메뉴 건너뛰기




Volumn 177, Issue 2, 2014, Pages 464-477

Suppression of allo-human leucocyte antigen (HLA) antibodies secreted by B memory cells in vitro: Intravenous immunoglobulin (IVIg)versus a monoclonal anti-HLA-E IgG that mimics HLA-I reactivities of IVIg

Author keywords

Allo HLA IgG; B memory cells; HLA reactivity; Immunosuppression; Intravenous immunoglobulin (IVIg)

Indexed keywords

ALLOANTIBODY; BETA 2 MICROGLOBULIN; HLA ANTIBODY; HLA B ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; TFL 007; UNCLASSIFIED DRUG;

EID: 84903955275     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12307     Document Type: Article
Times cited : (13)

References (51)
  • 3
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: understand their relation
    • Ahmed R, Gray D. Immunological memory and protective immunity: understand their relation. Science 1996; 272:54-60.
    • (1996) Science , vol.272 , pp. 54-60
    • Ahmed, R.1    Gray, D.2
  • 4
    • 33749018225 scopus 로고    scopus 로고
    • Competence and competition: the challenge of becoming a long-live plasma cell
    • Radbruch A, Muehlinghaus G, Luger EO etal. Competence and competition: the challenge of becoming a long-live plasma cell. Nat Rev Immunol 2006; 6:741-750.
    • (2006) Nat Rev Immunol , vol.6 , pp. 741-750
    • Radbruch, A.1    Muehlinghaus, G.2    Luger, E.O.3
  • 5
    • 70449732274 scopus 로고    scopus 로고
    • Induction of allergen-specific plasma cells by mucosal allergen challenge
    • Luger EO, Fokuhl V, Wegmann M etal. Induction of allergen-specific plasma cells by mucosal allergen challenge. J Allergy Clin Immunol 2009; 124:819-826.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 819-826
    • Luger, E.O.1    Fokuhl, V.2    Wegmann, M.3
  • 6
    • 50549089591 scopus 로고    scopus 로고
    • Human leukocyte Ag Abs and chronic rejection: from association to causation
    • Terasaki PI, Cai J. Human leukocyte Ag Abs and chronic rejection: from association to causation. Transplantation 2008; 86:377-383.
    • (2008) Transplantation , vol.86 , pp. 377-383
    • Terasaki, P.I.1    Cai, J.2
  • 7
    • 23944450383 scopus 로고    scopus 로고
    • Humoral theory of transplantation: further evidence
    • Terasaki PI, Cai J. Humoral theory of transplantation: further evidence. Curr Opin Immunol 2005; 17:541-545.
    • (2005) Curr Opin Immunol , vol.17 , pp. 541-545
    • Terasaki, P.I.1    Cai, J.2
  • 9
    • 79960856720 scopus 로고    scopus 로고
    • Desensitization in HLA-incompatible kidney recipients and survival
    • Montgomery RA, Lonze BE, King KE etal. Desensitization in HLA-incompatible kidney recipients and survival. N Engl J Med 2011; 365:318-326.
    • (2011) N Engl J Med , vol.365 , pp. 318-326
    • Montgomery, R.A.1    Lonze, B.E.2    King, K.E.3
  • 10
    • 33947579518 scopus 로고    scopus 로고
    • Extremely high association between appearance of HLA Abs and failure of kidney grafts in a five-year longitudinal study
    • Mao Q, Terasaki PI, Cai J etal. Extremely high association between appearance of HLA Abs and failure of kidney grafts in a five-year longitudinal study. Am J Transplant 2007; 7:864-871.
    • (2007) Am J Transplant , vol.7 , pp. 864-871
    • Mao, Q.1    Terasaki, P.I.2    Cai, J.3
  • 11
    • 0036766457 scopus 로고    scopus 로고
    • Desensitization and subsequent kidney transplantation of patients using intravenous immunoglobulins (IVIg)
    • Glotz D, Antoine C, Julia P etal. Desensitization and subsequent kidney transplantation of patients using intravenous immunoglobulins (IVIg). Am J Transplant 2002; 2:758-760.
