Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)- based scaffolds for tissue engineering

Brazilian Journal of Medical and Biological Research

Volumn 47, Issue 7, 2014, Pages 533-539

  Chang, H M ^a   Wang, Z H ^b   Luo, H N ^b   Xu, M ^b   Ren, X Y ^b   Zheng, G X ^b   Wu, B J ^b   Zhang, X H ^b   Lu, X Y ^b   Chen, F ^b   Jing, X H ^b   Wang, L ^b  

^a XI'AN MEDICAL UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Biomaterial; PHBHHx; Tissue engineering

Indexed keywords

AMPHOPHILE; ARGININE GLYCINE ASPARTATE TRIPEPTIDE; DRUG CARRIER; LONG ACTING INSULIN; NANOPARTICLE; POLY(3 HYDROXYBUTYRATE CO 3 HYDROXYHEXANOATE); POLYHYDROXYALKANOIC ACID; TISSUE SCAFFOLD; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; 3 HYDROXYBUTYRIC ACID; BIOMATERIAL; HEXANOIC ACID DERIVATIVE; POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYHEXANOATE);

BIOCOMPATIBILITY; BIODEGRADABILITY; DRUG DELIVERY SYSTEM; ELECTROSPINNING; EPITHELIZATION; EVAPORATION; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; LEACHING; NEURAL STEM CELL; PHASE SEPARATION; REVIEW; SCANNING ELECTRON MICROSCOPY; SURFACE MODIFICATION; SURFACE PROPERTY; TISSUE ENGINEERING; TISSUE REPAIR; ULTRAVIOLET RADIATION; BONE; CARTILAGE; CHEMISTRY; HUMAN; PHYSIOLOGY; PROCEDURES; REGENERATION; SMOOTH MUSCLE; TISSUE SCAFFOLD;

3-HYDROXYBUTYRIC ACID; BIOCOMPATIBLE MATERIALS; BONE AND BONES; CAPROATES; CARTILAGE; FREEZE DRYING; HUMANS; MUSCLE, SMOOTH; REGENERATION; SURFACE PROPERTIES; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84903766711     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20143930     Document Type: Review

References (58)

