Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish

PLoS Biology

Volumn 6, Issue 11, 2008, Pages 2450-2464

  Jiang, Zhi ^a   Song, Jianbo ^b   Qi, Fei ^a   Xiao, An ^a   An, Xizhou ^a   Liu, Ning Ai ^b   Zhu, Zuoyang ^a   Zhang, Bo ^a   Lin, Shuo ^a,b  

^a Peking University   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE A; LUCIFERASE; MESSENGER RNA; RETINOIC ACID; EXDPF PROTEIN, ZEBRAFISH; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PTF1; ZEBRAFISH PROTEIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BINDING SITE; CELL CYCLE; CELL DIFFERENTIATION; ENDOCRINE CELL; EXOCRINE CELL; EXPERIMENTAL ANIMAL; NONHUMAN; PANCREAS; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; ZEBRA FISH; ANIMAL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PANCREAS ISLET; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION;

DANIO RERIO; MAMMALIA;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CONSERVED SEQUENCE; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; ISLETS OF LANGERHANS; MICE; ORGANOGENESIS; PANCREAS, EXOCRINE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRETINOIN; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 56849127125     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0060293     Document Type: Article

References (60)

1. Lernmark A (1987) Islet cell antibodies. Diabet Med 4: 285-292.
2. Donath MY, Halban PA (2004) Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications. Diabetologia 47: 581-589.
3. Cowgill SM, Muscarella P (2003) The genetics of pancreatic cancer. Am J Surg 186: 279-286.
4. Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371: 606-609.
5. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, et al. (1996) PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122: 983-995.
6. Slack JM (1995) Developmental biology of the pancreas. Development 121: 1569-1580.
7. Edlund H (2002) Pancreatic organogenesis - Developmental mechanisms and implications for therapy. Nat Rev Genet 3: 524-532.
8. Lammert E, Cleaver O, Melton D (2003) Role of endothelial cells in early pancreas and liver development. Mech Dev 120: 59-64.
9. Jorgensen MC, Ahnfelt-Ronne J, Hald J, Madsen OD, Serup P, et al. (2007) An illustrated review of early pancreas development in the mouse. Endocr Rev 28: 685-705.
10. Teitelman G, Alpert S, Polak JM, Martinez A, Hanahan D (1993) Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118: 1031-1039.
11. Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, et al. (2005) Genetic determinants of pancreatic epsilon-cell development. Dev Biol 286: 217-224.
12. Herrera PL, Huarte J, Sanvito F, Meda P, Orci L, et al. (1991) Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113: 1257-1265.
13. Argenton F, Zecchin E, Bortolussi M (1999) Early appearance of pancreatic hormone-expressing cells in the zebrafish embryo. Mech Dev 87: 217-221.
14. Biemar F, Argenton F, Schmidtke R, Epperlein S, Peers B, et al. (2001) Pancreas development in zebrafish: Early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet. Dev Biol 230: 189-203.
15. Huang H, Vogel SS, Liu N, Melton DA, Lin S (2001) Analysis of pancreatic development in living transgenic zebrafish embryos. Mol Cell Endocrinol 177: 117-124.
16. Field HA, Dong PD, Beis D, Stainier DY (2003) Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Dev Biol 261: 197-208.
17. Norgaard GA, Jensen JN, Jensen J (2003) FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol 264: 323-338.
18. Song YD, Lee EJ, Yashar P, Pfaff LE, Kim SY, et al. (2007) Islet cell differentiation in liver by combinatorial expression of transcription factors neurogenin-3, BETA2, and RIPE3b1. Biochem Biophys Res Commun 354: 334-339.
19. Kumar M, Jordan N, Melton D, Grapin-Botton A (2003) Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol 259: 109-122.
20. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, et al. (1999) Notch signalling controls pancreatic cell differentiation. Nature 400: 877-881.
21. Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, et al. (2000) Control of endodermal endocrine development by Hes-1. Nat Genet 24: 36-44.
22. Murtaugh LC, Stanger BZ, Kwan KM, Melton DA (2003) Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A 100: 14920-14925.
23. Hebrok M, Kim SK, Melton DA (1998) Notochord repression of endodermal sonic hedgehog permits pancreas development. Genes Dev 12: 1705-1713.
24. Stafford D, Hornbruch A, Mueller PR, Prince VE (2004) A conserved role for retinoid signaling in vertebrate pancreas development. Dev Genes Evol 214: 432-441.
25. Stafford D, Prince VE (2002) Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr Biol 12: 1215-1220.
26. Chen Y, Pan FC, Brandes N, Afelik S, Solter M, et al. (2004) Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev Biol 271: 144-160.
27. Martin M, Gallego-Llamas J, Ribes V, Kedinger M, Niederreither K, et al. (2005) Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol 284: 399-411.