    • (2002) Am J Transplant , vol.2 , pp. 758-760
    • Glotz, D.1    Antoine, C.2    Julia, P.3
  • 12
    • 0042838104 scopus 로고    scopus 로고
    • Intravenous immune globulin treatment inhibits crossmatch positivity and allows for successful transplantation of incompatible organs in living-donor and cadaver recipients
    • Jordan SC, Vo A, Bunnapradist S etal. Intravenous immune globulin treatment inhibits crossmatch positivity and allows for successful transplantation of incompatible organs in living-donor and cadaver recipients. Transplantation 2003; 76:631-636.
    • (2003) Transplantation , vol.76 , pp. 631-636
    • Jordan, S.C.1    Vo, A.2    Bunnapradist, S.3
  • 13
    • 47549105407 scopus 로고    scopus 로고
    • Rituximab and intravenous immune globulin for desensitization during renal transplantation.
    • Vo AA, Lukovsky M, Toyoda M etal. Rituximab and intravenous immune globulin for desensitization during renal transplantation. N Engl J Med 2008; 359:242-251.
    • (2008) N Engl J Med , vol.359 , pp. 242-251
    • Vo, A.A.1    Lukovsky, M.2    Toyoda, M.3
  • 14
    • 10744228964 scopus 로고    scopus 로고
    • Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection
    • Rocha PN, Butterly DW, Greenberg A etal. Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection. Transplantation 2003; 75:1490-1495.
    • (2003) Transplantation , vol.75 , pp. 1490-1495
    • Rocha, P.N.1    Butterly, D.W.2    Greenberg, A.3
  • 16
    • 0026422422 scopus 로고
    • The use of intravenous immune globulin in immuno-deficiency diseases
    • Buckley RH, Schiff RI. The use of intravenous immune globulin in immuno-deficiency diseases. N Engl J Med 1991; 325:110-117.
    • (1991) N Engl J Med , vol.325 , pp. 110-117
    • Buckley, R.H.1    Schiff, R.I.2
  • 17
    • 0025940345 scopus 로고
    • Intravenous immunoglobulins (IVIg) in the treatment of autoimmune diseases
    • Kaveri SV, Dietrich G, Hurez V, Kazatchkine MD. Intravenous immunoglobulins (IVIg) in the treatment of autoimmune diseases. Clin Exp Immunol 1991; 86:192-198.
    • (1991) Clin Exp Immunol , vol.86 , pp. 192-198
    • Kaveri, S.V.1    Dietrich, G.2    Hurez, V.3    Kazatchkine, M.D.4
  • 18
    • 0029830923 scopus 로고    scopus 로고
    • Utilization of intravenous immunoglobulin to ameliorate all-Abs in a highly sensitized patient with a cardiac assist device awaiting heart transplantation. Fluorescence-activated cell sorter analysis
    • McIntyre JA, Higgins N, Britton R etal. Utilization of intravenous immunoglobulin to ameliorate all-Abs in a highly sensitized patient with a cardiac assist device awaiting heart transplantation. Fluorescence-activated cell sorter analysis. Transplantation 1996; 62:691-693.
    • (1996) Transplantation , vol.62 , pp. 691-693
    • McIntyre, J.A.1    Higgins, N.2    Britton, R.3
  • 19
    • 0027228037 scopus 로고
    • Suppression of HLA-specific alloAbs by high-dose intravenous immunoglobulins (IVIg). A potential tool for transplantation of immunized patients
    • Glotz D, Haymann JP, Sansonetti N etal. Suppression of HLA-specific alloAbs by high-dose intravenous immunoglobulins (IVIg). A potential tool for transplantation of immunized patients. Transplantation 1993; 56:335-337.
