Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish

DMM Disease Models and Mechanisms

Volumn 7, Issue 7, 2014, Pages 837-845

  Zhang, Shuqing ^a   Xu, Minrui ^a   Huang, Jian ^a   Tang, Lili ^a   Zhang, Yanqing ^a   Wu, Jingyao ^a   Lin, Shuo ^b   Wang, Han ^a  

^a SOOCHOW UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bach1b; Heme; MafK; Nrf2a; Porphyria; Zebrafish; Zymogens

Indexed keywords

ENZYME PRECURSOR; HEME; HETERODIMER; PEPTIDASE; TRANSCRIPTION FACTOR NRF2; MESSENGER RNA; PEPTIDE HYDROLASE; ZEBRAFISH PROTEIN;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; NONHUMAN; PORPHYRIA; PRECURSOR; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; ZEBRA FISH; 3T3 CELL LINE; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HEPATIC PORPHYRIA; IN SITU HYBRIDIZATION; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE MOTIF; PANCREAS; PROMOTER REGION; PROTEIN MOTIF; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CHROMATIN IMMUNOPRECIPITATION; ENZYME PRECURSORS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HEME; IN SITU HYBRIDIZATION; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; NUCLEOTIDE MOTIFS; PANCREAS, EXOCRINE; PEPTIDE HYDROLASES; PORPHYRIAS, HEPATIC; PROMOTER REGIONS, GENETIC; PROTEIN MULTIMERIZATION; RNA, MESSENGER; SIGNAL TRANSDUCTION; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84903980894     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.014951     Document Type: Article

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