Stabilization and cytoskeletal-association of LDL receptor mRNA are mediated by distinct domains in its 3' untranslated region

Journal of Lipid Research

Volumn 39, Issue 5, 1998, Pages 1025-1032

  Wilson, G M ^a,b,c   Vasa, M Z ^a   Deeley, R G ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Hepatoblastoma; Phorbol esters; Polyribosomes; Posttranscriptional regulation

Indexed keywords

BETA GLOBIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PHORBOL ESTER;

AMINO ACID SEQUENCE; ARTICLE; CELLULAR DISTRIBUTION; CYTOSKELETON; GENE EXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HEPATOBLASTOMA; HUMAN; HUMAN CELL; POLYSOME; PRIORITY JOURNAL; RNA ANALYSIS; RNA TRANSLATION; TRANSCRIPTION REGULATION;

EID: 0031895061     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0022-2275(20)33870-0     Document Type: Article

References (36)

1. Goldstein, J. L., and M. S. Brown. 1984. Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol. J. Lipid Res. 25: 1450-1461.
2. Brown, M. S., and J. L. Goldstein. 1986. A receptor-mediated pathway for cholesterol homeostasis. Science. 232: 34-47.
3. Davis, R. A. 1991. Lipoprotein structure and secretion. In Biochemistry of Lipids, Lipoproteins, and Membranes. 2nd edition. D. E. Vance, and J. Vance, editors. Elsevier Science Publishers, Amsterdam. Chapter 14: 403-426.
4. Russell, D. W., and K. D. R. Setchell. 1992. Bile acid biosynthesis. Biochemistry. 31: 4737-4748.
5. Dietschy, J. M., and J. D. Wilson. 1970. Regulation of cholesterol metabolism (part 3). N. Engl. J. Med. 282: 1241-1249.
6. Goldstein, J. L., and M. S. Brown. 1977. The low-density lipoprotein pathway and its relation to atherosclerosis. Annu. Rev. Biochem. 46: 897-930.
7. Hobbs, H. H., D. W. Russell, M. S. Brown, and J. L. Goldstein. 1990. The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein. Annu. Rev. Genet. 24: 133-170.
8. Bilheimer, D. W., J. L. Goldstein, S. M. Grundy, T. E. Starzl, and M.S. Brown. 1984. Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. N. Engl. J. Med. 311: 1658-1664.
9. Grossman, M., S. E. Raper, K. Kozarsky, E. A. Stein, J. F. Engelhardt, D. Muller, P. J. Lupien, and J. M. Wilson. 1994. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolemia. Nature Genet. 6: 335-341.
10. Javitt, N. B. 1990. HepG2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids. FASEB J. 4: 161-168.
11. Knowles, B. B., C. C. Howe, and D. P. Aden. 1980. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science. 209: 497-499.
12. Kraft, H. G., S. J. Demosky, K. Schumacher, H. B. Brewer, and J. M. Hoeg. 1992. Regulation of LDL receptor, apoB, and apoE protein and mRNA in HepG2 cells. DNA Cell Biol. 11: 291-300.
13. Tam, S.-P., L. Brisette, R. Ramharack, and R. G. Deeley. 1991. Differences between the regulation of 3-hydroxy-3-methylglutarylcoenzyme A reductase and low density lipoprotein receptor in human hepatoma cells and fibroblasis reside primarily at the translational and post-translational levels. J. Biol. Chem. 266: 16764-16773.
14. Illingworth, D. R., S. Lindsey, and F. C. Hagemenas. 1984. Regulation of low-density lipoprotein receptors in the human hepatoma cell line HepG2. Exp. Cell Res. 155: 518-526.
15. Kamps, J. A. A. M., and T. J. C. van Berkel. 1992. Complete down-regulation of low-density-lipoprotein-receptor activity in the human hepatoma cell line HepG2 by β-migrating very-low-density-lipoprotein and non-lipoprotein cholesterol. Eur. J. Biochem. 206: 973-978.