1. Wang YW, Yang F, Wu Q, Cheng YC, Yu PH, Chen J, et al. Effect of composition of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) on growth of fibroblast and osteoblast. Biomaterials 2005; 26: 755-761, doi: 10.1016/j.biomaterials. 2004.03.023.
2. Chen GQ, Wu Q, Wang YW, Zheng Z. Application of microbial polyesters-polyhydroxyalkanoates as tissue engineering materials. Key Engineering Materials 2005; 288-289: 437-440, doi: 10.4028/www.scientific.net/KEM. 288-289.437.
3. Qu XH, Wu Q, Zhang KY, Chen GQ. In vivo studies of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) based polymers: biodegradation and tissue reactions. Biomaterials 2006; 27: 3540-3548.
4. Yang HX, Sun M, Zhang Y, Zhou P. Degradable PHBHHx modified by the silk fibroin for the applications of cardiovascular tissue engineering. Materials Science 2011, doi: 10.5402/2011/ 389872.
5. You M, Peng G, Li J, Ma P, Wang Z, Shu W, et al. Chondrogenic differentiation of human bone marrow mesenchymal stem cells on polyhydroxyalkanoate (PHA) scaffolds coated with PHA granule binding protein PhaP fused with RGD peptide. Biomaterials 2011; 32: 2305-2313, doi: 10.1016/j.biomaterials.2010.12.009.
6. Wang Y, Gao R, Wang PP, Jian J, Jiang XL, Yan C, et al. The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPARgamma signaling. Biomaterials 2012; 33: 485-493, doi: 10.1016/j.biomaterials.2011.09.089.
7. Wang Y, Jiang XL, Peng SW, Guo XY, Shang GG, Chen JC, et al. Induced apoptosis of osteoblasts proliferating on polyhydroxyalkanoates. Biomaterials 2013; 34: 3737-3746, doi: 10.1016/j.biomaterials.2013.01.088.
8. Yu BY, Chen PY, Sun YM, Lee YT, Young TH. Response of human mesenchymal stem cells (hMSCs) to the topographic variation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) films. J Biomater Sci Polym Ed 2012; 23: 1-26, doi: 10.1163/092050610X541386.
9. Ye C, Hu P, Ma MX, Xiang Y, Liu RG, Shang XW. PHB/ PHBHHx scaffolds and human adipose-derived stem cells for cartilage tissue engineering. Biomaterials 2009; 30: 4401-4406, doi: 10.1016/j.biomaterials.2009.05.001.
10. Webb WR, Dale TP, Lomas AJ, Zeng G, Wimpenny I, El Haj AJ, et al. The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model. Biomaterials 2013; 34: 6683-6694, doi: 10.1016/ j.biomaterials.2013.05.041.
11. Bryant SJ, Anseth KS. Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J Biomed Mater Res A 2003; 64: 70-79, doi: 10.1002/jbm.a.10319.
12. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000; 21: 2529-2543, doi: 10.1016/ S0142-9612(00)00121-6.
13. Hollister SJ. Porous scaffold design for tissue engineering. Nat Mater 2005; 4: 518-524, doi: 10.1038/nmat1421.
14. Zhong T, Deng C, Gao Y, Chen M, Zuo B. Studies of in situforming hydrogels by blending PLA-PEG-PLA copolymer with silk fibroin solution. J Biomed Mater Res A 2012; 100: 1983-1989, doi: 10.1002/jbm.a.33307.
15. Jeong CG, Hollister SJ. A comparison of the influence of material on in vitro cartilage tissue engineering with PCL, PGS, and POC 3D scaffold architecture seeded with chondrocytes. Biomaterials 2010; 31: 4304-4312, doi: 10.1016/j.biomaterials.2010.01.145.
16. Jin R, Moreira Teixeira LS, Dijkstra PJ, Karperien M, van Blitterswijk CA, Zhong ZY, et al. Injectable chitosan-based hydrogels for cartilage tissue engineering. Biomaterials 2009; 30: 2544-2551, doi: 10.1016/j.biomaterials.2009.01.020.
17. Wang CC, Yang KC, Lin KH, Liu HC, Lin FH. A highly organized three-dimensional alginate scaffold for cartilage tissue engineering prepared by microfluidic technology. Biomaterials 2011; 32: 7118-7126, doi: 10.1016/j.biomaterials.2011.06.018.
18. Talukdar S, Nguyen QT, Chen AC, Sah RL, Kundu SC. Effect of initial cell seeding density on 3D-engineered silk fibroin scaffolds for articular cartilage tissue engineering. Biomaterials 2011; 32: 8927-8937, doi: 10.1016/j.biomaterials.2011.08.027.
19. Zheng Z, Bei FF, Tian HL, Chen GQ. Effects of crystallization of polyhydroxyalkanoate blend on surface physicochemical properties and interactions with rabbit articular cartilage chondrocytes. Biomaterials 2005; 26: 3537-3548, doi: 10.1016/j.biomaterials.2004.09.041.
20. Pereira TF, Silva MAC, Oliveira MF, Maia IA, Silva JVL, Costa MF, et al. Effect of process parameters on the properties of selective laser sintered Poly(3-hydroxybutyrate) scaffolds for bone tissue engineering. Virtual Phys Prototyp 2012; 7: 275-285, doi: 10.1080/17452759.2012.738551.