    • (1993) Transplantation , vol.56 , pp. 335-337
    • Glotz, D.1    Haymann, J.P.2    Sansonetti, N.3
  • 20
    • 0028269585 scopus 로고
    • Intravenous immunoglobulin suppression of HLA alloantibody in highly sensitized transplant candidates and transplantation with a histoincompatible organ
    • Tyan DB, Li VA, Czer L, Trento A, Jordan SC. Intravenous immunoglobulin suppression of HLA alloantibody in highly sensitized transplant candidates and transplantation with a histoincompatible organ. Transplantation 1994; 57:553-562.
    • (1994) Transplantation , vol.57 , pp. 553-562
    • Tyan, D.B.1    Li, V.A.2    Czer, L.3    Trento, A.4    Jordan, S.C.5
  • 21
    • 84877631995 scopus 로고    scopus 로고
    • Therapeutic preparations of IVIg contain naturally occurring anti-HLA-E Abs that react with HLA-Ia (HLA-A/-B/-Cw) alleles
    • Ravindranath MH, Terasaki PI, Pham T, Jucaud V, Kawakita S. Therapeutic preparations of IVIg contain naturally occurring anti-HLA-E Abs that react with HLA-Ia (HLA-A/-B/-Cw) alleles. Blood 2013; 121:2013-2028.
    • (2013) Blood , vol.121 , pp. 2013-2028
    • Ravindranath, M.H.1    Terasaki, P.I.2    Pham, T.3    Jucaud, V.4    Kawakita, S.5
  • 22
    • 0037606012 scopus 로고    scopus 로고
    • Intravenous immunoglobulins induce the in vitro differentiation of human B lymphocytes and the secretion of IgG
    • de Grandmont MJ, Racine C, Roy A, Lemieux R, Néron S. Intravenous immunoglobulins induce the in vitro differentiation of human B lymphocytes and the secretion of IgG. Blood 2003; 101:3065-3073.
    • (2003) Blood , vol.101 , pp. 3065-3073
    • de Grandmont, M.J.1    Racine, C.2    Roy, A.3    Lemieux, R.4    Néron, S.5
  • 23
    • 69949124668 scopus 로고    scopus 로고
    • Intravenous immunoglobulin preparations have no direct effect on B cell proliferation and immunoglobulin production
    • Heidt S, Roelen DL, Eijsink C, Eikmans M, Claas FH, Mulder A. Intravenous immunoglobulin preparations have no direct effect on B cell proliferation and immunoglobulin production. Clin Exp Immunol 2009; 158:99-105.
    • (2009) Clin Exp Immunol , vol.158 , pp. 99-105
    • Heidt, S.1    Roelen, D.L.2    Eijsink, C.3    Eikmans, M.4    Claas, F.H.5    Mulder, A.6
  • 24
    • 0025732213 scopus 로고
    • Stimulation of B and T cells by in vivo high dose immunoglobulin administration in normal mice
    • Sundblad A, Huetz F, Portnoi D, Coutinho A. Stimulation of B and T cells by in vivo high dose immunoglobulin administration in normal mice. J Autoimmun 1991; 4:325-339.
    • (1991) J Autoimmun , vol.4 , pp. 325-339
    • Sundblad, A.1    Huetz, F.2    Portnoi, D.3    Coutinho, A.4
  • 25
    • 0028168265 scopus 로고
    • Observations on the mode of action of normal immunoglobulin at high doses
    • Sundblad A, Marcos MA, Malanchere E etal. Observations on the mode of action of normal immunoglobulin at high doses. Immunol Rev 1994; 139:125-158.
    • (1994) Immunol Rev , vol.139 , pp. 125-158
    • Sundblad, A.1    Marcos, M.A.2    Malanchere, E.3
  • 26
    • 0025844927 scopus 로고
    • Suppression of immunoglobulin production of lymphocytes by intravenous immunoglobulin
    • Kondo N, Ozawa T, Mushiake K etal. Suppression of immunoglobulin production of lymphocytes by intravenous immunoglobulin. J Clin Immunol 1991; 11:152-158.
