Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease

Environmental Health Perspectives

Volumn 116, Issue 7, 2008, Pages 898-906

  Delfino, Ralph J ^a   Staimer, Norbert ^a   Tjoa, Thomas ^a   Polidori, Andrea ^b   Arhami, Mohammad ^b   Gillen, Daniel L ^c   Kleinman, Michael T ^a   Vaziri, Nosratola D ^a   Longhurst, John ^a   Zaldivar, Frank ^a   Sioutas, Constantinos ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Southern California ^*  (United States)

^c Ringgold Standard Institution Informatics   (United States)

Author keywords

Acute phase proteins; Cytokins; Enzymes; Epidemiology; Longitudinal data analysis; Oxidative stress; Panel study; Particulate air pollution

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTITHROMBOCYTIC AGENT; BIOCHEMICAL MARKER; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; CARBON; CARBON MONOXIDE; COPPER ZINC SUPEROXIDE DISMUTASE; D DIMER; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRIN; FIBRINOGEN; GLUTATHIONE PEROXIDASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MYELOPEROXIDASE; NITROGEN DIOXIDE; ORGANIC CARBON; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 2; VASCULAR CELL ADHESION MOLECULE 1;

AEROSOL; AGED; AIR POLLUTION; AMBIENT AIR; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; COMBUSTION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; FIBRINOGEN BLOOD LEVEL; HEMOLYSATE; HUMAN; INFLAMMATION; MALE; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TEMPERATURE MEASUREMENT; THROMBOCYTE ACTIVATION; UNITED KINGDOM;

AEROSOLS; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CORONARY ARTERY DISEASE; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; INFLAMMATION; MALE; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER; PLATELET ACTIVATION; RISK;

EID: 46749144614     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11189     Document Type: Article

References (44)

