Development of the HPA axis: Where and when do sex differences manifest?

Frontiers in Neuroendocrinology

Volumn 35, Issue 3, 2014, Pages 285-302

  Panagiotakopoulos, Leonidas ^a   Neigh, Gretchen N ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Adrenals; CRF; Development; Glucocorticoids; Hippocampus; Hormones; HPA axis; Hypothalamus; Pituitary; Sex

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RECEPTOR; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; TRANSCORTIN;

ADENOHYPOPHYSIS; ADRENAL CORTEX; BRAIN DEVELOPMENT; BRAIN FUNCTION; CIRCADIAN RHYTHM; EMBRYO DEVELOPMENT; HORMONE ACTION; HORMONE SYNTHESIS; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LIFESPAN; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SYNTHESIS; PUBERTY; REVIEW; SEX DIFFERENCE; ANIMAL; BEHAVIOR; FEMALE; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SEXUAL DEVELOPMENT;

ANIMALS; BEHAVIOR; CORTICOTROPIN-RELEASING HORMONE; FEMALE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; SEX CHARACTERISTICS; STRESS, PHYSIOLOGICAL;

EID: 84903787049     PISSN: 00913022     EISSN: 10956808     Source Type: Journal    
DOI: 10.1016/j.yfrne.2014.03.002     Document Type: Review

References (281)

1. Almlof T., Gustafsson J.A., Wright A.P. Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor. Mol. Cell. Biol. 1997, 17:934-945.
2. Almlof T., Wallberg A.E., Gustafsson J.A., Wright A.P. Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors. Biochemistry 1998, 37:9586-9594.
3. Altman J., Bayer S.A. Development of the diencephalon in the rat. III. Ontogeny of the specialized ventricular linings of the hypothalamic third ventricle. J. Comp. Neurol. 1978, 182:995-1015.
4. Altman J., Bayer S.A. Development of the diencephalon in the rat. II. Correlation of the embryonic development of the hypothalamus with the time of origin of its neurons. J. Comp. Neurol. 1978, 182:973-993.
5. Altman J., Bayer S.A. Development of the diencephalon in the rat. I. Autoradiographic study of the time of origin and settling patterns of neurons of the hypothalamus. J Comp Neurol 1978, 182:945-971.
6. Altman J., Bayer S.A. The development of the rat hypothalamus. Adv. Anat. Embryol. Cell Biol. 1986, 100:1-178.
7. Antoni F.A. Receptors mediating the CRH effects of vasopressin and oxytocin. Ann. N. Y. Acad. Sci. 1987, 512:195-204.
8. Antoni F.A., Holmes M.C., Makara G.B., Karteszi M., Laszlo F.A. Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor. Peptides 1984, 5:519-522.
9. Axelrod J., Reisine T.D. Stress hormones: their interaction and regulation. Science 1984, 224:452-459.
10. Azhar S., Nomoto A., Reaven E. Hormonal regulation of adrenal microvillar channel formation. J. Lipid Res. 2002, 43:861-871.
11. Bamberger C.M., Bamberger A.M., de Castro M., Chrousos G.P. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J. Clin. Invest. 1995, 95:2435-2441.
12. Bangasser D.A., Curtis A., Reyes B.A., Bethea T.T., Parastatidis I., Ischiropoulos H., Van Bockstaele E.J., Valentino R.J. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. Mol. Psychiatry 2010, 15(877):896-904.
13. Bao A.M., Fischer D.F., Wu Y.H., Hol E.M., Balesar R., Unmehopa U.A., Zhou J.N., Swaab D.F. A direct androgenic involvement in the expression of human corticotropin-releasing hormone. Mol. Psychiatry 2006, 11:567-576.
14. Barent R.L., Nair S.C., Carr D.C., Ruan Y., Rimerman R.A., Fulton J., Zhang Y., Smith D.F. Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes. Mol. Endocrinol. 1998, 12:342-354.
15. Beaudry J.L., Riddell M.C. Effects of glucocorticoids and exercise on pancreatic beta-cell function and diabetes development. Diabetes Metab. Res. Rev. 2012, 28:560-573.
16. Bebbington P., Brugha T., Meltzer H., Farrell M., Ceresa C., Jenkins R., Lewis G. Psychiatric disorder and dysfunction in the UK National Survey of Psychiatric Morbidity. Soc. Psychiatry Psychiatr. Epidemiol. 2000, 35:191-197.
17. Beer H.D., Fassler R., Werner S. Glucocorticoid-regulated gene expression during cutaneous wound repair. Vitam. Horm. 2000, 59:217-239.
18. Belanoff J.K., Gross K., Yager A., Schatzberg A.F. Corticosteroids and cognition. J. Psychiatr. Res. 2001, 35:127-145.
19. Berretta S. Cortico-amygdala circuits: role in the conditioned stress response. Stress 2005, 8:221-232.
20. Blackwell G.J., Carnuccio R., Di Rosa M., Flower R.J., Parente L., Persico P. Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids. Nature 1980, 287:147-149.
21. Bohler H.C., Zoeller R.T., King J.C., Rubin B.S., Weber R., Merriam G.R. Corticotropin releasing hormone mRNA is elevated on the afternoon of proestrus in the parvocellular paraventricular nuclei of the female rat. Brain Res. Mol. Brain Res. 1990, 8:259-262.
22. Born J., Kern W., Fehm-Wolfsdorf G., Fehm H.L. Cortisol effects on attentional processes in man as indicated by event-related potentials. Psychophysiology 1987, 24:286-292.
23. Born J., Hitzler V., Pietrowsky R., Pauschinger P., Fehm H.L. Influences of cortisol on auditory evoked potentials (AEPs) and mood in humans. Neuropsychobiology 1989, 20:145-151.
24. Born J., Ditschuneit I., Schreiber M., Dodt C., Fehm H.L. Effects of age and gender on pituitary-adrenocortical responsiveness in humans. Eur. J. Endocrinol. 1995, 132:705-711.
25. Bosch N.M., Riese H., Reijneveld S.A., Bakker M.P., Verhulst F.C., Ormel J., Oldehinkel A.J. Timing matters: long term effects of adversities from prenatal period up to adolescence on adolescents' cortisol stress response. The TRAILS study. Psychoneuroendocrinology 2012, 37:1439-1447.
26. Bourke C.H., Harrell C.S., Neigh G.N. Stress-induced sex differences: adaptations mediated by the glucocorticoid receptor. Horm. Behav. 2012, 62:210-218.
27. Bourke C.H., Raees M.Q., Malviya S., Bradburn C.A., Binder E.B., Neigh G.N. Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner. Psychoneuroendocrinology 2013, 38:84-93.
28. Bratt A.M., Kelley S.P., Knowles J.P., Barrett J., Davis K., Davis M., Mittleman G. Long term modulation of the HPA axis by the hippocampus. Behavioral, biochemical and immunological endpoints in rats exposed to chronic mild stress. Psychoneuroendocrinology 2001, 26:121-145.
29. Braun C.M., Huang S.K., Bashian G.G., Kagey-Sobotka A., Lichtenstein L.M., Essayan D.M. Corticosteroid modulation of human, antigen-specific Th1 and Th2 responses. J. Allergy Clin. Immunol. 1997, 100:400-407.
