Nogo-A: Multiple roles in CNS development, maintenance, and disease

Neuroscientist

Volumn 20, Issue 4, 2014, Pages 372-386

  Schmandke, Antonio ^a,b   Schmandke, Andre ^a,b   Schwab, Martin E ^a,b  

^a University of Zurich Brain Research Institute   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

ALS; Alzheimer's; CNS; development; disease; multiple sclerosis; Nogo A; schizophrenia; spinal cord injury; stroke

Indexed keywords

EID: 84903781258     PISSN: 10738584     EISSN: 10894098     Source Type: Journal    
DOI: 10.1177/1073858413516800     Document Type: Review

References (102)

1. Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K. Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat Neurosci. 2001 ; 4 (4). 367-73
2. Akbik FV, Bhagat SM, Patel PR, Cafferty WB, Strittmatter SM. Anatomical plasticity of adult brain is titrated by Nogo Receptor 1. Neuron. 2013 ; 77 (5). 859-66
3. Aloy EM, Weinmann O, Pot C, Kasper H, Dodd DA, Rulicke T. Synaptic destabilization by neuronal Nogo-A. Brain Cell Biol. 2006 ; 35 (2-3). 137-56
4. Amano M, Chihara K, Nakamura N, Fukata Y, Yano T, Shibata M. Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase. Genes Cells. 1998 ; 3 (3). 177-88
5. Atwal JK, Pinkston-Gosse J, Syken J, Stawicki S, Wu Y, Shatz C. PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science. 2008 ; 322 (5903). 967-70
6. Bamburg JR, Bernstein BW. Roles of ADF/cofilin in actin polymerization and beyond. F1000 Biol Rep. 2010 ; 2: 62
7. Budel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci. 2008 ; 28 (49). 13161-72
8. Buffo A, Zagrebelsky M, Huber AB, Skerra A, Schwab ME, Strata P. Application of neutralizing antibodies against NI-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured purkinje cell axons. J Neurosci. 2000 ; 20 (6). 2275-86
9. Caroni P, Schwab ME. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron. 1988a ; 1 (1). 85-96
10. Caroni P, Schwab ME. Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J Cell Biol. 1988b ; 106 (4). 1281-8
11. Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature. 2000 ; 403 (6768). 434-9
12. Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT. Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A. 2012 ; 109 (4). 1299-304
13. David S, Aguayo AJ. Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science. 1981 ; 214 (4523). 931-3
14. Delekate A, Zagrebelsky M, Kramer S, Schwab ME, Korte M. NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale. Proc Natl Acad Sci U S A. 2011 ; 108 (6). 2569-74
15. Dodd DA, Niederoest B, Bloechlinger S, Dupuis L, Loeffler JP, Schwab ME. Nogo-A, -B, and -C are found on the cell surface and interact together in many different cell types. J Biol Chem. 2005 ; 280 (13). 12494-502
16. Domeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang K, Nikulina E. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron. 2002 ; 35 (2). 283-90
17. Duffy P, Schmandke A, Schmandke A, Sigworth J, Narumiya S, Cafferty WB. Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord. J Neurosci. 2009 ; 29 (48). 15266-76
18. Dupuis L, Gonzalez de Aguilar JL, di Scala F, Rene F, de Tapia M, Pradat PF. Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis. Neurobiol Dis. 2002 ; 10 (3). 358-65
19. Emerick AJ, Neafsey EJ, Schwab ME, Kartje GL. Functional reorganization of the motor cortex in adult rats after cortical lesion and treatment with monoclonal antibody IN-1. J Neurosci. 2003 ; 23 (12). 4826-30
20. Fontoura P, Ho PP, DeVoss J, Zheng B, Lee BJ, Kidd BA. Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J Immunol. 2004 ; 173 (11). 6981-92
21. Fournier AE, GrandPre T, Strittmatter SM. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001 ; 409 (6818). 341-6
22. Glenner GG, Wong CW, Quaranta V, Eanes ED. The amyloid deposits in Alzheimer's disease: their nature and pathogenesis. Appl Pathol. 1984 ; 2 (6). 357-69
23. GrandPre T, Li S, Strittmatter SM. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature. 2002 ; 417 (6888). 547-51
24. GrandPre T, Nakamura F, Vartanian T, Strittmatter SM. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature. 2000 ; 403 (6768). 439-44