    • (1991) J Clin Immunol , vol.11 , pp. 152-158
    • Kondo, N.1    Ozawa, T.2    Mushiake, K.3
  • 27
    • 58149461556 scopus 로고    scopus 로고
    • Peripheral blood B cells producing donor-specific HLA Abs in vitro
    • Han M, Rogers JA, Lavingia B, Stastny P. Peripheral blood B cells producing donor-specific HLA Abs in vitro. Hum Immunol 2009; 70:29-34.
    • (2009) Hum Immunol , vol.70 , pp. 29-34
    • Han, M.1    Rogers, J.A.2    Lavingia, B.3    Stastny, P.4
  • 28
    • 0028090333 scopus 로고
    • Suppression of cytokine-dependent human T-cell proliferation by intravenous immunoglobulin
    • Amran D, Renz H, Lack G, Bradley K, Gelfand EW. Suppression of cytokine-dependent human T-cell proliferation by intravenous immunoglobulin. Clin Immunol Immunopathol 1994; 73:180-186.
    • (1994) Clin Immunol Immunopathol , vol.73 , pp. 180-186
    • Amran, D.1    Renz, H.2    Lack, G.3    Bradley, K.4    Gelfand, E.W.5
  • 29
    • 0027532066 scopus 로고
    • In vitro effects of an immunoglobulin preparation for intravenous use (IVIG) on T-cells activation
    • Sbrana S, Ruocco L, Vanacore R, Azzarà A, Ambrogi F. In vitro effects of an immunoglobulin preparation for intravenous use (IVIG) on T-cells activation. Allerg Immunol (Paris) 1993; 25:35-37.
    • (1993) Allerg Immunol (Paris) , vol.25 , pp. 35-37
    • Sbrana, S.1    Ruocco, L.2    Vanacore, R.3    Azzarà, A.4    Ambrogi, F.5
  • 30
    • 79151469181 scopus 로고    scopus 로고
    • Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: a mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies
    • Bayry J, Fournier EM, Maddur MS etal. Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: a mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies. J Autoimmun 2011; 36:9-15.
    • (2011) J Autoimmun , vol.36 , pp. 9-15
    • Bayry, J.1    Fournier, E.M.2    Maddur, M.S.3
  • 31
    • 0032194166 scopus 로고    scopus 로고
    • Therapeutic preparations of normal polyspecific IgG (IVIg) induce apoptosis in human lymphocytes and monocytes: a novel mechanism of action of IVIg involving the Fas apoptotic pathway
    • Prasad NK, Papoff G, Zeuner A etal. Therapeutic preparations of normal polyspecific IgG (IVIg) induce apoptosis in human lymphocytes and monocytes: a novel mechanism of action of IVIg involving the Fas apoptotic pathway. J Immunol 1998; 161:3781-3790.
    • (1998) J Immunol , vol.161 , pp. 3781-3790
    • Prasad, N.K.1    Papoff, G.2    Zeuner, A.3
  • 32
    • 74449086088 scopus 로고    scopus 로고
    • HLA-E monoclonal Abs recognize shared peptide sequences on classical HLA class Ia: relevance to human natural HLA Abs
    • Ravindranath MH, Taniguichi M, Chen CW etal. HLA-E monoclonal Abs recognize shared peptide sequences on classical HLA class Ia: relevance to human natural HLA Abs. Mol Immunol 2010; 47:1121-1131.
    • (2010) Mol Immunol , vol.47 , pp. 1121-1131
    • Ravindranath, M.H.1    Taniguichi, M.2    Chen, C.W.3
  • 33
    • 78650628650 scopus 로고    scopus 로고
    • Anti-HLA-E mAntibody 3D12 mimics MEM-E/02 in binding to HLA-B and HLA-C alleles: web-tools validate the immunogenic epitopes of HLA-E recognized by the Abs
    • Ravindranath MH, Pham T, El-Awar N, Kaneku H, Terasaki PI. Anti-HLA-E mAntibody 3D12 mimics MEM-E/02 in binding to HLA-B and HLA-C alleles: web-tools validate the immunogenic epitopes of HLA-E recognized by the Abs. Mol Immunol 2011; 48:423-430.
