    Seegmiller, A.C.2    Katrangi, W.3    Laposata, M.4
  • 20
    • 84855703315 scopus 로고    scopus 로고
    • DHA and EPA reverse cystic fi brosis-related FA abnormalities by suppressing FA desaturase expression and activity
    • Njoroge, S. W., M. Laposata, W. Katrangi, and A. C. Seegmiller. 2012. DHA and EPA reverse cystic fi brosis-related FA abnormalities by suppressing FA desaturase expression and activity. J. Lipid Res. 53: 257-265.
    • (2012) J. Lipid Res. , vol.53 , pp. 257-265
    • Njoroge, S.W.1    Laposata, M.2    Katrangi, W.3    Seegmiller, A.C.4
  • 21
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    • Mihaylova, M. M., and R. J. Shaw. 2011. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat. Cell Biol. 13: 1016-1023.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 22
    • 0347318052 scopus 로고    scopus 로고
    • The AMP-activated protein kinase cascade-A unifying system for energy control
    • Carling, D. 2004. The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem. Sci. 29: 18-24.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 18-24
    • Carling, D.1
  • 23
    • 50049091255 scopus 로고    scopus 로고
    • AMPK: A key regulator of energy balance in the single cell and the whole organism
    • Hardie, D. G. 2008. AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond). 32 ( Suppl 4 ): S7-S12.
    • (2008) T J Obes. Lond. , vol.32 SUPPL 4
    • Hardie, D.G.1
  • 24
    • 84883445123 scopus 로고    scopus 로고
    • CFTR: A hub for kinases and crosstalk of cAMP and Ca2+
    • Kunzelmann, K., and A. Mehta. 2013. CFTR: a hub for kinases and crosstalk of cAMP and Ca2+. FEBS J. 280: 4417-4429.
    • (2013) FEBS J. , vol.280 , pp. 4417-4429
    • Kunzelmann, K.1    Mehta, A.2
  • 25
    • 33645231670 scopus 로고    scopus 로고
    • Up-regulation of AMP-activated kinase by dysfunctional cystic fi brosis transmembrane conductance regulator in cystic fi brosis airway epithelial cells mitigates excessive infl ammation
    • Hallows, K. R., A. C. Fitch, C. A. Richardson, P. R. Reynolds, J. P. Clancy, P. C. Dagher, L. A. Witters, J. K. Kolls, and J. M. Pilewski. 2006. Up-regulation of AMP-activated kinase by dysfunctional cystic fi brosis transmembrane conductance regulator in cystic fi brosis airway epithelial cells mitigates excessive infl ammation. J. Biol. Chem. 281: 4231-4241.
    • (2006) J. Biol. Chem. , vol.281 , pp. 4231-4241
    • Hallows, K.R.1    Fitch, A.C.2    Richardson, C.A.3    Reynolds, P.R.4    Clancy, J.P.5    Dagher, P.C.6    Witters, L.A.7    Kolls, J.K.8    Pilewski, J.M.9
  • 27
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley, S. A., J. Boudeau, J. L. Reid, K. J. Mustard, L. Udd, T. P. Mäkelä, D. R. Alessi, and D. G. Hardie. 2003. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2: 28.
    • (2003) J. Biol. , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Mäkelä, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 28
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulindependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
    • Hawley, S. A., D. A. Pan, K. J. Mustard, L. Ross, J. Bain, A. M. Edelman, B. G. Frenguelli, and D. G. Hardie. 2005. Calmodulindependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2: 9-19.
    • (2005) Cell Metab. , vol.2 , pp. 9-19
    • Hawley, S.A.1    Pan, D.A.2    Mustard, K.J.3    Ross, L.4    Bain, J.5    Edelman, A.M.6    Frenguelli, B.G.7    Hardie, D.G.8
  • 29
    • 38149091749 scopus 로고    scopus 로고
    • Calcium homeostasis is abnormal in cystic fi brosis airway epithelial cells but is normalized after rescue of F508del-CFTR
    • Antigny, F., C. Norez, F. Becq, and C. Vandebrouck. 2008. Calcium homeostasis is abnormal in cystic fi brosis airway epithelial cells but is normalized after rescue of F508del-CFTR. Cell Calcium. 43: 175-183.
    • (2008) Cell Calcium. , vol.43 , pp. 175-183
    • Antigny, F.1    Norez, C.2    Becq, F.3    Vandebrouck, C.4
  • 32
    • 78650675175 scopus 로고    scopus 로고
    • Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fi brosis transmembrane conductance regulator channel dysfunction in cystic fi brosis
    • Antigny, F., C. Norez, L. Dannhoffer, J. Bertrand, D. Raveau, P. Corbi, C. Jayle, F. Becq, and C. Vandebrouck. 2011. Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fi brosis transmembrane conductance regulator channel dysfunction in cystic fi brosis. Am. J. Respir. Cell Mol. Biol. 44: 83-90.