16. Auwerx, J. H., A. Chait, G. Wolfbauer, and S. S. Deeb. 1989. Involvement of second messengers in regulation of the low-density lipoprotein receptor gene. Mol. Cell. Biol. 9: 2298-2302.
17. Auwerx, J. H., A. Chait, and S. S. Deeb. 1989. Regulation of the low density lipoprotein receptor and hydroxymethylglutaryl coenzyme A reductase genes by protein kinase C and a putative negative regulatory protein. Proc. Natl. Acad. Sci. USA. 86: 1133-1137.
18. Kamps, J. A. A. M., and T. J. C. van Berkel. 1993. Regulation of low-density-lipoprotein receptors in the human hepatoma cell line HepG2. Eur. J. Biochem. 213: 989-994.
19. Iyengar, R. 1996. Gating by cyclic AMP: expanded role for an old signalling pathway. Science. 271: 461-463.
20. Clapham, D.E. 1995. Calcium signalling. Cell. 80: 259-268.
21. Haller, H., C. Lindschau, and F. C. Luft. 1994. Role of protein kinase C in intracellular signalling. Ann. NY Acad. Sci. 733: 313-324.
22. Wilson, G. M., E. A. Roberts, and R. G. Deeley. 1997. Modulation of LDL receptor mRNA stability by phorbol esters in human liver cell culture models. J. Lipid Res. 38: 437-446.
23. Wilson, G. M., and R. G. Deeley. 1995. An episomal expression vector system for monitoring sequence-specific effects on mRNA stability in human cell lines. Plasmid. 33: 198-207.
24. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. 2nd edition. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 1.53-1.73.
25. Feinberg, A. P., and B. Vogelstein. 1984. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 137: 266-267.
26. Freund, J. E. 1988. Modern Elementary Statistics. 7th edition. Prentice-Hall, Englewood Cliffs, NJ. 429-436.
27. Zambetti, G., L. Wilming, E. G. Fey, S. Penman, J. Stein, and G. Stein. 1990. Differential association of membrane-bound and non-membrane bound polysomes with the cytoskeleton. Exp. Cell. Res. 191: 246-255.
28. Chen, C-Y. A., and A-B. Shyu. 1995. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20: 465-470.
29. Zubiaga, A. M., J. G. Belasco, and M. E. Greenberg. 1995. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol. 15: 2219-2230.
30. Ross, J. 1995. mRNA stability in mammalian cells. Microbial. Rev. 59: 423-450.
31. DeMaria, C. T., and G. Brewer. 1996. AUF1 binding affinity to A+U-rich elements correlates with rapid mRNA degradation. J. Biol. Chem. 271: 12179-12184.
32. Chen, F. Y., F. M. Amara, and J. A. Wright. 1994. Defining a novel ribonucleotide reductase R1 mRNA cis-element that binds to a unique cytoplasmic trans-acting protein.Nucleic Acids Res. 22: 4796-4797.
33. Amara, F. M., J. Sun, and J. A. Wright. 1996. Defining a novel cis-element in the 3′-untranslated region of mammalian ribonucleotide reductase component R2 mRNA. cis-trans-interactions and message stability. J. Biol. Chem. 271: 20126-20131.
34. Chen, F. Y., F. M. Amara, and J. A. Wright. 1993. Mammalian ribonucleotide reductase R1 mRNA stability under normal and phorbol ester stimulating conditions: involvement of a cis-trans interaction at the 3′ untranslated region. EMBO J. 12: 3977-3986.
35. Ross, A. F., Y. Oleynikov, E. H. Kislauskis, K. L. Taneja, and R. H. Singer. 1997. Characterization of a β-actin mRNA zipcode-binding protein. Mol. Cell. Biol. 17: 2158-2165.
36. Hesketh, J. E. 1996. Sorting of messenger RNAs in the cytoplasm: mRNA localization and the cytoskeleton. Exp. Cell Res. 225: 219-236.