30. Brien T.G. Human corticosteroid binding globulin. Clin. Endocrinol. (Oxf.) 1981, 14:193-212.
31. Bright G.M. Corticosteroid-binding globulin influences kinetic parameters of plasma cortisol transport and clearance. J. Clin. Endocrinol. Metab. 1995, 80:770-775.
32. Bright G.M., Darmaun D. Corticosteroid-binding globulin modulates cortisol concentration responses to a given production rate. J. Clin. Endocrinol. Metab. 1995, 80:764-769.
33. Brody S. Psychiatric observations in patients treated with cortisone and ACTH. Psychosom. Med. 1952, 14:94-103.
34. Brown M.S., Kovanen P.T., Goldstein J.L. Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex. Recent Prog. Horm. Res. 1979, 35:215-257.
35. Buchanan T.W., Kern S., Allen J.S., Tranel D., Kirschbaum C. Circadian regulation of cortisol after hippocampal damage in humans. Biol. Psychiatry 2004, 56:651-656.
36. Buren J., Liu H.X., Jensen J., Eriksson J.W. Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur. J. Endocrinol. 2002, 146:419-429.
37. Burgess L.H., Handa R.J. Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats. Endocrinology 1992, 131:1261-1269.
38. Buske-Kirschbaum A., von Auer K., Krieger S., Weis S., Rauh W., Hellhammer D. Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?. Psychosom. Med. 2003, 65:806-810.
39. Cameron A., Henley D., Carrell R., Zhou A., Clarke A., Lightman S. Temperature-responsive release of cortisol from its binding globulin: a protein thermocouple. J. Clin. Endocrinol. Metab. 2010, 95:4689-4695.
40. Chandran U.R., Attardi B., Friedman R., Dong K.W., Roberts J.L., DeFranco D.B. Glucocorticoid receptor-mediated repression of gonadotropin-releasing hormone promoter activity in GT1 hypothalamic cell lines. Endocrinology 1994, 134:1467-1474.
41. Charmandari E., Tsigos C., Chrousos G. Endocrinology of the stress response. Annu. Rev. Physiol. 2005, 67:259-284.
42. Charron J., Drouin J. Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter. Proc. Natl. Acad. Sci. USA 1986, 83:8903-8907.
43. Chen R., Lewis K.A., Perrin M.H., Vale W.W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc. Natl. Acad. Sci. USA 1993, 90:8967-8971.
44. Chretien M., Seidah N.G. Chemistry and biosynthesis of pro-opiomelanocortin. ACTH, MSH's, endorphins and their related peptides. Mol. Cell. Biochem. 1981, 34:101-127.
45. Chrousos G.P. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int. J. Obes. Relat. Metab. Disord. 2000, 24(Suppl. 2):S50-S55.
46. Chrousos G.P., Gold P.W. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. J. Am. Med. Assoc. 1992, 267:1244-1252.
47. Chung B.C., Guo I.C., Chou S.J. Transcriptional regulation of the CYP11A1 and ferredoxin genes. Steroids 1997, 62:37-42.
48. Clark L.D., Bauer W., Cobb S. Preliminary observations on mental disturbances occurring in patients under therapy with cortisone and ACTH. N. Engl. J. Med. 1952, 246:205-216.
49. Clark A.J., McLoughlin L., Grossman A. Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. Lancet 1993, 341:461-462.
50. Cohen J.J. Glucocorticoid-induced apoptosis in the thymus. Semin. Immunol. 1992, 4:363-369.
51. Collins A., Frankenhaeuser M. Stress responses in male and female engineering students. J. Human Stress 1978, 4:43-48.
52. Connelly M.A., Williams D.L. SR-BI and cholesterol uptake into steroidogenic cells. Trends Endocrinol. Metab. 2003, 14:467-472.
53. Contreras L.N., Masini A.M., Danna M.M., Kral M., Bruno O.D., Rossi M.A., Andrada J.A. Glucocorticoids: their role on gonadal function and LH secretion. Minerva Endocrinol. 1996, 21:43-46.
54. Cook C.J. Glucocorticoid feedback increases the sensitivity of the limbic system to stress. Physiol. Behav. 2002, 75:455-464.
55. Coolens J.L., Van Baelen H., Heyns W. Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. J. Steroid Biochem. 1987, 26:197-202.
56. Coutinho A.E., Chapman K.E. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol. Cell. Endocrinol. 2011, 335:2-13.
57. Dahl R.E., Siegel S.F., Williamson D.E., Lee P.A., Perel J., Birmaher B., Ryan N.D. Corticotropin releasing hormone stimulation test and nocturnal cortisol levels in normal children. Pediatr. Res. 1992, 32:64-68.
58. Daley C.A., Macfarlane M.S., Sakurai H., Adams T.E. Effect of stress-like concentrations of cortisol on follicular development and the preovulatory surge of LH in sheep. J. Reprod. Fertil. 1999, 117:11-16.
59. Dallman M.F., Engeland W.C., McBride M.H. The neural regulation of compensatory adrenal growth. Ann. N. Y. Acad. Sci. 1977, 297:373-392.
60. Danielsen M., Northrop J.P., Jonklaas J., Ringold G.M. Domains of the glucocorticoid receptor involved in specific and nonspecific deoxyribonucleic acid binding, hormone activation, and transcriptional enhancement. Mol. Endocrinol. 1987, 1:816-822.
61. Davies T.H., Ning Y.M., Sanchez E.R. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J. Biol. Chem. 2002, 277:4597-4600.
62. Davis M., Emory E. Sex differences in neonatal stress reactivity. Child Dev. 1995, 66:14-27.
63. de Quervain D.J., Roozendaal B., McGaugh J.L. Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature 1998, 394:787-790.
64. DeBold C.R., DeCherney G.S., Jackson R.V., Sheldon W.R., Alexander A.N., Island D.P., Rivier J., Vale W., Orth D.N. Effect of synthetic ovine corticotropin-releasing factor: prolonged duration of action and biphasic response of plasma adrenocorticotropin and cortisol. J. Clin. Endocrinol. Metab. 1983, 57:294-298.
65. Debold C.R., Jackson R.V., Kamilaris T.C., Sheldon W.R., Decherney G.S., Island D.P., Orth D.N. Effects of ovine corticotropin-releasing hormone on adrenocorticotropin secretion in the absence of glucocorticoid feedback inhibition in man. J. Clin. Endocrinol. Metab. 1989, 68:431-437.
66. DeCherney G.S., DeBold C.R., Jackson R.V., Sheldon W.R., Island D.P., Orth D.N. Diurnal variation in the response of plasma adrenocorticotropin and cortisol to intravenous ovine corticotropin-releasing hormone. J. Clin. Endocrinol. Metab. 1985, 61:273-279.
67. Denis M., Gustafsson J.A. The Mr approximately 90,000 heat shock protein: an important modulator of ligand and DNA-binding properties of the glucocorticoid receptor. Cancer Res. 1989, 49:2275s-2281s.
68. Denis M., Gustafsson J.A., Wikstrom A.C. Interaction of the Mr = 90,000 heat shock protein with the steroid-binding domain of the glucocorticoid receptor. J. Biol. Chem. 1988, 263:18520-18523.
69. Dermitzaki I., Tsatsanis C., Alexaki V.I., Castanas E., Margioris A.N. Roles of protein kinase A (PKA) and PKC on corticotropin-releasing hormone (CRH)-induced elevation of cytosolic calcium from extra-and intra-cellular sources. Hormones (Athens) 2004, 3:252-258.
