Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors

Toxicological Sciences

Volumn 140, Issue 1, 2014, Pages 135-143

  Kennedy, Gregory D ^a   Nukaya, Manabu ^a   Moran, Susan M ^b   Glover, Edward ^b   Weinberg, Samuel ^b   Balbo, Silvia ^c   Hecht, Stephen S ^c   Pitot, Henry C ^b   Drinkwater, Norman R ^b   Bradfield, Christopher A ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Aryl hydrocarbon receptor (AHR); Dioxin; IL 1 like cytokine; Liver; Tumor promotion

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA RECEPTOR; INTERLEUKIN 1BETA RECEPTOR; LYMPHOTOXIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; 2,3,7,8-TETRABROMODIBENZO-4-DIOXIN; DIETHYLNITROSAMINE; DIOXIN; OCTANOIC ACID DERIVATIVE; TRIACYLGLYCEROL; TRIOCTANOIN;

ACUTE TOXICITY; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CANCER MODEL; CONTROLLED STUDY; DRUG MECHANISM; GENE LOCUS; KNOCKOUT MOUSE; LIVER CANCER; LIVER TOXICITY; LIVER TUMOR; MALE; MOUSE; NONHUMAN; NULL ALLELE; OBSERVATIONAL STUDY; SIGNAL TRANSDUCTION; TUMOR PROMOTION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; COCARCINOGENESIS; EXPERIMENTAL LIVER NEOPLASM; GENETICS; IMMUNOLOGY; METABOLISM;

ANIMALS; CAPRYLATES; COCARCINOGENESIS; DIETHYLNITROSAMINE; DIOXINS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, INTERLEUKIN-1; RECEPTORS, TUMOR NECROSIS FACTOR; TRIGLYCERIDES;

EID: 84903847607     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu065     Document Type: Article

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