    • (2011) Am. J. Respir. Cell Mol. Biol. , vol.44 , pp. 83-90
    • Antigny, F.1    Norez, C.2    Dannhoffer, L.3    Bertrand, J.4    Raveau, D.5    Corbi, P.6    Jayle, C.7    Becq, F.8    Vandebrouck, C.9
  • 33
    • 70449158340 scopus 로고
    • A simple method for the isolation and purifi cation of total lipides from animal tissues
    • Folch, J., M. Lees, and G. H. Sloane Stanley. 1957. A simple method for the isolation and purifi cation of total lipides from animal tissues. J. Biol. Chem. 226: 497-509.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 34
    • 0033823601 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa induction of apoptosis in respiratory epithelial cells: Analysis of the effects of cystic fi brosis transmembrane conductance regulator dysfunction and bacterial virulence factors
    • Rajan, S., G. Cacalano, R. Bryan, A. J. Ratner, C. U. Sontich, A. van Heerckeren, P. Davis, and A. Prince. 2000. Pseudomonas aeruginosa induction of apoptosis in respiratory epithelial cells: analysis of the effects of cystic fi brosis transmembrane conductance regulator dysfunction and bacterial virulence factors. Am. J. Respir. Cell Mol. Biol. 23: 304-312.
    • (2000) Am. J. Respir. Cell Mol. Biol. , vol.23 , pp. 304-312
    • Rajan, S.1    Cacalano, G.2    Bryan, R.3    Ratner, A.J.4    Sontich, C.U.5    Van Heerckeren, A.6    Davis, P.7    Prince, A.8
  • 36
    • 0037013222 scopus 로고    scopus 로고
    • STO-609, a specifi c inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase
    • Tokumitsu, H., H. Inuzuka, Y. Ishikawa, M. Ikeda, I. Saji, and R. Kobayashi. 2002. STO-609, a specifi c inhibitor of the Ca(2+)/calmodulin- dependent protein kinase kinase. J. Biol. Chem. 277: 15813-15818.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15813-15818
    • Tokumitsu, H.1    Inuzuka, H.2    Ishikawa, Y.3    Ikeda, M.4    Saji, I.5    Kobayashi, R.6
  • 37
    • 80053254762 scopus 로고    scopus 로고
    • Characterization of the CaMKKbeta-AMPK signaling complex
    • Green, M. F., K. A. Anderson, and A. R. Means. 2011. Characterization of the CaMKKbeta-AMPK signaling complex. Cell. Signal. 23: 2005-2012.
    • (2011) Cell. Signal. , vol.23 , pp. 2005-2012
    • Green, M.F.1    Anderson, K.A.2    Means, A.R.3
  • 40
    • 85047689953 scopus 로고
    • 5-aminoimidazole-4-carboxamide ribonucleoside. A specifi c method for activating AMP-activated protein kinase in intact cells?
    • Corton, J. M., J. G. Gillespie, S. A. Hawley, and D. G. Hardie. 1995. 5-aminoimidazole-4-carboxamide ribonucleoside. A specifi c method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. 229: 558-565.
    • (1995) Eur. J. Biochem. , vol.229 , pp. 558-565
    • Corton, J.M.1    Gillespie, J.G.2    Hawley, S.A.3    Hardie, D.G.4
  • 41
    • 79961209660 scopus 로고    scopus 로고
    • Increased elongase 6 and Delta9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fi brosis
    • Thomsen, K. F., M. Laposata, S. W. Njoroge, O. C. Umunakwe, W. Katrangi, and A. C. Seegmiller. 2011. Increased elongase 6 and Delta9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fi brosis. Lipids. 46: 669-677.
    • (2011) Lipids. , vol.46 , pp. 669-677
    • Thomsen, K.F.1    Laposata, M.2    Njoroge, S.W.3    Umunakwe, O.C.4    Katrangi, W.5    Seegmiller, A.C.6
  • 42
    • 84876293970 scopus 로고    scopus 로고
    • Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fi brosis
    • Katrangi, W., J. Lawrenz, A. C. Seegmiller, and M. Laposata. 2013. Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fi brosis. Lipids. 48: 333-342.
    • (2013) Lipids. , vol.48 , pp. 333-342
    • Katrangi, W.1    Lawrenz, J.2    Seegmiller, A.C.3    Laposata, M.4
  • 43
    • 77956398915 scopus 로고    scopus 로고
    • CFTR depletion results in changes in fatty acid composition and promotes lipogenesis in intestinal Caco 2/15 cells
    • Mailhot, G., R. Rabasa-Lhoret, A. Moreau, Y. Berthiaume, and E. Levy. 2010. CFTR depletion results in changes in fatty acid composition and promotes lipogenesis in intestinal Caco 2/15 cells. PLoS ONE. 5: e10446.
