Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells

Cancer Letters

Volumn 254, Issue 1, 2007, Pages 119-127

  Zunino, Susan J ^a   Ducore, Jonathan M ^b   Storms, David H ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Leukemia; Mitochondria; Parthenolide; Reactive oxygen species; ROS

Indexed keywords

CELL NUCLEUS DNA; HYPOCHLORITE; NITRIC OXIDE; PARTHENOLIDE; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER RISK; CELL DEATH; CELL MEMBRANE; CHROMOSOME TRANSLOCATION; DEPOLARIZATION; DRUG INHIBITION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL;

APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; LEUKEMIA, B-CELL, ACUTE; LEUKEMIA, PRE-B-CELL; MEMBRANE POTENTIAL, MITOCHONDRIAL; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; RISK FACTORS; SESQUITERPENES; TUMOR CELLS, CULTURED;

TANACETUM PARTHENIUM;

EID: 34447319405     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.03.002     Document Type: Article

References (28)

1. Faderl S., Kantarjian H.M., Talpaz M., and Estrov Z. Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia. Blood 91 (1998) 3995-4019
2. Greaves M.F., and Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat. Rev. 3 (2003) 1-11
3. Knight D.W. Feverfew: chemistry and biological activity. Nat. Prod. Rep. 12 (1995) 271-276
4. Brown A.M., Edwards C.M., Davey M.R., Power J.B., and Lowe K.C. Pharmacological activity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.): assessment by inhibition of human polymorphonuclear leukocyte chemiluminescence in vitro. J. Pharm. Pharmacol. 49 (1997) 558-561
5. Jain N.K., and Kulkarni S.K. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. J. Ethnopharmacol. 68 (1999) 251-259
6. Hehner S.P., Hofmann T.G., Dröge W., and Schmitz M.L. The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex. J. Immunol. 163 (1999) 5617-5623
7. Garcia-Pineres A.J., Castro V., Mora G., Schmidt T.J., Strunck E., Pahl H.L., and Merfort I. Cysteine 38 in p65/NFkappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J. Biol. Chem. 276 (2001) 39713-39720
8. Wen J., You K.-R., Lee S.-Y., Song C.H., and Kim D.G. Oxidative stress-mediated apoptosis, the anticancer effect of the sesquiterpene lactone parthenolide. J. Biol. Chem. 277 (2002) 38954-38964
9. Dörrie J., Gerauer H., Wachter Y., and Zunino S.J. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res. 61 (2001) 4731-4739
10. Dörrie J., Sapala K., and Zunino S.J. Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells. Cancer Lett. (2001) 33-39
11. Kellner C., and Zunino S.J. Nitric oxide is synthesized in acute leukemia cells after exposure to phenolic antioxidants and initially protects against mitochondrial membrane depolarization. Cancer Lett. (2004) 43-52
12. Greil J., Gramatzki M., Burger R., Marschalek R., Peltner M., Trautman U., Hansen-Hagge T.E., Bartram C.R., Fey G.H., Stehr K., and Beck J. The acute lymphoblastic leukemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7. Brit. J. Haematol. 86 (1994) 275-283
13. Stong R.C., Korsmeyer S.J., Parkin J.L., Arthur D.C., and Kersey J.H. Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics. Blood 65 (1985) 21-31
14. Vermes I., Haanen C., Steffens-Nakkan H., and Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin V. J. Immunol. Methods 184 (1995) 39-51
15. Cossarizza A., Kalashnikova G., Grassilli E., Chiappelli F., Salvioli S., Capri M., Barbieri D., Troiano L., Monti D., and Franceschi C. Mitochondrial modifications during rat thymocyte apoptosis: a study at the single cell level. Exp. Cell Res. 214 (1994) 323-330
16. Ghafourifar P., Bringold U., Klein S.D., and Richter C. Mitochondrial nitric oxide synthase, oxidative stress, and apoptosis. Biol. Signals Recept. 10 (2001) 57-65
17. Rothe G., and Valet G. Flow cytometry analysis of respiratory burst activity in phagocytes with hydroethidine and 2′-7′-dichlorofluorescein. J. Leukoc. Biol. 47 (1990) 440-448
18. Setsukinai K., Urano Y., Kakinuma K., Majima H.J., and Nagano T. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J. Biol. Chem. 278 (2003) 3170-3175
19. Emmendörffer A., Hecht M., Lohmann-Matthes M., and Roesler J. A fast and easy method to determine the production of reactive oxygen intermediates by human and murine phagocytes using dihydrorhodamine 123. J. Immunol. Methods 131 (1990) 269-275
20. Cleeter M.W., Cooper J.M., Darley-Usmar V.M., Moncada S., and Shapira A.H. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. Fed. Eur. Biochem. Soc. Lett. 345 (1994) 50-54
21. Brown G.C., and Cooper C.E. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. Fed. Eur. Biochem. Soc. Lett. 356 (1994) 295-298
22. Folkes L.K., Candeias L.P., and Wardman P. Kinetics and mechanisms of hypochlorous acid reactions. Arch. Biochem. Biophys. 323 (1995) 120-126
23. Englert R.P., and Shacter E. Distinct modes of cell death induced by different reactive oxygen species: amino acyl chloramines mediate hypochlorous acid-induced apoptosis. J. Biol. Chem. 277 (2002) 20518-20526
24. Herrera F., Martin V., Rodriguez-Blanco J., Garcia-Santos G., Antolin I., and Rodriguez C. Intracellular redox state regulation by parthenolide. Biochem. Biophys. Res. Commun. 332 (2005) 321-325
25. Guzman M.L., Rossi R.M., Karnischky L., Li X., Peterson D.R., Howard D.S., and Jordan C.T. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 105 (2005) 4163-4169
26. Sweeney C.J., Mehrotra S., Sadaria M.R., Kumar S., Shortle N.H., Roman Y., Sheridan C., Campbell R.A., Murry D.J., Badve S., and Nakshatri H. The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer. Mol. Cancer Ther. 4 (2005) 1004-1012
27. Patel N.M., Nozaki S., Shortle N.H., Bhat-Nakshatri P., Newton T.R., Rice S., Gelfanov V., Boswell S.H., Goulet Jr. R.J., Sledge Jr. G.W., and Nakshatri H. Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IkBα super-repressor and parthenolide. Oncogene 19 (2000) 4159-4169
28. Weston V.J., Austen B., Wei W., Marston E., Alvi A., Lawson S., Darbyshire P.J., Griffiths M., Hill F., Mann J.R., Moss P.A.H., Taylor A.M.R., and Stankovic T. Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-κB survival pathway signaling. Blood 104 (2004) 1465-1473