The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort

Journal of Hypertension

Volumn 27, Issue 1, 2009, Pages 55-60

  Kelley Hedgepeth, Alyson ^a   Peter, Inga ^b   Montefusco, Maria Claudia ^a   Levy, Daniel ^c,d   Benjamin, Emelia J ^c,e,f   Vasan, Ramachandran S ^c,e   Mendelsohn, Michael E ^a   Housman, David ^g   Huggins, Gordon S ^a,i   Mitchell, Gary F ^h  

^a Molecular Cardiology Research Institute   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c FRAMINGHAM HEART STUDY   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BOSTON UNIVERSITY   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h CARDIOVASCULAR ENGINEERING INC   (United States)

ⁱ TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Genetics; KCNMB1; Single nucleotide polymorphism; Vascular tonometry

Indexed keywords

ACETYLSALICYLIC ACID; ANTIHYPERTENSIVE AGENT; CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNMB1 PROTEIN, HUMAN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT; UNCLASSIFIED DRUG;

ADULT; ARTERY BLOOD FLOW; ARTERY DIAMETER; ARTICLE; BETA CHAIN; BLOOD PRESSURE; BRACHIAL ARTERY; CAROTID ARTERY PULSE; CONTROLLED STUDY; FEMALE; FLOW RATE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HUMAN; HYPERTENSION; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PULSE PRESSURE; PULSE WAVE; TONOMETRY; AGED; COHORT ANALYSIS; GENETICS; HISTOLOGY; MIDDLE AGED; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; BLOOD PRESSURE; BRACHIAL ARTERY; COHORT STUDIES; FEMALE; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 58849102630     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328317c8ae     Document Type: Article

References (25)

1. Brayden JE, Nelson MT. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science 1992; 256:532-535.
2. Brenner R, Perez GJ, Bonev AD, Eckman DM, Kosek JC, Wiler SW, et al. Vasoregulation by the beta1 subunit of the calcium-activated potassium channel. Nature 2000; 407:870-876.
3. Wang B, Brenner R. An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating. J Gen Physiol 2006; 128:731-744.
4. Fernandez-Fernandez JM, Tomas M, Vazquez E, Orio P, Latorre R, Senti M, et al. Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. J Clin Invest 2004; 113:1032-1039.
5. Senti M, Fernandez-Fernandez JM, Tomas M, Vazquez E, Elosua R, Marrugat J, Valverde MA. Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk. Circ Res 2005; 97:1360-1365.
6. Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, et al. The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade. JHum Hypertens 2008; 22:512-515.
7. Beitelshees AL,Gong Y,Wang D, Schork NJ, Cooper-Dehoff RM, Langaee TY, et al. KCNMB1 genotype in?uences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril Study (INVEST). Pharmacogenet Genomics 2007; 17:719-729.
8. Franklin SS, Khan SA, Wong ND, Larson MG, Levy D. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study. Circulation 1999; 100:354-360.
9. Meaume S, Benetos A, Henry OF, Rudnichi A, Safar ME. Aortic pulse wave velocity predicts cardiovascular mortality in subjects 70 years of age. Arterioscler Thromb Vasc Biol 2001; 21:2046-2050.
10. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37:1236-1241.
11. Mitchell GF, Moye LA, Braunwald E, Rouleau JL, Bernstein V, Geltman EM, et al. Sphygmomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function. SAVE investigators. Survival and Ventricular Enlargement. Circulation 1997; 96:4254-4260.
12. Mitchell GF, DeStefano AL, LarsonMG, Benjamin EJ, Chen MH, Vasan RS, et al. Heritability and a genome-wide linkage scan for arterial stiffness, wave re?ection, and mean arterial pressure: the Framingham Heart Study. Circulation 2005; 112:194-199.
13. Kannel WB, Feinleib M, McNamara PM, Garrison RJ, Castelli WP. An investigation of coronary heart disease in families. The Framingham Offspring Study. Am J Epidemiol 1979; 110:281-290.
14. Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, et al. Association between estrogen receptor alpha gene variation and cardiovascular disease. JAMA 2003; 290:2263-2270.
15. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265.
16. Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, et al. Changes in arterial stiffness and wave re?ection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension 2004; 43:1239-1245.
17. Murgo JP,Westerhof N, Giolma JP, Altobelli SA. Aortic input impedance in normal man: relationship to pressure wave forms. Circulation 1980; 62:105-116.
18. Vita JA, Keaney JF Jr, Larson MG, Keyes MJ, Massaro JM, Lipinska I, et al. Brachial artery vasodilator function and systemic in?ammation in the Framingham Offspring Study. Circulation 2004; 110:3604-3609.
19. Gollasch M, Tank J, Luft FC, Jordan J, Maass P, Krasko C, et al. The BK channel beta1 subunit gene is associated with human barore?ex and blood pressure regulation. J Hypertens 2002; 20:927-933.
20. SAS Institute Inc. (1999), SAS/STAT user's guide, Version 8, Cary, NC: SAS Institute Inc.
21. Pluznick JL, Wei P, Carmines PK, Sansom SC. Renal ?uid and electrolyte handling in BKCa-beta1-/- mice. Am J Physiol Renal Physiol 2003; 284:F1274-F1279.
22. Cai B, Gong D, Pan Z, Liu Y, Qian H, Zhang Y, et al. Large-conductance Ca2-activated K currents blocked and impaired by homocysteine in human and rat mesenteric artery smooth muscle cells. Life Sci 2007; 80:2060-2066.
23. Bukiya AN, Liu J, Toro L, Dopico AM. Beta1 (KCNMB1) subunits mediate lithocholate activation of large-conductance Ca2-activated K channels and dilation in small, resistance-size arteries. Mol Pharmacol 2007; 72:359-369.
24. Matsushita M, Tanaka Y, Koike K. Studies on the mechanisms underlying beta-adrenoceptor-mediated relaxation of rat abdominal aorta. J Smooth Muscle Res 2006; 42:217-225.
25. Mandala M, Heppner TJ, Bonev AD, Nelson MT. Effect of endogenous and exogenous nitric oxide on calcium sparks as targets for vasodilation in rat cerebral artery. Nitric Oxide 2007; 16:104-109.