    • (2011) Mol Immunol , vol.48 , pp. 423-430
    • Ravindranath, M.H.1    Pham, T.2    El-Awar, N.3    Kaneku, H.4    Terasaki, P.I.5
  • 34
    • 77956405838 scopus 로고    scopus 로고
    • Abs to HLA-E in nonalloimmunized males: pattern of HLA-Ia reactivity of anti-HLA-E-positive sera
    • Ravindranath MH, Kaneku H, El-Awar N, Morales-Buenrostro LE, Terasaki PI. Abs to HLA-E in nonalloimmunized males: pattern of HLA-Ia reactivity of anti-HLA-E-positive sera. J Immunol 2010; 185:1935-1948.
    • (2010) J Immunol , vol.185 , pp. 1935-1948
    • Ravindranath, M.H.1    Kaneku, H.2    El-Awar, N.3    Morales-Buenrostro, L.E.4    Terasaki, P.I.5
  • 35
    • 33947589232 scopus 로고    scopus 로고
    • Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation
    • Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B. Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation. Blood 2007; 109:2806-2814.
    • (2007) Blood , vol.109 , pp. 2806-2814
    • Coupel, S.1    Moreau, A.2    Hamidou, M.3    Horejsi, V.4    Soulillou, J.P.5    Charreau, B.6
  • 36
    • 33847155383 scopus 로고    scopus 로고
    • Open conformers: the hidden face of MHC-I molecules
    • Arosa FA, Santos SG, Powis SJ. Open conformers: the hidden face of MHC-I molecules. Trends Immunol 2007; 28:115-123.
    • (2007) Trends Immunol , vol.28 , pp. 115-123
    • Arosa, F.A.1    Santos, S.G.2    Powis, S.J.3
  • 37
    • 0028304289 scopus 로고
    • Intravenous gammaglobulin: pharmacology, clinical uses and mechanisms of action
    • Schiff RI. Intravenous gammaglobulin: pharmacology, clinical uses and mechanisms of action. Pediatr Allergy Immunol 1994; 5:63-87.
    • (1994) Pediatr Allergy Immunol , vol.5 , pp. 63-87
    • Schiff, R.I.1
  • 38
    • 0025673584 scopus 로고
    • Anti-HLA Abs(Ab1) and anti-idiotypic Abs (Ab2) directed against Anti-HLA Ab1 in various preparations of polyspecific immunoglobulins for intravenous use
    • Barocci S, Fenoglio D, Leprini A, Nocera A. Anti-HLA Abs(Ab1) and anti-idiotypic Abs (Ab2) directed against Anti-HLA Ab1 in various preparations of polyspecific immunoglobulins for intravenous use. Boll Soc Ital Biol Sper 1990; 66:1193-1200.
    • (1990) Boll Soc Ital Biol Sper , vol.66 , pp. 1193-1200
    • Barocci, S.1    Fenoglio, D.2    Leprini, A.3    Nocera, A.4
  • 39
    • 0034774879 scopus 로고    scopus 로고
    • Fc gamma RIIB as a potential molecular target for intravenous gamma globulin therapy
    • Ott VL, Fong DC, Cambier JC. Fc gamma RIIB as a potential molecular target for intravenous gamma globulin therapy. J Allergy Clin Immunol 2001; 108 (Suppl.):S95-98.
    • (2001) J Allergy Clin Immunol , vol.108 , Issue.SUPPL.
    • Ott, V.L.1    Fong, D.C.2    Cambier, J.C.3
  • 40
    • 84862258442 scopus 로고    scopus 로고
    • Effect of high-dose intravenous immunoglobulin on anti-HLA Abs in sensitized kidney transplant candidates
    • Nair V, Sawinski D, Akalin E etal. Effect of high-dose intravenous immunoglobulin on anti-HLA Abs in sensitized kidney transplant candidates. Clin Transplant 2012; 26:E261-268.