25. He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R. Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nat Med. 2004 ; 10 (9). 959-65
26. Hsieh SH, Ferraro GB, Fournier AE. Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase. J Neurosci. 2006 ; 26 (3). 1006-15
27. Hu F, Strittmatter SM. The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism. J Neurosci. 2008 ; 28 (5). 1262-9
28. Huber AB, Weinmann O, Brosamle C, Oertle T, Schwab ME. Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions. J Neurosci. 2002 ; 22 (9). 3553-67
29. Huebner EA, Kim BG, Duffy PJ, Brown RH, Strittmatter SM. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. J Biol Chem. 2011 ; 286 (20). 18026-36
30. Jokic N, Gonzalez de Aguilar JL, Dimou L, Lin S, Fergani A, Ruegg MA. The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. EMBO Rep. 2006 ; 7 (11). 1162-7
31. Joset A, Dodd DA, Halegoua S, Schwab ME. Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling. J Cell Biol. 2010 ; 188 (2). 271-85
32. Karlen A, Karlsson TE, Mattsson A, Lundstromer K, Codeluppi S, Pham TM. Nogo receptor 1 regulates formation of lasting memories. Proc Natl Acad Sci U S A. 2009 ; 106 (48). 20476-81
33. Karnezis T, Mandemakers W, McQualter JL, Zheng B, Ho PP, Jordan KA. The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat Neurosci. 2004 ; 7 (7). 736-44
34. Kartje GL, Schulz MK, Lopez-Yunez A, Schnell L, Schwab ME. Corticostriatal plasticity is restricted by myelin-associated neurite growth inhibitors in the adult rat. Ann Neurol. 1999 ; 45 (6). 778-86
35. Kempf A, Schwab ME. Nogo-A represses anatomical and synaptic plasticity in the central nervous system. Physiology (Bethesda). 2013 ; 28 (3). 151-63
36. Kim JE, Liu BP, Park JH, Strittmatter SM. Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron. 2004 ; 44 (3). 439-51
37. Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y. Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. J Neurosci. 2008 ; 28 (11). 2753-65
38. Lee JK, Kim JE, Sivula M, Strittmatter SM. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci. 2004 ; 24 (27). 6209-17
39. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet. 2003 ; 73 (1). 34-48
40. Li M, Shi J, Wei Z, Teng FY, Tang BL, Song J. Structural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration. Eur J Biochem. 2004a ; 271 (17). 3512-22
41. Li M, Song J. The N- and C-termini of the human Nogo molecules are intrinsically unstructured: bioinformatics, CD, NMR characterization, and functional implications. Proteins. 2007 ; 68 (1). 100-8
42. Li S, Liu BP, Budel S, Li M, Ji B, Walus L. Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. J Neurosci. 2004b ; 24 (46). 10511-20
43. Liebscher T, Schnell L, Schnell D, Scholl J, Schneider R, Gullo M. Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Ann Neurol. 2005 ; 58 (5). 706-19
44. Lindau N.T., Bänninger B.J., Gullo M., Good N.A., Bachmann L.C., Starkey M.L., Schwab M.E.. Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy. Brain. 2013 ;:
45. Liu J, Juo SH, Dewan A, Grunn A, Tong X, Brito M. Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12. Mol Psychiatry. 2003a ; 8 (3). 333-42
46. Liu YY, Jin WL, Liu HL, Ju G. Electron microscopic localization of Nogo-A at the postsynaptic active zone of the rat. Neurosci Lett. 2003b ; 346 (3). 153-6
47. Markus TM, Tsai SY, Bollnow MR, Farrer RG, O'Brien TE, Kindler-Baumann DR. Recovery and brain reorganization after stroke in adult and aged rats. Ann Neurol. 2005 ; 58 (6). 950-3
48. Mathis C, Schroter A, Thallmair M, Schwab ME. Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cereb Cortex. 2010 ; 20 (10). 2380-90
49. McDonald CL, Steinbach K, Kern F, Schweigreiter R, Martin R, Bandtlow CE. Nogo receptor is involved in the adhesion of dendritic cells to myelin. J Neuroinflammation. 2011 ; 8: 113
50. McGee AW, Yang Y, Fischer QS, Daw NW, Strittmatter SM. Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor. Science. 2005 ; 309 (5744). 2222-6
51. Meng Y, Zhang Y, Tregoubov V, Janus C, Cruz L, Jackson M. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron. 2002 ; 35 (1). 121-33
52. Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci. 2004 ; 7 (3). 221-8
