Synaptophysin and the dopaminergic system in hippocampus are involved in the protective effect of rutin against trimethyltin-induced learning and memory impairment

Nutritional Neuroscience

Volumn 17, Issue 5, 2014, Pages 222-229

  Zhang, Lei ^a   Zhao, Qi ^b   Chen, Chun Hai ^a   Qin, Qi Zhong ^b   Zhou, Zhou ^a   Yu, Zheng Ping ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Dopaminergic system; Rutin; Spatial memory; Synaptophysin; Trimethyltin

Indexed keywords

DIHYROXY PHENYLACETIC ACID; DOPAMINE; HOMOVANILLIC ACID; NEUROMODULIN; PHENYLACETIC ACID DERIVATIVE; RUTOSIDE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; PROTECTIVE AGENT; TRIMETHYLTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOPAMINERGIC SYSTEM; ELECTROCHEMICAL DETECTION; HIPPOCAMPUS; LATENT PERIOD; LEARNING DISORDER; MALE; MEMORY DISORDER; METABOLITE; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; LEARNING; MAZE TEST; MEMORY; MEMORY DISORDERS; METABOLISM; TOXICITY;

ANIMALS; DOPAMINE; GAP-43 PROTEIN; HIPPOCAMPUS; LEARNING; MALE; MAZE LEARNING; MEMORY; MEMORY DISORDERS; MICE; MICE, INBRED BALB C; PROTECTIVE AGENTS; RUTIN; SYNAPTOPHYSIN; TRIMETHYLTIN COMPOUNDS;

EID: 84903756631     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830513Y.0000000085     Document Type: Article

References (47)

