FcγRIIB as a potential molecular target for intravenous gamma globulin therapy

Journal of Allergy and Clinical Immunology

Volumn 108, Issue 4, 2001, Pages S95-S98

  Ott, Vanessa L ^a   Fong, Dana C ^a   Cambier, John C ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Fc RIIB; Inhibitory receptors; IVIG; SHIP; Signal transduction

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN FC FRAGMENT;

ANTIGEN SPECIFICITY; ATOPY; AUTOIMMUNITY; COMPLEX FORMATION; CONFERENCE PAPER; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOTHERAPY; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; TARGET CELL;

ANTIGENS, CD; GAMMA-GLOBULINS; IMMUNOGLOBULINS, INTRAVENOUS; MODELS, BIOLOGICAL; PHOSPHORIC MONOESTER HYDROLASES; RECEPTORS, IGG; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 0034774879     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2001.117822     Document Type: Article

References (17)

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2. Negative regulation of hematopoietic cell activation and proliferation by Fc gamma RIIB
3. The unexpected complexity of Fc gamma RIIB signal transduction
4. Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor
5. The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gamma RIIB in B cells under negative signaling
6. Superclustering of B cell receptor and Fc gamma RIIB 1 activates Src homology 2-containing protein tyrosine phosphatase-1
7. Insufficient phosphorylation prevents Fc gamma RIIB from recruiting the SH2 domain-containing protein tyrosine phosphatase SHP-I
8. Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by Fc gamma RIIB
9. Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs
10. Mutational analysis reveals multiple distinct sites within Fc gamma receptor IIB that function in inhibitory signaling
11. Specific motifs recognized by the SH2 domains of Csk. 3BP2, fps/fes. GRB-2, HCP, SHC, Syk, and Vav
12. The inositol 5′-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation
13. Partially distinct molecular mechanisms mediate inhibitory FcγRIIB signaling in resting and activated B cells
14. Negative signaling in B cells: SHIP Grbs Shc
15. The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells
16. Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling
17. Activating and inhibitory signaling in mast cells: New opportunities for therapeutic intervention?