Reaction mechanism of adenylyltransferase DrrA from Legionella pneumophila elucidated by time-resolved fourier transform infrared spectroscopy

Journal of the American Chemical Society

Volumn 136, Issue 26, 2014, Pages 9338-9345

  Gavriljuk, Konstantin ^a   Schartner, Jonas ^a   Itzen, Aymelt ^b   Goody, Roger S ^c   Gerwert, Klaus ^a   Kötting, Carsten ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b Munich Center for Integrated Protein Science   (Germany)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; PROTEINS;

ADENYLYLTRANSFERASE; CATALYTIC MECHANISMS; GLUTAMINE SYNTHETASE; LEGIONELLA PNEUMOPHILA; SITE DIRECTED MUTAGENESIS; TIME-RESOLVED FOURIER TRANSFORM INFRARED SPECTROSCOPIES; TRANSIENT COMPLEXES; VESICULAR TRAFFICKING;

FOURIER TRANSFORM INFRARED SPECTROSCOPY;

ADENOSINE TRIPHOSPHATE; NUCLEOTIDYLTRANSFERASE; PHOSPHATE; TYROSINE; ADENOSINE PHOSPHATE; BACTERIAL PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAB PROTEIN; RAB1B PROTEIN, HUMAN; SIDM PROTEIN, LEGIONELLA PNEUMOPHILA;

ADENYLATION; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; INFRARED SPECTROSCOPY; LEGIONELLA PNEUMOPHILA; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOPHILICITY; PHOTOLYSIS; REACTION ANALYSIS; SITE DIRECTED MUTAGENESIS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; KINETICS; METABOLISM; PROTEIN CONFORMATION;

ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHATES; PROTEIN CONFORMATION; RAB1 GTP-BINDING PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TYROSINE;

EID: 84903749830     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja501496d     Document Type: Article

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