Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3′-untranslated region and AU-rich element-binding protein

Biochemical and Biophysical Research Communications

Volumn 409, Issue 2, 2011, Pages 155-159

  Yashiro, Takuya ^a   Yokoi, Yuka ^a   Shimizu, Makoto ^a   Inoue, Jun ^a   Sato, Ryuichiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

AU rich element; Bile acid; LDL receptor; MAPK; MRNA stability

Indexed keywords

CHENODEOXYCHOLIC ACID; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1;

3' UNTRANSLATED REGION; ARTICLE; CHIMERA; CROSS LINKING; CYTOPLASM; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; STOP CODON; ULTRAVIOLET RADIATION;

3' UNTRANSLATED REGIONS; CELL LINE, TUMOR; CHENODEOXYCHOLIC ACID; ENZYME ACTIVATION; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN D; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTEIN BINDING; RECEPTORS, LDL; RNA STABILITY; RNA, MESSENGER;

EID: 79957880399     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.04.006     Document Type: Article

References (18)

1. Wang X., Sato R., Brown M.S., Hua X., Goldstein J.L. SREBP-1 a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 1994, 77:53-62.
2. Sato R., Yang J., Wang X., Evans M.J., Ho Y.K., Goldstein J.L., Brown M.S. Assignment of the membrane attachment DNA binding and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J. Biol. Chem. 1994, 269:17267-17273.
3. Benjannet S., Rhainds D., Essalmani R., Mayne J., Wickham L., Jin W., Asselin M.C., Hamelin J., Varret M., Allard D., Trillard M., Abifadel M., Tebon A., Attie A.D., Rader D.J., Boileau C., Brissette L., Chrétien M., Prat A., Seidah N.G. NARC-1/PCSK9 and its natural mutants zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J. Biol. Chem. 2004, 279:48865-48875.
4. Zelcer N., Hong C., Boyadjian R., Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 2009, 325:100-104.
5. Nakahara M., Fujii H., Maloney P.R., Shimizu M., Sato R. Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA. J. Biol. Chem. 2002, 277:37229-37234.
6. Kong W., Wei J., Abidi P., Lin M., Inaba S., Li C., Wang Y., Wang Z., Si S., Pan H., Wang S., Wu J., Li Z., Liu J., Jiang J.D. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat. Med. 2004, 10:1344-1351.
7. Abidi P., Zhou Y., Jiang J.D., Liu J. Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2170-2176.
8. Abdelmohsen K., Pullmann R., Lal A., Kim H.H., Galban S., Yang X., Blethrow J.D., Walker M., Shubert J., Gillespie D.A., Furneaux H., Gorospe M. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol. Cell 2007, 25:543-557.
9. Ishimaru D., Zuraw L., Ramalingam S., Sengupta T.K., Bandyopadhyay S., Reuben A., Fernandes D.J., Spicer E.K. Mechanism of regulation of bcl-2 mRNA by nucleolin and Arich element-binding factor 1 (AUF1). J. Biol. Chem. 2010, 285:27182-27191.
10. Hitti E., Iakovleva T., Brook M., Deppenmeier S., Gruber A.D., Radzioch D., Clark A.R., Blackshear P.J., Kotlyarov A., Gaestel M. Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression stability and binding to adenine/uridine-rich element. Mol. Cell. Biol. 2006, 26:2399-2407.
11. Li H., Chen W., Zhou Y., Abidi P., Sharpe O., Robinson W.H., Kraemer F.B., Liu J. Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements. J. Lipid Res. 2009, 50:820-831.
12. Pioli P.A., Hamilton B.J., Connolly J.E., Brewer G., Rigby W.F. Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1. J. Biol. Chem. 2002, 277:35738-35745.
13. Irisawa M., Inoue J., Ozawa N., Mori K., Sato R. The sterol-sensing ER membrane protein TRC8 hampers ER-to-Golgi transport of SREBP-2/SCAP and reduces SREBP-2 cleavage. J. Biol. Chem. 2009, 284:28995-29004.
14. Abidi P., Chen W., Kraemer F.B., Li H., Liu J. The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. J. Lipid Res. 2006, 47:2134-2147.
15. Wilson G.M., Roberts E.A., Deeley R.G. Modulation of LDL receptor mRNA stability by phorbol esters in human liver cell culture models. J. Lipid Res. 1997, 38:437-446.
16. Wilson G.M., Vasa M.Z., Deeley R.G. Stabilization and cytoskeletal-association of LDL receptor mRNA are mediated by distinct domains in its 3′ untranslated region. J. Lipid Res. 1998, 39:1025-1032.
17. Vargas N.B., Brewer B.Y., Rogers T.B., Wilson G.M. Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells. J. Lipid Res. 2009, 50:386-397.
18. Goto D., Okimoto T., Ono M., Shimotsu H., Abe K., Tsujita Y., Kuwano M. Upregulation of low density lipoprotein receptor by gemfibrozil a hypolipidemic agent in human hepatoma cells through stabilization of mRNA transcripts. Arterioscler. Thromb. Vasc. Biol. 1997, 17:2707-2712.