A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression

Journal of Lipid Research

Volumn 55, Issue 7, 2014, Pages 1397-1407

  Singh, Amar Bahadur ^a,b   Kan, Chin Fung Kelvin ^a   Shende, Vikram ^a,b   Dong, Bin ^a   Liu, Jingwen ^a  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenylateuridylate rich element binding proteins; Heterogeneous nuclear ribonucleoprotein D; Hypercholesterolemia; Low density lipoprotein; Messenger ribonucleic acid stability; Posttranscriptional regulation

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HAMSTER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DENSITY LIPOPROTEIN RECEPTOR GENE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RECEPTOR BINDING; REGULATORY MECHANISM; RNA DEGRADATION; RNA STABILITY; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; PHARMACOLOGY; TRANSGENIC MOUSE;

3' UNTRANSLATED REGIONS; ANIMALS; CHOLESTEROL, DIETARY; GENE EXPRESSION REGULATION; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN D; LIVER; MALE; MICE; MICE, TRANSGENIC; RECEPTORS, LDL; RNA STABILITY;

EID: 84903985923     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M049429     Document Type: Article

References (36)

1. Spady, D. K. 1992. Hepatic clearance of plasma low density lipoproteins. Semin. Liver Dis. 12: 373-385.
2. Brown, M. S., and J. L. Goldstein. 1986. A receptor-mediated pathway for cholesterol homeostasis. Science. 232: 34-47.
3. Goldstein, J. L., and M. S. Brown. 1990. Regulation of the mevalonate pathway. Nature. 343: 425-430.
4. Marcoux, C., M. Tremblay, A. Fredenrich, H. Jacques, L. Krimbou, K. Nakajima, J. Davignon, and J. S. Cohn. 1998. Plasma remnantlike particle lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects. Atherosclerosis. 139: 161-171.
5. Homma, Y. 2004. Predictors of atherosclerosis. J. Atheroscler. Thromb. 11: 265-270.
6. Brown, M. S., and J. L. Goldstein. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of the membrane bound transcription factor. Cell. 89: 331-340.
7. Brown, M. S., and J. L. Goldstein. 1999. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl. Acad. Sci. USA. 96: 11041-11048.
8. Wilson, G. M., M. Z. Vasa, and R. G. Deeley. 1998. Stabilization and cytoskeletal-association of LDL receptor mRNA are mediated by distinct domains in its 3 ?OElig; untranslated region. J. Lipid Res. 39: 1025-1032.
9. Wilson, G. M., E. A. Roberts, and R. G. Deeley. 1997. Modulation of LDL receptor mRNA stability by phorbol esters in human liver cell culture models. J. Lipid Res. 38: 437-446.
10. Goto, D., T. Okimoto, M. Ono, H. Shimotsu, K. Abe, Y. Tsujita, and M. Kuwano. 1997. Upregulation of low density lipoproteinreceptor by gemfi brozil, a hypolipidemic agent, in human hepatoma cells through stabilization of mRNA transcripts. Arterioscler. Thromb. Vasc. Biol. 17: 2707-2712.
11. Kong, W., J. Wei, P. Abidi, M. Lin, S. Inaba, C. Li, Y. Wang, Z. Wang, S. Si, H. Pan, et al. 2004. Berberine is a promising novel cholesterollowering drug working through a unique mechanism distinct from statins. Nat. Med. 10: 1344-1351.
12. Parker, R., and H. Song. 2004. The enzyme and control of eukaryotic mRNA turnover. Nat. Struct. Mol. Biol. 11: 121-127.
13. Sheng, Z., H. Otani, M. S. Brown, and J. L. Goldenstein. 1995. Independent regulation of sterol regulatory element-binding pro teins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA. 92: 935-938.
14. Shimomura, I., Y. Bashmakov, H. Shimano, J. D. Horton, J. L. Goldstein, and M. S. Brown. 1997. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Proc. Natl. Acad. Sci. USA. 94: 12354-12359.
15. Korn, B. S., I. Shimomura, Y. Bashmakov, R. E. Hammer, J. D. Horton, J. L. Goldstein, and M. S. Brown. 1998. Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). J. Clin. Invest. 102: 2050-2060.
16. Yamamoto, T., C. G. Davis, M. S. Brown, W. J. Schneider, M. L. Casey, J. L. Goldstein, and D. W. Russell. 1984. The human LDL receptor: A cysteine-rich protein with multiple Alu sequence in its mRNA. Cell. 39: 27-38.