70. Deuster P.A., Petrides J.S., Singh A., Lucci E.B., Chrousos G.P., Gold P.W. High intensity exercise promotes escape of adrenocorticotropin and cortisol from suppression by dexamethasone: sexually dimorphic responses. J. Clin. Endocrinol. Metab. 1998, 83:3332-3338.
71. Dijkstra I., Binnekade R., Tilders F.J. Diurnal variation in resting levels of corticosterone is not mediated by variation in adrenal responsiveness to adrenocorticotropin but involves splanchnic nerve integrity. Endocrinology 1996, 137:540-547.
72. Duchesne A., Dufresne M.M., Sullivan R.M. Sex differences in corticolimbic dopamine and serotonin systems in the rat and the effect of postnatal handling. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009, 33:251-261.
73. Earle T.L., Linden W., Weinberg J. Differential effects of harassment on cardiovascular and salivary cortisol stress reactivity and recovery in women and men. J. Psychosom. Res. 1999, 46:125-141.
74. Entringer S., Kumsta R., Hellhammer D.H., Wadhwa P.D., Wust S. Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults. Horm. Behav. 2009, 55:292-298.
75. Essex M.J., Shirtcliff E.A., Burk L.R., Ruttle P.L., Klein M.H., Slattery M.J., Kalin N.H., Armstrong J.M. Influence of early life stress on later hypothalamic-pituitary-adrenal axis functioning and its covariation with mental health symptoms: a study of the allostatic process from childhood into adolescence. Dev. Psychopathol. 2011, 23:1039-1058.
76. Faust J.R., Goldstein J.L., Brown M.S. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells. J. Biol. Chem. 1977, 252:4861-4871.
77. Feldman S., Conforti N. Participation of the dorsal hippocampus in the glucocorticoid feedback effect on adrenocortical activity. Neuroendocrinology 1980, 30:52-55.
78. Fendler K., Karmos G., Telegdy G. The effect of hippocampal lesion on pituitary-adrenal function. Acta Physiol. Acad. Sci. Hung. 1961, 20:293-297.
79. Fernandez-Guasti A., Fiedler J.L., Herrera L., Handa R.J. Sex, stress, and mood disorders: at the intersection of adrenal and gonadal hormones. Horm. Metab. Res. 2012, 44:607-618.
80. Fitzgerald K.T. The structure and function of the pars tuberalis of the vertebrate adenohypophysis. Gen. Comp. Endocrinol. 1979, 37:383-399.
81. Francke U., Foellmer B.E. The glucocorticoid receptor gene is in 5q31-q32 [corrected]. Genomics 1989, 4:610-612.
82. Frodl T., O'Keane V. How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiol. Dis. 2013, 52:24-37.
83. Gagner J.P., Drouin J. Opposite regulation of pro-opiomelanocortin gene transcription by glucocorticoids and CRH. Mol. Cell. Endocrinol. 1985, 40:25-32.
84. Gaillard R.C., Grossman A., Gillies G., Rees L.H., Besser G.M. Angiotensin II stimulates the release of ACTH from dispersed rat anterior pituitary cells. Clin. Endocrinol. (Oxf.) 1981, 15:573-578.
85. Gainer H. Precursors of vasopressin and oxytocin. Prog. Brain Res. 1983, 60:205-215.
86. Gala R.R., Westphal U. Corticosteroid-binding globulin in the rat: studies on the sex difference. Endocrinology 1965, 77:841-851.
87. Gallucci W.T., Baum A., Laue L., Rabin D.S., Chrousos G.P., Gold P.W., Kling M.A. Sex differences in sensitivity of the hypothalamic-pituitary-adrenal axis. Health Psychol. 1993, 12:420-425.
88. Gambacciani M., Liu J.H., Swartz W.H., Tueros V.S., Rasmussen D.D., Yen S.S. Intrinsic pulsatility of ACTH release from the human pituitary in vitro. Clin. Endocrinol. (Oxf.) 1987, 26:557-563.
89. Gaskin J.H., Kitay J.I. Adrenocortical function in the hamster. Sex differences and effects of gonadal hormones. Endocrinology 1970, 87:779-786.
90. Giguere V., Labrie F., Cote J., Coy D.H., Sueiras-Diaz J., Schally A.V. Stimulation of cyclic AMP accumulation and corticotropin release by synthetic ovine corticotropin-releasing factor in rat anterior pituitary cells: site of glucocorticoid action. Proc. Natl. Acad. Sci. USA 1982, 79:3466-3469.
91. Gillies G.E., Linton E.A., Lowry P.J. Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin. Nature 1982, 299:355-357.
92. Goel N., Bale T.L. Examining the intersection of sex and stress in modelling neuropsychiatric disorders. J. Neuroendocrinol. 2009, 21:415-420.
93. Gray T.S., Carney M.E., Magnuson D.J. Direct projections from the central amygdaloid nucleus to the hypothalamic paraventricular nucleus: possible role in stress-induced adrenocorticotropin release. Neuroendocrinology 1989, 50:433-446.
94. Greenspan S.L., Rowe J.W., Maitland L.A., McAloon-Dyke M., Elahi D. The pituitary-adrenal glucocorticoid response is altered by gender and disease. J. Gerontol. 1993, 48:M72-M77.
95. Greer E.R., Caldwell J.D., Johnson M.F., Prange A.J., Pedersen C.A. Variations in concentration of oxytocin and vasopressin in the paraventricular nucleus of the hypothalamus during the estrous cycle in rats. Life Sci. 1986, 38:2311-2318.
96. Gustafsson J.A., Wikstrom A.C., Denis M. The non-activated glucocorticoid receptor: structure and activation. J. Steroid Biochem. 1989, 34:53-62.
97. Gwinup G., Steinberg T., King C.G., Vernikos-Danellis J. Vasopressin-induced ACTH secretion in man. J. Clin. Endocrinol. Metab. 1967, 27:927-930.
98. Hache R.J., Tse R., Reich T., Savory J.G., Lefebvre Y.A. Nucleocytoplasmic trafficking of steroid-free glucocorticoid receptor. J. Biol. Chem. 1999, 274:1432-1439.
99. Hahn J.D., Kalamatianos T., Coen C.W. Studies on the neuroanatomical basis for stress-induced oestrogen-potentiated suppression of reproductive function: evidence against direct corticotropin-releasing hormone projections to the vicinity of luteinizing hormone-releasing hormone cell bodies in female rats. J. Neuroendocrinol. 2003, 15:732-742.
100. Haleem D.J., Kennett G., Curzon G. Adaptation of female rats to stress: shift to male pattern by inhibition of corticosterone synthesis. Brain Res. 1988, 458:339-347.
101. Hammond G.L., Smith C.L., Underhill D.A. Molecular studies of corticosteroid binding globulin structure, biosynthesis and function. J. Steroid Biochem. Mol. Biol. 1991, 40:755-762.
102. Handa R.J., Weiser M.J. Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis. Front. Neuroendocrinol. 2013.
103. Hankin B.L., Badanes L.S., Abela J.R., Watamura S.E. Hypothalamic-pituitary-adrenal axis dysregulation in dysphoric children and adolescents: cortisol reactivity to psychosocial stress from preschool through middle adolescence. Biol. Psychiatry 2010, 68:484-490.
104. Hasselgren P.O., Fischer J.E. Counter-regulatory hormones and mechanisms in amino acid metabolism with special reference to the catabolic response in skeletal muscle. Curr. Opin. Clin. Nutr. Metab. Care 1999, 2:9-14.