    • (2012) Clin Transplant , vol.26
    • Nair, V.1    Sawinski, D.2    Akalin, E.3
  • 41
    • 84864280878 scopus 로고    scopus 로고
    • Infusion of high-dose intravenous immunoglobulin fails to lower the strength of human leukocyte Ag Abs in highly sensitized patients
    • Alachkar N, Lonze BE, Zachary AA etal. Infusion of high-dose intravenous immunoglobulin fails to lower the strength of human leukocyte Ag Abs in highly sensitized patients. Transplantation 2012; 94:165-171.
    • (2012) Transplantation , vol.94 , pp. 165-171
    • Alachkar, N.1    Lonze, B.E.2    Zachary, A.A.3
  • 42
    • 84865646329 scopus 로고    scopus 로고
    • Lack of effect in desensitization with intravenous immunoglobulin and rituximantibody in highly sensitized patients
    • Marfo K, Ling M, Bao Y etal. Lack of effect in desensitization with intravenous immunoglobulin and rituximantibody in highly sensitized patients. Transplantation 2012; 94:345-351.
    • (2012) Transplantation , vol.94 , pp. 345-351
    • Marfo, K.1    Ling, M.2    Bao, Y.3
  • 43
    • 0142179990 scopus 로고    scopus 로고
    • CD40 stimulation of human peripheral B lymphocytes: distinct response from naive and memory cells
    • Fecteau JF, Neron S. CD40 stimulation of human peripheral B lymphocytes: distinct response from naive and memory cells. J Immunol 2005; 171:4621-4629.
    • (2005) J Immunol , vol.171 , pp. 4621-4629
    • Fecteau, J.F.1    Neron, S.2
  • 44
    • 29144519767 scopus 로고    scopus 로고
    • IL-21 induces differentiation of human naive and memory B cells into Ab-secreting plasma cells
    • Ettinger R, Sims GP, Fairhurst AM etal. IL-21 induces differentiation of human naive and memory B cells into Ab-secreting plasma cells. J Immunol 2005; 175:7867-7879.
    • (2005) J Immunol , vol.175 , pp. 7867-7879
    • Ettinger, R.1    Sims, G.P.2    Fairhurst, A.M.3
  • 45
    • 0035869281 scopus 로고    scopus 로고
    • Interleukin-6 is a growth factor for non-malignant human plasmablasts
    • Jego G, Bataille R, Pellat-Deceunynck C. Interleukin-6 is a growth factor for non-malignant human plasmablasts. Blood 2001; 97:1817-1822.
    • (2001) Blood , vol.97 , pp. 1817-1822
    • Jego, G.1    Bataille, R.2    Pellat-Deceunynck, C.3
  • 46
    • 73949109704 scopus 로고    scopus 로고
    • An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization
    • Jourdan M, Caraux A, De Vos J etal. An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization. Blood 2009; 114:5173-5181.
    • (2009) Blood , vol.114 , pp. 5173-5181
    • Jourdan, M.1    Caraux, A.2    De Vos, J.3
  • 47
    • 76149139419 scopus 로고    scopus 로고
    • B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing antibody responses in humans
    • Avery DT, Deenick EK, Ma CS etal. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing antibody responses in humans. J Exp Med 2010; 207:155-171.
    • (2010) J Exp Med , vol.207 , pp. 155-171
    • Avery, D.T.1    Deenick, E.K.2    Ma, C.S.3
  • 49
    • 0036566507 scopus 로고    scopus 로고
    • Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal Abs is defined by additional requirements imposed by both amino acid sequence and quaternary structure
    • Polyak MJ, Deans JP. Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal Abs is defined by additional requirements imposed by both amino acid sequence and quaternary structure. Blood 2002; 99:3256-3262.
    • (2002) Blood , vol.99 , pp. 3256-3262
    • Polyak, M.J.1    Deans, J.P.2
  • 51
    • 14844360373 scopus 로고    scopus 로고
    • CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis
    • Roura-Mir C, Catálfamo M, Cheng TY etal. CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis. J Immunol 2005; 174:3773-3780.
    • (2005) J Immunol , vol.174 , pp. 3773-3780
    • Roura-Mir, C.1    Catálfamo, M.2    Cheng, T.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.