17. Yashiro, T., Y. Yokoi, M. Shimizu, J. Inoue, and R. Sato. 2011. Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3 ?OElig;-untranslated region and AU-rich element-binding protein. Biochem. Biophys. Res. Commun. 409: 155-159.
18. Barreau, C., L. Paillard, and H. S. Osborne. 2005. Survey and summary AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res. 33: 7138-7150.
19. Zhang, T., V. Kruys, G. Huez, and C. Gueydan. 2002. AU-rich element-mediated translational control: complexity and multiple activity of trans-activating factors. Biochem. Soc. Trans. 30: 952-958.
20. Meyer, S., C. Temme, and E. Wahle. 2004. Messenger RNA turnover in eukaryotes: pathways and enzymes. Crit. Rev. Biochem. Mol. Biol. 39: 197-216.
21. Li, H., W. Chen, Y. Zhou, P. Abidi, O. Sharpe, W. H. Robinson, and J. Liu. 2009. Identifi cation of mRNA-binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements. J. Lipid Res. 50: 820-831.
22. Yashiro, T., M. Nanmoku, M. Shimizu, J. Inoue, and R. Sato. 2013. 5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERKdependent HuR binding to an AU-rich element. Atherosclerosis. 226: 95-101.
23. Lin, S., W. Wang, G. M. Wilson, X. Yang, G. Brewer, N. J. Holbrook, and M. Gorospe. 2000. Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover. Mol. Cell. Biol. 20: 7903-7913.
24. Pont, A. R., N. Sadri, S. J. Hsiao, S. Smith, and R. J. Schneider. 2012. mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription. Mol. Cell. 47: 5-15.
25. Briata, P., C. Y. Chen, M. Giovarelli, M. Pasero, M. Trabucchi, A. Ramos, and R. Gherzi. 2011. KSRP, many functions for a single protein. Front. Biosci. (Landmark Ed. ) 16: 1787-1796.
26. Ruggiero, T., M. Trabucchi, M. Ponassi, G. Corte, C. Y. Chen, L. al-Haj, K. S. Khabar, P. Briata, and R. Gherzi. 2007. Identifi cation of a set of KSRP target transcripts upregulated by PI3K-AKT signaling. BMC Mol. Biol. 8: 28.
27. Raineri, I., D. Wegmueller, B. Gross, U. Certa, and C. Moroni. 2004. Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference. Nucleic Acids Res. 32: 1279-1288.
28. Singh, A. B., H. Li, C. F. Kan, B. Dong, M. R. Nicolls, and J. Liu. 2014. The Critical role of mRNA destabilizing protein heterogeneous nuclear ribonucleoprotein D in 3 ?OElig; untranslated region-mediated decay of low-density lipoprotein receptor mRNA in liver tissue. Arterioscler. Thromb. Vasc. Biol. 34: 8-16.
29. Dong, B., C. F. Kan, A. B. Singh, and J. Liu. 2013. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway. J. Lipid Res. 54: 1241-1254.
30. Gratacós, F. M., and G. Brewer. 2010. The role of AUF1 in regulated mRNA decay. RNA. 1: 457-473.
31. Lofl in, P., C-Y. A. Chen, and A-B. Shyu. 1999. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element. Genes Dev. 13: 1884-1897.
32. Barker, A., M. R. Epis, C. J. Porter, B. R. Hopkins, M. C. J. Wilce, J. A. Wilce, K. M. Giles, and P. J. Leedman. 2012. Sequence requirements for RNA binding by HuR and AUF1. J. Biochem. 151: 423-437.
33. Spann, N. J., L. X. Garmire, J. G. McDonald, D. S. Myers, S. B. Milne, N. Shibata, D. Reichart, J. N. Fox, I. Shaked, D. Heudobler, et al. 2012. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and infl ammatory responses. Cell. 151: 138-152.
34. Jakobsson, T., E. Treuter, J-A. Gustafsson, and K. R. Steffensen. 2012. Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. Trends Pharmacol. Sci. 33: 394-404.
35. Mazan-Mamczarz, K., Y. Kuwano, M. Zhan, E. J. White, J. L. Martindale, A. Lai, and M. Gorospe. 2009. Identifi cation of a signature motif in target mRNAs of RNA-binding protein AUF1. Nucleic Acids Res. 37: 204-214.
36. Zucconi, B. E., and G. M. Wilson. 2013. Assembly of functional ribonucleoprotein complexes by AU-rich element RNA-binding protein 1 (AUF1) requires base-dependent and-independent RNA contacts. J. Biol. Chem. 288: 28034-28048.