105. Hatzinger M., Brand S., Perren S., Von Wyl A., Stadelmann S., von Klitzing K., Holsboer-Trachsler E. In pre-school children, cortisol secretion remains stable over 12months and is related to psychological functioning and gender. J. Psychiatr. Res. 2013, 47(11):1809-1814.
106. Hauger R.L., Aguilera G. Regulation of corticotropin-releasing hormone receptors and hypothalamic pituitary adrenal axis responsiveness during cold stress. J. Neuroendocrinol. 1992, 4:617-624.
107. Hauger R.L., Aguilera G. Regulation of pituitary corticotropin releasing hormone (CRH) receptors by CRH: interaction with vasopressin. Endocrinology 1993, 133:1708-1714.
108. Hauger R.L., Millan M.A., Lorang M., Harwood J.P., Aguilera G. Corticotropin-releasing factor receptors and pituitary adrenal responses during immobilization stress. Endocrinology 1988, 123:396-405.
109. Hayashi K.T., Moberg G.P. Influence of the hypothalamic-pituitary-adrenal axis on the menstrual cycle and the pituitary responsiveness to estradiol in the female rhesus monkey (Macaca mulatta). Biol. Reprod. 1990, 42:260-265.
110. Heinsbroek R.P., Van Haaren F., Feenstra M.G., Endert E., Van de Poll N.E. Sex- and time-dependent changes in neurochemical and hormonal variables induced by predictable and unpredictable footshock. Physiol. Behav. 1991, 49:1251-1256.
111. Hellemans K.G., Sliwowska J.H., Verma P., Weinberg J. Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders. Neurosci. Biobehav. Rev. 2010, 34:791-807.
112. Hermus A.R., Pieters G.F., Smals A.G., Benraad T.J., Kloppenborg P.W. Plasma adrenocorticotropin, cortisol, and aldosterone responses to corticotropin-releasing factor: modulatory effect of basal cortisol levels. J. Clin. Endocrinol. Metab. 1984, 58:187-191.
113. Het S., Ramlow G., Wolf O.T. A meta-analytic review of the effects of acute cortisol administration on human memory. Psychoneuroendocrinology 2005, 30:771-784.
114. Hirata F. Lipomodulin: a possible mediator of the action of glucocorticoids. Adv. Prostaglandin Thromboxane Leukot. Res. 1983, 11:73-78.
115. Hiroshige T., Abe K., Wada S., Kaneko M. Sex difference in circadian periodicity of CRF activity in the rat hypothalamus. Neuroendocrinology 1973, 11:306-320.
116. Hochberg Z. Mechanisms of steroid impairment of growth. Horm. Res. 2002, 58(Suppl. 1):33-38.
117. Hollenberg S.M., Weinberger C., Ong E.S., Cerelli G., Oro A., Lebo R., Thompson E.B., Rosenfeld M.G., Evans R.M. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 1985, 318:635-641.
118. Holzbauer M., Newport H.M. Adrenal secretion rates and adrenal tissue concentrations of pregnenolone, progesterone, 11 beta OH-androstenedione and some other steroids in young pigs and dogs. J. Physiol. 1969, 200:821-848.
119. Horrocks P.M., Jones A.F., Ratcliffe W.A., Holder G., White A., Holder R., Ratcliffe J.G., London D.R. Patterns of ACTH and cortisol pulsatility over twenty-four hours in normal males and females. Clin. Endocrinol. (Oxf.) 1990, 32:127-134.
120. Hu M.C., Hsu N.C., Pai C.I., Wang C.K., Chung B. Functions of the upstream and proximal steroidogenic factor 1 (SF-1)-binding sites in the CYP11A1 promoter in basal transcription and hormonal response. Mol. Endocrinol. 2001, 15:812-818.
121. Hutchison K.A., Dittmar K.D., Czar M.J., Pratt W.B. Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90. J. Biol. Chem. 1994, 269:5043-5049.
122. Kageyama K. Regulation of gonadotropins by corticotropin-releasing factor and urocortin. Front. Endocrinol. (Lausanne) 2013, 4:12.
123. Kaneko M., Yokoyama F., Hoshino Y., Takahagi K., Murata S., Watanabe M., Kumashiro H. Hypothalamic-pituitary-adrenal axis function in chronic schizophrenia: association with clinical features. Neuropsychobiology 1992, 25:1-7.
124. Kanelakis K.C., Morishima Y., Dittmar K.D., Galigniana M.D., Takayama S., Reed J.C., Pratt W.B. Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery. J. Biol. Chem. 1999, 274:34134-34140.
125. Keller-Wood M.E., Dallman M.F. Corticosteroid inhibition of ACTH secretion. Endocr. Rev. 1984, 5:1-24.
126. Khilnani P., Munoz R., Salem M., Gelb C., Todres I.D., Chernow B. Hormonal responses to surgical stress in children. J. Pediatr. Surg. 1993, 28:1-4.
127. Kirschbaum C., Schommer N., Federenko I., Gaab J., Neumann O., Oellers M., Rohleder N., Untiedt A., Hanker J., Pirke K.M., Hellhammer D.H. Short-term estradiol treatment enhances pituitary-adrenal axis and sympathetic responses to psychosocial stress in healthy young men. J. Clin. Endocrinol. Metab. 1996, 81:3639-3643.
128. Kirschbaum C., Wolf O.T., May M., Wippich W., Hellhammer D.H. Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci. 1996, 58:1475-1483.
129. Kirschbaum C., Kudielka B.M., Gaab J., Schommer N.C., Hellhammer D.H. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosom. Med. 1999, 61:154-162.
130. Kiss J.Z., Mezey E., Skirboll L. Corticotropin-releasing factor-immunoreactive neurons of the paraventricular nucleus become vasopressin positive after adrenalectomy. Proc. Natl. Acad. Sci. USA 1984, 81:1854-1858.
131. Kissebah A.H., Krakower G.R. Regional adiposity and morbidity. Physiol. Rev. 1994, 74:761-811.
132. Klein Z.A., Romeo R.D. Changes in hypothalamic-pituitary-adrenal stress responsiveness before and after puberty in rats. Horm. Behav. 2013, 64:357-363.
133. Kramer R.E., Gallant S., Brownie A.C. Actions of angiotensin II on aldosterone biosynthesis in the rat adrenal cortex. Effects on cytochrome P-450 enzymes of the early and late pathway. J. Biol. Chem. 1980, 255:3442-3447.
134. Krishnan K.R., Ritchie J.C., Saunders W., Wilson W., Nemeroff C.B., Carroll B.J. Nocturnal and early morning secretion of ACTH and cortisol in humans. Biol. Psychiatry 1990, 28:47-57.
135. Kudielka B.M., Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biol. Psychol. 2005, 69:113-132.
136. Kudielka B.M., Buske-Kirschbaum A., Hellhammer D.H., Kirschbaum C. HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender. Psychoneuroendocrinology 2004, 29:83-98.
137. Kullmann M., Schneikert J., Moll J., Heck S., Zeiner M., Gehring U., Cato A.C. RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis. J. Biol. Chem. 1998, 273:14620-14625.
138. Kumar R., Volk D.E., Li J., Lee J.C., Gorenstein D.G., Thompson E.B. TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain. Proc. Natl. Acad. Sci. USA 2004, 101:16425-16430.
