Structure of the disordered C terminus of Rab7 GTPase induced by binding to the rab geranylgeranyl transferase catalytic complex reveals the mechanism of rab prenylation

Journal of Biological Chemistry

Volumn 284, Issue 19, 2009, Pages 13185-13192

  Wu, Yao Wen ^a   Goody, Roger S ^a   Abagyan, Ruben ^b   Alexandrov, Kirill ^c  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOCHEMICAL EXPERIMENTS; C TERMINUS; CATALYTIC COMPLEXES; COMPLEX STRUCTURE; COMPOSITE MODELS; COMPUTATIONAL APPROACH; COMPUTATIONAL MODEL; DOCKING SOLUTIONS; DUAL ROLE; ENERGY CONFORMATION; FLEXIBLE PARTS; GRID POTENTIALS; HIGH-RESOLUTION STRUCTURES; HYDROPHOBIC SEQUENCES; INDIVIDUAL PROTEINS; INTERNAL COORDINATES; MOBILE PARTS; PRENYLATION; PROTEIN PRENYLATION; REALISTIC MODELING; SELECTION OF THE BEST; SPECIFIC INTERACTION; TARGET PROTEINS; TERMINAL CYSTEINE; TERNARY COMPLEX;

AMINES; AMINO ACIDS; BINDING ENERGY; ENZYMES; FLEXIBLE STRUCTURES; MODEL STRUCTURES; ORGANIC ACIDS; SUBSTRATES;

BINDING SITES;

GERANYLTRANSFERASE; GUANOSINE TRIPHOSPHATASE; RAB7 PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PRENYLATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; CALORIMETRY; CATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; DITERPENES; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PRENYLATION; RAB GTP-BINDING PROTEINS; RATS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 67649690942     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900579200     Document Type: Article

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