    • (2010) PLoS ONE. , vol.5
    • Mailhot, G.1    Rabasa-Lhoret, R.2    Moreau, A.3    Berthiaume, Y.4    Levy, E.5
  • 44
    • 15444376938 scopus 로고    scopus 로고
    • Cystic fi brosis airway epithelial Ca2+ i signaling: Themechanism for the larger agonist-mediated Ca2+ i signals in human cystic fi brosis airway epithelia
    • Ribeiro, C. M., A. M. Paradiso, M. A. Carew, S. B. Shears, and R. C. Boucher. 2005. Cystic fi brosis airway epithelial Ca2+ i signaling: themechanism for the larger agonist-mediated Ca2+ i signals in human cystic fi brosis airway epithelia. J. Biol. Chem. 280: 10202-10209.
    • (2005) J. Biol. Chem. , vol.280 , pp. 10202-10209
    • Ribeiro, C.M.1    Paradiso, A.M.2    Carew, M.A.3    Shears, S.B.4    Boucher, R.C.5
  • 45
    • 24044466139 scopus 로고    scopus 로고
    • Chronic airway infection/infl ammation induces a Ca2+i-dependent hyperinfl ammatory response in human cystic fi brosis airway epithelia
    • Ribeiro, C. M., A. M. Paradiso, U. Schwab, J. Perez-Vilar, L. Jones, W. O'Neal, and R. C. Boucher. 2005. Chronic airway infection/infl ammation induces a Ca2+i-dependent hyperinfl ammatory response in human cystic fi brosis airway epithelia. J. Biol. Chem. 280: 17798-17806.
    • (2005) J. Biol. Chem. , vol.280 , pp. 17798-17806
    • Ribeiro, C.M.1    Paradiso, A.M.2    Schwab, U.3    Perez-Vilar, J.4    Jones, L.5    O'Neal, W.6    Boucher, R.C.7
  • 46
    • 0035165915 scopus 로고    scopus 로고
    • Polarized signaling via purinoceptors in normal and cystic fi brosis airway epithelia
    • Paradiso, A. M., C. M. Ribeiro, and R. C. Boucher. 2001. Polarized signaling via purinoceptors in normal and cystic fi brosis airway epithelia. J. Gen. Physiol. 117: 53-67.
    • (2001) J. Gen. Physiol. , vol.117 , pp. 53-67
    • Paradiso, A.M.1    Ribeiro, C.M.2    Boucher, R.C.3
  • 47
  • 48
    • 0018702406 scopus 로고
    • Substrate specifi city studies on the malonyl-CoA-dependent chain elongation of all-cis polyunsaturated fatty acids by rat liver microsomes
    • Ludwig, S. A., and H. Sprecher. 1979. Substrate specifi city studies on the malonyl-CoA-dependent chain elongation of all-cis polyunsaturated fatty acids by rat liver microsomes. Arch. Biochem. Biophys. 197: 333-341.
    • (1979) Arch. Biochem. Biophys. , vol.197 , pp. 333-341
    • Ludwig, S.A.1    Sprecher, H.2
  • 49
    • 33646018341 scopus 로고    scopus 로고
    • Fatty acid elongases in mammals: Their regulation and roles in metabolism
    • Jakobsson, A., R. Westerberg, and A. Jacobsson. 2006. Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog. Lipid Res. 45: 237-249.
    • (2006) Prog. Lipid Res. , vol.45 , pp. 237-249
    • Jakobsson, A.1    Westerberg, R.2    Jacobsson, A.3
  • 50
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    • Jäger, S., C. Handschin, J. St-Pierre, and B. M. Spiegelman. 2007. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. USA. 104: 12017-12022.
    • (2007) Proc. Natl. Acad. Sci. USA. , vol.104 , pp. 12017-12022
    • Jäger, S.1    Handschin, C.2    St-Pierre, J.3    Spiegelman, B.M.4
  • 52
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega, R. B., J. M. Huss, and D. P. Kelly. 2000. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20: 1868-1876.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 53
    • 0142010520 scopus 로고    scopus 로고
    • Regulation of human delta-6 desaturase gene transcription: Identifi cation of a functional direct repeat-1 element
    • Tang, C., H. P. Cho, M. T. Nakamura, and S. D. Clarke. 2003. Regulation of human delta-6 desaturase gene transcription: identifi cation of a functional direct repeat-1 element. J. Lipid Res. 44: 686-695.
    • (2003) J. Lipid Res. , vol.44 , pp. 686-695
    • Tang, C.1    Cho, H.P.2    Nakamura, M.T.3    Clarke, S.D.4
  • 57
    • 67650073195 scopus 로고    scopus 로고
    • Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells
    • Bartling, T. R., and M. L. Drumm. 2009. Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L35-L43.
    • (2009) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.297
    • Bartling, T.R.1    Drumm, M.L.2
  • 58
    • 58149359833 scopus 로고    scopus 로고
    • Oxidative stress causes IL8 promoter hyperacetylation in cystic fi brosis airway cell models
    • Bartling, T. R., and M. L. Drumm. 2009. Oxidative stress causes IL8 promoter hyperacetylation in cystic fi brosis airway cell models. Am. J. Respir. Cell Mol. Biol. 40: 58-65.
    • (2009) Am. J. Respir. Cell Mol. Biol. , vol.40 , pp. 58-65
    • Bartling, T.R.1    Drumm, M.L.2


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