53. Mimura F, Yamagishi S, Arimura N, Fujitani M, Kubo T, Kaibuchi K. Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. J Biol Chem. 2006 ; 281 (23). 15970-9
54. Mingorance-Le Meur A, Zheng B, Soriano E, del Rio JA. Involvement of the myelin-associated inhibitor Nogo-A in early cortical development and neuronal maturation. Cereb Cortex. 2007 ; 17 (10). 2375-86
55. Montani L, Gerrits B, Gehrig P, Kempf A, Dimou L, Wollscheid B. Neuronal Nogo-A modulates growth cone motility via Rho-GTP/LIMK1/cofilin in the unlesioned adult nervous system. J Biol Chem. 2009 ; 284 (16). 10793-807
56. Nash M, Pribiag H, Fournier AE, Jacobson C. Central nervous system regeneration inhibitors and their intracellular substrates. Mol Neurobiol. 2009 ; 40 (3). 224-35
57. Niederost B, Oertle T, Fritsche J, McKinney RA, Bandtlow CE. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. J Neurosci. 2002 ; 22 (23). 10368-76
58. Novak G, Kim D, Seeman P, Tallerico T. Schizophrenia and Nogo: elevated mRNA in cortex, and high prevalence of a homozygous CAA insert. Brain Res Mol Brain Res. 2002 ; 107 (2). 183-9
59. Oertle T, van der Haar ME, Bandtlow CE, Robeva A, Burfeind P, Buss A. Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions. J Neurosci. 2003 ; 23 (13). 5393-406
60. Park JB, Yiu G, Kaneko S, Wang J, Chang J, He XL. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron. 2005 ; 45 (3). 345-51
61. Park JH, Gimbel DA, GrandPre T, Lee JK, Kim JE, Li W. Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci. 2006a ; 26 (5). 1386-95
62. Park JH, Widi GA, Gimbel DA, Harel NY, Lee DH, Strittmatter SM. Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice. J Neurosci. 2006b ; 26 (51). 13279-86
63. Pernet V, Joly S, Christ F, Dimou L, Schwab ME. Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation. J Neurosci. 2008 ; 28 (29). 7435-44
64. Petrinovic MM, Duncan CS, Bourikas D, Weinman O, Montani L, Schroeter A. Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system. Development. 2010 ; 137 (15). 2539-50
65. Petrinovic MM, Hourez R, Aloy EM, Dewarrat G, Gall D, Weinmann O. Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum. Proc Natl Acad Sci U S A. 2013 ; 110 (3). 1083-8
66. Pradat PF, Bruneteau G, Gonzalez de Aguilar JL, Dupuis L, Jokic N, Salachas F. Muscle Nogo-A expression is a prognostic marker in lower motor neuron syndromes. Ann Neurol. 2007 ; 62 (1). 15-20
67. Prinjha R, Moore SE, Vinson M, Blake S, Morrow R, Christie G. Inhibitor of neurite outgrowth in humans. Nature. 2000 ; 403 (6768). 383-4
68. Raiker SJ, Lee H, Baldwin KT, Duan Y, Shrager P, Giger RJ. Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. J Neurosci. 2010 ; 30 (37). 12432-45
69. Raineteau O, Fouad K, Noth P, Thallmair M, Schwab ME. Functional switch between motor tracts in the presence of the mAb IN-1 in the adult rat. Proc Natl Acad Sci U S A. 2001 ; 98 (12). 6929-34
70. Rex CS, Chen LY, Sharma A, Liu J, Babayan AH, Gall CM. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol. 2009 ; 186 (1). 85-97
71. Rolando C, Parolisi R, Boda E, Schwab ME, Rossi F, Buffo A. Distinct roles of Nogo-a and Nogo receptor 1 in the homeostatic regulation of adult neural stem cell function and neuroblast migration. J Neurosci. 2012 ; 32 (49). 17788-9
72. Satoh J, Onoue H, Arima K, Yamamura T. Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis. J Neuropathol Exp Neurol. 2005 ; 64 (2). 129-38
73. Savio T, Schwab ME. Rat CNS white matter, but not gray matter, is nonpermissive for neuronal cell adhesion and fiber outgrowth. J Neurosci. 1989 ; 9 (4). 1126-33
74. Schmandke A, Mosberger AC, Schmandke A, Celen Z, Schwab ME. The neurite growth inhibitory protein Nogo-A has diverse roles in adhesion and migration. Cell Adhesion Migration. 2013a ; 7 (6). 1
75. Schmandke A, Schmandke A, Pietro MA, Schwab ME. An open source based high content screening method for cell biology laboratories investigating cell spreading and adhesion. PLoS One. 2013b ; 8 (10). e78212
76. Schmandke A, Schmandke A, Strittmatter SM. ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist.. 2007 ; 13 (5). 454-69