139. Kumsta R., Entringer S., Hellhammer D.H., Wust S. Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels. Psychoneuroendocrinology 2007, 32:1153-1157.
140. Kurihara I., Shibata H., Suzuki T., Ando T., Kobayashi S., Hayashi M., Saito I., Saruta T. Transcriptional regulation of steroid receptor coactivator-1 (SRC-1) in glucocorticoid action. Endocr. Res. 2000, 26:1033-1038.
141. 2+ entry in corticotropes is partially dependent on protein kinase A. Endocrinology 1995, 136:3925-3935.
142. 2+ channels in rat corticotropes. Endocrinology 1996, 137:2269-2277.
143. La Baer J., Yamamoto K.R. Analysis of the DNA-binding affinity, sequence specificity and context dependence of the glucocorticoid receptor zinc finger region. J. Mol. Biol. 1994, 239:664-688.
144. Lamberts S.W., Verleun T., Oosterom R., de Jong F., Hackeng W.H. Corticotropin-releasing factor (ovine) and vasopressin exert a synergistic effect on adrenocorticotropin release in man. J. Clin. Endocrinol. Metab. 1984, 58:298-303.
145. Lawson E.A., Donoho D., Miller K.K., Misra M., Meenaghan E., Lydecker J., Wexler T., Herzog D.B., Klibanski A. Hypercortisolemia is associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa. J. Clin. Endocrinol. Metab. 2009, 94:4710-4716.
146. Lawson E.A., Miller K.K., Bredella M.A., Phan C., Misra M., Meenaghan E., Rosenblum L., Donoho D., Gupta R., Klibanski A. Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa. Bone 2010, 46:458-463.
147. Leavitt M.G., Aberdeen G.W., Burch M.G., Albrecht E.D., Pepe G.J. Inhibition of fetal adrenal adrenocorticotropin receptor messenger ribonucleic acid expression by betamethasone administration to the baboon fetus in late gestation. Endocrinology 1997, 138:2705-2712.
148. Li X.F., Bowe J.E., Kinsey-Jones J.S., Brain S.D., Lightman S.L., O'Byrne K.T. Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female rat. J. Neuroendocrinol. 2006, 18:602-610.
149. Li X.F., Kinsey-Jones J.S., Cheng Y., Knox A.M., Lin Y., Petrou N.A., Roseweir A., Lightman S.L., Milligan S.R., Millar R.P., O'Byrne K.T. Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS One 2009, 4:e8334.
150. Li X.F., Knox A.M., O'Byrne K.T. Corticotrophin-releasing factor and stress-induced inhibition of the gonadotrophin-releasing hormone pulse generator in the female. Brain Res. 2010, 1364:153-163.
151. Libertun C., Lau C. Adrenocortical function in prepuberal rats: neonatal effects of testosterone. J. Endocrinol. 1972, 55:221-222.
152. Lin H.Y., Underhill C., Gardill B.R., Muller Y.A., Hammond G.L. Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage. J. Biol. Chem. 2009, 284:884-896.
153. Liu Z., Simpson E.R. Steroidogenic factor 1 (SF-1) and SP1 are required for regulation of bovine CYP11A gene expression in bovine luteal cells and adrenal Y1 cells. Mol. Endocrinol. 1997, 11:127-137.
154. LoCascio V., Bonucci E., Imbimbo B., Ballanti P., Adami S., Milani S., Tartarotti D., DellaRocca C. Bone loss in response to long-term glucocorticoid therapy. Bone Miner. 1990, 8:39-51.
155. Lundberg U. Sex differences in behaviour pattern and catecholamine and cortisol excretion in 3-6year old day-care children. Biol. Psychol. 1983, 16:109-117.
156. Lupien S.J., de Leon M., de Santi S., Convit A., Tarshish C., Nair N.P., Thakur M., McEwen B.S., Hauger R.L., Meaney M.J. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat. Neurosci. 1998, 1:69-73.
157. Lupien S.J., McEwen B.S., Gunnar M.R., Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat. Rev. Neurosci. 2009, 10:434-445.
158. Ma S., Morilak D.A. Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress. J. Neuroendocrinol. 2005, 17:22-28.
159. MacAdams M.R., White R.H., Chipps B.E. Reduction of serum testosterone levels during chronic glucocorticoid therapy. Ann. Intern. Med. 1986, 104:648-651.
160. Macleod S.C., Morse W.I., Hirsch S., Tompkins M.G., Jacey G. Oligomenorrhea. A double blind study of the effects of prednisone and placebo. Am. J. Obstet. Gynecol. 1964, 89:642-645.
161. Magenis R.E., Smith L., Nadeau J.H., Johnson K.R., Mountjoy K.G., Cone R.D. Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. Mamm. Genome 1994, 5:503-508.
162. Malendowicz L.K., Mlynarczyk W. Sex differences in adrenocortical structure and function. X. Lipid and corticosterone in the rat adrenal as affected by gonadectomy and testosterone or estradiol replacement. Endokrinologie 1982, 79:292-300.
163. Marin P., Darin N., Amemiya T., Andersson B., Jern S., Bjorntorp P. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 1992, 41:882-886.
164. Markovic D., Papadopoulou N., Teli T., Randeva H., Levine M.A., Hillhouse E.W., Grammatopoulos D.K. Differential responses of corticotropin-releasing hormone receptor type 1 variants to protein kinase C phosphorylation. J. Pharmacol. Exp. Ther. 2006, 319:1032-1042.
165. Marsh J.W., Vehe K.L., White H.M. Immunosuppressants. Gastroenterol. Clin. North Am. 1992, 21:679-693.
166. Mataradze G.D., Kurabekova R.M., Rozen V.B. The role of sex steroids in the formation of sex-differentiated concentrations of corticosteroid-binding globulin in rats. J. Endocrinol. 1992, 132:235-240.
167. Matthews K.A., Davis M.C., Stoney C.M., Owens J.F., Caggiula A.R. Does the gender relevance of the stressor influence sex differences in psychophysiological responses?. Health Psychol. 1991, 10:112-120.
168. Matthews K.A., Gump B.B., Owens J.F. Chronic stress influences cardiovascular and neuroendocrine responses during acute stress and recovery, especially in men. Health Psychol. 2001, 20:403-410.
169. McCormick C.M., Mahoney E. Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats. Horm. Behav. 1999, 35:90-101.
170. McCormick C.M., Furey B.F., Child M., Sawyer M.J., Donohue S.M. Neonatal sex hormones have "organizational" effects on the hypothalamic-pituitary-adrenal axis of male rats. Brain Res. Dev. Brain Res. 1998, 105:295-307.
171. McEwen B.S. Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol. Aging 2002, 23:921-939.
172. McEwen B.S. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol. Rev. 2007, 87:873-904.
173. McNally J.G., Muller W.G., Walker D., Wolford R., Hager G.L. The glucocorticoid receptor: rapid exchange with regulatory sites in living cells. Science 2000, 287:1262-1265.
174. Merali Z., Anisman H., James J.S., Kent P., Schulkin J. Effects of corticosterone on corticotrophin-releasing hormone and gastrin-releasing peptide release in response to an aversive stimulus in two regions of the forebrain (central nucleus of the amygdala and prefrontal cortex). Eur. J. Neurosci. 2008, 28:165-172.
175. Mesiano S., Jaffe R.B. Developmental and functional biology of the primate fetal adrenal cortex. Endocr. Rev. 1997, 18:378-403.
