A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells

Pancreas

Volumn 38, Issue 4, 2009, Pages

  Wang, Wei ^a   Adachi, Masaaki ^b   Zhang, Rong ^a   Zhou, Jin ^a   Zhu, Daling ^a,c  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

^c NONE   (China)

Author keywords

APL acute promyelocytic leukemia; ATO arsenic trioxide; HO 1 heme oxygenase; PTL parthenolide; ROS reactive oxygen species

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ACETYLCYSTEINE; ARSENIC TRIOXIDE; CYTOCHROME C; DIPHENYLIODONIUM SALT; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PARTHENOLIDE; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; GROWTH INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANOARSENIC DERIVATIVE; OXIDE; SESQUITERPENE;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL SURVIVAL; CELL VIABILITY; CLONOGENIC ASSAY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NICK END LABELING; NONHUMAN; NUDE MOUSE; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CELL PROLIFERATION; DRUG POTENTIATION; DRUG SCREENING; METABOLISM; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

ACETYLCYSTEINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; ARSENICALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLOW CYTOMETRY; GROWTH INHIBITORS; HUMANS; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; OXIDES; PANCREATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; SESQUITERPENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 66149145501     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181a0b6f2     Document Type: Article

References (25)

1. Keighley MR. Gastrointestinal cancers in Europe. Aliment Pharmacol Ther. 2003;18(suppl 3):7-30.
2. DiMagno EP, Reber HA,Tempero MA. AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. American Gastroenterological Association. Gastroenterology. 1999;117:1464-1484.
3. Simon B, Printz H. Epidemiological trends in pancreatic neoplasias. Dig Dis. 2001;19:6-14.
4. Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 2002;346:92-98. (Pubitemid 34438899)
5. Bredel M. Anticancer drug resistance in primary human brain tumors. Brain Res Rev. 2001;35:161-204. (Pubitemid 32411471)
6. Antman KH. Introduction: the history of arsenic trioxide in cancer therapy. Oncologist. 2001;6(suppl 2):1-2. (Pubitemid 32405842)
7. Shen ZX, Chen GQ, Ni JH, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood. 1997;89: 3354-3360.
8. Shen ZY, Tan LJ, Cai WJ, et al. Arsenic trioxide induces apoptosis of oesophageal carcinoma in vitro. Int J Mol Med. 1999;4:33-37.
9. Zhang TC, Cao EH, Li JF, et al. Induction of apoptosis and inhibition of human gastric cancer MGC-803 cell growth by arsenic trioxide. Eur J Cancer. 1999;35:1258-1263. (Pubitemid 29359187)
10. Uslu R, Sanli UA, Sezgin C, et al. Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines. Clin Cancer Res. 2000;6:4957-4964. (Pubitemid 32110442)
11. Akao Y, Nakagawa Y, Akiyama K. Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro. FEBS Lett. 1999;455:59-62. (Pubitemid 29322782)
12. Knight DW. Feverfew: chemistry and biological activity. Nat Prod Rep. 1995;12:271-276.
13. Zhang S, Ong CN, Shen HM. Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett. 2004;208:143-153. (Pubitemid 38624155)
14. Woynarowski JM, Konopa J. Inhibition of DNA biosynthesis in HeLa cells by cytotoxic and antitumor sesquiterpene lactones. Mol Pharmacol. 1981;19:97-102. (Pubitemid 11104877)
15. WangW, Adachi M, Kawamura R, et al. Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity. Apoptosis. 2006; 11:2225-2235. (Pubitemid 44885398)
16. Begonja AJ, Gambaryan S, Geiger J, et al. Platelet NAD(P)H-oxidase- generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway. Blood. 2005;106:2757-2760. (Pubitemid 41510751)
17. Ambudkar SV, Sauna ZE, Gottesman MM, et al. A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1). Trends Pharmacol Sci. 2005;26: 385-387.
18. Guzman ML, Rossi RM, Karnischky L, et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood. 2005;105:4163-4169. (Pubitemid 40720758)
19. Moon Y, Park G, Kim Y, et al. Arsenic trioxide (As2O3) sensitivity of carcinoma cell lines and cancer cells from patients with carcinomatosis peritonei. Ann Clin Lab Sci. 2004;34:271-276. (Pubitemid 39166989)
20. Gee JM, Shaw VE, Hiscox SE, et al. Deciphering antihormone-induced compensatory mechanisms in breast cancer and their therapeutic implications. Endocr Relat Cancer. 2006;13(suppl 1):S77-S88.
21. Geiszt M, Leto TL. NOX The Nox family of NAD(P)H oxidases: host defense and beyond. J Biol Chem. 2004;279:51715-51718. (Pubitemid 39656535)
22. Suh YA, Arnold RS, Lassegue B, et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature. 1999;401:79-82. (Pubitemid 29418446)
23. Burdon RH. Control of cell proliferation by reactive oxygen species. Biochem Soc Trans. 1996;24:1028-1032. (Pubitemid 126813392)
24. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998; 281:1309-1312.
25. Wen J, You KR, Lee SY, et al. Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J Biol Chem. 2002;277:38954-38964. (Pubitemid 35154761)