21. Martin DP, Peoples OP, Williams SE, Zhong LH. Nutritional and therapeutic uses of 3-hydroxyalkanoate oligomers. US Patent Appl 359086. 1999.
22. Chen W, Tong YW. PHBV microspheres as neural tissue engineering scaffold support neuronal cell growth and axondendrite polarization. Acta Biomater 2012; 8: 540-548, doi: 10.1016/j.actbio.2011.09.026.
23. Yang X, Zhao K, Chen GQ. Effect of surface treatment on the biocompatibility of microbial polyhydroxyalkanoates. Biomaterials 2002; 23: 1391-1397, doi: 10.1016/S0142-96 12(01)00260-5.
24. Zhao K, Deng Y, Chun CJ, Chen GQ. Polyhydroxyalkanoate (PHA) scaffolds with good mechanical properties and biocompatibility. Biomaterials 2003; 24: 1041-1045, doi: 10.1016/S0142-9612(02)00426-X.
25. Weng YX, Wang XL, Wang YZ. Biodegradation behavior of PHAs with different chemical structures under controlled composting conditions. Polymer Testing 2011; 30: 372-380, doi: 10.1016/j.polymertesting.2011.02.001.
26. Shishatskaya EI, Volova TG. A comparative investigation of biodegradable polyhydroxyalkanoate films as matrices for in vitro cell cultures. J Mater Sci Mater Med 2004; 15: 915-923, doi: 10.1023/B:JMSM.0000036280.98763.c1.
27. Unverdorben M, Spielberger A, Schywalsky M, Labahn D, Hartwig S, Schneider M, et al. A polyhydroxybutyrate biodegradable stent: preliminary experience in the rabbit. Cardiovasc Intervent Radiol 2002; 25: 127-132, doi: 10.1007/s00270-001-0118-3.
28. Tezcaner A, Bugra K, Hasirci V. Retinal pigment epithelium cell culture on surface modified poly(hydroxybutyrate-cohydroxyvalerate) thin films. Biomaterials 2003; 24: 4573-4583, doi: 10.1016/S0142-9612(03)00302-8.
29. Kose GT, Ber S, Korkusuz F, Hasirci V. Poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) based tissue engineering matrices. J Mater Sci Mater Med 2003; 14: 121-126, doi: 10.1023/A:1022063628099.
30. Zhou J, Peng SW, Wang YY, Zheng SB, Wang Y, Chen GQ. The use of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tarsal repair in eyelid reconstruction in the rat. Biomaterials 2010; 31: 7512-7518, doi: 10.1016/ j.biomaterials.2010.06.044.
31. Dong Y, Li P, Chen CB, Wang ZH, Ma P, Chen GQ. The improvement of fibroblast growth on hydrophobic biopolyesters by coating with polyhydroxyalkanoate granule binding protein PhaP fused with cell adhesion motif RGD. Biomaterials 2010; 31: 8921-8930, doi: 10.1016/j.biomaterials.2010.08.001.
32. Wang YW, Wu Q, Chen GQ. Attachment, proliferation and differentiation of osteoblasts on random biopolyester poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds. Biomaterials 2004; 25: 669-675, doi: 10.1016/S0142-9612(03)00561-1.
33. Wang L, Wang ZH, Shen CY, You ML, Xiao JF, Chen GQ. Differentiation of human bone marrow mesenchymal stem cells grown in terpolyesters of 3-hydroxyalkanoates scaffolds into nerve cells. Biomaterials 2010; 31: 1691-1698, doi: 10.1016/j.biomaterials.2009.11.053.
34. Yu BY, Chen PY, Sun YT, Lee YT, Young TH. The behaviors of human mesenchymal stem cells on the poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) membranes. Desalination 2008; 234: 204-211, doi: 10.1016/ j.desal.2007.09.087.
35. Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 2001; 344: 710-719, doi: 10.1056/NEJM200103083441002.
36. Khang G, Kim SW, Cho JC, Rhee JM, Yoon SC, Lee HB. Preparation and characterization of poly(3-hydroxybutyrateco-3-hydroxyvalerate)microspheres for the sustained release of 5-fluorouracil. Biomed Mater Eng 2001; 11: 89-103.
37. Peng Q, Sun X, Gong T, Wu CY, Zhang T, Tan J, et al. Injectable and biodegradable thermosensitive hydrogels loaded with PHBHHx nanoparticles for the sustained and controlled release of insulin. Acta Biomater 2013; 9: 5063-5069, doi: 10.1016/j.actbio.2012.09.034.
38. Shangguan YY, Wang YW, Wu Q, Chen GQ. The mechanical properties and in vitro biodegradation and biocompatibility of UV-treated poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). Biomaterials 2006; 27: 2349-2357, doi: 10.1016/j.biomaterials.2005.11.024.
39. Qu XH, Wu Q, Liang J, Zou B, Chen GQ. Effect of 3-hydroxyhexanoate content in poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) on in vitro growth and differentiation of smooth muscle cells. Biomaterials 2006; 27: 2944-2950, doi: 10.1016/j.biomaterials.2006.01.013.
