Lipidomic profiling in Crohn's disease: Abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 11, 2012, Pages 1839-1846

  Sewell, Gavin W ^a   Hannun, Yusuf A ^b   Han, Xianlin ^d   Koster, Grielof ^e   Bielawski, Jacek ^c   Goss, Victoria ^e   Smith, Philip J ^a   Rahman, Farooq Z ^f   Vega, Roser ^f   Bloom, Stuart L ^f   Walker, Ann P ^a   Postle, Anthony D ^e   Segal, Anthony W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b STONY BROOK UNIVERSITY   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d BURNHAM INSTITUTE   (United States)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^f UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Ceramide; Crohn's disease; Lipids; Macrophage; Phospholipid; Sphingolipid

Indexed keywords

CARDIOLIPIN; CERAMIDE; CHOLESTEROL; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; SPHINGOLIPID;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM; INTESTINE BIOPSY; ISOTOPE LABELING; LIPID COMPOSITION; LIPIDOMICS; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; PHOSPHOLIPID SYNTHESIS; TANDEM MASS SPECTROMETRY;

ADULT; BIOPSY; CASE-CONTROL STUDIES; CERAMIDES; CROHN DISEASE; DEMOGRAPHY; ESCHERICHIA COLI; FEMALE; HUMANS; ILEUM; MACROPHAGES; MALE; METABOLOMICS; MIDDLE AGED; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLINOSITOLS; PHOSPHATIDYLSERINES; SPHINGOLIPIDS;

ESCHERICHIA COLI;

EID: 84864454192     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.06.016     Document Type: Article

References (41)