28. Molotkov A, Molotkova N, Duester G (2005) Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Dev Dyn 232: 950-957.
29. Stafford D, White RJ, Kinkel MD, Linville A, Schilling TF, et al. (2006) Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells. Development 133: 949-956.
30. Shen CN, Marguerie A, Chien CY, Dickson C, Slack JM, et al. (2007) Alltrans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas. Differentiation 75: 62-74.
31. Kadison A, Kim J, Maldonado T, Crisera C, Prasadan K, et al. (2001) Retinoid signaling directs secondary lineage selection in pancreatic organogenesis. J Pediatr Surg 36: 1150-1156.
32. Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129: 2447-2457.
33. Gradwohl G, Dierich A, LeMeur M, Guillemot F (2000) neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 97: 1607-1611.
34. Krapp A, Knofler M, Ledermann B, Burki K, Berney C, et al. (1998) The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev 12: 3752-3763.
35. Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, et al. (2002) The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 32: 128-134.
36. Zecchin E, Mavropoulos A, Devos N, Filippi A, Tiso N, et al. (2004) Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Dev Biol 268: 174-184.
37. Lin JW, Biankin AV, Horb ME, Ghosh B, Prasad NB, et al. (2004) Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev Biol 270: 474-486.
38. Obata J, Yano M, Mimura H, Goto T, Nakayama R, et al. (2001) p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos. Genes Cells 6: 345-360.
39. Beres TM, Masui T, Swift GH, Shi L, Henke RM, et al. (2006) PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Mol Cell Biol 26: 117-130.
40. Cockell M, Stevenson BJ, Strubin M, Hagenbuchle O, Wellauer PK (1989) Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas. Mol Cell Biol 9: 2464-2476.
41. Rose SD, MacDonald RJ (1997) Evolutionary silencing of the human elastase I gene (ELA1). Hum Mol Genet 6: 897-903.
42. Rose SD, Swift GH, Peyton MJ, Hammer RE, MacDonald RJ (2001) The role of PTF1-P48 in pancreatic acinar gene expression. J Biol Chem 276: 44018-44026.
43. Wan H, Korzh S, Li Z, Mudumana SP, Korzh V, et al. (2006) Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter. Exp Cell Res 312: 1526-1539.
44. Dong P, Provost E, Leach SD, Stainier D (2008) Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas. Genes Dev 22: 1145-1450.
45. Tulachan SS, Doi R, Kawaguchi Y, Tsuji S, Nakajima S, et al. (2003) All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal/epithelial interactions in embryonic pancreas. Diabetes 52: 76-84.
46. Niederhuber JE, Brennan MF, Menck HR (1995) The National Cancer Data Base report on pancreatic cancer. Cancer 76: 1671-1677.
47. Moskaluk CA, Hruban RH, Kern SE (1997) p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 57: 2140-2143.
48. Luttges J, Galehdari H, Brocker V, Schwarte-Waldhoff I, Henne-Bruns D, et al. (2001) Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis. Am J Pathol 158: 1677-1683.
49. Yamano M, Fujii H, Takagaki T, Kadowaki N, Watanabe H, et al. (2000) Genetic progression and divergence in pancreatic carcinoma. Am J Pathol 156: 2123-2133.
50. Yang HW, Kutok JL, Lee NH, Piao HY, Fletcher CD, et al. (2004) Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish. Cancer Res 64: 7256-7262.
51. Park SW, Davison JM, Rhee J, Hruban RH, Maitra A, et al. (2008) Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology 134: 2080-2090.
52. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF (1995) Stages of embryonic development of the zebrafish. Dev Dyn 203: 253-310.
53. Thisse C, Thisse B, Schilling TF, Postlethwait JH (1993) Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development 119: 1203-1215.
54. Milewski WM, Duguay SJ, Chan SJ, Steiner DF (1998) Conservation of PDX-1 structure, function, and expression in zebrafish. Endocrinology 139: 1440-1449.
55. Begemann G, Marx M, Mebus K, Meyer A, Bastmeyer M (2004) Beyond the neckless phenotype: influence of reduced retinoic acid signaling on motor neuron development in the zebrafish hindbrain. Dev Biol 271: 119-129.
56. Hyatt TM, Ekker SC (1999) Vectors and techniques for ectopic gene expression in zebrafish. Methods Cell Biol 59: 117-126.
57. Pisharath H, Rhee JM, Swanson MA, Leach SD, Parsons MJ (2007) Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase. Mech Dev 124: 218-229.
58. Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, et al. (2004) Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development 131: 4213-4224.
59. Sun J, Kamei CN, Layne MD, Jain MK, Liao JK, et al. (2001) Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2. J Biol Chem 276: 18591-18596.
60. Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, et al. (1996) Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol 16: 952-959.