40. Li XT, Sun J, Chen S, Chen GQ. In vitro investigation of maleated poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for its biocompatibility to mouse fibroblast L929 and human microvascular endothelial cells. J Biomed Mater Res A 2008; 87: 832-842, doi: 10.1002/jbm.a.31890.
41. Li J, Yun H, Gong Y, Zhao N, Zhang X. Effects of surface modification of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) on physicochemical properties and on interactions with MC3T3-E1 cells. J Biomed Mater Res A 2005; 75: 985-998, doi: 10.1002/jbm.a.30504.
42. Lu XY, Wang LL, Yang ZQ, Lu HX. Strategies of polyhydroxyalkanoates modification for the medical application in neural regeneration/nerve tissue engineering. Adv Biosci Biotechnol 2013; 4: 731-740, doi: 10.4236/abb.2013.46097.
43. Mei N, Zhou P, Pan LF, Chen G, Wu CG, Chen X, et al. Biocompatibility of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) modified by silk fibroin. J Mater Sci Mater Med 2006; 17: 749-758, doi: 10.1007/s10856-006-9686-8.
44. Potter M, Steinbuchel A. Poly(3-hydroxybutyrate) granuleassociated proteins: impacts on poly(3-hydroxybutyrate) synthesis and degradation. Biomacromolecules 2005; 6: 552-560, doi: 10.1021/bm049401n.
45. Lee DE, Hong YD, Choi KH, Lee SY, Park PH, Choi SJ. Preparation and evaluation of 99mTc-labeled cyclic arginine-glycine-aspartate (RGD) peptide for integrin targeting. Appl Radiat Isot 2010; 68: 1896-1902, doi: 10.1016/ j.apradiso.2010.04.029.
46. Xu XY, Li XT, Peng SW, Xiao JF, Liu C, Fang G, et al. The behaviour of neural stem cells on polyhydroxyalkanoate nanofiber scaffolds. Biomaterials 2010; 31: 3967-3975, doi: 10.1016/j.biomaterials.2010.01.132.
47. Lomas AJ, Webb WR, Han J, Chen GQ, Sun X, Zhang Z, et al. Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)/collagen hybrid scaffolds for tissue engineering applications. Tissue Eng Part C Methods 2013; 19: 577-585, doi: 10.1089/ten.tec.2012.0457.
48. Wang YW, Wu Q, Chen GQ. Reduced mouse fibroblast cell growth by increased hydrophilicity of microbial polyhydroxyalkanoates via hyaluronan coating. Biomaterials 2003; 24: 4621-4629, doi: 10.1016/S0142-9612(03)00356-9.
49. Collins MN, Birkinshaw C. Hyaluronic acid based scaffolds for tissue engineering-a review. Carbohydr Polym 2013; 92: 1262-1279, doi: 10.1016/j.carbpol.2012.10.028.
50. Li XT, Zhang Y, Chen GQ. Nanofibrous polyhydroxyalkanoate matrices as cell growth supporting materials. Biomaterials 2008; 29: 3720-3728, doi: 10.1016/j.biomaterials.2008.06.004.
51. Sun M, Zhou P, Pan LF, Liu S, Yang HX. Enhanced cell affinity of the silk fibroin-modified PHBHHx material. J Mater Sci Mater Med 2009; 20: 1743-1751, doi: 10.1007/s10856-009-3739-8.
52. Wang Y, Bian YZ, Wu Q, Chen GQ. Evaluation of threedimensional scaffolds prepared from poly(3-hydroxybutyrateco-3-hydroxyhexanoate) for growth of allogeneic chondrocytes for cartilage repair in rabbits. Biomaterials 2008; 29: 2858-2868, doi: 10.1016/j.biomaterials.2008.03.021.
53. Deng Y, Zhao K, Zhang XF, Hu P, Chen GQ. Study on the three-dimensional proliferation of rabbit articular cartilagederived chondrocytes on polyhydroxyalkanoate scaffolds. Biomaterials 2002; 23: 4049-4056, doi: 10.1016/S0142-9612(02)00136-9.
54. Zhao K, Deng Y, Chen G-Q. Effects of surface morphology on the biocompatibility of polyhydroxyalkanoates. Biochem Eng J 2014; 16: 115-123.
55. Bian YZ, Wang Y, Aibaidoula G, Chen GQ, Wu Q. Evaluation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) conduits for peripheral nerve regeneration. Biomaterials 2009; 30: 217-225, doi: 10.1016/j.biomaterials.2008.09.0 36.
56. Qu XH, Wu Q, Liang J, Qu X, Wang SG, Chen GQ. Enhanced vascular-related cellular affinity on surface modified copolyesters of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx). Biomaterials 2005; 26: 6991-7001, doi: 10.1016/j.biomaterials.2005.05.034.
57. Lu XY, Zhang Y, Wang L. Preparation and in vitro drug-release behavior of 5-fluorouracil-loaded poly(hydroxybutyrate-cohydroxyhexanoate) nanoparticles and microparticles. J Appl Polym Sci 2010; 116: 2944-2950.
58. Peng Q, Zhang ZR, Gong T, Chen GQ, Sun X. A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles. Biomaterials 2012; 33: 1583-1588, doi: 10.1016/j.biomaterials.2011.10.072.