1. Arhami M, Kuhn T, Fine PM, Delfino RJ, Sioutas C. 2006. Effects of sampling artifacts and operating parameters on the performance of a semi-continuous particulate EC/OC monitor. Environ Sci Technol 40:945-953.
2. Bender R, Lange S. 2001. Adjusting for multiple testing - when and how7 J Clin Epidemiol 54:343-349.
3. Cabada JC, Pandis SN, Subramanian R, Robinson AL, Polidori A, Turpin B. 2004. Estimating the secondary organic aerosol contribution to PM2.5 using the EC tracer method. Aerosol Sci Technol 38:140-155.
4. Cho AK, Sioutas C, Schmitz DA, Kumagai Y, Singh M, Miguel AH, et al. 2005. Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. Environ Res 99:40-47.
5. Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS. 2007. The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am J Respir Crit Care Med 176:370-376.
6. Cox FA, Stiller-Winkler R, Hadnagy W, Ranft U, Idel H. 1999. Soluble tumor necrosis factor (sTNF-RII) in sera of children and traffic-derived particulate air pollution. Zentralbl Hyg Umweltmed 202:489-500.
7. Delfino RJ, Sioutas C, Malik S. 2005. Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ Health Perspect 113:934-946.
8. Dubowsky SD, Suh H, Schwartz J, Coull BA, Gold DR. 2006. Diabetes, obesity, and hypertension may enhance associations between air pollution and markers of systemic inflammation. Environ Health Perspect 114:992-998.
9. Elder A, Oberdörster G. 2006. Translocation and effects of ultrafine particles outside of the lung. Clin Occup Environ Med 5:785-796.
10. Espinola-Klein C, Rupprecht HJ, Bickel C, Schnabel R, GenthZotz S, Torzewski M, et al. 2007. Glutathione peroxidase-1 activity, atherosclerotic burden, and cardiovascular prognosis. Am J Cardiol 99:808-812.
11. Folsom AR, Chambless LE, Ballantyne CM, Coresh J, Heiss G, Wu KK, et al. 2006. An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: the Atherosclerosis Risk in Communities Study. Arch Intern Med 166:1368-1373.
12. Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, et al. 2005. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113:1555-1560.
13. Hatzis C, Godleski JJ, Gonzalez-Flecha B, Wolfson JM, Koutrakis P. 2006. Ambient particulate matter exhibits direct inhibitory effects on oxidative stress enzymes. Environ Sci Technol 40:2805-2811.
14. Heaney ML, Golde DW. 1998. Soluble receptors in human disease. J Leukoc Biol 64:135-146.
15. Jurk K, Kehrel BE. 2005. Platelets: physiology and biochemistry. Semin Thromb Hemost 31381-392.
16. Lee K, Vallarino J, Dumyahn T, Ozkaynak H, Spengler JD. 1999. Ozone decay rates in residences. J Air Waste Manag Assoc 49:1238-1244.
17. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, et al. 2003. Ultrafine particulate pollutants induce oxidative stress and mitachondrial damage. Environ Health Perspect 111:455-460.
18. Manchester-Neesvig JB, Schauer JJ, Cass GR. 2003. The distribution of particle-phase organic compounds in the atmosphere and their use for source apportionment during the Southern California Children's Health Study. J Air Waste Monag Assoc 53:1065-1079.
19. Mills NL, Törnqvist H, Robinson SO, Gonzalez MC, Södarberg S, Sandström T, et al. 2007. Air pollution and atherothrombosis. Inhal Toxicol 19(suppl 1):81-89.
20. Ning Z, Geller MD, Moore KF, Sheesley RJ, Schauer JJ, Sioutas C. 2007. Daily variation of chemical characteristics of Urban ultrafine aerosols and inference of their sources. Environ Science Technol 41:6000-6006.
21. Ntziachristos L, Froines JR, Cho AK, Sioutas C, 2007. Relationship between redox activity and chemical speciation of size-fractionated particulate matter. Part Fibre Toxicol 4:5.
22. Oberdörster G. 2001. Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 74:1-8.
23. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, et al. 2004. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 351:2599-2610.
24. Penn A, Murphy G, Barker S, Henk W, Penn L. 2005. Combustion-derived ultrafine particles transport organic toxicants to target respiratory cells. Environ Health Perspect 113:956-963.
25. Peters A, von Klot S, Heier M, Trentinaglia I, Hoermann A, Wichmann HE, et al. 2004. Exposure to traffic and the onset of myocardial infarction. New Engl J Med 351: 1721-1730.
26. Pigeolet E, Corbisier P, Houbion A, Lambert D, Michiels C, Raes M, et al. 1990. Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev 51:283-297.
27. Polidori A, Arhami M, Delfino RJ, Allen R, Sioutas C. 2007. Indoor-outdoor relationships, trends and carbonaceous content of fine particulate matter in retirement communities of the Los Angeles basin. J Air Waste Manage Assoc 57:366-379.
28. Pope CA III, Dockery DW. 2006. Health effects of fine particulate air pollution: lines that connect. J Air Waste Manag Assoc 56:709-742.
29. Robinson AL, Donahue NM, Shrivastava MK, Weitkamp EA, Sage AM, Grieshop AP, et al. 2007. Rethinking organic aerosols: semivolatile emissions and photochemical aging. Science 315:1259-1262.
30. Rückerl R, Greven S, Ljungman P, Aalto P, Antoniades C, Bellander T, et al. 2007a. Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors. Environ Health Perspect 115:1072-1080.
31. Rückerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, et al. 2006. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med 173:432-441.
32. Rückerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdorster G, et al. 2007b. Ultrafine particles and platelet activation in patients with coronary heart disease - results from a prospective panel study. Part Fibre Toxicol 4:1.
33. Sagai M, Saito H, Ichinose T, Kodama M, Mori Y. 1993. Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse. Free Radical Biol Med 14:37-47.
34. 10) in the Los Angeles Basin. J Geophys Res Atmos 110:D07S08; doi:10.1029/ 2004JD004627.
35. Shinyashiki M, Rodriguez CR, Di Stefano EM, Sioutas C, Delfino RJ, Kumagai Y, et al. 2008. On the interaction between glyceraldehyde-3-phosphate dehydrogenase and airborne particles: evidence for electrophilic species. Atmos Environ 42:517-529.
36. Sioutas C, Delfino RJ, Singh M. 2005. Exposure assessment for atmospheric ultrafine particles (UFP) and implications in epidemiological research. Environ Health Perspect 113:947-955.
37. South Coast Air Quality Management District. 2007. Historical Data by Year. Available: http://www.aqmd.gov/smog/historicaldata.htm [accessed 21 November 2007].
38. Sullivan JH, Hubbard R, Liu SL, Shepherd K, Trenga CA, Koenig JQ, et al. 2007. A community study of the effect of particulate matter on blood measures of inflammation and thrombosis in an elderly population. Environ Health 6:3.
39. Törnqvist H, Mills NL, Gonzalez M, Miller MR, Robinson SD, Megson IL, et al. 2007. Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am J Respir Crit Care Med 176:395-400.
40. Tsantes AE, Bonovas S, Travlou A, Sitaras NM. 2006. Redox imbalance, macrocytosis, and RBC homeostasis. Antioxid Redox Signal 8:1205-1216.
41. Utell MJ, Frampton MW, Zareba W, Devlin RB, Cascio WE. 2002. Cardiovascular effects associated with air pollution: potential mechanisms and methods of testing. Inhal Toxicol 14:1231-1247.
42. Verbeke G, Molenberghs G. 2001. Linear Mixed Models for Longitudinal Data. New York:Springer.
43. Xiao Z, Théroux P. 2004. Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome. J Am Coll Cardiol 43:1982-1988.
44. Yue W, Schneider A, Stolzel M, Rückerl R, Cyrys J, Pan X, et al. 2007. Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients. Mutat Res 621:50-60.