Development of an automated multi-injection shotgun lipidomics approach using a triple quadrupole mass spectrometer

Lipids

Volumn 49, Issue 6, 2014, Pages 609-619

  Bowden, John A ^a   Bangma, Jackie T ^b   Kucklick, John R ^a  

^a NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Direct infusion; Flow injection analysis; Lipid profiling; Multi injection shotgun lipidomics; Shotgun lipidomics; Tandem mass spectrometry; Triple quadrupole mass spectrometry

Indexed keywords

CARDIOLIPIN; CERAMIDE; CHOLESTEROL; DIACYLGLYCEROL; FATTY ACID; LITHIUM CHLORIDE; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDIC ACID; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; SPHINGOMYELIN; SULFATIDE; TRIACYLGLYCEROL; LIPID;

ARTICLE; AUTOMATED MULTI INJECTION SHOTGUN LIPIDOMICS; AUTOMATION; COLLISIONALLY ACTIVATED DISSOCIATION; COMPARATIVE STUDY; CONTROLLED STUDY; DATA PROCESSING; ELECTROSPRAY MASS SPECTROMETRY; FLOW INJECTION ANALYSIS; FLOW RATE; HUMAN; INFORMATION PROCESSING; LIPIDOMICS; LIQUID CHROMATOGRAPHY; PLASMA; QUADRUPOLE MASS SPECTROMETRY; ANIMAL; BLOOD; ISOLATION AND PURIFICATION; STANDARD; STANDARDS; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, LIQUID; HUMANS; LIPIDS; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84903818760     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-014-3903-x     Document Type: Article

References (45)

