Nogo-receptors NgR1 and NgR2 do not mediate regulation of CD4 t helper responses and cns repair in experimental autoimmune encephalomyelitis

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Steinbach, Karin ^a   McDonald, Claire L ^b   Reindl, Markus ^b   Schweigreiter, Rüdiger ^b   Bandtlow, Christine ^b   Martin, Roland ^a,c  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

NOGO RECEPTOR 1 PROTEIN; NOGO RECEPTOR 2 PROTEIN; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; CD4 ANTIGEN; CELL SURFACE RECEPTOR; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; MAG PROTEIN, MOUSE; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN PROTEIN; OMG PROTEIN, MOUSE; PROTEIN NOGO;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; GENE DELETION; IMMUNOMODULATION; IMMUNOREGULATION; LEUKOCYTE MIGRATION; MOUSE; NERVE REGENERATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; ANIMAL; BRAIN; C57BL MOUSE; CENTRAL NERVOUS SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM;

MUS;

ANIMALS; ANTIGENS, CD4; BRAIN; CENTRAL NERVOUS SYSTEM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GPI-LINKED PROTEINS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MYELIN PROTEINS; MYELIN-ASSOCIATED GLYCOPROTEIN; RECEPTORS, CELL SURFACE; TH1 CELLS; TH17 CELLS;

EID: 80855133561     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026341     Document Type: Article

References (36)

1. Compston A, Coles A, (2008) Multiple sclerosis. Lancet 372: 1502-1517.
2. Sospedra M, Martin R, (2005) Immunology of multiple sclerosis. Annu Rev Immunol 23: 683-747.
3. Kornek B, Storch MK, Weissert R, Wallstroem E, Stefferl A, et al. (2000) Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 157: 267-276.
4. Lovas G, Szilagyi N, Majtenyi K, Palkovits M, Komoly S, (2000) Axonal changes in chronic demyelinated cervical spinal cord plaques. Brain 123 (Pt 2): 308-317.
5. Tallantyre EC, Bo L, Al-Rawashdeh O, Owens T, Polman CH, et al. Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis. Mult Scler 16: 406-411.
6. Schwab ME, (2010) Functions of Nogo proteins and their receptors in the nervous system. Nat Rev Neurosci 11: 799-811.
7. Silver J, Miller JH, (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5: 146-156.
8. Moore DL, Blackmore MG, Hu Y, Kaestner KH, Bixby JL, et al. (2009) KLF family members regulate intrinsic axon regeneration ability. Science 326: 298-301.
9. Fournier AE, GrandPre T, Strittmatter SM, (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409: 341-346.
10. Liu BP, Fournier A, GrandPre T, Strittmatter SM, (2002) Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297: 1190-1193.
11. Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, et al. (2002) Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417: 941-944.
12. Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, et al. (2005) The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. J Neurosci 25: 808-822.
13. Atwal JK, Pinkston-Gosse J, Syken J, Stawicki S, Wu Y, et al. (2008) PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science 322: 967-970.
14. Goh EL, Young JK, Kuwako K, Tessier-Lavigne M, He Z, et al. (2008) beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones. Mol Brain 1: 10.
15. Hu F, Strittmatter SM, (2008) The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism. J Neurosci 28: 1262-1269.
16. Pool M, Niino M, Rambaldi I, Robson K, Bar-Or A, et al. (2009) Myelin regulates immune cell adhesion and motility. Exp Neurol 217: 371-377.
17. Fry EJ, Ho C, David S, (2007) A role for Nogo receptor in macrophage clearance from injured peripheral nerve. Neuron 53: 649-662.
18. Satoh J, Onoue H, Arima K, Yamamura T, (2005) Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis. J Neuropathol Exp Neurol 64: 129-138.
19. David S, Fry EJ, Lopez-Vales R, (2008) Novel roles for Nogo receptor in inflammation and disease. Trends Neurosci 31: 221-226.
20. Fontoura P, Ho PP, DeVoss J, Zheng B, Lee BJ, et al. (2004) Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J Immunol 173: 6981-6992.
21. Karnezis T, Mandemakers W, McQualter JL, Zheng B, Ho PP, et al. (2004) The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat Neurosci 7: 736-744.
22. Yang Y, Liu Y, Wei P, Peng H, Winger R, et al. Silencing Nogo-A promotes functional recovery in demyelinating disease. Ann Neurol 67: 498-507.
23. Zheng B, Atwal J, Ho C, Case L, He XL, et al. (2005) Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A 102: 1205-1210.
24. Worter V, Schweigreiter R, Kinzel B, Mueller M, Barske C, et al. (2009) Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5. PLoS One 4: e5218.
25. McDonald CL, Steinbach K, Kern F, Schweigreiter R, Martin R, et al. Nogo receptor is involved in the adhesion of dendritic cells to myelin. J Neuroinflammation 8: 113.
26. Zhang L, Zheng S, Wu H, Wu Y, Liu S, et al. (2009) Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. J Neurosci 29: 6348-6352.
27. Moore PA, Belvedere O, Orr A, Pieri K, LaFleur DW, et al. (1999) BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285: 260-263.
28. Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, et al. (2000) TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404: 995-999.
29. Gross JA, Dillon SR, Mudri S, Johnston J, Littau A, et al. (2001) TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity 15: 289-302.
30. Di Lorenzo A, Manes TD, Davalos A, Wright PL, Sessa WC, (2011) Endothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. Blood 117: 2284-2295.
31. Yu J, Fernandez-Hernando C, Suarez Y, Schleicher M, Hao Z, et al. (2009) Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A 106: 17511-17516.
32. Wright PL, Yu J, Di YP, Homer RJ, Chupp G, et al. (2010) Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. J Exp Med 207: 2595-2607.
33. Schanda K, Hermann M, Stefanova N, Gredler V, Bandtlow C, et al. (2011) Nogo-B is associated with cytoskeletal structures in human monocyte-derived macrophages. BMC Res Notes 4: 6.
34. Miao RQ, Gao Y, Harrison KD, Prendergast J, Acevedo LM, et al. (2006) Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc Natl Acad Sci U S A 103: 10997-11002.
35. Voskuhl RR, Peterson RS, Song B, Ao Y, Morales LB, et al. (2009) Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci 29: 11511-11522.
36. Wang H, Munger KL, Reindl M, O'Reilly EJ, Levin LI, et al. (2008) Myelin oligodendrocyte glycoprotein antibodies and multiple sclerosis in healthy young adults. Neurology 71: 1142-1146.