1. Koda T, Kuroda Y, Imai H. Protective effect of rutin against spatial memory impairment induced by trimethyltin in rats. Nutr Res 2008;28:629-634.
2. Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 2001;56: 683-687.
3. Kim GN, Jang HD. Protective mechanism of quercetin and rutin using glutathione metabolism on HO-induced oxidative stress in HepG2 cells. Ann N Y Acad Sci 2009;1171:530-537.
4. 2+ ions: implications for their antioxidant properties. Biochem J 1998;330:1173-1178.
5. Tournaire C, Croux S, Maurette MT, Beck I, Hocquaux M, Braun AM, et al. Antioxidant activity of flavonoids: efficiency of singlet oxygen (1 delta g) quenching. J Photochem Photobiol B 1993;19:205-215.
6. Kamalakkannan N, Prince PSM. Rutin improves the antioxi-dant status in streptozotocin-induced diabetic rat tissues. Mol Cell Biochem 2006;293:211-219.
7. Khan MM, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan MB, et al. Rutin protects the neural damage induced by transient focal ischemia in rat. Brain Res 2009;1292:123-135.
8. La Casa C, Villegas I, Alarcon de la Lastra C, Motilva V, Martin Calero MJ. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 2000;71:45-53.
9. Koda T, Kuroda Y, Imai H. Rutin supplementation in the diet has protective effects against toxicant-induced hippocampal injury by suppression of microglial activation and pro-inflammatorycytokines: protective effect of rutin against toxicant-induced hippocampal injury. Cell Mol Neurobiol 2009;29:523-531.
10. Brown AW, Aldridge WN, Street BW, Verschoyle RD. The behavioral and neuropathologic sequelae of intoxication by trimethyltin compounds in the rat. Am J Pathol 1979;97:59-82.
11. Ogita K, Nishiyama N, Sugiyama C, Higuchi K, Yoneyama M, Yoneda Y. Regeneration of granule neurons after lesioning of hippocampal dentate gyrus: evaluation using adult mice treated with trimethyltin chloride as a model. J Neurosci Res 2005;82:609-621.
12. Geloso MC, Corvino V, Michetti F. Trimethyltin-induced hippo-campal degeneration as a tool to investigate neurodegenerative processes. Neurochem Int 2011;58:729-738.
13. Chen YC, Chen QS, Lei JL, Wang SL. Physical training modifies the age-related decrease of GAP-43 and synaptophysin in the hippocampal formation in C57BL/6J mouse. Brain Res 1998; 806:238-245.
14. Birch AM, McGarry NB, Kelly ÁM. Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner. Hippocampus 2013;23:437-450.
15. Klusa V, Muceniece R, Isajevs S, Isajeva D, Beitnere U, Mandrika I, et al. Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats. Pharmacol Biochem Behav 2013;106C:68-76.
16. Reddy PH, Mani G, Park BS, Jacques J, Murdoch G, Whetsell W, Jr., et al. Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction. J Alzheimers Dis 2005;7:103-117.
17. Vitiello B, Martin A, Hill J, Mack C, Molchan S, Martinez R, et al. Cognitive and behavioral effects of cholinergic, dopamin-ergic, and serotonergic blockade in humans. Neuropsychopharmacology 1997;16:15-24.
18. O'Carroll CM, Martin SJ, Sandin J, Frenguelli B, Morris RG. Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory. Learn Mem 2006;13:760-769.
19. Chowdhury R, Guitart-Masip M, Bunzeck N, Dolan RJ, Düzel E. Dopamine modulates episodic memory persistence in old age. J Neurosci 2012;32:14193-204.
20. Janbaz KH, Saeed SA, Gilani AH. Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents. Fitoterapia 2002;73:557-563.
21. Savov VM, Galabov AS, Tantcheva LP, Mileva MM, Pavlova EL, Stoeva ES, et al. Effects of rutin and quercetin on monooxy-genase activities in experimental influenza virus infection. Exp Toxicol Pathol 2006;58:59-64.
22. Domitrović R, Jakovac H, Vasiljev E, Marchesi V, Vladimir-Knežević S, Cvijanović O, Tadić Z, et al. Differential hepatopro-tective mechanisms of rutin and quercetin in CCl(4)-intoxicated BALB/cN mice. Acta Pharmacol Sin 2012;33:1260-1270.
23. Halladay AK, Wilson DT, Wagner GC, Reuhl KR. Trimethyltin-induced alterations in behavior are linked to changes in PSA-NCAM expression. Neurotoxicology 2006;27: 137-146.
24. Earley B, Burke M, Leonard BE. Behavioural, biochemical and histological effects of trimethyltin (TMT) induced brain damage in the rat. Neurochem Int 1992;21:351-366.
25. Chang LW, Wenger GR, McMillan DE, Dyer RS. Species and strain comparison of acute neurotoxic effects of trimethyltin intoxication. Neurobehav Toxicol Teratol 1983;5:443-459.
26. Whittington DL, Woodruff ML, Baisden RH. The time-course of trimethyltin-induced fiber and terminal degeneration in hippocampus. Neurotoxicol Teratol 1989;11:21-33.
27. Schmitt U, Tanimoto N, Seeliger M, Schaeffel F, Leube RE. Detection of behavioral alterations and learning deficits in mice lacking synaptophysin. Neuroscience 2009;162:234-243.
28. Tampellini D, Capetillo-Zarate E, Dumont M, Huang Z, Yu F, Lin MT, et al. Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice. J Neurosci 2010;30:14299-14304.
29. Little AR, Miller DB, Li S, Kashon ML, O'Callaghan JP. Trimethyltin-induced neurotoxicity: gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis. Neurotoxicol Teratol 2012;34:72-82.
30. Bomze HM, Bulsara KR, Iskandar BJ, Caroni P, Skene JH. Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons. Nat Neurosci 2001;4:38-43.
31. Monnet-Tschudi F, Zurich MG, Pithon E, van Melle G, Honegger P. Microglial responsiveness as a sensitive marker for trimethyltin (TMT) neurotoxicity. Brain Res 1995;690:8-14.
32. Dent MF, Neill DB. Dose-dependent effects of prefrontal dopa-mine on behavioral state in rats. Behav Neurosci 2012;126: 620-639.
33. Andersson H, Luthman J, Lindgvist E, Olson L. Time-course of trimethyltin effects on the monoaminergic systems of the rat brain. Neurotoxicology 1995;16:201-210.
34. DeHaven DL, Krigman MR, Mailman RB. Temporal changes in dopaminergic and serotonergic function caused by administration of trimethyltin to adult rats. Neurobehav Toxicol Teratol 1986;8:475-479.
35. Ali SF, Slikker W, Jr, Newport GD, Goad PT. Cholinergic and dopaminergic alterations in the mouse central nervous system following acute trimethyltin exposure. Acta Pharmacol Toxicol 1986;59:179-188.
36. Cools R, Barker RA, Sahakian BJ, Robbins TW. Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands. Cereb Cortex 2001;11:1136-1143.
37. Valtorta F, Pennuto M, Bonanomi D, Benfenati F. Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis? BioEssays 2004;26:445-453.
38. Shibaguchi H, Takemura K, Kan S, Kataoka Y, Kaibara M, Saito N, et al. Role of synaptophysin in exocytotic release of dopamine from Xenopus oocytes injected with rat brain mRNA. Cell Mol Neurobiol 2000;20:401-408.
39. Mignini F, Nasuti C, Artico M, Giovannetti F, Fabrizi C, Fumagalli L, et al. Effects of trimethyltin on hippocampal dopa-minergic markers and cognitive behaviour. Int J Immunopathol Pharmocol 2012;25:1107-1119.
40. Pu F, Mishima K, Irie K, Motohashi K, Tanaka Y, Orito K, et al. Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats. J Pharmacol Sci 2007;104:329-334.
41. Jenkins SM, Barone S. The neurotoxicant trimethyltin induces apoptosis via caspase activation, p38 protein kinase, and oxi-dative stress in PC12 cells. Toxicol Lett 2004;147:63-72.
42. Shuto M, Higuchi K, Sugiyama C, Yoneyama M, Kuramoto N, Nagashima R, et al. Endogenous and exogenous glucocorticoids prevent trimethyltin from causing neuronal degeneration of the mouse brain in vivo: involvement of oxidative stress pathways. J Pharmocol Sci 2009;110:424-436.
43. Yoneyama M, Nishiyama N, Shuto N, Sugiyama C, Kawada K, Seko K, et al. In vivo depletion of endogenous glutathione facilitates trimethyltin-induced neuronal damage in the dentate gyrus of mice by enhancing oxidative stress. Neurochem Int 2008;52: 761-769.
44. Kerry N, Rice-Evans C. Inhibition of peroxynitrite-mediated oxidation of dopamine by flavonoid and phenolic antioxidants and their structural relationship. J Neurochem 1999;73:247-253.
45. Nones J, Costa AP, Leal RB, Gomes FC, Trentin AG. The fla-vonoids hesperidin and rutin promote neural crest survival. Cell Tissue Res 2012;350:305-315.
46. Pyrzanowska J, Piechal A, Blecharz-Klin K, Joniec-Maciejak I, Zobel A, Widy-Tyszkiewicz E. Influence of long-term administration of rutin on spatial memory as well as concentration of brain neurotransmitters in aged rats. Pharmacol Rep 2012;64: 808-816.
47. Khan MM, Raza SS, Javed H, Ahmad A, Khan A, Islam F, et al. Rutin protects dopaminergic neurons from oxidative stress in an animal model of Parkinson's disease. Neurotox Res 2012;22:1-15.