1. Gross RW, Han X (2011) Lipidomics at the interface of structure and function in systems biology. Chem Biol 18:284-291
2. Watson AD (2006) Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res 47:2101-2111
3. Wenk MR (2005) The emerging field of lipidomics. Nat Rev Drug Discov 4:594-610
4. Shevchenko A, Simons K (2010) Lipidomics: coming to grips with lipid diversity. Nat Rev Mol Cell Biol 11:593-598
5. Han X, Rozen S, Boyle SH, Hellegers C, Cheng H, Burke JR, Welsh-Bohmer KA, Doraiswamy PM, Kaddurah-Daouk R (2011) Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics. PLoS ONE 6:e21643
6. Han X (2010) Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease. Biochim Biophys Acta (BBA) Mol Cell Biol Lipids 1801:774-783
7. Han X (2007) Potential mechanisms contributing to sulfatide depletion at the earliest clinically recognizable stage of Alzheimer's disease: a tale of shotgun lipidomics. J Neurochem 103:171-179
8. Hu C, van der Heijden R, Wang M, van der Greef J, Hankemeier T, Xu G (2009) Analytical strategies in lipidomics and applications in disease biomarker discovery. J Chromatogr B Analyt Technol Biomed Life Sci 877:2836-2846
9. Gross RW, Han X (2007) Lipidomics in diabetes and the metabolic syndrome. Methods Enzymol 433:73-90
10. Aguilera CM, Gil-Campos M, Canete R, Gil A (2008) Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome. Clin Sci 114:183-193 (Pubitemid 351293994)
11. Pietiläinen KH, Sysi-Aho M, Rissanen A, Seppänen-Laakso T, Yki-Järvinen H, Kaprio J, Oresic M (2007) Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects-a monozygotic twin study. PLoS ONE 2:e218
12. Stegemann C, Drozdov I, Shalhoub J, Humphries J, Ladroue C, Didangelos A, Baumert M, Allen M, Davies AH, Monaco C, Smith A, Xu Q, Mayr M (2011) Comparative lipidomics profiling of human atherosclerotic plaques. Circ Cardiovasc Genet 4:232-242
13. Ekroos K, Jänis M, Tarasov K, Hurme R, Laaksonen R (2010) Lipidomics: a tool for studies of atherosclerosis. Curr Atheroscler Rep 12:273-281
14. Min H, Lim S, Chung B, Moon M (2011) Shotgun lipidomics for candidate biomarkers of urinary phospholipids in prostate cancer. Anal Bioanal Chem 399:823-830
15. Sewell GW, Hannun YA, Han X, Koster G, Bielawski J, Goss V, Smith PJ, Rahman FZ, Vega R, Bloom SL, Walker AP, Postle AD, Segal AW (2012) Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. Int J Biochem Cell Biol 44:1839-1846
16. Gross RW, Han X (2009) Shotgun lipidomics of neutral lipids as an enabling technology for elucidation of lipid-related diseases. Am J Phys Endocrinol Metab 297:E297-E303
17. Han X, Yang K, Cheng H, Fikes KN, Gross RW (2005) Shotgun lipidomics of phosphoethanolamine-containing lipids in biological samples after one-step in situ derivatization. J Lipid Res 46:1548-1560 (Pubitemid 43109820)
18. Jiang X, Cheng H, Yang K, Gross RW, Han X (2007) Alkaline methanolysis of lipid extracts extends shotgun lipidomics analyses to the low-abundance regime of cellular sphingolipids. Anal Biochem 371:135-145 (Pubitemid 350015971)
19. Schwudke D, Schuhmann K, Herzog R, Bornstein SR, Shevchenko A (2011) Shotgun lipidomics on high resolution mass spectrometers. Cold Spring Harb Perspect Biol 3:a004614
20. Song H, Ladenson J, Turk J (2009) Algorithms for automatic processing of data from mass spectrometric analyses of lipids. J Chromatogr B 877:2847-2854
21. Herzog R, Schuhmann K, Schwudke D, Sampaio JL, Bornstein SR, Schroeder M, Shevchenko A (2012) LipidXplorer: a software for consensual cross-platform lipidomics. PLoS ONE 7:e29851
22. Yang K, Cheng H, Gross RW, Han X (2009) Automated lipid identification and quantification by multidimensional mass spec-trometry- based shotgun lipidomics. Anal Chem 81:4356-4368
23. Ståhlman M, Ejsing CS, Tarasov K, Perman J, Borén J, Ekroos K (2009) High-throughput shotgun lipidomics by quadrupole time-of-flight mass spectrometry. J Chromatogr B 877:2664-2672
24. Jung HR, Sylvänne T, Koistinen KM, Tarasov K, Kauhanen D, Ekroos K (2011) High throughput quantitative molecular lipidomics. Biochim Biophys Acta Mol Cell Biol Lipids 1811:925-934
25. Han X, Yang K, Gross RW (2008) Microfluidics-based electrospray ionization enhances the intrasource separation of lipid classes and extends identification of individual molecular species through multi-dimensional mass spectrometry: development of an automated high-throughput platform for shotgun lipidomics. Rapid Commun Mass Spectrom 22:2115-2124 (Pubitemid 351956698)
26. Hermansson M, Uphoff A, Käkelä R, Somerharju P (2005) Automated quantitative analysis of complex lipidomes by liquid chromatography/mass spectrometry. Anal Chem 77:2166-2175 (Pubitemid 40463834)
27. Scherer M, Leuthäuser-Jaschinski K, Ecker J, Schmitz G, Liebisch G (2010) A rapid and quantitative LC-MS/MS method to profile sphingolipids. J Lipid Res 51:2001-2011
28. Myers DS, Ivanova PT, Milne SB, Brown HA (2011) Quantitative analysis of glycerophospholipids by LC/MS: acquisition, data handling, and interpretation. Biochim Biophys Acta Mol Cell Biol Lipids 1811:748-757
29. Sandra K, Pereira AS, Vanhoenacker G, David F, Sandra P (2010) Comprehensive blood plasma lipidomics by liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr A 1217:4087-4099
30. Han X, Gross RW (1994) Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids. PNAS 91:10635-10639 (Pubitemid 24329053)
31. Han X, Gross RW (2005) Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom Rev 24:367-412 (Pubitemid 40665798)
32. Han X, Yang J, Cheng H, Ye H, Gross RW (2004) Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry. Anal Biochem 330:317-331 (Pubitemid 38760108)
33. Han X, Yang K, Gross RW (2012) Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses. Mass Spectrom Rev 31:134-178
34. Schuhmann K, Almeida R, Baumert M, Herzog R, Bornstein SR, Shevchenko A (2011) Shotgun lipidomics on a LTQ Orbitrap mass spectrometer by successive switching between acquisition polarity modes. J Mass Spectrom 47:96-104
35. Wiesner P, Leidl K, Boettcher A, Schmitz G, Liebisch G (2009) Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 50:574-585
36. Liebisch G, Lieser B, Rathenberg J, Drobnik W, Schmitz G (2004) High-throughput quantification of phosphatidylcholine and sphingomyelin by electrospray ionization tandem mass spectrometry coupled with isotope correction algorithm. Biochim Biophys Acta Mol Cell Biol Lipids 1686:108-117 (Pubitemid 39446883)
37. Liebisch G, Drobnik W, Lieser B, Schmitz G (2002) High-throughput quantification of lysophosphatidylcholine by electrospray ionization tandem mass spectrometry. Clin Chem 48:2217-2224 (Pubitemid 35397565)
38. Köfeler HC, Fauland A, Rechberger GN, Trötzmüller M (2012) Mass spectrometry based lipidomics: an overview of technological platforms. Metabolites 2:19-38
39. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Phys 37:911-917
40. Bowden JA, Albert CJ, Barnaby OS, Ford DA (2011) Analysis of cholesteryl esters and diacylglycerols using lithiated adducts and electrospray ionization-tandem mass spectrometry. Anal Biochem 417:202-210
41. Han X, Gross RW (2001) Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal Biochem 295:88-100 (Pubitemid 32721744)
42. Hsu FF, Bohrer A, Turk J (1998) Formation of lithiated adducts of glycerophosphocholine lipids facilitates their identification by electrospray ionization tandem mass spectrometry. J Am Soc Mass Spectrom 9:516-526
43. Hsu FF, Turk J (1999) Structural characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisionally activated dissociation on a triple stage quadrupole instrument. J Am Soc Mass Spectrom 10:587-599
44. Han X, Gross RW (2003) Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res 44:1071-1079 (Pubitemid 37279625)
45. Liebisch G, Binder M, Schifferer R, Langmann T, Schulz B, Schmitz G (2006) High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS). Biochim Biophys Acta Mol Cell Biol Lipids 1761:121-128