Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis

Lipids

Volumn 48, Issue 4, 2013, Pages 333-342

  Katrangi, Waddah ^a   Lawrenz, Joshua ^a   Seegmiller, Adam C ^a   Laposata, Michael ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

Alpha linolenic acid; Cystic fibrosis; Linoleic acid; Polyunsaturated fatty acid metabolism

Indexed keywords

LINOLEIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; EPITHELIUM CELL; FATTY ACID METABOLISM; HUMAN; HUMAN CELL;

ALPHA-LINOLENIC ACID; CELL LINE; CYSTIC FIBROSIS; FATTY ACIDS; FATTY ACIDS, OMEGA-3; HUMANS; LIPID METABOLISM;

EID: 84876293970     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-013-3768-4     Document Type: Article

References (35)

1. O'Sullivan BP, Freedman SD (2009) Cystic fibrosis. Lancet 373:1891-1904
2. Borowitz D, Baker RD, Stallings V (2002) Consensus report on nutrition for pediatric patients with cystic fibrosis. J Pediatr Gastroenterol Nutr 35:246-259
3. Smith C, Winn A, Seddon P, Ranganathan S (2011) A fat lot of good: balance and trends in fat intake in children with cystic fibrosis. J Cyst Fibros 11:154-157
4. Al-Turkmani MR, Freedman SD, Laposata M (2007) Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. Prostaglandins Leukot Essent Fat Acids 77:309-318
5. Strandvik B (2010) Fatty acid metabolism in cystic fibrosis. Prostaglandins Leukot Essent Fat Acids 83:121-129
6. Aldamiz-Echevarria L, Prieto JA, Andrade F, Elorz J, Sojo A, Lage S, Sanjurjo P, Vazquez C, Rodriguez-Soriano J (2009) Persistence of essential fatty acid deficiency in cystic fibrosis despite nutritional therapy. Pediatr Res 66:585-589
7. Freedman SD, Katz MH, Parker EM, Laposata M, Urman MY, Alvarez JG (1999) A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice. Proc Natl Acad Sci USA 96:13995-14000
8. Mimoun M, Coste TC, Lebacq J, Lebecque P, Wallemacq P, Leal T, Armand M (2009) Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid. J Nutr 139:2358-2364
9. Andersson C, Al-Turkmani MR, Savaille JE, Alturkmani R, Katrangi W, Cluette-Brown JE, Zaman MM, Laposata M, Freedman SD (2008) Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism. J Lipid Res 49:1692-1700
10. Strandvik B, Gronowitz E, Enlund F, Martinsson T, Wahlstrom J (2001) Essential fatty acid deficiency in relation to genotype in patients with cystic fibrosis. J Pediatr 139:650-655
11. Van Biervliet S, Vanbillemont G, Van Biervliet JP, Declercq D, Robberecht E, Christophe A (2007) Relation between fatty acid composition and clinical status or genotype in cystic fibrosis patients. Ann Nutr Metab 51:541-549
12. Guilbault C, Wojewodka G, Saeed Z, Hajduch M, Matouk E, De Sanctis JB, Radzioch D (2009) Cystic fibrosis fatty acid imbalance is linked to ceramide deficiency and corrected by fenretinide. Am J Respir Cell Mol Biol 41:100-106
13. Maqbool A, Schall JI, Garcia-Espana JF, Zemel BS, Strandvik B, Stallings VA (2008) Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis. J Pediatr Gastroenterol Nutr 47:635-644
14. Nakamura MT, Nara TY (2003) Essential fatty acid synthesis and its regulation in mammals. Prostaglandins Leukot Essent Fatty Acids 68:145-150
15. Njoroge SW, Seegmiller AC, Katrangi W, Laposata M (2011) Increased Delta5- and Delta6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis. Biochim Biophys Acta 1811:431-440
16. Thomsen KF, Laposata M, Njoroge SW, Umunakwe OC, Katrangi W, Seegmiller AC (2011) Increased elongase 6 and Delta9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis. Lipids 46:669-677
17. Njoroge SW, Laposata M, Katrangi W, Seegmiller AC (2012) DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. J Lipid Res 53:257-265
18. Zaman MM, Martin CR, Andersson C, Bhutta AQ, Cluette-Brown JE, Laposata M, Freedman SD (2010) Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. Am J Physiol Lung Cell Mol Physiol 299:L599-L606
19. Kris-Etherton PM, Taylor DS, Yu-Poth S, Huth P, Moriarty K, Fishell V, Hargrove RL, Zhao G, Etherton TD (2000) Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr 71:179S-188S
20. Rajan S, Cacalano G, Bryan R, Ratner AJ, Sontich CU, van Heerckeren A, Davis P, Prince A (2000) Pseudomonas aeruginosa induction of apoptosis in respiratory epithelial cells: analysis of the effects of cystic fibrosis transmembrane conductance regulator dysfunction and bacterial virulence factors. Am J Respir Cell Mol Biol 23:304-312
21. Al-Turkmani MR, Andersson C, Alturkmani R, Katrangi W, Cluette-Brown JE, Freedman SD, Laposata M (2008) A mechanism accounting for the low cellular level of linoleic acid in cystic fibrosis and its reversal by DHA. J Lipid Res 49:1946-1954
22. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509
23. Siguel EN, Maclure M (1987) Relative activity of unsaturated fatty acid metabolic pathways in humans. Metabolism 36:664-669
24. Lands WE (1992) Biochemistry and physiology of n-3 fatty acids. FASEB J 6:2530-2536
25. Rodriguez A, Sarda P, Nessmann C, Boulot P, Leger CL, Descomps B (1998) Delta6- and delta5-desaturase activities in the human fetal liver: kinetic aspects. J Lipid Res 39:1825-1832
26. Freedman SD, Blanco PG, Zaman MM, Shea JC, Ollero M, Hopper IK, Weed DA, Gelrud A, Regan MM, Laposata M, Alvarez JG, O'Sullivan BP (2004) Association of cystic fibrosis with abnormalities in fatty acid metabolism. N Engl J Med 350:560-569
27. Raatz SK, Bibus D, Thomas W, Kris-Etherton P (2001) Total fat intake modifies plasma fatty acid composition in humans. J Nutr 131:231-234
28. Simopoulos AP (1998) Overview of evolutionary aspects of omega 3 fatty acids in the diet. World Rev Nutr Diet 83:1-11
29. Blasbalg TL, Hibbeln JR, Ramsden CE, Majchrzak SF, Rawlings RR (2011) Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr 93:950-962
30. Rodriguez-Leyva D, Dupasquier CM, McCullough R, Pierce GN (2010) The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. Can J Cardiol 26:489-496
31. Stark AH, Crawford MA, Reifen R (2008) Update on alpha-linolenic acid. Nutr Rev 66:326-332
32. Gerster H (1998) Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? Int J Vitam Nutr Res 68:159-173
33. Mohrhauer H, Holman RT (1963) Effect of linolenic acid upon the metabolism of linoleic acid. J Nutr 81:67-74
34. Sayanova OV, Beaudoin F, Michaelson LV, Shewry PR, Napier JA (2003) Identification of primula fatty acid delta 6-desaturases with n-3 substrate preferences. FEBS Lett 542:100-104
35. Zheng X, Ding Z, Xu Y, Monroig O, Morais S, Tocher DR (2009) Physiological roles of fatty acyl desaturases and elongases in marine fish: characterisation of cDNAs of fatty acyl delta6-desaturase and elovl5 elongase of cobia (Rachycentron canadum). Aquaculture 290:122-131