1. D.K. Amre, S. D'Souza, K. Morgan, G. Seidman, P. Lambrette, and G. Grimard Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn's disease in children American Journal of Gastroenterology 102 2007 2016 2025
2. S. Aozaki Decreased membrane fluidity in erythrocytes from patients with Crohn's disease Gastroenterologia Japonica 24 1989 246 254
3. D. Balgoma, O. Montero, M.A. Balboa, and J. Balsinde Calcium-independent phospholipase A2-mediated formation of 1,2-diarachidonoyl-glycerophosphoinositol in monocytes FEBS Journal 275 2008 6180 6191
4. J.C. Barrett, S. Hansoul, D.L. Nicolae, J.H. Cho, R.H. Duerr, and J.D. Rioux Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease Nature Genetics 40 2008 955 962
5. J. Bielawski, J.S. Pierce, J. Snider, B. Rembiesa, Z.M. Szulc, and A. Bielawska Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry Methods in Molecular Biology 579 2009 443 467
6. E.G. Bligh, and W.J. Dyer A rapid method of total lipid extraction and purification Canadian Journal of Biochemistry and Physiology 37 1959 911 917
7. A. Braun, I. Treede, D. Gotthardt, A. Tietje, A. Zahn, and R. Ruhwald Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis Inflammatory Bowel Diseases 15 2009 1705 1720
8. D.K. Breslow, S.R. Collins, B. Bodenmiller, R. Aebersold, K. Simons, and A. Shevchenko Orm family proteins mediate sphingolipid homeostasis Nature 463 2010 1048 1053
9. R. Cooney, J. Baker, O. Brain, B. Danis, T. Pichulik, and P. Allan NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation Nature Medicine 16 2010 90 97
10. J. Ecker, G. Liebisch, M. Englmaier, M. Grandl, H. Robenek, and G. Schmitz Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes Proceedings of the National Academy of Sciences of the United States of America 107 2010 7817 7822
11. A.M. El, B.X. Wu, L.M. Obeid, and Y.A. Hannun Bioactive sphingolipids in the modulation of the inflammatory response Pharmacology & Therapeutics 112 2006 171 183
12. M. Esteve-Comas, M.C. Nunez, F. Fernandez-Banares, A. bad-Lacruz, A. Gil, and E. Cabre Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease Gut 34 1993 1370 1373
13. M. Esteve-Comas, M. Ramirez, F. Fernandez-Banares, A. bad-Lacruz, A. Gil, and E. Cabre Plasma polyunsaturated fatty acid pattern in active inflammatory bowel disease Gut 33 1992 1365 1369
14. R. Fabia, A. Ar'Rajab, R. Willen, R. Andersson, B. Ahren, and K. Larsson Effects of phosphatidylcholine and phosphatidylinositol on acetic-acid-induced colitis in the rat Digestion 53 1992 35 44
15. A. Franke, D.P. McGovern, J.C. Barrett, K. Wang, G.L. Radford-Smith, and T. Ahmad Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci Nature Genetics 42 2010 1118 1125
16. B.J. Geerling, A.C. Houwelingen, A. Badart-Smook, R.W. Stockbrugger, and R.J. Brummer Fat intake and fatty acid profile in plasma phospholipids and adipose tissue in patients with Crohn's disease, compared with controls American Journal of Gastroenterology 94 1999 410 417
17. X. Han, J. Yang, H. Cheng, H. Ye, and R.W. Gross Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry Analytical Biochemistry 330 2004 317 331
18. R.F. Harvey, and J.M. Bradshaw A simple index of Crohn's-disease activity Lancet 1 1980 514-
19. M. Hermansson, K. Hokynar, and P. Somerharju Mechanisms of glycerophospholipid homeostasis in mammalian cells Progress in Lipid Research 50 2011 240 257
20. D. Hollander, C.M. Vadheim, E. Brettholz, G.M. Petersen, T. Delahunty, and J.I. Rotter Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor Annals of Internal Medicine 105 1986 883 885
21. A.G. Howe, and C.R. McMaster Regulation of vesicle trafficking, transcription, and meiosis: lessons learned from yeast regarding the disparate biologies of phosphatidylcholine Biochimica et Biophysica Acta 1534 2001 65 77
22. S. Jozefowski, M. Czerkies, A. Lukasik, A. Bielawska, J. Bielawski, and K. Kwiatkowska Ceramide and ceramide 1-phosphate are negative regulators of TNF-alpha production induced by lipopolysaccharide Journal of Immunology 185 2010 6960 6973
23. J.E. Lennard-Jones Classification of inflammatory bowel disease Scandinavian Journal of Gastroenterology 170 Suppl. 1989 2 6
24. P.C. Low, R. Misaki, K. Schroder, A.C. Stanley, M.J. Sweet, and R.D. Teasdale Phosphoinositide 3-kinase delta regulates membrane fission of Golgi carriers for selective cytokine secretion Journal of Cell Biology 190 2010 1053 1065
25. M.L. MacKichan, and A.L. DeFranco Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog Journal of Biological Chemistry 274 1999 1767 1775
26. X. Mulet, R.H. Templer, R. Woscholski, and O. Ces Evidence that phosphatidylinositol promotes curved membrane interfaces Langmuir 24 2008 8443 8447
27. G. Odorizzi, M. Babst, and S.D. Emr Phosphoinositide signaling and the regulation of membrane trafficking in yeast Trends in Biochemical Sciences 25 2000 229 235
28. C.D. Palmer, F.Z. Rahman, G.W. Sewell, A. Ahmed, M. Ashcroft, and S.L. Bloom Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease PLoS ONE 4 2009 e7787-
29. A.D. Postle, N.G. Henderson, G. Koster, H.W. Clark, and A.N. Hunt Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes Chemistry and Physics of Lipids 164 2011 549 555
30. C.A. Rouzer, P.T. Ivanova, M.O. Byrne, H.A. Brown, and L.J. Marnett Lipid profiling reveals glycerophospholipid remodeling in zymosan-stimulated macrophages Biochemistry 46 2007 6026 6042
31. K.A. Rozenova, G.M. Deevska, A.A. Karakashian, and M.N. Nikolova-Karakashian Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha)-converting enzyme activity and TNFalpha secretion in macrophages Journal of Biological Chemistry 285 2010 21103 21113
32. F. Scarlatti, C. Bauvy, A. Ventruti, G. Sala, F. Cluzeaud, and A. Vandewalle Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1 Journal of Biological Chemistry 279 2004 18384 18391
33. L. Schaeffer, H. Gohlke, M. Muller, I.M. Heid, L.J. Palmer, and I. Kompauer Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids Human Molecular Genetics 15 2006 1745 1756
34. G.W. Sewell, D.J. Marks, and A.W. Segal The immunopathogenesis of Crohn's disease: a three-stage model Current Opinion in Immunology 21 2009 506 513
35. R. Shoda, K. Matsueda, S. Yamato, and N. Umeda Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan American Journal of Clinical Nutrition 63 1996 741 745
36. A.M. Smith, F.Z. Rahman, B. Hayee, S.J. Graham, D.J. Marks, and G.W. Sewell Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease Journal of Experimental Medicine 206 2009 1883 1897
37. C.R. Stevens, V.G. Oberholzer, J.A. Walker-Smith, and A.D. Phillips Lactosylceramide in inflammatory bowel disease: a biochemical study Gut 29 1988 580 587
38. Y. Tian, C. Pate, A. Andreolotti, L. Wang, E. Tuomanen, and K. Boyd Cytokine secretion requires phosphatidylcholine synthesis Journal of Cell Biology 181 2008 945 957
39. T.M. Trebble, N.K. Arden, S.A. Wootton, M.A. Mullee, P.C. Calder, and G.C. Burdge Peripheral blood mononuclear cell fatty acid composition and inflammatory mediator production in adult Crohn's disease Clinical Nutrition 23 2004 647 655
40. E. Westcott, A. Windsor, C. Mattacks, C. Pond, and S. Knight Fatty acid compositions of lipids in mesenteric adipose tissue and lymphoid cells in patients with and without Crohn's disease and their therapeutic implications Inflammatory Bowel Diseases 11 2005 820 827
41. W. Zheng, J. Kollmeyer, H. Symolon, A. Momin, E. Munter, and E. Wang Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy Biochimica et Biophysica Acta 1758 2006 1864 1884