Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site

Journal of Biological Chemistry

Volumn 289, Issue 27, 2014, Pages 18860-18872

  Tang, Qiong Yao ^a,b   Zhang, Zhe ^a,b   Meng, Xuan Yu ^a   Cui, Meng ^a   Logothetis, Diomedes E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

BK-CHANNEL; COORDINATION SITES; KEY ELEMENTS; MOLECULAR DETERMINANTS; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; STRUCTURAL DETERMINANTS; STRUCTURAL ELEMENTS;

CALCIUM;

CALCIUM; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE;

ALPHA HELIX; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RCK1 CALCIUM COORDINATION SITE; STRUCTURE ANALYSIS;

BK CHANNEL; CA2+; CALCIUM-BINDING PROTEIN; GATING; KDRDD LOOP; MEMBRANE LIPID; MOLECULAR MODELING; PIP2; POTASSIUM CHANNEL; RCK1;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM; CELL MEMBRANE; CYTOSOL; ION CHANNEL GATING; KV1.1 POTASSIUM CHANNEL; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84903837530     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.538033     Document Type: Article

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