77. Schnell L, Schwab ME. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature. 1990 ; 343 (6255). 269-72
78. Schwab ME. Functions of Nogo proteins and their receptors in the nervous system. Nat Rev Neurosci. 2010 ; 11 (12). 799-811
79. Schwab ME, Caroni P. Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro. J Neurosci. 1988 ; 8 (7). 2381-93
80. Schwab ME, Schnell L. Channeling of developing rat corticospinal tract axons by myelin-associated neurite growth inhibitors. J Neurosci. 1991 ; 11 (3). 709-21
81. Schwab ME, Thoenen H. Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors. J Neurosci. 1985 ; 5 (9). 2415-23
82. Sickmeier M, Hamilton JA, LeGall T, Vacic V, Cortese MS, Tantos A. DisProt: the database of disordered proteins. Nucleic Acids Res. 2007 ; 35: D786-93
83. Spillmann AA, Bandtlow CE, Lottspeich F, Keller F, Schwab ME. Identification and characterization of a bovine neurite growth inhibitor (bNI-220). J Biol Chem. 1998 ; 273 (30). 19283-93
84. Steinbach K, McDonald CL, Reindl M, Schweigreiter R, Bandtlow C, Martin R. Nogo-receptors NgR1 and NgR2 do not mediate regulation of CD4 T helper responses and CNS repair in experimental autoimmune encephalomyelitis. PLoS One. 2011 ; 6 (11). e26341
85. Su Z, Cao L, Zhu Y, Liu X, Huang Z, Huang A. Nogo enhances the adhesion of olfactory ensheathing cells and inhibits their migration. J Cell Sci. 2007 ; 120 (Pt 11). 1877-87
86. Tews B, Schonig K, Arzt ME, Clementi S, Rioult-Pedotti MS, Zemmar A. Synthetic microRNA-mediated downregulation of Nogo-A in transgenic rats reveals its role as regulator of synaptic plasticity and cognitive function. Proc Natl Acad Sci U S A. 2013 ; 110 (16). 6583-8
87. Theotokis P, Lourbopoulos A, Touloumi O, Lagoudaki R, Kofidou E, Nousiopoulou E. Time course and spatial profile of Nogo-A expression in experimental autoimmune encephalomyelitis in C57BL/6 mice. J Neuropathol Exp Neurol. 2012 ; 71 (10). 907-20
88. Vasudevan SV, Schulz J, Zhou C, Cocco MJ. Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surface. Proc Natl Acad Sci U S A. 2010 ; 107 (15). 6847-51
89. Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA. A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell. 2006 ; 124 (3). 573-86
90. Walchli T, Pernet V, Weinmann O, Shiu JY, Guzik-Kornacka A, Decrey G. Nogo-A is a negative regulator of CNS angiogenesis. Proc Natl Acad Sci U S A. 2013 ; 110 (21). E1943-52
91. Wang J, Chan CK, Taylor JS, Chan SO. The growth-inhibitory protein Nogo is involved in midline routing of axons in the mouse optic chiasm. J Neurosci Res. 2008 ; 86 (12). 2581-90
92. Wang J, Wang L, Zhao H, Chan SO. Localization of an axon growth inhibitory molecule Nogo and its receptor in the spinal cord of mouse embryos. Brain Res. 2010 ; 1306: 8-17
93. Wang KC, Kim JA, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. 2002a ; 420 (6911). 74-8
94. Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 2002b ; 417 (6892). 941-4
95. Wang X, Chun SJ, Treloar H, Vartanian T, Greer CA, Strittmatter SM. Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J Neurosci. 2002c ; 22 (13). 5505-15
96. Wiessner C, Bareyre FM, Allegrini PR, Mir AK, Frentzel S, Zurini M. Anti-Nogo-A antibody infusion 24 hours after experimental stroke improved behavioral outcome and corticospinal plasticity in normotensive and spontaneously hypertensive rats. J Cereb Blood Flow Metab. 2003 ; 23 (2). 154-65
97. Willi R, Schwab ME. Nogo and Nogo receptor: relevance to schizophrenia? Neurobiol Dis.. 2013 ; 54: 150-7
98. Willi R, Weinmann O, Winter C, Klein J, Sohr R, Schnell L. Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes. J Neurosci. 2010 ; 30 (2). 556-67
99. Yan J, Zhou X, Guo JJ, Mao L, Wang YJ, Sun J. Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro. J Neurochem. 2012 ; 120 (5). 721-31
100. Yang YS, Harel NY, Strittmatter SM. Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. J Neurosci. 2009 ; 29 (44). 13850-9
101. Zhou X, Hu X, He W, Tang X, Shi Q, Zhang Z. Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition. FASEB J. 2011 ; 25 (9). 3146-56
102. Zorner B, Schwab ME. Anti-Nogo on the go: from animal models to a clinical trial. Ann N Y Acad Sci. 2010 ; 1198: E22-34