Effects of four chemotherapeutic agents, bleomycin, etoposide, cisplatin, and cyclophosphamide, on DNA damage and telomeres in a mouse spermatogonial cell line

Biology of Reproduction

Volumn 90, Issue 4, 2014, Pages

  Liu, Mingxi ^a   Hales, Barbara F ^a   Robaire, Bernard ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Alkylating agents; Anticancer drugs; Cell culture; DNA double strand breaks; Fluorescence in situ hybridization; spermatogonia; Telomerase; Telomeres; Toxicology; H2AX

Indexed keywords

ALKYLATING AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; BLEOMYCIN; CISPLATIN; CYCLOPHOSPHAMIDE; ETOPOSIDE; HISTONE H2AX; IMMUNOSUPPRESSIVE AGENT; PERFOSFAMIDE; TELOMERASE; ANTINEOPLASTIC ANTIBIOTIC; MEMBRANE ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CELL LINE; CHROMOSOME; CONTROLLED STUDY; DNA DAMAGE; DRUG EXPOSURE; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC STABILITY; GERM LINE; IMMUNOFLUORESCENCE; MALE; MALE INFERTILITY; NONHUMAN; PRIORITY JOURNAL; PROGENY; SIGNAL TRANSDUCTION; SOMATIC CELL; SPERMATOGENESIS; SPERMATOGONIUM; TELOMERE; ANIMAL; CYTOLOGY; DOUBLE STRANDED DNA BREAK; DRUG EFFECTS; MOUSE; TOXICITY;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIGENS, SURFACE; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLEOMYCIN; CELL LINE; CISPLATIN; CYCLOPHOSPHAMIDE; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; ETOPOSIDE; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICE; SPERMATOGONIA; TELOMERE;

EID: 84903779445     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.114.117754     Document Type: Article

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