176. Meyer A.H., Ullmer C., Schmuck K., Morel C., Wishart W., Lubbert H., Engels P. Localization of the human CRF2 receptor to 7p21-p15 by radiation hybrid mapping and FISH analysis. Genomics 1997, 40:189-190.
177. Michelson D., Stratakis C., Hill L., Reynolds J., Galliven E., Chrousos G., Gold P. Bone mineral density in women with depression. N. Engl. J. Med. 1996, 335:1176-1181.
178. Millan M.A., Samra A.B., Wynn P.C., Catt K.J., Aguilera G. Receptors and actions of corticotropin-releasing hormone in the primate pituitary gland. J. Clin. Endocrinol. Metab. 1987, 64:1036-1041.
179. Miller W.L., Achermann J.C., Fluck C.E. The adrenal cortex and its disorders. Pediatric Endocrinology 2008, 487-489. Saunders, Philadelphia. M. Sperling (Ed.).
180. Mitchell J.C., Li X.F., Breen L., Thalabard J.C., O'Byrne K.T. The role of the locus coeruleus in corticotropin-releasing hormone and stress-induced suppression of pulsatile luteinizing hormone secretion in the female rat. Endocrinology 2005, 146:323-331.
181. Mizuno H., Uemura K., Moriyama A., Wada Y., Asai K., Kimura S., Kato T. Glucocorticoid induced the expression of mRNA and the secretion of lipocortin 1 in rat astrocytoma cells. Brain Res. 1997, 746:256-264.
182. Mountjoy K.G., Robbins L.S., Mortrud M.T., Cone R.D. The cloning of a family of genes that encode the melanocortin receptors. Science 1992, 257:1248-1251.
183. Muller F., O'Rahilly R. The development of the human brain from a closed neural tube at stage 13. Anat. Embryol. (Berl.) 1988, 177:203-224.
184. Musa B.U., Seal U.S., Doe R.P. Elevation of certain plasma proteins in man following estrogen administration: a dose-response relationship. J. Clin. Endocrinol. Metab. 1965, 25:1163-1166.
185. Myers D.A., McDonald T.J., Dunn T.G., Moss G.E., Nathanielsz P.W. Effect of implantation of dexamethasone adjacent to the paraventricular nucleus on messenger ribonucleic acid for corticotropin-releasing hormone and proopiomelanocortin during late gestation in fetal sheep. Endocrinology 1992, 130:2167-2172.
186. Naville D., Bordet E., Berthelon M.C., Durand P., Begeot M. Activator protein-1 is necessary for angiotensin-II stimulation of human adrenocorticotropin receptor gene transcription. Eur. J. Biochem. 2001, 268:1802-1810.
187. Netter F.H. Atlas of Human Anatomy 2010, Saunders/Elsevier, Philadelphia, PA.
188. Niijima A., Winter D.L. The effect of catecholamines on unit activity in afferent nerves from the adrenal glands. J. Physiol. 1968, 195:647-656.
189. Niijima A., Winter D.L. Baroreceptors in the adrenal gland. Science 1968, 159:434-435.
190. Oakley A.E., Breen K.M., Clarke I.J., Karsch F.J., Wagenmaker E.R., Tilbrook A.J. Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: influence of ovarian steroids. Endocrinology 2009, 150:341-349.
191. O'Byrne K.T., Lunn S.F., Dixson A.F. Naloxone reversal of stress-induced suppression of LH release in the common marmoset. Physiol. Behav. 1989, 45:1077-1080.
192. Oldehinkel A.J., Bouma E.M. Sensitivity to the depressogenic effect of stress and HPA-axis reactivity in adolescence: a review of gender differences. Neurosci. Biobehav. Rev. 2011, 35:1757-1770.
193. Orr T.E., Mann D.R. Role of glucocorticoids in the stress-induced suppression of testicular steroidogenesis in adult male rats. Horm. Behav. 1992, 26:350-363.
194. Orth D.N., Mount C.D. Specific high-affinity binding protein for human corticotropin-releasing hormone in normal human plasma. Biochem. Biophys. Res. Commun. 1987, 143:411-417.
195. Ota M., Hori H., Sato N., Sasayama D., Hattori K., Teraishi T., Obu S., Nakata Y., Kunugi H. Hypothalamic-pituitary-adrenal axis hyperactivity and brain differences in healthy women. Neuropsychobiology 2013, 68:205-211.
196. Otte C., Hart S., Neylan T.C., Marmar C.R., Yaffe K., Mohr D.C. A meta-analysis of cortisol response to challenge in human aging: importance of gender. Psychoneuroendocrinology 2005, 30:80-91.
197. Owen J.A. Physiology of the menstrual cycle. Am. J. Clin. Nutr. 1975, 28:333-338.
198. Palkovits M. Anatomy of neural pathways affecting CRH secretion. Ann. N. Y. Acad. Sci. 1987, 512:139-148.
199. Papanicolaou D.A., Yanovski J.A., Cutler G.B., Chrousos G.P., Nieman L.K. A single midnight serum cortisol measurement distinguishes Cushing's syndrome from pseudo-Cushing states. J. Clin. Endocrinol. Metab. 1998, 83:1163-1167.
200. Pasquali R., Cantobelli S., Casimirri F., Capelli M., Bortoluzzi L., Flamia R., Labate A.M., Barbara L. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J. Clin. Endocrinol. Metab. 1993, 77:341-346.
201. Peattie D.A., Harding M.W., Fleming M.A., DeCenzo M.T., Lippke J.A., Livingston D.J., Benasutti M. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. Proc. Natl. Acad. Sci. USA 1992, 89:10974-10978.
202. Peeters F., Nicholson N.A., Berkhof J. Cortisol responses to daily events in major depressive disorder. Psychosom. Med. 2003, 65:836-841.
203. Peiffer A., Barden N. Estrogen-induced decrease of glucocorticoid receptor messenger ribonucleic acid concentration in rat anterior pituitary gland. Mol. Endocrinol. 1987, 1:435-440.
204. Penhoat A., Jaillard C., Saez J.M. Corticotropin positively regulates its own receptors and cAMP response in cultured bovine adrenal cells. Proc. Natl. Acad. Sci. USA 1989, 86:4978-4981.
205. Perogamvros I., Ray D.W., Trainer P.J. Regulation of cortisol bioavailability - effects on hormone measurement and action. Nat. Rev. Endocrinol. 2012, 8:717-727.
206. Perrin M.H., Vale W.W. Corticotropin releasing factor receptors and their ligand family. Ann. N. Y. Acad. Sci. 1999, 885:312-328.
207. Pesonen A.K., Raikkonen K., Feldt K., Heinonen K., Osmond C., Phillips D.I., Barker D.J., Eriksson J.G., Kajantie E. Childhood separation experience predicts HPA axis hormonal responses in late adulthood: a natural experiment of World War II. Psychoneuroendocrinology 2010, 35:758-767.
208. Picard-Hagen N., Penhoat A., Hue D., Jaillard C., Durand P. Glucocorticoids enhance corticotropin receptor mRNA levels in ovine adrenocortical cells. J. Mol. Endocrinol. 1997, 19:29-36.
209. Pilkis S.J., Granner D.K. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu. Rev. Physiol. 1992, 54:885-909.
210. Polymeropoulos M.H., Torres R., Yanovski J.A., Chandrasekharappa S.C., Ledbetter D.H. The human corticotropin-releasing factor receptor (CRHR) gene maps to chromosome 17q12-q22. Genomics 1995, 28:123-124.
211. Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., Vale W.W. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Nature 1991, 349:423-426.
212. Qureshi A.C., Bahri A., Breen L.A., Barnes S.C., Powrie J.K., Thomas S.M., Carroll P.V. The influence of the route of oestrogen administration on serum levels of cortisol-binding globulin and total cortisol. Clin. Endocrinol. (Oxf.) 2007, 66:632-635.
213. Ratajczak T., Ward B.K., Minchin R.F. Immunophilin chaperones in steroid receptor signalling. Curr. Top. Med. Chem. 2003, 3:1348-1357.
214. Reynolds R.M., Hii H.L., Pennell C.E., McKeague I.W., Kloet E.R., Lye S., Stanley F.J., Mattes E., Foster J.K. Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis. Psychoneuroendocrinology 2013, 38:1271-1280.
215. Riddell D.C., Mallonee R., Phillips J.A., Parks J.S., Sexton L.A., Hamerton J.L. Chromosomal assignment of human sequences encoding arginine vasopressin-neurophysin II and growth hormone releasing factor. Somat. Cell Mol. Genet. 1985, 11:189-195.
216. Rivier C.L., Plotsky P.M. Mediation by corticotropin releasing factor (CRF) of adenohypophysial hormone secretion. Annu. Rev. Physiol. 1986, 48:475-494.
217. Rivier C., Brownstein M., Spiess J., Rivier J., Vale W. In vivo corticotropin-releasing factor-induced secretion of adrenocorticotropin, beta-endorphin, and corticosterone. Endocrinology 1982, 110:272-278.
218. Rivier C., Rivier J., Vale W. Stress-induced inhibition of reproductive functions: role of endogenous corticotropin-releasing factor. Science 1986, 231:607-609.
219. Rizza R.A., Mandarino L.J., Gerich J.E. Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action. J. Clin. Endocrinol. Metab. 1982, 54:131-138.
220. Robinson B.G., D'Angio L.A., Pasieka K.B., Majzoub J.A. Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing. Mol. Cell. Endocrinol. 1989, 61:175-180.
221. Roelfsema F., van den Berg G., Frolich M., Veldhuis J.D., van Eijk A., Buurman M.M., Etman B.H. Sex-dependent alteration in cortisol response to endogenous adrenocorticotropin. J. Clin. Endocrinol. Metab. 1993, 77:234-240.
222. Romeo R.D. Pubertal maturation and programming of hypothalamic-pituitary-adrenal reactivity. Front. Neuroendocrinol. 2010, 31:232-240.
223. Rosmond R., Dallman M.F., Bjorntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J. Clin. Endocrinol. Metab. 1998, 83:1853-1859.
224. Rubin M., Safdieh J.E., Netter F.H. Netter's Concise Neuroanatomy 2007, Saunders/Elsevier, Philadelphia.
225. Russell G.M., Henley D.E., Leendertz J., Douthwaite J.A., Wood S.A., Stevens A., Woltersdorf W.W., Peeters B.W., Ruigt G.S., White A., Veldhuis J.D., Lightman S.L. Rapid glucocorticoid receptor-mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males. J. Neurosci. 2010, 30:6106-6115.
226. Rybak S.M., Ramachandran J. Mechanism of induction of delta 5-3 beta-hydroxysteroid dehydrogenase-isomerase activity in rat adrenocortical cells by corticotropin. Endocrinology 1982, 111:427-433.
227. Sadler T.W. Embryology of neural tube development. Am. J. Med. Genet. C: Semin. Med. Genet. 2005, 135C:2-8.
228. Sakakura M., Takebe K., Nakagawa S. Inhibition of luteinizing hormone secretion induced by synthetic LRH by long-term treatment with glucocorticoids in human subjects. J. Clin. Endocrinol. Metab. 1975, 40:774-779.
229. Santini G., Patrignani P., Sciulli M.G., Seta F., Tacconelli S., Panara M.R., Ricciotti E., Capone M.L., Patrono C. The human pharmacology of monocyte cyclooxygenase 2 inhibition by cortisol and synthetic glucocorticoids. Clin. Pharmacol. Ther. 2001, 70:475-483.
230. Sapolsky R.M. Stress-induced suppression of testicular function in the wild baboon: role of glucocorticoids. Endocrinology 1985, 116:2273-2278.
231. Sapolsky R.M., Zola-Morgan S., Squire L.R. Inhibition of glucocorticoid secretion by the hippocampal formation in the primate. J. Neurosci. 1991, 11:3695-3704.
232. Savory J.G., Hsu B., Laquian I.R., Giffin W., Reich T., Hache R.J., Lefebvre Y.A. Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor. Mol. Cell. Biol. 1999, 19:1025-1037.
233. Sawchenko P.E., Arias C. Evidence for short-loop feedback effects of ACTH on CRF and vasopressin expression in parvocellular neurosecretory neurons. J. Neuroendocrinol. 1995, 7:721-731.
234. Scammell J.G., Denny W.B., Valentine D.L., Smith D.F. Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. Gen. Comp. Endocrinol. 2001, 124:152-165.
235. Schacke H., Docke W.D., Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol. Ther. 2002, 96:23-43.
236. Schakman O., Gilson H., Kalista S., Thissen J.P. Mechanisms of muscle atrophy induced by glucocorticoids. Horm. Res. 2009, 72(Suppl. 1):36-41.
237. Schiene-Fischer C., Yu C. Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. FEBS Lett. 2001, 495:1-6.
238. Schimmer B.P. Adenylate cyclase activity in adrenocorticotropic hormone-sensitive and mutant adrenocortical tumor cell lines. J. Biol. Chem. 1972, 247:3134-3138.
239. Schurmeyer T.H., Avgerinos P.C., Gold P.W., Gallucci W.T., Tomai T.P., Cutler G.B., Loriaux D.L., Chrousos G.P. Human corticotropin-releasing factor in man: pharmacokinetic properties and dose-response of plasma adrenocorticotropin and cortisol secretion. J. Clin. Endocrinol. Metab. 1984, 59:1103-1108.
240. Seale J.V., Wood S.A., Atkinson H.C., Lightman S.L., Harbuz M.S. Organizational role for testosterone and estrogen on adult hypothalamic-pituitary-adrenal axis activity in the male rat. Endocrinology 2005, 146:1973-1982.
241. Shapiro R.A., Xu C., Dorsa D.M. Differential transcriptional regulation of rat vasopressin gene expression by estrogen receptor alpha and beta. Endocrinology 2000, 141:4056-4064.
242. Shibahara S., Morimoto Y., Furutani Y., Notake M., Takahashi H., Shimizu S., Horikawa S., Numa S. Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. EMBO J. 1983, 2:775-779.
243. Siiteri P.K., Murai J.T., Hammond G.L., Nisker J.A., Raymoure W.J., Kuhn R.W. The serum transport of steroid hormones. Recent Prog. Horm. Res. 1982, 38:457-510.
244. Sperling M. Pediatric Endocrinology 2008, Saunders/Elsevier, Philadelphia, PA.
245. Sterrenburg L., Gaszner B., Boerrigter J., Santbergen L., Bramini M., Elliott E., Chen A., Peeters B.W., Roubos E.W., Kozicz T. Chronic stress induces sex-specific alterations in methylation and expression of corticotropin-releasing factor gene in the rat. PLoS One 2011, 6:e28128.
