RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation

Acta Pharmacologica Sinica

Volumn 35, Issue 7, 2014, Pages 929-936

  Lu, Can ^a   Zhou, Li Yan ^a   Xu, Hui Jun ^a   Chen, Xing Yu ^a   Tong, Zhong Sheng ^a   Liu, Xiao Dong ^a   Jia, Yong Sheng ^a   Chen, Yue ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

Apoptosis; Breast cancer; N acetyl cysteine; Parthenolide; Reactive oxygen species; Receptor interacting protein 3

Indexed keywords

ACETYLCYSTEINE; MESSENGER RNA; PARTHENOLIDE; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN 3; SUPEROXIDE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, HUMAN; SESQUITERPENE;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CELL GROWTH; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTRACELLULAR SPACE; MCF 7 CELL LINE; OXIDATIVE STRESS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BREAST; BREAST NEOPLASMS; DRUG EFFECTS; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE; UPREGULATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; REACTIVE OXYGEN SPECIES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SESQUITERPENES; UP-REGULATION;

EID: 84903846059     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.31     Document Type: Article

References (32)

1. Sun X, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM. RIP3, a novel apoptosis-inducing kinase. J Biol Chem 1999; 274: 16871-5
2. Zhang D, Lin J, Han J. Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol 2010; 7: 243-9
3. Feng S, Yang Y, Mei Y, Ma L, Zhu DE, Hoti N, et al. Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal 2007; 19: 2056-67
4. Van Herreweghe F, Festjens N, Declercq W, Vandenabeele P. Tumor necrosis factor-mediated cell death: To break or to burst, that's the question. Cell Mol Life Sci 2010; 67: 1567-79
5. Martinon F, Holler N, Richard C, Tschopp J. Activation of a proapoptotic amplification loop through inhibition of NF-kappaBdependent survival signals by caspase-mediated inactivation of RIP. FEBS Lett 2000; 468: 134-6
6. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009; 325: 332-6
7. Declercq W, Vanden Berghe T, Vandenabeele P. RIP kinases at the crossroads of cell death and survival. Cell 2009; 138: 229-32
8. Pozarowski P, Halicka DH, Darzynkiewicz Z. NF-kappaB inhibitor sesquiterpene parthenolide induces concurrently atypical apoptosis and cell necrosis: Difficulties in identification of dead cells in such cultures. Cytometry A 2003; 54: 118-24
9. Zhang S, Ong CN, Shen HM. Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett 2004; 208: 143-53
10. Kim JH, Liu L, Lee SO, Kim YT, You KR, Kim DG. Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis. Cancer Res 2005; 65: 6312-20
11. Yip-Schneider MT, Nakshatri H, Sweeney CJ, Marshall MS, Wiebke EA, Schmidt CM. Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells. Mol Cancer Ther 2005; 4: 587-94
12. Zhang S, Lin ZN, Yang CF, Shi X, Ong CN, Shen HM. Suppressed NFkappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-Alpha-induced apoptosis in human cancer cells. Carcinogenesis 2004; 25: 2191-9
13. Wang W, Adachi M, Zhang R, Zhou J, Zhu D. A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells. Pancreas 2009; 38: E114-23
14. Wen J, You KR, Lee SY, Song CH, Kim DG. Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J Biol Chem 2002; 277: 38954-64
15. Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The antiinflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol 2001; 8: 759-66
16. Anderson KN, Bejcek BE. Parthenolide induces apoptosis in glioblastomas without affecting NF-kappaB. J Pharmacol Sci 2008; 106: 318-20
17. Zunino SJ, Ducore JM, Storms DH. Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells. Cancer Lett 2007; 254: 119-27
18. He JX, Wang YQ, Feng JM, Li JX, Xu L, Li XH, et al. Differential sensitivity of RIP3-proficient and deficient murine fibroblasts to camptothecin anticancer drugs. Acta Pharmacol Sin 2012; 33: 426-8
19. Pazdernik NJ, Donner DB, Goebl MG, Harrington MA. Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB. Mol Cell Biol 1999; 19: 6500-8
20. Kasof GM, Prosser JC, Liu D, Lorenzi MV, Gomes BC. The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. FEBS Lett 2000; 473: 285-91
21. Yang Y, Ma J, Chen Y, Wu M. Nucleocytoplasmic shuttling of receptorinteracting protein 3 (RIP3): Identification of novel nuclear export and import signals in RIP3. J Biol Chem 2004; 279: 38820-9
22. Kurdi M, Booz GW. Evidence that IL-6-Type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: Parthenolide targets JAK1 activation by generating ROS. J Cell Physiol 2007; 212: 424-31
23. Sun Y, St Clair DK, Xu Y, Crooks PA, St Clair WH. A NADPH oxidasedependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res 2010; 70: 2880-90
24. Crack PJ, Taylor JM. Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 2005; 38: 1433-44
25. Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, et al. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. Curr Biol 1999; 9: 539-42
26. Li M, Feng S, Wu M. Multiple roles for nuclear localization signal (NLS, aa 442-472) of receptor interacting protein 3 (RIP3). Biochem Biophys Res Commun 2008; 372: 850-5
27. Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NFkappa B activation. Nat Immunol 2004; 5: 503-7
28. Dell'Agli M, Galli GV, Bosisio E, D'Ambrosio M. Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives. Bioorg Med Chem Lett 2009; 19: 1858-60
29. ErmakG, Davies KJ. Calcium and oxidative stress: From cell signaling to cell death. Mol Immunol 2002; 38: 713-21
30. Simbula G, Columbano A, Ledda-Columbano GM, Sanna L, Deidda M, Diana A, et al. Increased ROS generation and p53 activation in alphalipoic acid-induced apoptosis of hepatoma cells. Apoptosis 2007; 12: 113-23
31. Reinecke F, Levanets O, Olivier Y, Louw R, Semete B, Grobler A, et al. Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-Treated HeLa cells. Biochem J 2006; 395: 405-15
32. Kang YH, Lee E, Choi MK, Ku JL, Kim SH, Park YG, et al. Role of reactive oxygen species in the induction of apoptosis by alphatocopheryl succinate. Int J Cancer 2004; 112: 385-92.