246. Stroud L.R., Salovey P., Epel E.S. Sex differences in stress responses: social rejection versus achievement stress. Biol. Psychiatry 2002, 52:318-327.
247. Suda T., Tomori N., Tozawa F., Mouri T., Demura H., Shizume K. Distribution and characterization of immunoreactive corticotropin-releasing factor in human tissues. J. Clin. Endocrinol. Metab. 1984, 59:861-866.
248. Suh B.Y., Liu J.H., Berga S.L., Quigley M.E., Laughlin G.A., Yen S.S. Hypercortisolism in patients with functional hypothalamic-amenorrhea. J. Clin. Endocrinol. Metab. 1988, 66:733-739.
249. Swanson L.W., Sawchenko P.E., Rivier J., Vale W.W. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 1983, 36:165-186.
250. Tamashiro K.L., Sakai R.R., Shively C.A., Karatsoreos I.N., Reagan L.P. Chronic stress, metabolism, and metabolic syndrome. Stress 2011, 14:468-474.
251. Tout K., de Haan M., Campbell E.K., Gunnar M.R. Social behavior correlates of cortisol activity in child care: gender differences and time-of-day effects. Child Dev. 1998, 69:1247-1262.
252. Tsigos C., Arai K., Hung W., Chrousos G.P. Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene. J. Clin. Invest. 1993, 92:2458-2461.
253. Tsigos C., Arai K., Latronico A.C., DiGeorge A.M., Rapaport R., Chrousos G.P. A novel mutation of the adrenocorticotropin receptor (ACTH-R) gene in a family with the syndrome of isolated glucocorticoid deficiency, but no ACTH-R abnormalities in two families with the triple A syndrome. J. Clin. Endocrinol. Metab. 1995, 80:2186-2189.
254. Tsukamura H., Nagatani S., Cagampang F.R., Kawakami S., Maeda K. Corticotropin-releasing hormone mediates suppression of pulsatile luteinizing hormone secretion induced by activation of alpha-adrenergic receptors in the paraventricular nucleus in female rats. Endocrinology 1994, 134:1460-1466.
255. Unlap T., Jope R.S. Inhibition of NFkB DNA binding activity by glucocorticoids in rat brain. Neurosci. Lett. 1995, 198:41-44.
256. Vale W., Spiess J., Rivier C., Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 1981, 213:1394-1397.
257. Vamvakopoulos N.C., Chrousos G.P. Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction. J. Clin. Invest. 1993, 92:1896-1902.
258. Veldhuis J.D., Iranmanesh A., Johnson M.L., Lizarralde G. Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man. J. Clin. Endocrinol. Metab. 1990, 71:452-463.
259. Viau V. Functional cross-talk between the hypothalamic-pituitary-gonadal and -adrenal axes. J. Neuroendocrinol. 2002, 14:506-513.
260. Viau V., Meaney M.J. Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat. Endocrinology 1991, 129:2503-2511.
261. Visser M., Swaab D.F. Life span changes in the presence of alpha-melanocyte-stimulating-hormone-containing cells in the human pituitary. J. Dev. Physiol. 1979, 1:161-178.
262. Vlahos R., Stewart A.G. Interleukin-1alpha and tumour necrosis factor-alpha modulate airway smooth muscle DNA synthesis by induction of cyclo-oxygenase-2: inhibition by dexamethasone and fluticasone propionate. Br. J. Pharmacol. 1999, 126:1315-1324.
263. Walker C.D., Perrin M., Vale W., Rivier C. Ontogeny of the stress response in the rat: role of the pituitary and the hypothalamus. Endocrinology 1986, 118:1445-1451.
264. Walsh D.A., Van Patten S.M. Multiple pathway signal transduction by the cAMP-dependent protein kinase. FASEB J 1994, 8:1227-1236.
265. Watts A.G., Swanson L.W. Efferent projections of the suprachiasmatic nucleus: II. Studies using retrograde transport of fluorescent dyes and simultaneous peptide immunohistochemistry in the rat. J. Comp. Neurol. 1987, 258:230-252.
266. Weinstein S.P., Wilson C.M., Pritsker A., Cushman S.W. Dexamethasone inhibits insulin-stimulated recruitment of GLUT4 to the cell surface in rat skeletal muscle. Metabolism 1998, 47:3-6.
267. Weiser M.J., Handa R.J. Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic-pituitary-adrenal axis via estrogen receptor alpha within the hypothalamus. Neuroscience 2009, 159:883-895.
268. Wochnik G.M., Ruegg J., Abel G.A., Schmidt U., Holsboer F., Rein T. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J. Biol. Chem. 2005, 280:4609-4616.
269. Wolf O.T., Convit A., de Leon M.J., Caraos C., Qadri S.F. Basal hypothalamo-pituitary-adrenal axis activity and corticotropin feedback in young and older men: relationships to magnetic resonance imaging-derived hippocampus and cingulate gyrus volumes. Neuroendocrinology 2002, 75:241-249.
270. Wolfram M., Bellingrath S., Kudielka B.M. The cortisol awakening response (CAR) across the female menstrual cycle. Psychoneuroendocrinology 2011, 36:905-912.
271. Won J.G., Orth D.N. Roles of intracellular and extracellular calcium in the kinetic profile of adrenocorticotropin secretion by perifused rat anterior pituitary cells. I. Corticotropin-releasing factor stimulation. Endocrinology 1990, 126:849-857.
272. Wynn P.C., Harwood J.P., Catt K.J., Aguilera G. Regulation of corticotropin-releasing factor (CRF) receptors in the rat pituitary gland: effects of adrenalectomy on CRF receptors and corticotroph responses. Endocrinology 1985, 116:1653-1659.
273. Wynn P.C., Harwood J.P., Catt K.J., Aguilera G. Corticotropin-releasing factor (CRF) induces desensitization of the rat pituitary CRF receptor-adenylate cyclase complex. Endocrinology 1988, 122:351-358.
274. Yang J., Liu J., DeFranco D.B. Subnuclear trafficking of glucocorticoid receptors in vitro: chromatin recycling and nuclear export. J. Cell Biol. 1997, 137:523-538.
275. Yerkes R.M., Dodson J.D. The relation of strength of stimulus to rapidity of habit formation. J. Comp. Neurol. Psychol. 1908, 459-482.
276. Young E.A., Abelson J., Lightman S.L. Cortisol pulsatility and its role in stress regulation and health. Front. Neuroendocrinol. 2004, 25:69-76.
277. Young E.A., Abelson J.L., Cameron O.G. Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depression. Biol. Psychiatry 2004, 56:113-120.
278. Yudt M.R., Cidlowski J.A. Molecular identification and characterization of a and b forms of the glucocorticoid receptor. Mol. Endocrinol. 2001, 15:1093-1103.
279. Yuen K.C., Chong L.E., Riddle M.C. Influence of glucocorticoids and growth hormone on insulin sensitivity in humans. Diabet. Med. 2013, 30:651-663.
280. Zabel B.U., Naylor S.L., Sakaguchi A.Y., Bell G.I., Shows T.B. High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization. Proc. Natl. Acad. Sci. USA 1983, 80:6932-6936.
281. Zimmerman E.A. The distribution of some identified peptide-containing pathways in the central nervous system including the basal ganglia. Prog. Clin. Biol. Res. 1981, 68:117-125.